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Mainstreaming Wastewater Surveillance for Infectious Disease
Michelle M. Mello, J.D., Ph.D., John S. Meschke, J.D., Ph.D., and Guy H. Palmer, D.V.M., Ph.D.
doi : 10.1056/NEJMp2301042
Vol. 388 No. 16
The Dobbs Decision — Exacerbating U.S. Health Inequity
S. Marie Harvey, Dr.P.H., Annie E. Larson, Ph.D., M.P.H., and Jocelyn T. Warren, Ph.D., M.P.H.
doi : 10.1056/NEJMp2216698
Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants
Beate Kampmann, M.D., Ph.D., Shabir A. Madhi, M.B., B.Ch., Ph.D., Iona Munjal, M.D., Eric A.F. Simões, M.D., Barbara A. Pahud, M.D., M.P.H., Conrado Llapur, M.D., Jeffrey Baker, M.D., Gonzalo Pérez Marc, M.D., David Radley, M.S., Emma Shittu, Ph.D., Julia Glanternik, M.D., Hasra Snaggs, M.D., James Baber, M.B., Ch.B., M.P.H., Philip Zachariah, M.D., Shaun L. Barnabas, M.B., Ch.B., Ph.D., Merlin Fausett, M.D., Tyler Adam, M.D., Nicole Perreras, M.D., Marlies A. Van Houten, M.D., Ph.D., Anu Kantele, M.D., Ph.D., Li-Min Huang, M.D., Ph.D., Louis J. Bont, M.D., Ph.D., Takeo Otsuki, M.D., Ph.D., Sergio L. Vargas, M.D., Joanna Gullam, M.B., Ch.B., M.D., Bruce Tapiero, M.D., Renato T. Stein, M.D., Fernando P. Polack, M.D., Heather J. Zar, M.B., B.Ch., Ph.D., Nina B. Staerke, M.D., Ph.D., MarÃa Duron Padilla, M.D., Peter C. Richmond, M.B., B.S., Kenneth Koury, Ph.D., Katherine Schneider, Ph.D., Elena V. Kalinina, Ph.D., David Cooper, Ph.D., Kathrin U. Jansen, Ph.D., Annaliesa S. Anderson, Ph.D., Kena A. Swanson, Ph.D., William C. Gruber, M.D., and Alejandra Gurtman, M.D. for the MATISSE Study Group*
doi : 10.1056/NEJMoa2216480
Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)–associated lower respiratory tract illness in newborns and infants is uncertain.
Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults
Edward E. Walsh, M.D., Gonzalo Pérez Marc, M.D., Agnieszka M. Zareba, M.D., Ph.D., Ann R. Falsey, M.D., Qin Jiang, M.S., Michael Patton, B.Sc., Fernando P. Polack, M.D., Conrado Llapur, M.D., Pablo A. Doreski, M.D., Kumar Ilangovan, M.D., Mika Rämet, M.D., Ph.D., Yasushi Fukushima, M.D., Ph.D., Nazreen Hussen, M.D., Louis J. Bont, M.D., Ph.D., Jose Cardona, M.D., Elliot DeHaan, M.D., Giselle Castillo Villa, M.D., Ph.D., Marinela Ingilizova, M.D., Daniel Eiras, M.D., M.P.H., Tarek Mikati, M.D., M.P.H., Rupal N. Shah, B.Sc., Katherine Schneider, Ph.D., David Cooper, Ph.D., Kenneth Koury, Ph.D., Maria-Maddalena Lino, M.D., Ph.D., Annaliesa S. Anderson, Ph.D., Kathrin U. Jansen, Ph.D., Kena A. Swanson, Ph.D., Alejandra Gurtman, M.D., William C. Gruber, M.D., and Beate Schmoele-Thoma, M.D. for the RENOIR Clinical Trial Group*
doi : 10.1056/NEJMoa2213836
Respiratory syncytial virus (RSV) infection causes considerable illness in older adults. The efficacy and safety of an investigational bivalent RSV prefusion F protein–based (RSVpreF) vaccine in this population are unknown.
Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
Marius M. Hoeper, M.D., David B. Badesch, M.D., H. Ardeschir Ghofrani, M.D., J. Simon R. Gibbs, M.D., Mardi Gomberg-Maitland, M.D., Vallerie V. McLaughlin, M.D., Ioana R. Preston, M.D., Rogerio Souza, M.D., Ph.D., Aaron B. Waxman, M.D., Ph.D., Ekkehard Grünig, M.D., Grzegorz Kopeć, M.D., Ph.D., Gisela Meyer, M.D., Karen M. Olsson, M.D., Stephan Rosenkranz, M.D., Yayun Xu, Ph.D., Barry Miller, M.S., Marcie Fowler, Ph.D., John Butler, M.D., Joerg Koglin, M.D., Ph.D., Janethe de Oliveira Pena, M.D., Ph.D., and Marc Humbert, M.D., Ph.D. for the STELLAR Trial Investigators*
doi : 10.1056/NEJMoa2213558
Burden of Typhoid and Paratyphoid Fever in India
Jacob John, M.D., Ph.D., Ashish Bavdekar, D.N.B., Temsunaro Rongsen-Chandola, Ph.D., Shanta Dutta, M.D., Ph.D., Madhu Gupta, M.D., Ph.D., Suman Kanungo, Ph.D., Bireshwar Sinha, M.D., Manikandan Srinivasan, M.D., Ankita Shrivastava, M.P.H., Adarsh Bansal, M.P.H., Ashita Singh, M.D., Roshine M. Koshy, M.D., Dasharatha R. Jinka, M.D., Mathew S. Thomas, M.D., Anna P. Alexander, M.D., Shajin Thankaraj, M.D., Sheena E. Ebenezer, M.D., Arun S. Karthikeyan, Ph.D., Dilesh Kumar, M.P.H., Swathi K. Njarekkattuvalappil, M.D., Reshma Raju, M.D., M.P.H., Nikhil Sahai, B.Tech., Balaji Veeraraghavan, M.D., Ph.D., Manoj V. Murhekar, M.D., Venkata R. Mohan, M.D., Sindhu K. Natarajan, M.D., Ph.D., Karthikeyan Ramanujam, Ph.D., Prasanna Samuel, Ph.D., Nathan C. Lo, M.D., Ph.D., Jason Andrews, M.D., Nicholas C. Grassly, D.Phil., and Gagandeep Kang, M.D., Ph.D. for the NSSEFI Study Team*
doi : 10.1056/NEJMoa2209449
In 2017, more than half the cases of typhoid fever worldwide were projected to have occurred in India. In the absence of contemporary population-based data, it is unclear whether declining trends of hospitalization for typhoid in India reflect increased antibiotic treatment or a true reduction in infection.
Cerebral Oximetry Monitoring in Extremely Preterm Infants
Mathias L. Hansen, M.D., Ph.D., Adelina Pellicer, M.D., Ph.D., Simon Hyttel-Sørensen, M.D., Ph.D., Ebru Ergenekon, M.D., Ph.D., Tomasz Szczapa, M.D., Ph.D., Cornelia Hagmann, M.D., Ph.D., Gunnar Naulaers, M.D., Ph.D., Jonathan Mintzer, M.D., Monica Fumagalli, M.D., Ph.D., Gabriel Dimitriou, M.D., Ph.D., Eugene Dempsey, M.D., Ph.D., Jakub Tkaczyk, M.D., Guoqiang Cheng, M.D., Siv Fredly, M.D., Ph.D., Anne M. Heuchan, M.D., Gerhard Pichler, M.D., Hans Fuchs, M.D., D.M.Sc., Saudamini Nesargi, D.N.B.,
doi : 10.1056/NEJMoa2207554
The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking.
Desquamative Interstitial Pneumonia
Mohammed Al-Halawani, M.D., and Rachel K. Stevens, M.D.
doi : 10.1056/NEJMicm2211399
Incidental Neuroblastoma
Qiong Yao, M.D., Ph.D., and Xi-hong Hu, M.D., Ph.D.
doi : 10.1056/NEJMicm2209267
Case 12-2023: A 44-Year-Old Woman with Muscle Weakness and Myalgia
Marcy B. Bolster, M.D., Alexis M. Cahalane, M.B., B.Ch., B.A.O., Steven K. Grinspoon, M.D., and Eli M. Miloslavsky, M.D.
doi : 10.1056/NEJMcpc2211375
RSV Illness in the Young and the Old — The Beginning of the End?
Ruth A. Karron, M.D.
doi : 10.1056/NEJMe2302646
Continued Progress in Therapy for Pulmonary Arterial Hypertension
Darren B. Taichman, M.D., Ph.D., Jane A. Leopold, M.D., and Greg Elliott, M.D.
doi : 10.1056/NEJMe2300324
Immune Checkpoint Inhibitors — The Need for Innovation
P. Connor Johnson, M.D., Justin F. Gainor, M.D., Ryan J. Sullivan, M.D., Dan L. Longo, M.D., and Bruce Chabner, M.D.
doi : 10.1056/NEJMsb2300232
