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Mass Confusion
Timothy S. H. Kwok, Heejun Kang, Lingxin Zhang, Tarek Abdelhalim
doi : 10.1002/acr.24995
Light in the Feet: A Case of Severe Regional Osteoporosis
Attiya Randolph, Glenn C. Gaviola, Mary Piazza Maiberger, Wen Chen, Sabyasachi Sen, Ryan Karsner, Gail S. Kerr
doi : 10.1002/acr.24975
To Wean or Not to Wean: That is the Question
Melissa L. Mannion, Randy Q. Cron
doi : 10.1002/acr.24992
Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry
Sarah Ringold, Anne C. Dennos, Yukiko Kimura, Timothy Beukelman, Peter Shrader, Thomas A. Phillips, Melanie Kohlheim, Laura E. Schanberg, Rae S. M. Yeung, Daniel B. Horton, on behalf of the Childhood Arthritis and Rheumatology Research Alliance Registry Investigators
doi : 10.1002/acr.24994
Children with well-controlled juvenile idiopathic arthritis (JIA) frequently experience flares after medication discontinuation, but the outcomes of these flares have not been well described. The objective of this study was to characterize the rates and predictors of disease recapture among children with JIA who restarted medication to treat disease flare.
Multicenter Study of Utility and Acceptability of Depression and Anxiety Screening in Adolescents and Young Adults With Childhood-Onset Systemic Lupus
Tamar B. Rubinstein, Marija Dionizovik-Dimanovski, Alaina M. Davis, Chelsey Smith, Lauren Faust, Beth Rutstein, Manda Mitchell, Jordan T. Jones, Julia G. Harris, Martha Rodriguez, Melissa Tesher, Karen Onel, Vilma Gabbay, Ruth E. K. Stein, Emily von Scheven, Andrea M. Knight, for the CARRA Mental Health Workgroup
doi : 10.1002/acr.24825
To determine the utility and acceptability for depression and anxiety screening of adolescents and young adults (AYA) with childhood-onset systemic lupus erythematosus (cSLE) in the pediatric rheumatology setting.
Continuing Professional Development in Rheumatology for Primary Care Clinicians: A Systematic Review
Rachel C. Robbins, Joseph M. Maciuba, Lauren A. Maggio, Anita Samuel
doi : 10.1002/acr.24891
To determine the quality of published rheumatology-focused continuing professional development (CPD) for primary care clinicians (PCCs) for improving the care of patients with rheumatic diseases.
Hydroxychloroquine Use and Cardiovascular Events Among Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis
April Jorge, Na Lu, Hyon Choi, John M. Esdaile, Diane Lacaille, J. Antonio Avina-Zubieta
doi : 10.1002/acr.24850
We evaluated the potential temporal association between hydroxychloroquine (HCQ) use and cardiovascular (CV) events among patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).
Depressed Symptomatology in Systemic Lupus Erythematosus Patients
Sara R. Kellahan, Xinliang Huang, Daphne Lew, Hong Xian, Seth Eisen, Alfred H. J. Kim
doi : 10.1002/acr.24833
Depression is a prevalent (24–30%) and significant comorbidity in patients with systemic lupus erythematosus (SLE). In the present study, we leveraged the longitudinal SLE cohort at the Washington University Lupus Clinic to address 1) what is the longitudinal course of depressed affect among outpatients with SLE and 2) what is the longitudinal relationship between SLE disease activity and depressed affect?
Psychosocial Burden Predicts Sustained Remission in Early Rheumatoid Arthritis: Unraveling the Complex Interplay of Well-Being and Disease Activity
Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens, Patrick Verschueren
doi : 10.1002/acr.24847
This study investigated how psychosocial aspects of disease affect the probability of achieving sustained remission in early rheumatoid arthritis (RA) and explored the directionality of this relationship.
Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis
Lydia E. Federico, Tate M. Johnson, Bryant R. England, Katherine D. Wysham, Michael D. George, Brian Sauer, Bartlett C. Hamilton, Carlos D. Hunter, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Joshua F. Baker
doi : 10.1002/acr.24885
To assess whether circulating levels of adiponectin, leptin, and fibroblast growth factor 21 (FGF-21) are associated with incident cardiovascular disease (CVD) in rheumatoid arthritis (RA).
Pain Sensitization as a Potential Mediator of the Relationship Between Sleep Disturbance and Subsequent Pain in Rheumatoid Arthritis
Jing Song, Lutfiyya N. Muhammad, Tuhina Neogi, Dorothy D. Dunlop, Alyssa Wohlfahrt, Marcy B. Bolster, Clifton O. Bingham III, Daniel J. Clauw, Wendy Marder, Yvonne C. Lee
doi : 10.1002/acr.24888
Many patients with rheumatoid arthritis (RA) experience sleep disturbances, commonly attributed to joint pain. Sleep disturbances could also influence pain. One mechanism may be through dysregulated pain processing, manifested by enhanced pain sensitivity.
Risk of Prostate Cancer in US Veterans With Rheumatoid Arthritis
Austin M. Wheeler, Punyasha Roul, Yangyuna Yang, Kaitlyn M. Brittan, Harlan Sayles, Namrata Singh, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England
doi : 10.1002/acr.24890
Patients with rheumatoid arthritis (RA) have an increased risk of select cancers, including lymphoma and lung cancer. Whether RA influences prostate cancer risk is uncertain. We aimed to determine the risk of prostate cancer in patients with RA compared to patients without RA in the Veterans Health Administration (VA).
Individual Regression Modeling of Spinal Mobility Measurements in Long-Term Ankylosing Spondylitis: In-Depth Analyses With Comparison to Norm Data
Kristina Hörnberg, Lotta Ljung, Anna Södergren, Björn Sundström
doi : 10.1002/acr.24895
Normal age-related decline and temporary restrictions in mobility complicate the understanding of spinal mobility deterioration over time in patients with ankylosing spondylitis (AS). In this study, we aimed to determine whether spinal mobility deterioration occurred linearly in patients with AS.
Association of Race and Risk of Future Scleroderma Renal Crisis at Systemic Sclerosis Diagnosis
Crystal J. Forman, Stephen W. Olson, Sarah M. Gordon, James B. Hughes, Rodger S. Stitt, Wayne T. Bailey, Jess D. Edison, Robert Nee
doi : 10.1002/acr.24807
Scleroderma renal crisis (SRC) is a rare and severe manifestation of systemic sclerosis (SSc). Although it is well documented that Black patients with SSc have worse morbidity and mortality than non-Black patients, racial predilection for SRC is underreported. We examine the association of race and future development of SRC in an SSc cohort.
Cause-Specific Mortality in Patients With Gout in the US Veterans Health Administration: A Matched Cohort Study
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Alison D. Petro, Tuhina Neogi, James R. O'Dell, Ted R. Mikuls
doi : 10.1002/acr.24881
To compare all-cause and cause-specific mortality risk between patients with gout and patients without gout in the Veteran's Health Administration (VHA).
Canakinumab's Effect Against Subsequent Gout Flares and High-Sensitivity C-Reactive Protein Levels: A Causal Mediation Analysis
Kazuki Yoshida, Robert J. Glynn, Hyon K. Choi, Brendan M. Everett, Yi Li, Jean G. MacFadyen, Paul M. Ridker, Daniel H. Solomon
doi : 10.1002/acr.24832
The objective of this study was to quantify the value of early suppression of high-sensitivity C-reactive protein (hsCRP) levels as a biomarker of the protective role of canakinumab against future gout flares.
Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group
Sara K. Tedeschi, Fabio Becce, Tristan Pascart, Ali Guermazi, Jean-François Budzik, Nicola Dalbeth, Georgios Filippou, Annamaria Iagnocco, Minna J. Kohler, Jean-Denis Laredo, Stacy E. Smith, F. Joseph Simeone, Janeth Yinh, Hyon Choi, Abhishek Abhishek
doi : 10.1002/acr.24898
To develop definitions for imaging features being considered as potential classification criteria for calcium pyrophosphate deposition (CPPD) disease, additional to clinical and laboratory criteria, and to compile example images of CPPD on different imaging modalities.
Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial
Kim Allison, Sarah Jones, Rana S. Hinman, Andrew M. Briggs, Priya Sumithran, Jonathan Quicke, Melanie Holden, Neville Chiavaroli, Sam Crofts, Elena George, Nadine Foster, Kim Bennell
doi : 10.1002/acr.24828
To evaluate effects of an online education program about weight management for osteoarthritis on physical therapists' self-reported confidence in knowledge and skills in weight management and attitudes toward obesity.
Health Literacy and Appropriateness of Self-Care and Pain Management in Osteoarthritis: An Understanding of the Patient's Perspective
David J. Hunter, Andrew J. McLachlan, Peter R. Carroll, Tom A. N. Wakefield, Rodney Stosic
doi : 10.1002/acr.24851
Management guidelines encourage self-care in patients with symptomatic osteoarthritis (OA). We undertook this study to investigate the relationship between health literacy (HL) and appropriateness of selection of self-care strategies in people with self-reported symptoms of OA.
Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative
Gabby B. Joseph, Charles E. McCulloch, Michael C. Nevitt, John Lynch, Nancy E. Lane, Thomas M. Link
doi : 10.1002/acr.24875
To assess the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years.
Long-Term Mortality of Patients With Osteoarthritis After Joint Replacement: Prognostic Value of Preoperative and Postoperative Pain and Function
Matthias Klimek, Gisela Büchele, Martin Rehm, Jan Beyersmann, Klaus-Peter Günther, Hermann Brenner, Til Stürmer, Rolf E. Brenner, Dietrich Rothenbacher
doi : 10.1002/acr.24808
To investigate whether osteoarthritis (OA)-specific assessment values (i.e., Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale, Hanover Functionality Status Questionnaire) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the hip or knee.
Opioid Use Among Medicare Beneficiaries With Knee Osteoarthritis: Prevalence and Correlates of Chronic Use
Elena Losina, Shuang Song, Gordon P. Bensen, Jeffrey N. Katz
doi : 10.1002/acr.24844
To determine the prevalence of chronic and occasional opioid use and identify risk factors of opioid use among persons with knee osteoarthritis (OA).
Association Between Metabolically Different Adiposity Subtypes and Osteoarthritis: A Mendelian Randomization Study
Anwar Mulugeta, Tesfahun C. Eshetie, Gizat M. Kassie, Daniel Erku, Alemayehu Mekonnen, Amanda Lumsden, Elina Hyppönen
doi : 10.1002/acr.24884
In this Mendelian randomization (MR) study, the objective was to investigate the causal effect of metabolically different adiposity subtypes on osteoarthritis.
Cardiovascular Risk Profile and Osteoarthritis�Considering Sex and Multisite Joint Involvement: A Canadian Longitudinal Study on Aging
Anthony V. Perruccio, Shatabdy Zahid, Calvin Yip, J. Denise Power, Mayilee Canizares, George A. Heckman, Elizabeth M. Badley
doi : 10.1002/acr.24826
The objective of this study was to investigate a profile of cardiovascular disease (CVD) risk factors by sex among individuals with and without osteoarthritis (OA) and to consider single-site and multisite joint OA.
Test–Retest Reliability and Sensitivity to Change of Ultrasound-Based Methods of Measuring Synovial Inflammation in Knee Osteoarthritis
Holly T. Philpott, Trevor B. Birmingham, Robert Dima, Ryan Pinto, Dianne Bryant, C. Thomas Appleton
doi : 10.1002/acr.24882
To assess test–retest reliability of musculoskeletal ultrasound (US) measures of inflammation in patients with knee osteoarthritis (OA) and to assess the sensitivity to change of US measures of inflammation in patients with knee OA.
Association of Calcaneal Bone Marrow Lesions and Plantar Fascia Imaging Biomarkers With Chronic Plantar Heel Pain: A Case–Control Study
Jason Rogers, Graeme Jones, Jill L. Cook, Kathryn Squibb, Andrew Halliday, Karen Wills, Aroub Lahham, Tania Winzenberg
doi : 10.1002/acr.24887
To determine associations between chronic plantar heel pain (CPHP) and imaging biomarkers derived from magnetic resonance imaging (MRI) and ultrasonography.
Extent of and Reasons for Discontinuation and Nonpublication of Interventional Trials on Connective Tissue Diseases: An Observational Study
Alejandro Brigante, Barbara Russo, Denis Mongin, Kim Lauper, Danièle Allali, Delphine S. Courvoisier, Michele Iudici
doi : 10.1002/acr.24854
To assess the proportion, the reasons, and the factors associated with the discontinuation or nonpublication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs).
Ustekinumab Safety in Pregnancy: A Comprehensive Review
Jonah H. Gorodensky, Sasha Bernatsky, Waqqas Afif, Kristian B. Filion, Ã‰velyne Vinet
doi : 10.1002/acr.24813
Chronic inflammatory conditions, including inflammatory bowel diseases (IBD), psoriasis, and psoriatic arthritis, are prevalent among women of reproductive age; patients with active disease during pregnancy may be at an increased risk of adverse birth outcomes.
Unique Serum Immune Phenotypes and Stratification of Oklahoma Native American Rheumatic Disease Patients
Samantha Slight-Webb, Carla J. Guthridge, Joseph Kheir, Hua Chen, Ly Tran, Tim Gross, Virginia Roberts, Sohail Khan, Michael Peercy, Bobby Saunkeah, Joel M. Guthridge, Judith A. James
doi : 10.1002/acr.24795
Native American (NA) populations have higher rates of rheumatic disease and present with overlapping disease symptoms and nontraditional serologic features, thus presenting an urgent need for better biomarkers in NA diagnostics.
