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Do Quality-of-Life Measures Represent Patient Outcomes in Stroke Trials?.
Quinn, Terence J. MD *; Muir, Keith W. MD *
doi : 10.1212/WNL.0000000000206840
Volume 100(13) pgs. 597-642,e1329-e1328 March 28, 2023
Is Soluble ST2 a Novel Biomarker of Intracerebral Hemorrhage?.
Nadareishvili, Zurab MD, PhD; Lorenzano, Svetlana MD, PhD, MSc, FESO
Unilateral Focused Ultrasound Subthalamotomy for Parkinson Disease: Long-term Efficacy and Safety.
Moro, Elena MD, PhD; Romito, Luigi Michele MD, PhD
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage.
Bevers, Matthew B. MD, PhD; Booraem, Caroline BA; Li, Karen BBA; Sreekrishnan, Anirudh MD; Sastre, Cristina PhD; Falcone, Guido J. MD; Sheth, Kevin Navin MD; Sansing, Lauren H. MD, MS; Kimberly, W. Taylor MD, PhD
doi : 10.1212/WNL.0000000000206764
Perihematomal edema (PHE) contributes to poor outcome after deep intraparenchymal hemorrhage (IPH), which is characterized by neuroinflammation and an influx of peripherally derived innate immune cells.
Supportive Self-Management Program for People With Chronic Headaches and Migraine: A Randomized Controlled Trial and Economic Evaluation.
Underwood, Martin MD; Achana, Felix PhD; Carnes, Dawn PhD; Eldridge, Sandra PhD; Ellard, David R. PhD; Griffiths, Frances PhD; Haywood, Kirstie PhD; Hee, Siew Wan PhD; Higgins, Helen MSc; Mistry, Dipesh PhD; Mistry, Hema PhD; Newton, Sian MSc; Nichols, Vivien MSc; Norman, Chloe; Padfield, Emma; Patel, Shilpa DHealthPsy; Petrou, Stavros PhD; Pincus, Tamar PhD; Potter, Rachel PhD; Sandhu, Harbinder DHealthPsy; Stewart, Kimberley; Taylor, Stephanie J.C. MD; Matharu, Manjit S. PhD
doi : 10.1212/WNL.0000000000201518
Chronic headache disorders are a major cause of pain and disability. Education and supportive self-management approaches could reduce the burden of headache disability.
Cross-Trait Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis.
Horton, Mary K. PhD, MPH; Robinson, Sarah C. MPH; Shao, Xiaorong MA; Quach, Hong BA; Quach, Diana BA; Choudhary, Vidhu MA; Bellesis, Kalliope H. BA; Dorin, Pete MPA; Mei, Jin BA; Chinn, Terrence MS; Meyers, Travis J. PhD, MPH; Bakshi, Nandini MD; Marcus, Jacqueline F. MD; Waubant, Emmanuelle MD, PhD; Schaefer, Catherine A. PhD *; Barcellos, Lisa F. PhD, MPH *
doi : 10.1212/WNL.0000000000206791
Migraine is common among people with multiple sclerosis (MS), but the reasons for this are unknown. We tested 3 hypothesized mechanisms for this observed comorbidity, including migraine is a risk factor of MS, genetic variants are shared between the conditions, and migraine is because of MS.
Epidemiology of Developmental and Epileptic Encephalopathy and of Intellectual Disability and Epilepsy in Children.
Poke, Gemma BSc, MBBS; Stanley, James PhD; Scheffer, Ingrid E. PhD, MBBS; Sadleir, Lynette G. MBChB, MD
doi : 10.1212/WNL.0000000000206758
We aimed to determine the population-based cumulative incidence and prevalence of developmental and epileptic encephalopathies (DEEs) and intellectual disability and epilepsy (ID+E) in children.
Safety, Efficacy, and Tolerability of Modified Atkins Diet in Persons With Drug-Resistant Epilepsy: A Randomized Controlled Trial.
Manral, Mala PhD; Dwivedi, Rekha PhD; Gulati, Sheffali MD, DM; Kaur, Kirandeep PhD; Nehra, Ashima PhD; Pandey, Ravindra Mohan PhD; Upadhyay, Ashish Datt PhD; Sapra, Savita PhD; Tripathi, Manjari MD, DM
doi : 10.1212/WNL.0000000000206776
Modified Atkins diet (MAD) has emerged as an adjuvant therapy in drug-resistant epilepsy (DRE). Most studies are in children; there is limited evidence for DRE in adults.
Cognitive and Functional Trajectories in Older Adults With Prediagnostic Parkinson Disease.
Bock, Meredith A. MD; Vittinghoff, Eric PhD; Bahorik, Amber L. PhD; Leng, Yue PhD; Fink, Howard MD, MPH; Yaffe, Kristine MD
doi : 10.1212/WNL.0000000000206762
There is increasing interest in characterizing the earliest phases of Parkinson disease (PD). However, few studies have investigated prediagnostic trajectories of cognition and function.
Prospective Long-term Follow-up of Focused Ultrasound Unilateral Subthalamotomy for Parkinson Disease.
Martinez-Fernandez, Raul MD, PhD; Natera-Villalba, Elena MD; Manez Miro, Jorge U. MD; Rodriguez-Rojas, Rafael PhD; Marta del Alamo, Marta MD; Pineda-Pardo, Jose Angel PhD; Ammann, Claudia PhD; Obeso, Ignacio PhD; Mata-Marin, David MsC; Hernandez-Fernandez, Frida PhD; Gasca-Salas, Carmen MD, PhD; Matarazzo, Michele MD; Alonso-Frech, Fernando MD, PhD; Obeso, Jose A. MD, PhD
doi : 10.1212/WNL.0000000000206771
Unilateral magnetic resonance-guided focused ultrasound subthalamotomy (FUS-STN) has been shown to improve the cardinal motor features of Parkinson disease (PD). Whether this effect is sustained is not known.
Clinical Subgroups and Factors Associated With Progression in Patients With Inclusion Body Myositis.
Michelle, Elizabeth Harlan MD *; Pinal-Fernandez, Iago MD, PhD, PhD *; Casal-Dominguez, Maria MD, PhD *; Albayda, Jemima MD; Paik, Julie J. MD, MHS; Tiniakou, Eleni MD; Adler, Brittany MD; Mecoli, Christopher A. MD, MHS; Danoff, Sonye K. MD, PhD; Christopher-Stine, Lisa MD, MPH; Mammen, Andrew L. MD, PhD *; Lloyd, Thomas E. MD, PhD *
doi : 10.1212/WNL.0000000000206777
Sporadic inclusion body myositis (IBM) is the most common acquired myopathy in individuals older than 50 years. The disorder is slowly progressive, and although many therapies have been investigated, response has generally been poor.
Tumefactive Demyelination in MOG Ab-Associated Disease, Multiple Sclerosis, and AQP-4-IgG-Positive Neuromyelitis Optica Spectrum Disorder.
Cacciaguerra, Laura MD; Morris, Pearse MBBCh; Tobin, W. Oliver MBBCh, PhD; Chen, John J. MD, PhD; Banks, Samantha A. MD; Elsbernd, Paul MD; Redenbaugh, Vyanka MD; Tillema, Jan-Mendelt MD; Montini, Federico MD; Sechi, Elia MD; Lopez-Chiriboga, A. Sebastian MD; Zalewski, Nicholas MD; Guo, Yong MD, PhD; Rocca, Maria A. MD; Filippi, Massimo MD; Pittock, Sean J. MD; Lucchinetti, Claudia F. MD; Flanagan, Eoin P. MBBCh
doi : 10.1212/WNL.0000000000206820
Studies on tumefactive brain lesions in myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated disease (MOGAD) are lacking. We sought to characterize the frequency clinical, laboratory, and MRI features of these lesions in MOGAD and compare them with those in multiple sclerosis (MS) and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD).
Detection of SARS-CoV-2 Nucleocapsid and Microvascular Disease in the Brain: A Case Report.
DeMarino, Catherine PhD; Lee, Myoung-Hwa PhD; Cowen, Maria MS; Steiner, Joseph P. PhD; Inati, Sara MD; Shah, Ashish H. MD; Zaghloul, Kareem A. MD, PhD; Nath, Avindra MD
doi : 10.1212/WNL.0000000000201682
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause a wide range of neurologic complications; however, its neuropenetrance during the acute phase of the illness is unknown.
Skin Biopsy Used for the Diagnosis of Hereditary Diffuse Leukoencephalopathy With Spheroids.
Song, Chengyuan MD *; Wu, Fengjuan MD *; Liu, Yiming MD; Wu, Xinwei MD; Zhao, Yuying MD
Clinical Reasoning: A 26-Year-Old Woman With Recurrent Pain, Weakness, and Atrophy in Bilateral Upper Limbs During Pregnancy and Puerperium.
Zeng, Tian-fang MD *; Ding, Xin MD *; Yang, Dan MD; Wu, Chang-Chuan MD; Xie, Dan-Dan MD; Zhang, Wen-Min MD
doi : 10.1212/WNL.0000000000201705
AB We present the case of a 26-year-old woman with recurrent episodes of severe pain, weakness, and atrophy in her bilateral upper extremities during pregnancy and puerperium.
Teaching NeuroImage: Palmaris Brevis Sign: Clue to Localizing Ulnar Nerve Neuropathy.
Iyer, Vasudeva G. MD
Teaching Video NeuroImage: Alternating Skew Deviation as a Manifestation of Anti-GAD65-Associated Cerebellitis.
Bell, Carter BA; Drummond, Patrick S. MD; Grossman, Scott N. MD
Educational and Supportive Self-Management Program for the Treatment of Chronic Headache.
Preston, Juliette MD, MS
Editors' Note: Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan.
Bruno, Askiel; Nichols, Fenwick T.
Author Response: Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan.
Siegler, James E.; Nagel, Simon; Nguyen, Thanh N.
Disentangling the Association Between Neurologic Deficits, Patient-Reported Impairments, and Quality of Life After Ischemic Stroke.
van der Ende, Nadinda A.M. MD; den Hartog, Sanne J. MD; Broderick, Joseph P. MD, PhD; Khatri, Pooja MD; Visser-Meily, Johanna M.A. PhD; van Leeuwen, Nikki MD, PhD; Lingsma, Hester F. PhD; Roozenbeek, Bob MD, PhD; Dippel, Diederik W.J. MD, PhD; and the IMS III Investigators
doi : 10.1212/WNL.0000000000206747
The EuroQol Group 5-Dimension Self-Reported Questionnaire (EQ-5D) is a well-established instrument to assess quality of life and generates generic utility values for health states reported by patients, derived from assessments by the general public.
