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Ensuring Public Trust in an Empowered FDA
Joseph S. Ross, M.D., M.H.S., Karina M. Berg, M.D., and Reshma Ramachandran, M.D., M.P.P., M.H.S.
doi : 10.1056/NEJMp2300438
Vol. 388 No. 14
Why Diverse Clinical Trial Participation Matters
Aaron L. Schwartz, M.D., Ph.D., Marcella Alsan, M.D., Ph.D., Alanna A. Morris, M.D., and Scott D. Halpern, M.D., Ph.D.
doi : 10.1056/NEJMp2215609
A Quixotic Quest for Independence — Benefits, Risks, and the Human Heart
Stephen Landy, M.D.
doi : 10.1056/NEJMp2216655
Trial of Endovascular Thrombectomy for Large Ischemic Strokes
Amrou Sarraj, M.D., Ameer E. Hassan, D.O., Michael G. Abraham, M.D., Santiago Ortega-Gutierrez, M.D., Scott E. Kasner, M.D., M. Shazam Hussain, M.D., Michael Chen, M.D., Spiros Blackburn, M.D., Clark W. Sitton, M.D., Leonid Churilov, Ph.D., Sophia Sundararajan, M.D., Yin C. Hu, M.D.,
doi : 10.1056/NEJMoa2214403
Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations.
Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct
Xiaochuan Huo, M.D., Ph.D., Gaoting Ma, M.D., Ph.D., Xu Tong, M.D., Ph.D., Xuelei Zhang, M.D., Ph.D., Yuesong Pan, Ph.D., Thanh N. Nguyen, M.D., Guangxiong Yuan, M.D., Hongxing Han, Ph.D., Wenhuo Chen, Ph.D., Ming Wei, M.D., Jiangang Zhang, M.D., Zhiming Zhou, M.D., Xiaoxi Yao, B.S., Guoqing Wang, M.D., Weigen Song, B.S., Xueli Cai, Ph.D., Guangxian Nan, M.D., Di Li, M.D., A. Yi-Chou Wang, Ph.D., Wentong Ling, B.S., Chuwei Cai, Ph.D., Changming Wen, Ph.D., En Wang, Ph.D., Liyong Zhang, M.D., Changchun Jiang, Ph.D., Yajie Liu, M.D., Geng Liao, Ph.D., Xiaohui Chen, M.D., Tianxiao Li, M.D., Shudong Liu, M.D., Jinglun Li, M.D., Feng Gao, M.D., Ph.D., Ning Ma, M.D., Ph.D., Dapeng Mo, M.D., Ph.D., Ligang Song, M.D., Xuan Sun, M.D., Ph.D., Xiaoqing Li, M.D., Ph.D., Yiming Deng, M.D., Ph.D., Gang Luo, M.D., Ph.D., Ming Lv, M.D., Hongwei He, M.D., Aihua Liu, M.D., Jingbo Zhang, M.D., Shiqing Mu, M.D., Lian Liu, M.D., Jing Jing, Ph.D., Ximing Nie, M.D., Zeyu Ding, M.D., Wanliang Du, M.D., Xingquan Zhao, M.D., Ph.D., Pengfei Yang, M.D., Ph.D., Liping Liu, M.D., Ph.D., Yilong Wang, M.D., Ph.D., David S. Liebeskind, M.D., Vitor M. Pereira, Ph.D., Zeguang Ren, M.D., Yongjun Wang, M.D., Ph.D., and Zhongrong Miao, M.D., Ph.D. for the ANGEL-ASPECT Investigators*
doi : 10.1056/NEJMoa2213379
The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations.
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
Francesca Del Bufalo, M.D., Biagio De Angelis, Ph.D., Ignazio Caruana, Ph.D., Giada Del Baldo, M.D., Maria A. De Ioris, M.D., Ph.D., Annalisa Serra, M.D., Angela Mastronuzzi, M.D., Ph.D., Maria G. Cefalo, M.D., Daria Pagliara, M.D., Matteo Amicucci, M.S.N., Giuseppina Li Pira, Ph.D., Giovanna Leone, M.D., Valentina Bertaina, Ph.D., Matilde Sinibaldi, Ph.D., Stefano Di Cecca, Ph.D., Marika Guercio, Ph.D., Zeinab Abbaszadeh, Ph.D., Laura Iaffaldano, Ph.D., Monica Gunetti, Ph.D., Stefano Iacovelli, Ph.D., Rossana Bugianesi, Ph.D., Stefania Macchia, Ph.D., Mattia Algeri, M.D., Pietro Merli, M.D., Federica Galaverna, M.D., Ph.D., Rachid Abbas, Ph.D., Maria C. Garganese, M.D., Maria F. Villani, M.D., Giovanna S. Colafati, M.D., Federico Bonetti, M.D., Marco Rabusin, M.D., Katia Perruccio, M.D., Veronica Folsi, M.D., Concetta Quintarelli, Ph.D., and Franco Locatelli, M.D., Ph.D. for the Precision Medicine Team–IRCCS Ospedale Pediatrico Bambino Gesù*
doi : 10.1056/NEJMoa2210859
Immunotherapy with chimeric antigen receptor (CAR)–expressing T cells that target the disialoganglioside GD2 expressed on tumor cells may be a therapeutic option for patients with high-risk neuroblastoma.
Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections
Anne F. Luetkemeyer, M.D., Deborah Donnell, Ph.D., Julia C. Dombrowski, M.D., M.P.H., Stephanie Cohen, M.D., M.P.H., Cole Grabow, M.P.H., Clare E. Brown, Ph.D., Cheryl Malinski, B.S., Rodney Perkins, R.N., M.P.H., Melody Nasser, B.A., Carolina Lopez, B.A., Eric Vittinghoff, Ph.D., Susan P. Buchbinder, M.D., Hyman Scott, M.D., M.P.H., Edwin D. Charlebois, Ph.D., M.P.H., Diane V. Havlir, M.D., Olusegun O. Soge, Ph.D., and Connie Celum, M.D., M.P.H. for the DoxyPEP Study Team*
doi : 10.1056/NEJMoa2211934
Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.
Primary Budd–Chiari Syndrome
Juan Carlos Garcia-Pagán, M.D., Ph.D., and Dominique-Charles Valla, M.D.
doi : 10.1056/NEJMra2207738
Acute Ocular Toxoplasmosis
Wan-Hua Cho, M.D., and Wan-Ju A. Lee, M.D., Ph.D.
doi : 10.1056/NEJMicm2211525
An Alternate Explanation
Tom Alsaigh, M.D., Gurpreet Dhaliwal, M.D., Eri Fukaya, M.D., Ph.D., Nicholas J. Leeper, M.D., and Nazish Sayed, M.D., Ph.D.
doi : 10.1056/NEJMcps2210419
Improved Prospects for Thrombectomy in Large Ischemic Stroke
Pierre Fayad, M.D.
doi : 10.1056/NEJMe2300193
CAR T Cells for Neuroblastoma
Oladapo O. Yeku, M.D., Ph.D., and Dan L. Longo, M.D.
doi : 10.1056/NEJMe2300317
Understanding the Genetic Risk of IDH-Mutant Glioma
Tracy T. Batchelor, M.D., M.P.H., and Kyle M. Walsh, Ph.D.
doi : 10.1056/NEJMcibr2213112
Cambridge Prophylactic Protocol, Retinal Detachment, and Stickler Syndrome
doi : 10.1056/NEJMc2211320
Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events
doi : 10.1056/NEJMc2301922
