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Editorial introduction
doi : 10.1097/BOR.0000000000000808
Current Opinion in Rheumatology. 33(4):v, July 2021.
Diagnostic delay in axial spondyloarthritis – a past or current problem?
Poddubnyy, Denis; Sieper, Joachim
doi : 10.1097/BOR.0000000000000802
Current Opinion in Rheumatology. 33(4):307-312, July 2021.
To evaluate recent data on diagnostic delay in axial spondyloarthritis (axSpA), factors affecting the delay, potential ways of early diagnosis improvement, and risks associated with early diagnostic approaches.
Educational needs and challenges in axial spondyloarthritis
Kumthekar, Anand; Bittar, Mohamad; Dubreuil, Maureen
doi : 10.1097/BOR.0000000000000806
Current Opinion in Rheumatology. 33(4):313-318, July 2021.
Axial spondyloarthritis (axSpA) affects 0.5–1% of the population in many regions of the world. This review summarizes the challenges in medical education around axSpA with attention to evidence around delayed diagnosis, clinician familiarity with typical axSpA features, such as inflammatory back pain and adherence to accepted management principles.
Inflammatory back pain: a concept, not a diagnosis
Coath, Fiona Louise; Gaffney, Karl
doi : 10.1097/BOR.0000000000000807
Current Opinion in Rheumatology. 33(4):319-325, July 2021.
The concept of inflammatory back pain (IBP) describes a cohort of patients with chronic back pain (CBP) who have distinct clinical characteristics, rather than being a diagnosis in and of itself. IBP is a common and important feature of axial spondyloarthritis (axSpA) but this is not the only differential. This review examines the utility of IBP in both primary and secondary care settings.
Low-dose computed tomography for axial spondyloarthritis: update on use and limitations
Lambert, Robert G.W.; Hermann, Kay Geert A.; Diekhoff, Torsten
doi : 10.1097/BOR.0000000000000803
Current Opinion in Rheumatology. 33(4):326-332, July 2021.
Recent developments in low-dose computed tomography (ldCT) have greatly reduced radiation exposure levels. This article reviews what a ldCT is and its use and limitations for imaging axial spondyloarthritis.
Out of the shadow of interleukin-17A: the role of interleukin-17F and other interleukin-17 family cytokines in spondyloarthritis
Yeremenko, Nataliya
doi : 10.1097/BOR.0000000000000805
Current Opinion in Rheumatology. 33(4):333-340, July 2021.
The last decade has witnessed tremendous advances in revealing an important role for the interleukin (IL)-17 cytokine family in the pathogenesis of spondyloarthritis (SpA). Although most attention has been focused on IL-17A, a potential role of other IL-17 family members in inflammation and tissue remodelling is emerging. Herein, I review recent studies covering the role of IL-17B-F cytokines in the pathogenesis of SpA.
Intestinal dysbiosis in spondyloarthritis – chicken or egg?
Breban, Maxime; Beaufrère, Marie; Glatigny, Simon
doi : 10.1097/BOR.0000000000000800
Current Opinion in Rheumatology. 33(4):341-347, July 2021.
The well-established link between intestinal inflammation and spondyloarthritis (SpA) remains largely unexplained. Recent sequencing technologies have given access to a thorough characterization of the gut microbiota in healthy and disease conditions. This showed that inflammatory bowel disease (IBD) is associated with dysbiosis – i.e., disturbed gut microbiota composition – which may contribute to disease pathogenesis. Whether gut dysbiosis exists in SpA and could contribute to disease development or be a bystander consequence of chronic inflammation is a question of major interest.
Janus kinase–signal transducers and activators of transcription cell signaling in Spondyloarthritis: rationale and evidence for JAK inhibition
Raychaudhuri, Suravi; Cheema, Karmtej Singh; Raychaudhuri, Smriti K.; Raychaudhuri, Siba P
doi : 10.1097/BOR.0000000000000810
Current Opinion in Rheumatology. 33(4):348-355, July 2021.
The Janus kinase–signal transducers and activators of transcription (JAK–STAT) signaling proteins represent a group of intracellular kinase molecules that play a central role in the signaling pathways induced by cytokines, chemokines, and certain growth factors associated with systemic and local inflammation of autoimmune diseases including in Spondyloarthritis (SpA). Here, we will discuss (i) the functional significance of the JAK–STAT kinase cascades in the inflammatory-proliferative processes of SpA and its cellular/molecular mechanisms (ii) progress in the development of oral synthetic JAK inhibitors (JAKi) and their therapeutic efficacies in SpA.
Patient educational needs and challenges in psoriatic arthritis
Adebajo, Adewale O.; Akintayo, Richard O.
doi : 10.1097/BOR.0000000000000801
Current Opinion in Rheumatology. 33(4):356-362, July 2021.
To provide an overview of the recent research publications on educational needs of patients with psoriatic arthritis (PsA) and the associated challenges.
Twenty years of clinical trials in axial spondyloarthritis: what can we learn for the future?
Sieper, Joachim; Poddubnyy, Denis
doi : 10.1097/BOR.0000000000000804
Current Opinion in Rheumatology. 33(4):363-369, July 2021.
We have now about 20?years of experience with the treatment of axial spondyloarthritis with biologics, which raises the question what we can learn from past experience, and which open questions should be addressed in future investigations.
