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End of a Declared Public Health Emergency — Implications for U.S. Emergency Use Authorizations
Peter W. Marks, M.D., Ph.D., Hilary D. Marston, M.D., M.P.H., and Lindsey R. Baden, M.D.
doi : 10.1056/NEJMp2300392
Vol. 388 No. 13
Medication-Associated Diethylene Glycol Mass Poisoning — A Preventable Cause of Illness and Death
Joshua Schier, M.D., M.P.H., Arthur Chang, M.D., and Vikas Kapil, D.O., M.P.H.
doi : 10.1056/NEJMp2215840
Digital Minimalism — An Rx for Clinician Burnout
Nina Singh, B.S., Katharine Lawrence, M.D., M.P.H., Christine Sinsky, M.D., and Devin M. Mann, M.D.
doi : 10.1056/NEJMp2215297
Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth
Alan T.N. Tita, M.D., Ph.D., Waldemar A. Carlo, M.D., Elizabeth M. McClure, Ph.D., Musaku Mwenechanya, M.D., Elwyn Chomba, M.B., Ch.B., Jennifer J. Hemingway-Foday, M.P.H., Avinash Kavi, M.D., Mrityunjay C. Metgud, M.D., Shivaprasad S. Goudar, M.D., Richard Derman, M.D., M.P.H., Adrien Lokangaka, M.D., M.P.H., Antoinette Tshefu, M.D., Ph.D., M.P.H., Melissa Bauserman, M.D., M.P.H., Carl Bose, M.D., Poonam Shivkumar, M.D., Manju Waikar, M.D., Archana Patel, M.D., Ph.D., Patricia L. Hibberd, M.D., Ph.D., Paul Nyongesa, M.D., Fabian Esamai, M.B., Ch.B., M.P.H., Ph.D., Osayame A. Ekhaguere, M.B., B.S., M.P.H., Sherri Bucher, Ph.D., Saleem Jessani, M.B., B.S., Shiyam S. Tikmani, M.B., B.S., Sarah Saleem, M.B., B.S., Robert L. Goldenberg, M.D., Sk M. Billah, M.P.H., Ruth Lennox, M.B., Ch.B., Rashidul Haque, M.D., William Petri, M.D., Lester Figueroa, M.D., Manolo Mazariegos, M.D., M.P.H., Nancy F. Krebs, M.D., Janet L. Moore, M.S., Tracy L. Nolen, D.Ph., and Marion Koso-Thomas, M.D., M.P.H. for the A-PLUS Trial Group*
doi : 10.1056/NEJMoa2212111
The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would reduce maternal and offspring sepsis or death.
Transcatheter Arterialization of Deep Veins in Chronic Limb-Threatening Ischemia
Mehdi H. Shishehbor, D.O., M.P.H., Ph.D., Richard J. Powell, M.D., Miguel F. Montero-Baker, M.D., Anahita Dua, M.D., Jorge L. MartÃnez-Trabal, M.D., Matthew C. Bunte, M.D., Arthur C. Lee, M.D., Andrew S. Mugglin, Ph.D., Joseph L. Mills, M.D., Alik Farber, M.D., and Daniel G. Clair, M.D. for the PROMISE II Investigators*
doi : 10.1056/NEJMoa2212754
Approximately 20% of patients with chronic limb-threatening ischemia have no revascularization options, leading to above-ankle amputation. Transcatheter arterialization of the deep veins is a percutaneous approach that creates an artery-to-vein connection for delivery of oxygenated blood by means of the venous system to the ischemic foot to prevent amputation.
Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer
Yoshiaki Usui, M.D., Ph.D., Yukari Taniyama, Ph.D., Mikiko Endo, B.Sc., Yuriko N. Koyanagi, M.D., Ph.D., Yumiko Kasugai, M.M.Sc., Isao Oze, M.D., Ph.D., Hidemi Ito, M.D., Ph.D., M.P.H., Issei Imoto, M.D., Ph.D., Tsutomu Tanaka, M.D., Ph.D., Masahiro Tajika, M.D., Ph.D., Yasumasa Niwa, M.D., Ph.D., Yusuke Iwasaki, M.E., Tomomi Aoi, B.Sc., Nozomi Hakozaki, Sadaaki Takata, B.Sc., Kunihiko Suzuki, Chikashi Terao, M.D., Ph.D., Masanori Hatakeyama, M.D., Ph.D., Makoto Hirata, M.D., Ph.D., Kokichi Sugano, M.D., Ph.D., Teruhiko Yoshida, M.D., Ph.D., Yoichiro Kamatani, M.D., Ph.D., Hidewaki Nakagawa, M.D., Ph.D., Koichi Matsuda, M.D., Ph.D., Yoshinori Murakami, M.D., Ph.D., Amanda B. Spurdle, Ph.D., Keitaro Matsuo, M.D., Ph.D., and Yukihide Momozawa, D.V.M., Ph.D.
doi : 10.1056/NEJMoa2211807
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. pylori infection, on the risk of gastric cancer has not been widely evaluated.
Vedolizumab for the Treatment of Chronic Pouchitis
Simon Travis, D.Phil., Mark S. Silverberg, M.D., Ph.D., Silvio Danese, M.D., Ph.D., Paolo Gionchetti, M.D., Mark Löwenberg, M.D., Ph.D., Vipul Jairath, M.B., Ch.B., D.Phil., Brian G. Feagan, M.D., Brian Bressler, M.D., Marc Ferrante, M.D., Ph.D., Ailsa Hart, M.D., Dirk Lindner, M.Sc., Armella Escher, Ph.D., Stephen Jones, M.B., Ch.B., and Bo Shen, M.D. for the EARNEST Study Group*
doi : 10.1056/NEJMoa2208450
Approximately half the patients with ulcerative colitis who undergo restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) will subsequently have pouchitis, and among those patients, one fifth will have chronic pouchitis.
Artificial Intelligence and Machine Learning in Clinical Medicine, 2023
Charlotte J. Haug, M.D., Ph.D., and Jeffrey M. Drazen, M.D.
doi : 10.1056/NEJMra2302038
Neonatal Herpes Simplex Virus Infection
Laura Mantecón, M.D., Ph.D., and Gonzalo SolÃs, M.D., Ph.D.
doi : 10.1056/NEJMicm2035394
Gastrointestinal Kaposi’s Sarcoma
Deniz E. Tekcan Sanli, M.D., and Safak Kiziltas, M.D.
doi : 10.1056/NEJMicm2102502
Case 10-2023: A 27-Year-Old Man with Convulsions
David L. Perez, M.D., Daniel B. Hoch, M.D., and Jonah N. Cohen, Ph.D.
doi : 10.1056/NEJMcpc2211365
Artificial Intelligence in Medicine
Andrew L. Beam, Ph.D., Jeffrey M. Drazen, M.D., Isaac S. Kohane, M.D., Ph.D., Tze-Yun Leong, Ph.D., Arjun K. Manrai, Ph.D., and Eric J. Rubin, M.D., Ph.D.
doi : 10.1056/NEJMe2206291
Prophylactic Antibiotics for Vaginal Delivery — Benefits and Possible Harms
Jeanne S. Sheffield, M.D.
doi : 10.1056/NEJMe2300479
Arterial Gerrymandering — Converting Veins to Arteries to Save Ischemic Limbs
Douglas E. Drachman, M.D.
doi : 10.1056/NEJMe2216380
A Double Whammy on Gastric Cancer Risk
Anne Müller, Ph.D., and Jiazhuo He, M.D.
doi : 10.1056/NEJMe2215503
Audio Interview: Ending the Covid-19 Public Health Emergency
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2303745
Discharging Patients against Medical Advice
Clement D. Lee, M.D., Owen Bradfield, M.B., B.S., B.Med.Sc., L.L.B., M.B.A., Michelle M. Mello, J.D., Ph.D., and Mary Catherine Beach, M.D., M.P.H.
doi : 10.1056/NEJMclde2210118
Benefits, Limits, and Risks of GPT-4 as an AI Chatbot for Medicine
Peter Lee, Ph.D., Sebastien Bubeck, Ph.D., and Joseph Petro, M.S., M.Eng.
doi : 10.1056/NEJMsr2214184
Dark-Alley Ethics — How to Interpret Medical Exceptions to Bans on Abortion Provision
Katie Watson, J.D.
doi : 10.1056/NEJMms2216234
