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Brown Adipose Tissue—A Translational Perspective
André C Carpentier, Denis P Blondin, François Haman, Denis Richard
doi : 10.1210/endrev/bnac015
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 143–192
Brown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases.
The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty
Vinicius N Brito, Ana P M Canton, Carlos Eduardo Seraphim, Ana Paula Abreu, Delanie B Macedo, Berenice B Mendonca, Ursula B Kaiser, Jesús Argente, Ana Claudia Latronico
doi : 10.1210/endrev/bnac020
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 193–221
The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including congenital and acquired causes that can be associated with structural or functional brain alterations.
A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets
Adam Ramzy, Paul J Belmonte, Mitchell J S Braam, Shogo Ida, Emily M Wilts, Megan K Levings, Alireza Rezania, Timothy J Kieffer
doi : 10.1210/endrev/bnac021
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 222–253
For the past century, insulin injections have saved millions of lives, but glycemic instability is still a persistent challenge for people with diabetes, leading to tremendous morbidity and premature mortality. Research in the field of islet transplantation has demonstrated that replacing insulin-producing β cells can restore euglycemia comparable to individuals without diabetes.
Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice
Moshe Phillip, Revital Nimri, Richard M Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P Kovatchev, Laurel H Messer, Christopher G Parkin, Louise Ambler-Osborn, Stephanie A Amiel, Lia Bally, Roy W Beck, Sarah Biester, Torben Biester, Julia E Blanchette, Emanuele Bosi, Charlotte K Boughton, Marc D Breton, Sue A Brown, Bruce A Buckingham, Albert Cai, Anders L Carlson, Jessica R Castle, Pratik Choudhary, Kelly L Close, Claudio Cobelli, Amy B Criego, Elizabeth Davis, Carine de Beaufort, Martin I de Bock, Daniel J DeSalvo, J Hans DeVries, Klemen Dovc, Francis J Doyle, III, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P Forlenza, Geraldine Gallen, Satish K Garg, Dana C Gershenoff, Linda A Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B Hirsch, Korey K Hood, Diana Isaacs, David C Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A Lal, Lalantha Leelarathna, David M Maahs, Helen R Murphy, Kirsten Nørgaard, David O’Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C Riddell, David Rodbard, Steven J Russell, Desmond A Schatz, Viral N Shah, Jennifer L Sherr, Gregg D Simonson, R Paul Wadwa, Candice Ward, Stuart A Weinzimer, Emma G Wilmot, Tadej Battelino
doi : 10.1210/endrev/bnac022
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 254–280
The significant and growing global prevalence of diabetes continues to challenge people with diabetes (PwD), healthcare providers, and payers. While maintaining near-normal glucose levels has been shown to prevent or delay the progression of the long-term complications of diabetes, a significant proportion of PwD are not attaining their glycemic goals.
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans
Leticia E Sewaybricker, Alyssa Huang, Suchitra Chandrasekaran, Susan J Melhorn, Ellen A Schur
doi : 10.1210/endrev/bnac023
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 281–296
Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models.
Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas
Mirela-Diana Ilie, Alexandre Vasiljevic, Philippe Bertolino, Gérald Raverot
doi : 10.1210/endrev/bnac024
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 297–311
Pituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior pituitary gland. Most frequently, they are benign tumors, but may sometimes display an aggressive course, and in some cases metastasize
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia
Rodrigo A Toledo, Camilo Jimenez, Gustavo Armaiz-Pena, Carlota Arenillas, Jaume Capdevila, Patricia L M Dahia
doi : 10.1210/endrev/bnac025
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 312–322
Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted inhibition of this pathway.
Tumor-induced Osteomalacia: A Comprehensive Review
Salvatore Minisola, Seiji Fukumoto, Weibo Xia, Alessandro Corsi, Luciano Colangelo, Alfredo Scillitani, Jessica Pepe, Cristiana Cipriani, Rajesh V Thakker
doi : 10.1210/endrev/bnac026
Endocrine Reviews, Volume 44, Issue 2, April 2023, Pages 323–353
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient morbidity. TIO is an underdiagnosed disease, whose awareness should be increased among physicians for timely and proper management of patients.
Correction to: “Brown Adipose Tissue—A Translational Perspective�
doi : 10.1210/endrev/bnac027
Endocrine Reviews, Volume 44, Issue 2, April 2023, Page 354
Correction to: “The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty�
doi : 10.1210/endrev/bnac036
Endocrine Reviews, Volume 44, Issue 2, April 2023, Page 355
