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Courts’ Disregard for Women’s Health and Safety — Intimate Partner Violence, Firearms, and “History and Tradition�
Elizabeth Tobin-Tyler, J.D.
doi : 10.1056/NEJMp2301620
Vol. 388 No. 15
Improving Care Integration for Dually Eligible Beneficiaries
David C. Grabowski, Ph.D.
doi : 10.1056/NEJMp2215502
Treating Chronic Pain in Sickle Cell Disease — The Need for a Biopsychosocial Model
Janet E. Childerhose, Ph.D., Robert M. Cronin, M.D., Maryanna D. Klatt, Ph.D., and Andrew Schamess, M.D.
doi : 10.1056/NEJMp2301143
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
Steven E. Nissen, M.D., A. Michael Lincoff, M.D., Danielle Brennan, M.S., Kausik K. Ray, M.D., Denise Mason, B.S.N., John J.P. Kastelein, M.D., Paul D. Thompson, M.D., Peter Libby, M.D., Leslie Cho, M.D., Jorge Plutzky, M.D., Harold E. Bays, M.D., Patrick M. Moriarty, M.D., Venu Menon, M.D., Diederick E. Grobbee, M.D., Ph.D., Michael J. Louie, M.D., M.P.H., Chien-Feng Chen, Ph.D., Na Li, Ph.D., LeAnne Bloedon, M.S., Paula Robinson, M.S., Maggie Horner, M.B.A., William J. Sasiela, Ph.D., Jackie McCluskey, R.N., Deborah Davey, R.N., Pedro Fajardo-Campos, M.D., Predrag Petrovic, M.D., Jan Fedacko, M.D., Ph.D., Witold Zmuda, M.D., Ph.D., Yury Lukyanov, M.D., and Stephen J. Nicholls, M.B., B.S., Ph.D. for the CLEAR Outcomes Investigators*
doi : 10.1056/NEJMoa2215024
Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain.
Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery
Luis D. Pacheco, M.D., Rebecca G. Clifton, Ph.D., George R. Saade, M.D., Steven J. Weiner, M.S., Samuel Parry, M.D., John M. Thorp, Jr., M.D., Monica Longo, M.D., Ph.D., Ashley Salazar, R.N., M.S.N., W.H.N.P., Wendy Dalton, R.N., Alan T.N. Tita, M.D., Ph.D., Cynthia Gyamfi-Bannerman, M.D., Suneet P. Chauhan, M.D., Torri D. Metz, M.D., Kara Rood, M.D., Dwight J. Rouse, M.D., Jennifer L. Bailit, M.D., M.P.H., William A. Grobman, M.D., Hyagriv N. Simhan, M.D., and George A. Macones, M.D. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network*
doi : 10.1056/NEJMoa2207419
Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.
Dersimelagon in Erythropoietic Protoporphyrias
Manisha Balwani, M.D., Herbert L. Bonkovsky, M.D., Cynthia Levy, M.D., Karl E. Anderson, M.D., D. Montgomery Bissell, M.D., Charles Parker, M.D., Fumihiro Takahashi, Ph.D., Robert J. Desnick, Ph.D., M.D., and Kirstine Belongie, Ph.D. for the Endeavor Investigators*
doi : 10.1056/NEJMoa2208754
Erythropoietic protoporphyria and X-linked protoporphyria are inborn errors of heme biosynthesis that cause elevated circulating levels of metal-free protoporphyrin and phototoxicity. Both disorders are characterized by excruciating phototoxic attacks after exposure to visible light. Dersimelagon is a new, orally administered, selective melanocortin 1 receptor agonist that increases levels of skin eumelanin.
Effect of Donor Sex on Recipient Mortality in Transfusion
Michaël Chassé, M.D., Ph.D., Dean A. Fergusson, M.H.A., Ph.D., Alan Tinmouth, M.D., Jason P. Acker, M.B.A., Ph.D., Iris Perelman, M.Sc., Angie Tuttle, Shane W. English, M.D., Steven Hawken, Ph.D., Alan J. Forster, M.D., Nadine Shehata, M.D., Kednapa Thavorn, Ph.D., Kumanan Wilson, M.D., Nancy Cober, Heather Maddison, and Melanie Tokessy
doi : 10.1056/NEJMoa2211523
Conflicting observational evidence exists regarding the association between the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform transfusion practice and policy is limited.
Air Pollution and Mortality at the Intersection of Race and Social Class
Kevin P. Josey, Ph.D., Scott W. Delaney, Sc.D., J.D., Xiao Wu, Ph.D., Rachel C. Nethery, Ph.D., Priyanka DeSouza, Ph.D., Danielle Braun, Ph.D., and Francesca Dominici, Ph.D.
doi : 10.1056/NEJMsa2300523
Black Americans are exposed to higher annual levels of air pollution containing fine particulate matter (particles with an aerodynamic diameter of ≤2.5 μm [PM2.5]) than White Americans and may be more susceptible to its health effects.
Screening for Prostate Cancer
Paul F. Pinsky, Ph.D., and Howard Parnes, M.D.
doi : 10.1056/NEJMcp2209151
Coffee Bean Sign in Cecal Volvulus
Pascal Gavriilidis, M.D., Ph.D., and Francisco Reyes Milian, M.D.
doi : 10.1056/NEJMicm2210796
Periorbital Edema in Dermatomyositis
Caoilfhionn M. Connolly, M.D., and Lisa Christopher-Stine, M.D., M.P.H.
doi : 10.1056/NEJMicm2210861
Case 11-2023: A 67-Year-Old Man with Mantle-Cell Lymphoma and Hypoxemia
Eric P. Schmidt, M.D., Jo-Anne O. Shepard, M.D., and Li Liu, M.D., Ph.D.
doi : 10.1056/NEJMcpc2211516
Benefits of Bempedoic Acid — Clearer Now
John H. Alexander, M.D., M.H.S.
doi : 10.1056/NEJMe2301490
Bempedoic Acid and the Prevention of Cardiovascular Disease
John F. Keaney, Jr., M.D.
doi : 10.1056/NEJMe2300793
Audio Interview: When to Get a Second Covid-19 Booster Shot
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2304374
Stroke, Myocardial Infarction, and Pulmonary Embolism after Bivalent Booster
doi : 10.1056/NEJMc2302134
