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May 2023 Stroke Highlights.
Romero, Jose Rafael MD
doi : 10.1161/STROKEAHA.123.043310
Volume 54(5) pgs. 1171-1461,e190-e230 May 2023
Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke.
De Matteis, Eleonora MD; De Santis, Federico MD; Ornello, Raffaele MD, PhD; Censori, Bruno MD; Puglisi, Valentina MD; Vinciguerra, Luisa MD; Giossi, Alessia MD; Di Viesti, Pietro MD; Inchingolo, Vincenzo MD; Fratta, Giovanni Matteo MD; Diomedi, Marina MD; Bagnato, Maria Rosaria MD; Cenciarelli, Silvia MD; Bedetti, Chiara MD;
doi : 10.1161/STROKEAHA.122.041660
Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient ischemic attack (TIA) without substantially increasing the hemorrhagic risk. We aimed at understanding whether and how real-world use of DAPT differs from RCTs.
Perfusion Imaging Mismatch Profiles in the Early Thrombectomy Window: A Single-Center Analysis.
Schwarz, Ghil MD; Agostoni, Elio C. MD; Saliou, Guillaume MD, PhD; Hajdu, Steven David MD; Salerno, Alexander MD; Dunet, Vincent MD, PhD; Michel, Patrik MD; Strambo, Davide MD
doi : 10.1161/STROKEAHA.122.041981
Little is known on the role of mismatch profile in patients undergoing early endovascular treatment (EVT). We aimed to describe pretreatment perfusion parameters and mismatch profiles in anterior circulation large vessel occlusion acute ischemic stroke undergoing EVT in the early time window and assess their association with time from stroke onset and outcomes.
Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
Rose, Deborah MD; Cavalier, Annie MD; Kam, Wayneho MD; Cantrell, Sarah MLIS, AHIP; Lusk, Jay BSc; Schrag, Matthew MD, PhD; Yaghi, Shadi MD; Stretz, Christoph MD; de Havenon, Adam MD, MS; Saldanha, Ian J. MBBS, MPH, PhD; Wu, Teddy Y. MBChB, PhD; Ranta, Anna MD, PhD; Barber, P. Alan MBChB, PhD; Marriott, Elizabeth MD; Feng, Wayne MD, MS; Kosinski, Andrzej S. MS, PhD; Laskowitz, Daniel MD; Poli, Sven MD; Mac Grory, Brian MB BCh BAO, MRCP
doi : 10.1161/STROKEAHA.122.042335
Prior systematic reviews have compared the efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke, assigning their relative complications as a secondary objective.
Frequency and Size of In Situ Thrombus Within Patent Foramen Ovale.
Yan, Chaowu PhD, MD; Li, Hua MD; Wang, Cheng PhD, MD; Yu, Hang MD; Guo, Tingting MD; Wan, Linyuan PhD, MD; Yundan, Pingcuo MD; Wang, Lei PhD, MD; Fang, Wei PhD, MD
doi : 10.1161/STROKEAHA.122.041524
High-resolution optical coherence tomography can detect in situ thrombi within patent foramen ovale (PFO), which can become a dangerous embolic source.
Iatrogenic Cerebral Amyloid Angiopathy Post Neurosurgery: Frequency, Clinical Profile, Radiological Features, and Outcome.
Kaushik, Kanishk MD; van Etten, Ellis S. MD, PhD; Siegerink, Bob PhD; Kappelle, L. Jaap MD, PhD; Lemstra, Afina W. MD, PhD; Schreuder, Floris H.B.M. MD, PhD; Klijn, Catharina J.M. MD, PhD; Peul, Wilco C. MD, PhD; Terwindt, Gisela M. MD, PhD; van Walderveen, Marianne A.A. MD, PhD; Wermer, Marieke J.H. MD, PhD
doi : 10.1161/STROKEAHA.122.041690
Prion-like transmission of amyloid-[latin sharp s] through cadaveric dura, decades after neurosurgical procedures, has been hypothesized as an iatrogenic cause of cerebral amyloid angiopathy (CAA).
Seed to Bleed: Iatrogenic Cerebral Amyloid Angiopathy.
Greenberg, Steven M. MD, PhD; Charidimou, Andreas MD, PhD
Vascular Risk Predicts Plasma Amyloid [beta] 42/40 Through Cerebral Amyloid Burden in Apolipoprotein E [epsilon]4 Carriers.
Sapkota, Shraddha PhD; Erickson, Kelsey BS, BA; Fletcher, Evan PhD; Tomaszewski Farias, Sarah E. PhD; Jin, Lee-Way MD, PhD; DeCarli, Charles MD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1161/STROKEAHA.122.041854
Understanding the neurobiological underpinnings between established multimodal dementia risk factors and noninvasive blood-based biomarkers may lead to greater precision and earlier identification of older adults at risk of accelerated decline and dementia.
NOTCH2NLC GGC Repeat Expansion in Patients With Vascular Leukoencephalopathy.
Liao, Yi-Chu MD, PhD; Wei, Cheng-Yu MD; Chang, Fu-Pang MD; Chou, Ying-Tsen PhD; Hsu, Shao-Lun MD; Chung, Chih-Ping MD, PhD; Mizuguchi, Takeshi MD, PhD; Matsumoto, Naomichi MD, PhD; Yet, Shaw-Fang PhD; Lee, Yi-Chung MD, PhD
doi : 10.1161/STROKEAHA.122.041848
Neuronal intranuclear inclusion disease (NIID), caused by GGC (guanine-guanine-cytosine) repeat expansion in NOTCH2NLC, has several clinical and radiological features akin to cerebral small vessel disease (cSVD).
Bony Stroke: Ischemic Stroke Caused by Mechanical Stress on Brain Supplying Arteries From Anatomical Bone or Cartilage Anomalies.
Haertl, Johanna MD; Renz, Martin MD; Wunderlich, Silke MD; Hemmer, Bernhard MD; Hofauer, Benedikt MD; Gempt, Jens MD; Kallmayer, Michael MD; Boeckh-Behrens, Tobias MD; Kirschke, Jan S. MD; Ikenberg, Benno David MD
doi : 10.1161/STROKEAHA.122.041946
Bone or cartilage anomalies with affection of brain supplying arteries are a potential structural cause for ischemic stroke. In the following, we termed this entity bony stroke.
Incremental Value of Stroke-Induced Structural Disconnection in Predicting Global Cognitive Impairment After Stroke.
Pan, Chensheng MD; Chen, Guohua MD; Jing, Ping MD; Li, Guo PhD; Li, Yuanhao MD; Miao, Jinfeng MD; Sun, Wenzhe MD; Wang, Yanyan MD; Lan, Yan MD; Qiu, Xiuli MD; Zhao, Xin MD; Mei, Junhua MD; Huang, Shanshan MD, PhD; Lian, Lifei MD; Zhu, Zhou MD, PhD; Zhu, Suiqiang MD
doi : 10.1161/STROKEAHA.122.042127
Poststroke cognitive impairment (PSCI) is highly prevalent in stroke survivors and correlated with unfavorable clinical outcomes. This study aimed to identify the neural substrate of PSCI using atlas-based disconnectome analysis and assess the value of disconnection score, a baseline measure for stroke-induced structural disconnection, in PSCI prediction.
Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study.
Ueki, Kana MD; Matsuo, Ryu MD, PhD; Kuwashiro, Takahiro MD, PhD; Irie, Fumi MD, PhD; Wakisaka, Yoshinobu MD, PhD; Ago, Tetsuro MD, PhD; Kamouchi, Masahiro MD, PhD; Kitazono, Takanari MD, PhD; on behalf of the Fukuoka Stroke Registry Investigators; Ishitsuka, Takao MD, PhD; Ibayashi, Setsuro MD, PhD; Chair; Kusuda, Kenji MD, PhD; Fujii, Kenichiro MD, PhD; Nagao, Tetsuhiko MD, PhD; Okada, Yasushi MD, PhD; Vice-Chair; Yasaka, Masahiro MD, PhD; Ooboshi, Hiroaki MD, PhD; Irie, Katsumi MD, PhD; Omae, Tsuyoshi MD, PhD; Toyoda, Kazunori MD, PhD; Nakane, Hiroshi MD, PhD; Sugimori, Hiroshi MD, PhD; Arakawa, Shuji MD, PhD; Fukuda, Kenji MD, PhD; Kitayama, Jiro MD, PhD; Fujimoto, Shigeru MD, PhD; Arihiro, Shoji MD; Kuroda, Junya MD, PhD; Fukushima, Yoshihisa MD; Nakamura, Kuniyuki MD, PhD; Kiyohara, Takuya MD, PhD; Hata, Jun MD, PhD; Kumai, Yasuhiro MD, PhD
doi : 10.1161/STROKEAHA.122.040958
It remains unclear how chronic kidney disease and its underlying pathological conditions, kidney dysfunction, and kidney damage, are associated with cardiovascular outcomes.
Chronic Kidney Disease and Stroke Outcomes: Beyond Serum Creatinine.
Bruce, Samuel S. MD, MA; Parikh, Neal S. MD, MS
Changes in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life.
Sedaghat, Sanaz PhD; Ji, Yuekai MSc; Empana, Jean-Philippe PhD; Hughes, Timothy M. PhD; Mosley, Thomas H. PhD; Gottesman, Rebecca F. MD; Griswold, Michael PhD; Jack, Clifford R. Jr MD; Lutsey, Pamela L. PhD; van Sloten, Thomas T. MD
doi : 10.1161/STROKEAHA.122.041374
Cardiovascular health may be used for prevention of cerebral vascular disease; however, data on the association of cardiovascular health across midlife and late-life with late-life cerebral vascular disease are lacking.
C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke: An Individual Participant Data Meta-Analysis.
McCabe, John J. PhD ,,,*; Walsh, Cathal PhD ,,*; Gorey, Sarah MB; Harris, Katie PhD; Hervella, Pablo PhD; Iglesias-Rey, Ramon PhD; Jern, Christina PhD; Li, Linxin DPhil; Miyamoto, Nobukazu MD; Montaner, Joan PhD; Pedersen, Annie PhD; Purroy, Francisco PhD; Rothwell, Peter M. FMedSci; Sudlow, Catherine PhD; Ueno, Yuji MD; Vicente-Pascual, Mikel MD; Whiteley, William PhD; Woodward, Mark PhD; Kelly, Peter J. MD
doi : 10.1161/STROKEAHA.122.040529
Anti-inflammatory therapies reduce recurrent vascular events in coronary disease. Existing studies have reported highly conflicting findings for the association of blood inflammatory markers with vascular recurrence after stroke leading to uncertainty about the potential of anti-inflammatory therapies after stroke and no consensus about the utility of measurement of inflammatory markers in current guidelines.
Inflammatory Markers and Risk of Cardiovascular Events in Ischemic Stroke.
Boghozian, Roobina PhD; Falcione, Sarina BSc; Jickling, Glen C. MD
Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study.
Sandvig, Heidi Vihovde MD; Aam, Stina MD, PhD; Alme, Katinka Nordheim MD, PhD; Askim, Torunn PhD; Beyer, Mona K. MD, PhD; Ellekjaer, Hanne MD, PhD; Ihle-Hansen, Hege MD, PhD; Lydersen, Stian PhD; Mollnes, Tom Eirik MD, PhD; Munthe-Kaas, Ragnhild MD, PhD; Naess, Halvor MD, PhD; Saltvedt, Ingvild MD, PhD; Seljeseth, Yngve Muller MD; Thingstad, Pernille PhD; Wethal, Torgeir MD, PhD; Knapskog, Anne-Brita MD, PhD
doi : 10.1161/STROKEAHA.122.041965
Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment.
Lipoprotein(a) Is Associated With the Progression and Vulnerability of New-Onset Carotid Atherosclerotic Plaque.
Duan, Youling MD; Zhao, Dong MD, PhD; Sun, Jiayi MD; Liu, Jun MD; Wang, Miao MD, PhD; Hao, Yongchen MD, PhD; Li, Jiangtao MD; Liu, Tianxiao MD; Xiao, Luoxi MD; Hao, Yiming MD; Wang, Haimei MD; Qi, Yue MD, PhD; Liu, Jing MD, PhD
doi : 10.1161/STROKEAHA.122.042323
Although important progress has been made in understanding Lp(a) (lipoprotein[a])-mediated stroke risk, the contribution of Lp(a) to the progression of vulnerable plaque features associated with stroke risk remains unclear.
Race, Ethnic, Sex, and Socioeconomic Inequities in Interhospital Transfer for Acute Ischemic Stroke in the United States.
Oh, Daniel M. MD; Markovic, Daniela MS; Towfighi, Amytis MD
doi : 10.1161/STROKEAHA.122.038133
Patients with stroke in the United States can be transferred for higher level of care. Little is known about possible inequities in interhospital transfers (IHTs) for acute ischemic stroke.
Projected Global Trends in Ischemic Stroke Incidence, Deaths and Disability-Adjusted Life Years From 2020 to 2030.
Pu, Liyuan MPH ,,*; Wang, Li MM ,*; Zhang, Ruijie MM; Zhao, Tian MM; Jiang, Yannan BS; Han, Liyuan MD
doi : 10.1161/STROKEAHA.122.040073
We projected global trends in ischemic stroke from 2020 to 2030 according to age, sex, and socio-demographic index (SDI) quintile.
Genetic Susceptibility to Mood Disorders and Risk of Stroke: A Polygenic Risk Score and Mendelian Randomization Study.
Sun, Jiangming PhD; Borne, Yan PhD; Edsfeldt, Andreas MD, PhD; Wang, Yunpeng PhD; Pan, Mengyu MS; Regeneron Genetics Center; Melander, Olle MD, PhD; Engstrom, Gunnar MD, PhD; Goncalves, Isabel MD, PhD; Abecasis, Goncalo Ph.D.; Baras, Aris M.D.; Cantor, Michael M.D.; Coppola, Giovanni M.D.; Economides, Aris Ph.D.; Lotta, Luca A. M.D., Ph.D.; Overton, John D. Ph.D.; Reid, Jeffrey G. Ph.D.; Shuldiner, Alan M.D.; Beechert, Christina; Forsythe, Caitlin M.S.; Fuller, Erin D.; Gu, Zhenhua M.S.; Lattari, Michael; Lopez, Alexander M.S.; Overton, John D. Ph.D.; Schleicher, Thomas D. M.S.; Padilla, Maria Sotiropoulos M.S.; Toledo, Karina; Widom, Louis; Wolf, Sarah E. M.S.; Pradhan, Manasi M.S.; Manoochehri, Kia; Ulloa, Ricardo H.; Bai, Xiaodong Ph.D.; Balasubramanian, Suganthi Ph.D.; Barnard, Leland Ph.D.; Blumenfeld, Andrew; Eom, Gisu; Habegger, Lukas Ph.D.; Hahn, Young; Hawes, Alicia B.S.; Khalid, Shareef; Reid, Jeffrey G. Ph.D.; Maxwell, Evan K. Ph.D.; Salerno, William Ph.D.; Staples, Jeffrey C. Ph.D.; Yadav, Ashish M.S.; Jones, Marcus B. Ph.D.; Mitnaul, Lyndon J. Ph.D.
doi : 10.1161/STROKEAHA.122.041026
Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke.
Sex and Racial Disparity in Outcome of Aneurysmal Subarachnoid Hemorrhage in the United States: A 20-Year Analysis.
Schupper, Alexander J. MD; Hardigan, Trevor A. MD, PhD; Mehta, Amol MD; Yim, Benjamin MD; Yaeger, Kurt A. MD; De Leacy, Reade MD; Fifi, Johanna T. MD; Mocco, J MD; Majidi, Shahram MD
doi : 10.1161/STROKEAHA.122.041488
Aneurysmal subarachnoid hemorrhage is associated with high rate of morbidity and mortality. We aimed to assess prognostic impact of sex, race, and ethnicity in these patients.
Deep Learning Algorithm Enables Cerebral Venous Thrombosis Detection With Routine Brain Magnetic Resonance Imaging.
Yang, Xiaoxu MD ,*; Yu, Pengxin MSc ,*; Zhang, Haoyue MSc; Zhang, Rongguo PhD; Liu, Yuehong MD; Li, Haoyuan MD; Sun, Penghui MSc; Liu, Xin MD; Wu, Yu MSc; Jia, Xiuqin PhD; Duan, Jiangang MD, PhD; Ji, Xunming MD, PhD; Yang, Qi MD, PhD
doi : 10.1161/STROKEAHA.122.041520
Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease. Routine brain magnetic resonance imaging is commonly used to diagnose CVT.
Dissociable Contributions of Thalamic-Subregions to Cognitive Impairment in Small Vessel Disease.
Li, Hao MD; Cai, Mengfei MD, PhD; Jacob, Mina A. MD; Norris, David G. PhD; Marques, Jose P. PhD; Chamberland, Maxime PhD; Duering, Marco MD; Kessels, Roy P.C. MD, PhD; de Leeuw, Frank-Erik MD, PhD; Tuladhar, Anil M. MD, PhD
doi : 10.1161/STROKEAHA.122.041687
Structural network damage is a potentially important mechanism by which cerebral small vessel disease (SVD) can cause cognitive impairment. As a central hub of the structural network, the role of thalamus in SVD-related cognitive impairments remains unclear.
TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR Family CARD Domain Containing Protein 4) Inflammasome Related Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in Ischemic Stroke.
Deng, Yiming MD, PhD; Li, Zeyan MSc; Sun, Xuan MD, PhD; Ma, Ning MD, PhD; Song, Ligang MD, PhD; Chen, Duanduan PhD; Gao, Feng MD, PhD
doi : 10.1161/STROKEAHA.122.038757
Neuroinflammation plays extremely crucial roles in the neurological damage mediated by ischemic stroke. TRIM29 (tripartite motif containing 29) has previously been proposed to contribute to the regulation of innate immunity, however, the effect of TRIM29 on ischemic stroke induced neurodegenerative processes and neuroinflammation still largely unexplored.
Stroke After SARS-CoV-2 mRNA Vaccine: A Nationwide Registry Study.
Ihle-Hansen, Hakon MD, PhD; Boas, Hakon PhD; Tapia, German PhD; Hagberg, Guri MD, PhD; Ihle-Hansen, Hege MD, PhD; Berild, Jacob Dag MD; Selmer, Randi MD, PhD; Karlstad, Oystein PhD; Gulseth, Hanne Lovdal MD, PhD; Ariansen, Inger MD, PhD
doi : 10.1161/STROKEAHA.122.040430
Whether the SARS-CoV-2 mRNA vaccines may cause a transient increased stroke risk is uncertain.
Effect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample.
de Havenon, Adam MD, MS; Zhou, Lily W. MD, MS; Yaghi, Shadi MD; Frontera, Jennifer A. MD; Sheth, Kevin N. MD
doi : 10.1161/STROKEAHA.122.041929
There is a paucity of nationally representative data regarding the impact of COVID-19 on acute ischemic stroke (AIS) outcome.
Independent and Joint Association of Leukocyte Telomere Length and Lifestyle Score With Incident Stroke.
Zhang, Haiqing PhD ,*; Lai, Xuefeng; Fang, Qin PhD; Ma, Lin MM; Liu, Miao PhD; Yang, Huihua PhD; Guo, Wenting PhD; He, Meian PhD; Yang, Liangle PhD; Zhang, Xiaomin PhD
Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data.
de Havenon, Adam MD; Bangad, Aaron BA; Skolarus, Lesli E. MD, MS; Aldridge, Chad M. DPT; Braun, Robynne G. MD, PhD; Cole, John W. MD; Cramer, Steven C. MD; Lindgren, Arne G. MD, PhD; Sunmonu, N. Abimbola MD, PhD; Worrall, Bradford B. MD, MSc; Lohse, Keith R. PhD
Plasma CGRP Levels Are Not Associated With Collateral Flow and Outcome After Stroke.
Bahr-Hosseini, Mersedeh MD ,,*; Mei[latin sharp s]ner, Nina ,*; Reidler, Paul MD; Saver, Jeffrey L. MD; Tiedt, Steffen MD, PhD
Acute Spinal Subdural Hematoma in a Patient With Multiple Spinal Aneurysms.
Abdalkader, Mohamad MD; Shulman, Julie G. MD; Sahoo, Anurag MD; Ford, Thomas MD; Nguyen, Thanh N. MD
Floating Carotid Thrombus in a Patient With Essential Thrombocytemia due to Calreticulin Mutation.
Psychogios, Klearchos MD; Kargiotis, Odysseas MD; Safouris, Apostolos MD; Repousis, Panagiotis MD; Tsivgoulis, Georgios MD
Cerebral Venous T2-Susceptibility-Weighted Imaging-Mismatch: A Potential Surrogate of Severe Hypoxic-Ischemic Encephalopathy.
Kaiser, Daniel P.O. MD; Gawlitza, Matthias MD; Linn, Jennifer MD; Engellandt, Kay MD
Cerebral Vasculitis due to Invasive Disseminated Streptococcus intermedius Infection in an Immunocompetent Adult.
Hiraga, Akiyuki MD; Kurumada, Kentaro MD; Kojima, Kazuho MD; Kuwabara, Satoshi MD
Neuro-Hospitalist-Hospital Capacity Strain Impacting Stroke Care.
Adelman, Eric E. MD; Leppert, Michelle H. MD, MBA
Precision Medicine in Neurocritical Care for Cerebrovascular Disease Cases.
Petersen, Nils H. MD; Sheth, Kevin N. MD; Jha, Ruchira M. MD
doi : 10.1161/STROKEAHA.122.036402
AB Scientific advances have informed many aspects of acute stroke care but have also highlighted the complexity and heterogeneity of cerebrovascular diseases.
Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.
Stamenkovic, Stefan PhD ,*; Li, Yuandong PhD ,*; Waters, Jack PhD; Shih, Andy PhD
doi : 10.1161/STROKEAHA.122.037156
AB The increasing socio-economic burden of Alzheimer disease (AD) and AD-related dementias has created a pressing need to define targets for therapeutic intervention.
Prehospital Stroke Care Part 2: On-Scene Evaluation and Management by Emergency Medical Services Practitioners.
Richards, Christopher T. MD, MS; Oostema, J. Adam MD, MS; Chapman, Sherita N. MD; Mamer, Lauren E. MD, PhD; Brandler, Ethan S. MD, MPH; Alexandrov, Anne W. PhD, AGACNP-BC, ANVP-BC; Czap, Alexandra L. MD; Martinez-Gutierrez, Juan Carlos MD; Martin-Gill, Christian MD, MPH; Panchal, Ashish R. MD, PhD; McMullan, Jason T. MD, MS; Zachrison, Kori S. MD, MSc
doi : 10.1161/STROKEAHA.123.039792
AB The prehospital phase is a critical component of delivering high-quality acute stroke care. This topical review discusses the current state of prehospital acute stroke screening and transport, as well as new and emerging advances in prehospital diagnosis and treatment of acute stroke.
Early Brain Injury After Subarachnoid Hemorrhage: Incidence and Mechanisms.
Lauzier, David C. BS; Jayaraman, Keshav BA; Yuan, Jane Y. BS; Diwan, Deepti PhD; Vellimana, Ananth K. MD; Osbun, Joshua W. MD, MSCI; Chatterjee, Arindam R. MD; Athiraman, Umeshkumar MD; Dhar, Rajat MD; Zipfel, Gregory J. MD
doi : 10.1161/STROKEAHA.122.040072
AB Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying therapeutic targets for this disease.
Stroke Prevention and Treatment in People With Type 2 Diabetes: Is There a Role for GLP-1 (Glucagon-Like Peptide-1) Analogues?.
Williams, David M. MBBS, MSc; Atkinson, Michael BMus, MBBCh; Evans, Marc MD
doi : 10.1161/STROKEAHA.122.042109
AB Stroke is a leading cause of disability and death, and people with type 2 diabetes (T2D) have a greater risk of stroke and death or disability from stroke.
When Will We Have What We Need to Advise Patients How to Manage Their Carotid Stenosis?: Lessons From SPACE-2.
Brott, Thomas G. MD; Meschia, James F. MD; Lal, Brajesh K. MD; Chamorro, Angel MD; Howard, Virginia J. PhD; Howard, George DrPH
doi : 10.1161/STROKEAHA.122.042172
AB The recently published SPACE-2 trial (Stent-Supported Percutaneous Angioplasty of the Carotid Artery Versus Endarterectomy-2) compared 3 treatments to prevent stroke in patients with asymptomatic carotid stenosis >=70%: (1) carotid endarterectomy plus best medical treatment (BMT), (2) transfemoral carotid artery stenting plus BMT, or (3) BMT alone.
Intensive Blood Pressure Control After Mechanical Thrombectomy for Acute Ischemic Stroke.
Morris, Nicholas A. MD; Jindal, Gaurav MD; Chaturvedi, Seemant MD
doi : 10.1161/STROKEAHA.122.041949
AB Optimal blood pressure targets following successful mechanical thrombectomy remain uncertain. While some observational studies suggest that the relationship between blood pressure and outcomes follows a U-shaped curve, others suggest a linear relationship where lower is better.
Pharmaceutical Interventions for Emotionalism After Stroke.
Hackett, Maree L. PhD; Allida, Sabine PhD; House, Allan O. DM
Tips and Advice on Preparing a Research Manuscript for Submission and Publication in a Peer-Reviewed Stroke Journal.
Lendaris, Andrea MD, MS; Esenwa, Charles MD, MS
Careers in Telestroke: Toward a Virtual and Tangible Purpose.
Jagolino-Cole, Amanda L. MD ,*; Zha, Alicia M. MD ,*; Sangha, Navdeep MD; Song, Shlee S. MD; Majersik, Jennifer J. MD, MS
Cerebral Perfusion Imaging and Plateau Waves.
Slawski, Diana MD; Lyman, Kyle A. MD, PhD; Thatikunta, Prateek MD; Gold, Carl A. MD, MS; Albers, Gregory W. MD
Correction to: Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study.
Correction to: Receipt of Mental Health Treatment in People Living With Stroke: Associated Factors and Long-Term Outcomes.
