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HEALING MECHANISMS AFTER MACULAR HOLE REPAIR SUGGESTS PROCESS OF FOVEATION.

Spaide, Richard F. MD

doi : 10.1097/IAE.0000000000003727

Volume 43(4) pgs. 539-715,e18-e27 April 2023

To evaluate the long-term healing of the fovea following macular hole surgery in light of the processes known to occur during the maturation of the fovea during childhood, in which there is migration of the inner retinal layers away from and the photoreceptors toward the center of the macula.

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INVERTED INTERNAL LIMITING MEMBRANE FLAP FOR SMALL-SIZED (<250 [micro]m) FULL-THICKNESS MACULAR HOLE: Anatomical and Functional Outcome.

Iuliano, Lorenzo MD, FICO, FEBO; Corbelli, Eleonora MD, FEBO; Bandello, Francesco MD, FEBO; Codenotti, Marco MD

doi : 10.1097/IAE.0000000000003728

To compare the anatomical and functional outcome of small (<250 [micro]m) and medium (250-400 [micro]m) full-thickness macular holes (FTMHs) treated with internal limiting membrane (ILM) inverted flap (IF) or with the standard technique.

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DIRECT MACULAR HOLE MANIPULATION RESULTS IN HIGH SUCCESS RATE IN SECONDARY MACULAR HOLE REPAIR.

Schonbach, Etienne M. MD *; Knight, Darren K. MD *; Wu, Chris Y. MD +; Arevalo, J. Fernando MD, PhD ++; Bittencourt de Souza, Luiza MD [S]; Cheng, Lingyun MD *; Chhablani, Jay MD [P]; Delalibera Pacheco, Katia MD **; Feucht, Nikolaus MD ++; Kozak, Igor MD, PhD ++++; Maia, Andre MD [S]; Maier, Mathias MD [S][S]; Roizenblatt, Marina MD [P][P]; Smiddy, William E. MD +; Sobol, Warren M. MD ***; Freeman, William R. MD *

doi : 10.1097/IAE.0000000000003712

To investigate closure rates and functional outcomes of surgery for refractory and recurrent macular holes (MHs) in a real-world setting. Methods: Retrospective review of secondary MH surgeries.

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MACULAR MORPHOLOGY AFTER MACULAR HOLE SURGERY USING THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE.

Mizuguchi, Tadashi PhD *; Horiguchi, Masayuki PhD *; Kakehi, Sayaka MD +; Ito, Yasuki PhD *

doi : 10.1097/IAE.0000000000003737

To investigate the influence of an excess inverted internal limiting membrane (ILM) flap that covers the fovea in idiopathic macular hole surgery on postoperative visual acuity and macular morphology.

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CLINICAL CHARACTERISTICS AND SURGICAL PROGNOSIS OF IDIOPATHIC MACULAR HOLES WITH EPIRETINAL PROLIFERATION.

Qi, Biying MD *,+; Yu, Yanping MD *,+; Yang, Xiaohan MD *,+; Zhang, Ke MD *,+; Wu, Xijin MD *,+; Wang, Xinbo MD *,+; Liu, Wu MD, PhD *,+

doi : 10.1097/IAE.0000000000003747

To investigate the clinical features and surgical outcomes of idiopathic macular holes with epiretinal proliferation (EP). Methods: This retrospective study included 282 eyes of 269 consecutive patients who underwent vitrectomy for idiopathic macular holes.

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CHARACTERISTICS OF THE MACULAR MICROVASCULATURE IN IDIOPATHIC EPIRETINAL MEMBRANE PATIENTS WITH AN ECTOPIC INNER FOVEAL LAYER.

Yu, Hwa-Young MD; Na, Yong-Jin MD; Lee, Sung-Chul MD, PhD; Lee, Min-Woo MD, PhD

doi : 10.1097/IAE.0000000000003710

To identify the characteristics of the retinal microvasculature in epiretinal membrane patients with ectopic inner foveal layer (EIFL). Methods: Patients were classified into two groups: those without EIFL (Group 1) and those with EIFL (Group 2).

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VITRECTOMY RESULTS FOR RHEGMATOGENOUS RETINAL DETACHMENT WITH CONCOMITANT MACULAR HOLE IN NONMYOPIC PATIENTS.

Iros, Mariano MD *; Sallam, Ahmed B. MD +; Lopez, Juan Manuel MD *,+,++; Glacet-Bernard, Agnes MD ++; Seknazi, Daniel MD ++; Souied, Eric H. MD, PhD ++

doi : 10.1097/IAE.0000000000003742

To report on results of pars plana vitrectomy with ILM peeling in patients with rhegmatogenous retinal detachment (RRD) and concomitant macular hole (MH) and to assess for preoperative associated conditions related to this type of RRD

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IMPACT OF MACULAR INTRARETINAL HEMORRHAGE AND MACULAR HOLE ON THE VISUAL PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE.

Doi, Shinichiro MD, PhD *; Kimura, Shuhei MD, PhD *; Saito, Shoko MD +; Inoue, Makoto MD, PhD +; Sakurai, Toshiya MD, PhD ++; Kobori, Akira MD [S]; Hisatomi, Toshio MD, PhD [P]; Imai, Hisanori MD, PhD **; Kuriyama, Shoji MD, PhD ++; Takasu, Ippei MD ++++; Hosokawa, Mio Morizane MD, PhD *; Shiode, Yusuke MD, PhD *; Matoba, Ryo MD, PhD *; Suzuki, Etsuji MD, PhD [S][S]; Morizane, Yuki MD, PhD *

doi : 10.1097/IAE.0000000000003725

To compare the effects of macular intraretinal hemorrhage (IRH) and macular hole (MH) on best-corrected visual acuity (BCVA) after displacement of submacular hemorrhage (SMH) due to retinal arterial macroaneurysm (RAM) rupture.

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ACUTE- AND DELAYED-ONSET ENDOPHTHALMITIS AFTER OPEN GLOBE INJURIES: Clinical Features and Visual Acuity Outcomes.

Hudson, Julia L. MD; Fan, Jason C. MD, PhD; Smiddy, William E. MD; Sridhar, Jayanth MD; Yannuzzi, Nicolas A. MD; Flynn, Harry W. Jr MD

doi : 10.1097/IAE.0000000000003707

The purpose of the study was to report the clinical features and best-corrected visual acuity outcomes in patients with acute- and delayed-onset endophthalmitis after open globe injuries.

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OUTCOMES OF RHEGMATOGENOUS RETINAL DETACHMENT REPAIR FOLLOWING INFECTIOUS ENDOPHTHALMITIS.

Wu, Frances MD; Kim, Leo A. MD, PhD

doi : 10.1097/IAE.0000000000003706

To determine the incidence of and identify risk factors for redetachment in eyes that underwent rhegmatogenous retinal detachment (RRD) repair after infectious endophthalmitis.

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IDENTIFICATION OF PATHOGENS IN THE INTRAOCULAR FLUID SAMPLES OF PATIENTS WITH ENDOGENOUS ENDOPHTHALMITIS USING RAPID NANOPORE TARGETED SEQUENCING.

Hao, Xinlei MD *; Wang, Ming PhD +; Yuan, Man MD *; Zhang, Rui MD ++; Jin, Wei PhD *; Yang, Anhuai PhD *

doi : 10.1097/IAE.0000000000003719

Nanopore targeted sequencing showed a higher positivity rate and a shorter turnaround time than did traditional culture in identifying pathogens in the intraocular fluid samples of patients with endogenous endophthalmitis.

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DEFINING "STRONG" VERSUS "WEAK" RESPONSE TO ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT FOR CENTER-INVOLVED DIABETIC MACULAR EDEMA.

Sun, Jennifer K. MD, MPH *; Beaulieu, Wesley T. PhD +; Melia, Michele MSc +; Ferris, Frederick L. III MD ++; Maturi, Raj K. MD [S],[P]; Nielsen, Jared S. MD, MBA **; Solomon, Sharon D. MD ++; Jampol, Lee M. MD ++++; for the DRCR Retina Network

doi : 10.1097/IAE.0000000000003730

To define "strong" versus "weak" antivascular endothelial growth factor (anti-VEGF) treatment response in eyes with center-involved diabetic macular edema (CI-DME).

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PATTERNS OF SUBRETINAL AND/OR INTRARETINAL FLUID RECURRENCE IN PATIENTS WHO RECEIVED AS-NEEDED RANIBIZUMAB THERAPY IN THE HARBOR TRIAL.

Adrean, Sean D. MD *; Chaili, Siyang MD *,+; Hill, Lauren MS ++; Amador-Patarroyo, Manuel J. MD ++

doi : 10.1097/IAE.0000000000003708

To evaluate subretinal fluid (SRF) and/or intraretinal fluid recurrence in patients with neovascular age-related macular degeneration who received as-needed (PRN) ranibizumab in a HARBOR (NCT00891735) post hoc analysis.

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IMPACT OF RETINAL FLUID-FREE MONTHS ON OUTCOMES IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Treatment Agnostic Analysis of the HAWK and HARRIER Studies.

Eichenbaum, David MD *,+; Brown, David M. MD ++; Ip, Michael MD [S]; Khanani, Arshad M. MD [P],**; Figueroa, Marta S. MD, PhD ++; McAllister, Ian L. MBBS, PhD ++++; Laude, Augustinus MBChB [S][S]; B, Guruprasad MBBS, MD [P][P]; Tang, Shuhan PhD [P][P]; Gmeiner, Benjamin PhD ***; Clemens, Andreas MD, PhD +++; Souied, Eric MD, PhD ++++++

doi : 10.1097/IAE.0000000000003699

To assess the effect of the total number of fluid-free months after loading on visual and anatomical outcomes in neovascular age-related macular degeneration patients receiving anti-vascular endothelial growth factor therapy.

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ADVANTAGES OF OPTICAL COHERENCE TOMOGRAPHY AS A HIGH DYNAMIC RANGE IMAGING MODALITY IN SUBRETINAL HYPERREFLECTIVE MATERIAL.

Montolio-Marzo, Santiago MD *; Gallego-Pinazo, Roberto MD, PhD +; Palacios-Pozo, Elena MD, PhD *,+; Dolz-Marco, Rosa MD, PhD +

doi : 10.1097/IAE.0000000000003705

To describe the utility of high dynamic range optical coherence tomography imaging to study subretinal hyperreflective material (SHRM) in patients with age-related macular degeneration.

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CHARACTERIZATION OF MACULAR NEOVASCULARIZATION IN BIETTI CRYSTALLINE DYSTROPHY USING MULTIMODAL IMAGING MODALITIES.

Li, Qian MD *; Zhang, Shengjuan MD +; Kang, Lihua MD *; Wang, Donglin MD ++; Jiao, Xiaodong MD, PhD [S]; Hejtmancik, J. Fielding MD, PhD [S]; Wang, Lifei MD +; Peng, Xiaoyan MD *

doi : 10.1097/IAE.0000000000003695

To characterize the clinical features of macular neovascularization (MNV) secondary to Bietti crystalline dystrophy. Methods: The imaging data of 157 eyes in 79 patients with Bietti crystalline dystrophy were retrospectively reviewed.

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OUTER RETINAL TUBULATION IN BIETTI CRYSTALLINE DYSTROPHY ASSOCIATED WITH THE RETINAL PIGMENT EPITHELIUM ATROPHY.

Wang, Yusong MD *,+; Chen, Jieqiong MD *,+,++,[S],[P]; Sun, Junran MD *,+,++,[S],[P]; Li, Tong MD *,+,++,[S],[P]; Yu, Suqin MD *,+,++,[S],[P]; Gong, Yuanyuan MD *,+,++,[S],[P]; Yu, Yang MB *,+,++,[S],[P]; Wan, Xiaoling PhD *,+,++,[S],[P]; Jia, Huixun MS *,+,++,[S],[P]; Wu, Jihong MD **,++,++++; Yuan, Fei MD [S][S]; Shen, Xi MD [P][P]; Wang, Zhiliang MD ***; Qiao, Tong MD +++; Wu, Qiang MD ++++++; Xu, Yu MD [S][S][S]; Wang, Zhaoyang MD [P][P][P]; Yang, Chenhao MD ****; Qu, Jifang MD ++++; Chen, Jianjun MD ++++++++; Sun, Xiaodong MD *,+,++,[S],[P]; Shanghai Inherited Retinal Diseases (SHIRD) Study Group

doi : 10.1097/IAE.0000000000003697

To determine the prognostic value of outer retinal tubulation (ORT) in the eyes of a Chinese cohort with Bietti crystalline dystrophy (BCD). Methods: This retrospective, multicenter cohort study enrolled 42 patients with clinically and genetically diagnosed BCD.

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BACILLARY LAYER DETACHMENT AND ASSOCIATED ABNORMALITIES IN RHEGMATOGENOUS RETINAL DETACHMENT.

Martins Melo, Isabela MD *,+; Bansal, Aditya MD *,+; Lee, Wei Wei MD *,+; Oquendo, Paola Lourdes MD *,+; Hamli, Hesham MD *,+; Muni, Rajeev H. MD, MSc, FRCSC *,+,++,[S]

doi : 10.1097/IAE.0000000000003696

To describe bacillary layer detachment and related abnormalities of the foveal bouquet in rhegmatogenous retinal detachment and assess their impact on photoreceptor recovery and full-thickness macular hole formation, using optical coherence tomography.

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UNITED KINGDOM DATABASE STUDY OF INTRAVITREAL DEXAMETHASONE IMPLANT (OZURDEX) FOR MACULAR EDEMA RELATED TO RETINAL VEIN OCCLUSION.

Soliman, Mohamed Kamel MD *,+; Zarranz-Ventura, Javier MD, PhD ++; Chakravarthy, Usha MD, PhD [S]; McKibbin, Martin FRCOphth [P]; Brand, Christopher FRCOphth **; Menon, Geeta FRCOphth ++; Cilliers, Helena FCS(Ophth)SA ++++; Natha, Salim MBChB, FRCOphth [S][S]; Ross, Adam MD, FRCOphth [P][P]; Sarhan, Mahmoud FRCOphth ***; Lobo, Aires FRCOphth +++; Chong, Victor FRCOphth ++++++; Mahmood, Sajjad FRCOphth [S][S][S]; Islam, Niaz FRCOphth [P][P][P]; Akerele, Toks FRCOphth ****; Shakarchi, Ahmed MD, MPH ++++; Sallam, Ahmed PhD, FRCOphth ++++,++++++++; for the United Kingdom Ozurdex in Retinal Vein Occlusion Electronic Medical Records (UK Ozurdex RVO EMR) Users Group

doi : 10.1097/IAE.0000000000003698

To study the treatment patterns, visual outcomes and safety profile of intravitreal dexamethasone implant (IDI) used for the treatment of macular edema secondary to retinal vein occlusion.

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Macular Hole Closure Without Endotamponade Application.

Stopa, Marcin MD, PhD, FEBO; Ciesielski, Maksym MD; Rakowicz, Piotr MD, PhD

doi : 10.1097/IAE.0000000000002850

We describe an alternative vitreoretinal technique that allows for the macular hole closure without filling the vitreous cavity with gas. Methods: A prospective interventional one-center case series from March 2019 to January 2020.

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RONA Technique: A Novel ILM Peeling Method for Treatment of Large Full-Thickness Macular Holes.

Nourinia, Ramin MD *; Nikzad, Parisa MD *; Abolhosseini, Mohammad MD +; Moshtaghion, Seyed-Mohamadmehdi MD +; Abtahi, Seyed-Hossein MD *,+

doi : 10.1097/IAE.0000000000003390

To present a new technique, RONA, for internal limiting membrane peeling and show its comparable success rate in closure of large full-thickness macular holes (FTMHs).

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Intraoperative Perfluorocarbon Liquid Tamponade Technique for Treatment of Extensive Retinal Detachment Secondary to a Myopic Macular Hole.

Lyu, Jiao MD, PhD; Xia, Fengjie MD; Zhao, Peiquan MD, PhD

doi : 10.1097/IAE.0000000000003429

To report an intraoperative perfluorocarbon liquid (PFCL) tamponade technique in treating extensive retinal detachment secondary to a myopic macular hole (MH) through pars plana vitrectomy.

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POSTERIOR SCLERAL INDENTATION IN LONG AXIAL LENGTH EYES (AXIAL LENGTH MORE THAN 34 MM) TO ASSIST IN PARS PLANA VITRECTOMY AND INTERNAL LIMITING MEMBRANE PEELING IN FULL-THICKNESS MACULAR HOLES.

Al Sabti, Khalid MD, FRCSC; Raizada, Seemant MD, FRCSEd

doi : 10.1097/IAE.0000000000003661

To assess a novel surgical technique to perform macular surgery in high myopic eyes, with axial lengths >34 mm, where standard-size intravitreal surgical instruments cannot reach the retinal surface during pars plana vitrectomy for internal limiting membrane peeling in myopic macular holes.

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Diagnostic and Therapeutic Challenge.

Bavaskar, Snehal; Bhende, Muna; Turski, Gabrielle N.; Lad, Eleonora M.

doi : 10.1097/IAE.0000000000003584

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Bilateral Optic Nerve Infiltration in High-Grade Systemic Lymphoma With Secondary Combined Central Retinal Artery and Vein Occlusions.

Yu, Gina MD; Sendino, Isabel MD; Mruthyunjaya, Prithvi MD, MHS; Ghoraba, Hashem H. MD, MSc

doi : 10.1097/IAE.0000000000003764

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Correspondence.

Uzun, Salih MD *; Uzun, Fatma MD +; Ercal, Ozlem MD ++

doi : 10.1097/IAE.0000000000003716

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Reply.

Damasceno, Nadyr A. MD, PhD *,+; Horowitz, Soraya A. MD *; Maia, Mauricio MD, PhD +; Farah, Michel E. MD, PhD +; Damasceno, Eduardo F. MD, PhD ++

doi : 10.1097/IAE.0000000000003724

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Correspondence.

Vaidya, Harshit DNB *,+,++; Moleiro, Ana Filipa MD *,+,[S],[P]; Sacconi, Riccardo MD, PhD; FEBO *,+; Querques, Giuseppe MD, PhD *,+

doi : 10.1097/IAE.0000000000003731

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Reply.

Lee, Ju-Yeun MD *,+,++; Bae, Kunho MD [S]

doi : 10.1097/IAE.0000000000003732

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Correspondence.

Chou, Hung-Da MD *,+; Chen, Kuan-Jen MD *,+; Hwang, Yih-Shiou MD, PhD *,+; Wu, Wei-Chi MD, PhD *,+; Lai, Chi-Chun MD *,+,++

doi : 10.1097/IAE.0000000000003751

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Reply.

Ventre, Luca MD *; Fallico, Matteo MD, PhD +; Longo, Antonio MD, PhD +; Parisi, Guglielmo MD *; Russo, Andrea MD, PhD +; Bonfiglio, Vincenza MD ++; Marolo, Paola MD *; Caselgrandi, Paolo MD *; Avitabile, Teresio MD +; Borrelli, Enrico MD [S]; Reibaldi, Michele MD, PhD *

doi : 10.1097/IAE.0000000000003752

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