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Decussating axons segregate within the anterior core of the primate optic chiasm
Jonathan C Horton, Mikayla D Dilbeck, John R Economides
doi : 10.1136/bjo-2022-322235
Background The axons of ganglion cells in the nasal retina decussate at the optic chiasm. It is unclear why tumours cause more injury to crossing nasal fibres, thereby giving rise to temporal visual field loss in each eye. To address this issue, the course of fibres through the optic chiasm was examined following injection of a different fluorescent tracer into each eye of a monkey.
Fully automated grading system for the evaluation of punctate epithelial erosions using deep neural networks
Jing-Hao Qu, Xiao-Ran Qin, Chen-Di Li, Rong-Mei Peng, Ge-Ge Xiao, Jian Cheng, Shao-Feng Gu, Hai-Kun Wang, Jing Hong
doi : 10.1136/bjophthalmol-2021-319755
Purpose The goal was to develop a fully automated grading system for the evaluation of punctate epithelial erosions (PEEs) using deep neural networks.
Ocular surface sphingolipids associate with the refractory nature of vernal keratoconjunctivitis: newer insights in VKC pathogenesis
Vignesh Menta, Shweta Agarwal, Ujjalkumar Subhash Das, Laxmi Moksha, Gurumurthy Srividya, Amrutha M Anandan, Bhaskar Srinivasan, Geetha Iyer, Thirumurthy Velpandian, Narayanasamy Angayarkanni
doi : 10.1136/bjophthalmol-2021-319324
Background The etiopathogenesis of vernal keratoconjunctivitis (VKC) is incompletely understood. Bioactive lipids play a key role in allergic disorders. This study focused on the sphingolipid metabolism on the ocular surface of VKC and to explore if it has a contributory role in the refractoriness of the disease.
Cystoid macular oedema after descemet membrane endothelial keratoplasty
Damien Guindolet, Odile Huynh, Gilles C Martin, Hugo Disegni, Georges Azar, Isabelle Cochereau, Eric Gabison
doi : 10.1136/bjophthalmol-2021-319455
Aims To determine the incidence and risk factors of cystoid macular oedema (CMO) following descemet membrane endothelial keratoplasty (DMEK) with or without combined cataract surgery (triple-DMEK).
Population-based study on the prevalence, clinical characteristics and vision-related quality of life in patients with corneal opacity resulting from infectious keratitis: results from the Corneal Opacity Rural Epidemiological study
Nimmy Raj, Noopur Gupta, Deepak Kumar, Praveen Vashist, Radhika Tandon
doi : 10.1136/bjophthalmol-2021-320077
Aim To estimate prevalence and characterise clinical features and vision-related quality of life (VR-QoL) of corneal opacities (COs) resulting from infectious keratitis in a rural North Indian population.
Ray tracing intraocular lens calculation performance improved by AI-powered postoperative lens position prediction
Tingyang Li, Aparna Reddy, Joshua D Stein, Nambi Nallasamy
doi : 10.1136/bjophthalmol-2021-320283
Aims To assess whether incorporating a machine learning (ML) method for accurate prediction of postoperative anterior chamber depth (ACD) improves cataract surgery refraction prediction performance of a commonly used ray tracing power calculation suite (OKULIX).
Surgeon effects on cataract refractive outcomes are minimal compared with patient comorbidity and gender: an analysis of 490 987 cases
Rachael Hughes, Petros Aristodemou, John M Sparrow, Stephen Kaye
doi : 10.1136/bjophthalmol-2021-320231
Aim To investigate effect of patient age, gender, comorbidities and surgeon on refractive outcomes following cataract surgery.
Presumed tuberculosis-related scleritis
Maite Sainz de La Maza, Ines Hernanz, Aina Moll-Udina, Marina Mesquida, Alfredo Adan, Jose Antonio Martinez, Gerard Espinosa, VÃctor Llorenç
doi : 10.1136/bjophthalmol-2021-319799
Aims To evaluate the clinical characteristics and therapeutic outcome of patients with recurrent scleritis of unknown demonstrable aetiology and positive QuantiFERON-TB Gold In-Tube test (QFT).
Usefulness of the QuantiFERON test for the diagnosis of tubercular uveitis and the predictions of response to antituberculosis treatment
William Danjou, Pierre Pradat, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Laurent Kodjikian, Salim Trad, Pascal Seve
doi : 10.1136/bjophthalmol-2021-318868
Aims Few studies have evaluated the contribution of QuantiFERON test for the diagnosis of tubercular uveitis in non-endemic countries for tuberculosis (TB). The objective of the present study was to evaluate the value of the QuantiFERON test in a large cohort of patients with uveitis for both the diagnosis of tubercular uveitis and antituberculosis treatment (ATT) response prediction.
Risk factors for microcystic macular oedema in glaucoma
Golnoush Mahmoudinezhad, Diana Salazar, Esteban Morales, Peter Tran, Janet Lee, Jean-Pierre Hubschman, Kouros Nouri-Mahdavi, Joseph Caprioli
doi : 10.1136/bjophthalmol-2021-320137
Background/aims To identify clinical characteristics and factors associated with microcystic macular edema (MME) in patients with primary open-angle glaucoma (POAG).
Generalisability and performance of an OCT-based deep learning classifier for community-based and hospital-based detection of gonioscopic angle closure
Jasmeen Randhawa, Michael Chiang, Natalia Porporato, Anmol A Pardeshi, Justin Dredge, Galo Apolo Aroca, Tin A Tun, Joanne HuiMin Quah, Marcus Tan, Risa Higashita, Tin Aung, Rohit Varma, Benjamin Y Xu
doi : 10.1136/bjophthalmol-2021-319470
Purpose To assess the generalisability and performance of a deep learning classifier for automated detection of gonioscopic angle closure in anterior segment optical coherence tomography (AS-OCT) images.
Safety and performance of a suprachoroidal sensor for telemetric measurement of intraocular pressure in the EYEMATE-SC trial
Peter Szurman, Kaweh Mansouri, H. Burkhard Dick, Andre Mermoud, Esther M Hoffmann, Marc Mackert, Robert N Weinreb, Harsha Laxmana Rao, Anna-Maria Seuthe
doi : 10.1136/bjophthalmol-2021-320023
Aim To investigate the safety and performance of a telemetric suprachoroidal intraocular pressure (IOP) sensor (EYEMATE-SC) and the accuracy of its IOP measurements in open angle glaucoma (OAG) patients undergoing simultaneous non-penetrating glaucoma surgery (NPGS).
OCT-based biomarkers for predicting treatment response in eyes with centre-involved diabetic macular oedema treated with anti-VEGF injections: a real-life retina clinic-based study
Simon KH Szeto, Vivian W. K. Hui, Fang Yao Tang, Dawei Yang, Zi han Sun, Shaheeda Mohamed, Carmen K M Chan, Timothy Y Y Lai, Carol Cheung
doi : 10.1136/bjophthalmol-2021-319587
Background/aims To determine whether a combination of baseline and change in spectral domain-optical coherence tomography (SD-OCT)-based biomarkers can predict visual outcomes in eyes with diabetic macular oedema (DMO) treated with antivascular endothelial growth factors (VEGF) injections.
Evaluation of diabetic retinopathy severity on ultrawide field colour images compared with ultrawide fluorescein angiograms
Mohamed Ashraf, Omar AbdelAl, Siamak Shokrollahi, Cloyd M Pitoc, Lloyd Paul Aiello, Paolo S Silva
doi : 10.1136/bjo-2022-322163
Purpose To compare Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity on ultrawide field (UWF) colour imaging (CI) and UWF fluorescein angiography (FA).
Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans
Grace M Richter, Jae Chang Lee, Nasir Khan, Alexander Vorperian, Brennan Hand, Bruce Burkemper, Xiao Zhou, Zhongdi Chu, Ruikang Wang, Rohit Varma, Amir H Kashani
doi : 10.1136/bjophthalmol-2021-319675
Purpose To determine the relationship of various systemic and ocular characteristics with perifoveal and macular vessel density in healthy African American eyes.
Retinal age gap as a predictive biomarker for mortality risk
Zhuoting Zhu, Danli Shi, Peng Guankai, Zachary Tan, Xianwen Shang, Wenyi Hu, Huan Liao, Xueli Zhang, Yu Huang, Honghua Yu, Wei Meng, Wei Wang, Zongyuan Ge, Xiaohong Yang, Mingguang He
doi : 10.1136/bjophthalmol-2021-319807
Aim To develop a deep learning (DL) model that predicts age from fundus images (retinal age) and to investigate the association between retinal age gap (retinal age predicted by DL model minus chronological age) and mortality risk.
PRO score: predictive scoring system for visual outcomes after rhegmatogenous retinal detachment repair
Louis Z Cai, Jeffrey Lin, Matthew R Starr, Anthony Obeid, Edwin H Ryan, Claire Ryan, Nora J Forbes, Diego Arias, Michael J Ammar, Luv G Patel, Antonio Capone, Geoffrey Guy Emerson, Daniel P Joseph, Dean Eliott, Omesh P Gupta, Carl D Regillo, Jason Hsu, Yoshihiro Yonekawa
doi : 10.1136/bjophthalmol-2021-320440
Background/aims To compare risk factors for poor visual outcomes in patients undergoing primary rhegmatogenous retinal detachment (RRD) repair and to develop a scoring system.
Long-term outcomes of administration of intravitreal triamcinolone acetonide after posterior vitreous detachment during pars plana vitrectomy for proliferative diabetic retinopathy
Mengyu Liao, Yunli Huang, Jiaxing Wang, Xiangda Meng, Yuanyuan Liu, Jinguo Yu, Hua Yan
doi : 10.1136/bjophthalmol-2021-320332
Aim To evaluate the long-term outcomes of intravitreal triamcinolone acetonide (TA) administration after posterior vitreous detachment (PVD) during pars plana vitrectomy (PPV) for patients with proliferative diabetic retinopathy (PDR).
Impact of COVID-19 lockdown on surgical procedures for retinal detachment in France: a national database study
Florian Baudin, Eric Benzenine, Anne-Sophie Mariet, Inès Ben Ghezala, Vincent Daien, Pierre-Henry Gabrielle, Catherine Quantin, Catherine P Creuzot-Garcher
doi : 10.1136/bjophthalmol-2021-319531
Background/aims The COVID-19 crisis and the decisions made regarding population lockdown may have changed patient care. We aimed to investigate the incidence rate of rhegmatogenous retinal detachment (RRD) cases during the COVID-19 lockdown period.
Inner retinal degeneration associated with optic nerve head drusen in pseudoxanthoma elasticum
Kristina Hess, Kristin Raming, Peter Charbel Issa, Philipp Herrmann, Frank G Holz, Maximilian Pfau
doi : 10.1136/bjophthalmol-2021-320088
Background/aims To determine the association of age, presence of optic nerve head drusen (ONHD) and number of previous intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections with inner retinal layer thicknesses in patients with pseudoxanthoma elasticum (PXE).
Prevalence and prognostic value of MYD88 and CD79B mutations in ocular adnexal large B-cell lymphoma: a reclassification of ocular adnexal large B-cell lymphoma
Marina Knudsen Kirkegaard, Marthe Minderman, Lene Dissing Sjö, Steven T Pals, Patrick R G Eriksen, Steffen Heegaard
doi : 10.1136/bjophthalmol-2021-319580
Aims To (1) reclassify ocular adnexal large B-cell lymphomas (OA-LBCLs) per 2016 WHO lymphoma classification and (2) determine the prevalence of MYD88 and CD79B mutations and their association with clinical parameters among OA-LBCLs.
PandAcuity in paediatrics: a novel clinical measure of visual function based on the panda illusion
Carina Kelbsch, Bettina Spieth, Eberhart Zrenner, Dorothea Besch, Torsten Straßer
doi : 10.1136/bjophthalmol-2021-319935
Background/aims To evaluate the PandAcuity test for visual function testing in a paediatric cohort and to examine its agreement with conventional visual acuity (VA) testing.
Impaired vision and physical activity in childhood and adolescence: findings from the Millennium Cohort Study
Lisanne Andra Horvat-Gitsels, Mario Cortina-Borja, Ameenat Lola Solebo, Jugnoo Sangeeta Rahi
doi : 10.1136/bjophthalmol-2021-320315
Background/aims Investigate if impaired vision is associated with reduced levels and differences in types of physical activity (PA) to identify barriers or enablers to achieving healthy PA levels.
