Rheumatology




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Atacicept—it’s not over until the wolf-lady sings (or maybe howls)

David A Isenberg, Celia J F Lin

doi : 10.1093/rheumatology/keac523

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1359–1361

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Structural changes in the sacroiliac joint imaging in axial spondyloarthritis: from conventional radiography to magnetic resonance imaging?

Laura Pina Vegas, Pascal Claudepierre

doi : 10.1093/rheumatology/keac521

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1362–1363

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Dr Yellapragada SubbaRow: the forgotten figure in the history of methotrexate

Narendra K Bagri, Atreya Ramanan, Athimalaipet V Ramanan

doi : 10.1093/rheumatology/keac520

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1364–1365

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PET/CT in giant cell arteritis: will the best imaging technique please stand up?

Lien Moreel, Albrecht Betrains, Daniel Blockmans

doi : 10.1093/rheumatology/keac550

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1366–1367

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JAK inhibitors in autoinflammatory syndromes? The long road from drug development to daily clinical use

Philippe Guilpain

doi : 10.1093/rheumatology/keac592

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1368–1369

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Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

Mark D Russell, Mrinalini Dey, Julia Flint, Philippa Davie, Alexander Allen, Amy Crossley, Margreta Frishman, Mary Gayed, Kenneth Hodson, Munther Khamashta, Louise Moore, Sonia Panchal, Madeleine Piper, Clare Reid, Katherine Saxby, Karen Schreiber, Naz Senvar, Sofia Tosounidou, Maud van de Venne, Louise Warburton, David Williams, Chee-Seng Yee, Caroline Gordon, Ian Giles, BSR Standards, Audit and Guidelines Working Group

doi : 10.1093/rheumatology/keac558

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1370–1387

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Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice

Karen Schreiber, Margreta Frishman, Mark D Russell, Mrinalini Dey, Julia Flint, Alexander Allen, Amy Crossley, Mary Gayed, Kenneth Hodson, Munther Khamashta, Louise Moore, Sonia Panchal, Madeleine Piper, Clare Reid, Katherine Saxby, Naz Senvar, Sofia Tosounidou, Maud van de Venne, Louise Warburton, David Williams, Chee-Seng Yee, Caroline Gordon, Ian Giles, BSR Standards, Audit and Guidelines Working Group

doi : 10.1093/rheumatology/keac559

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1388–1397

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Treating spondyloarthritis early: does it matter? Results from a systematic literature review

Dafne Capelusnik, Diego Benavent, Désirée van der Heijde, Robert Landewé, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compán, Sofia Ramiro

doi : 10.1093/rheumatology/keac532

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1398–1409

To summarize evidence on the relationship between early treatment (definition based on symptom/disease duration or radiographic damage) and treatment clinical response in patients with SpA.

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Withdrawal of MTX in rheumatoid arthritis patients on bDMARD/tsDMARD plus methotrexate at target: a systematic review and meta-analysis

Xiangpeng Wang, Ziyi Tang, Tianwen Huang, Huifang Hu, Yaxi Zhao, Yi Liu

doi : 10.1093/rheumatology/keac515

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1410–1416

To evaluate the effect of MTX withdrawal on disease activity and remission rate in patients at target after treatment with biologic DMARDs (bDMARDs)/targeted synthetic DMARDs (tsDMARDs) plus MTX.

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Comparative effectiveness of guselkumab in psoriatic arthritis: updates to a systematic literature review and network meta-analysis

Philip J Mease, Iain B McInnes, Lai-Shan Tam, Raji Rajalingam, Steve Peterson, Fareen Hassan, Soumya D Chakravarty, Christine Contré, Alison Armstrong, Wolf-Henning Boehncke, Christopher Ritchlin

doi : 10.1093/rheumatology/keac500

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1417–1425

The IL-23 p19-subunit inhibitor guselkumab has been previously compared with other targeted therapies for PsA through network meta-analysis (NMA). The objective of this NMA update was to include new guselkumab COSMOS trial data, and two key comparators: the IL-23 inhibitor risankizumab and the Janus kinase (JAK) inhibitor upadacitinib.

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Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis

Andrés González García, Julián Fernández-Martín, �ngel Robles Marhuenda

doi : 10.1093/rheumatology/keac481

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1426–1435

Idiopathic multicentric Castleman disease (iMCD) is an infrequent and life-threatening disorder characterized by systemic inflammatory symptoms, generalized lymphadenopathy, polyclonal lymphocyte proliferation and organ dysfunction caused by a hyperinflammatory state.

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Type H vessels—a bridge connecting subchondral bone remodelling and articular cartilage degeneration in osteoarthritis development

Yuan Liu, Hui-Qi Xie, Bin Shen

doi : 10.1093/rheumatology/keac539

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1436–1444

Recent studies have shed light on the cellular and molecular mechanisms that link subchondral bone remodelling and angiogenesis in knee osteoarthritis (OA).

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Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis

Georgina Nakafero, Matthew J Grainge, Tim Card, Christian D Mallen, Jonathan S Nguyen Van-Tam, Hywel C Williams, Abhishek Abhishek

doi : 10.1093/rheumatology/keac484

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1445–1450

To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare.

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Immune checkpoint inhibitor–induced arthralgia is tightly associated with improved overall survival in cancer patients

Ayaka Maeda, Kaoru Takase-Minegishi, Yohei Kirino, Naoki Hamada, Yosuke Kunishita, Ryusuke Yoshimi, Akira Meguro, Ho Namkoong, Nobuyuki Horita, Hideaki Nakajima, Yokohama City University irAE Working Group

doi : 10.1093/rheumatology/keac519

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1451–1459,

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COVID-19 vaccine hesitancy in inflammatory arthritis patients: serial surveys from a large longitudinal national Australian cohort

Christopher McMaster, David F L Liew, Susan Lester, Adam Rischin, Rachel J Black, Vibhasha Chand, Ashley Fletcher, Marissa N Lassere, Lyn March, Philip C Robinson, Rachelle Buchbinder, Catherine L Hill

doi : 10.1093/rheumatology/keac503

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1460–1466

To determine COVID-19 vaccine hesitancy rates in inflammatory arthritis patients and identify factors associated with changing vaccine hesitancy over time.

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Anti-PM-Scl antibodies–positive patients encompass three different groups with distinct prognoses

Paul Breillat, Kuberaka Mariampillai, Paul Legendre, Pauline Martins, Bertrand Dunogue, Jean Luc Charuel, Makoto Miyara, Claire Goulvestre, Romain Paule, Helene Vanquaethem, Felix Ackermann, Olivier Benveniste, Hilario Nunes, Luc Mouthon, Yves Allenbach, Yurdagul Uzunhan

doi : 10.1093/rheumatology/keac508

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1467–1475

To help identify homogeneous subgroups among patients with anti-PM-scleroderma-antibodies (PM-Scl-Abs) positive auto-immune diseases regardless of diagnostic classifications.

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Patient-individual tapering of DMARDs in rheumatoid arthritis patients in a real-world setting

Benjamin Birkner, Jürgen Rech, Edmund Edelmann, Frank Verheyen, Georg Schett, Tom Stargardt

doi : 10.1093/rheumatology/keac472

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1476–1484

We aim to provide real-world evidence on the effectiveness of patient-individual tapering of DMARDs for patients with RA in daily clinical practice using medical records and claims data.

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Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study

Simone Parisi, Anna Zanetti, Greta Carrara, Carlo Alberto Scirè, Annamaria Iagnocco, Georgios Filippou, the STARTER Investigators

doi : 10.1093/rheumatology/keac518

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1485–1492

This study is a sub-analysis from the patient cohort of the STARTER (Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission) study.

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In patients with acute mono/oligoarthritis, a targeted ultrasound scanning protocol shows great accuracy for the diagnosis of gout and CPPD

Edoardo Cipolletta, Emilio Filippucci, Abhishek Abhishek, Jacopo Di Battista, Gianluca Smerilli, Marco Di Carlo, Ferdinando Silveri, Rossella De Angelis, Fausto Salaffi, Walter Grassi, Andrea Di Matteo

doi : 10.1093/rheumatology/keac479

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1493–1500

To determine an US scanning protocol with the best accuracy for the diagnosis of gout and CPPD in patients with acute mono/oligo-arthritis of unknown origin.

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Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes

Jiandong Zhou, Xuejin Liu, Oscar Hou-In Chou, Lifang Li, Sharen Lee, Wing Tak Wong, Qingpeng Zhang, Carlin Chang, Tong Liu, Gary Tse, Fengshi Jing, Bernard Man Yung Cheung

doi : 10.1093/rheumatology/keac509

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1501–1510

The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) vs dipeptidyl peptidase-4 inhibitors (DPP4I) on the risk of new-onset gout remains unknown. This study aims to compare the effects of SGLT2I against DPP4I on gout risks.

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Prevalence of undiagnosed axial spondyloarthritis in inflammatory bowel disease patients with chronic back pain: secondary care cross-sectional study

Chong Seng Edwin Lim, Mark Tremelling, Louise Hamilton, Matthew Kim, Alexander Macgregor, Tom Turmezei, Karl Gaffney

doi : 10.1093/rheumatology/keac473

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1511–1518

To elucidate the prevalence of undiagnosed rheumatology-verified diagnosis of axial spondyloarthritis (RVD-axSpA) in patients attending routine secondary care IBD clinics with chronic back pain.

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The influence of age on the prevalence of inflammatory and structural MRI lesions in the sacroiliac joints of patients with and without axial spondyloarthritis

Xenofon Baraliakos, Anna Kuehn, Styliani Tsiami, Uta Kiltz, Martin Fruth, Juergen Braun

doi : 10.1093/rheumatology/keac505

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1519–1525

To compare the influence of age on inflammatory (bone marrow oedema [BME]) and structural (fat lesions [FL], erosions and ankylosis) MRI lesions in the sacroiliac joints (SIJ) of patients with and without axial spondyloarthritis (axSpA).

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Sustained glucocorticoid tapering in the phase 3 trials of anifrolumab: a post hoc analysis of the TULIP-1 and TULIP-2 trials

Ian N Bruce, Ronald F van Vollenhoven, Eric F Morand, Richard A Furie, Susan Manzi, William B White, Gabriel Abreu, Raj Tummala

doi : 10.1093/rheumatology/keac491

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1526–1534

Glucocorticoid sparing is a key priority for SLE management. We evaluated the effects of sustained glucocorticoid tapering in patients with SLE.

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Cardiac magnetic resonance imaging before and after therapeutic interventions for systemic sclerosis-associated myocarditis

Stylianos Panopoulos, Sophie Mavrogeni, Charalambos Vlachopoulos, Petros P Sfikakis

doi : 10.1093/rheumatology/keac504

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1535–1542

Cardiac magnetic resonance imaging (CMRI) is increasingly used to evaluate cardiac involvement in SSc. We assessed changes, including inflammatory and/or fibrotic myocardial lesions detected by CMRI, following therapeutic interventions for SSc-associated symptomatic myocarditis.

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A data-driven approach finds RNA polymerase III antibody and tendon friction rubs as enrichment tools for early diffuse scleroderma trials

Robyn T Domsic, Thomas A Medsger, Jr, Shiyao Gao, Maureen Laffoon, Suiyuan Huang, Stephen Wisniewski, Cathie Spino, Virginia Steen, Robert Lafyatis, Dinesh Khanna

doi : 10.1093/rheumatology/keac501

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1543–1551

Clinical trials in early diffuse SSc have consistently shown a placebo group response with a declining modified Rodnan skin score (mRSS), with negative outcomes. Our objective was to identify strategies using clinical characteristics or laboratory values to improve trial design.

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Survival and prognostic factors from a multicentre large cohort of unselected Italian systemic sclerosis patients

Fabio Cacciapaglia, Paolo Airò, Marco Fornaro, Paolo Trerotoli, Enrico De Lorenzis, Addolorata Corrado, Maria Grazia Lazzaroni, Gerlando Natalello, Fabio Montini, Alberto Altomare, Livio Urso, Lucrezia Verardi, Silvia Laura Bosello, Francesco Paolo Cantatore, Florenzo Iannone

doi : 10.1093/rheumatology/keac512

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1552–1558

Survival and death prognostic factors of SSc patients varied during the past decades. We aimed to update the 5- and 10-year survival rates and identify prognostic factors in a multicentre cohort of Italian SSc patients diagnosed after 2009.

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Glucocorticoids prescribing practices in systemic sclerosis: an analysis of the EUSTAR database

Michele Iudici, Denis Mongin, Elise Siegert, Patricia E Carreira, Jörg Distler, Jörg Henes, Elisabetta Zanatta, Eric Hachulla, Giacomo De Luca, Carolina de Souza Müller, Tânia Santiago, José-Luis Tandaipan, Breno Valdetaro Bianchi, Maria De Santis, Anna-Maria Hoffmann-Vold, Armando Gabrielli, Oliver Distler, Delphine Sophie Courvoisier, EUSTAR collaborators

doi : 10.1093/rheumatology/keac533

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1559–1567

To estimate the prevalence of long-term exposure to glucocorticoids (GCs) and to identify factors associated with, and variations in prescribing practices over time and across recruiting countries.

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PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis

Thomas Thibault, Bastien Durand-Bailloud, Agnès Soudry-Faure, Hélène Greigert, Clément Drouet, Hervé Devilliers, André Ramon, Yannick Bejot, Laurent Martin, Catherine Creuzot-Garcher, Nicolas Falvo, Sylvain Audia, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson

doi : 10.1093/rheumatology/keac430

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1568–1575

To investigate the performance of cranial PET/CT for the diagnosis of GCA.

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Predictive value of the adjusted Global Anti-Phospholipid Syndrome Score on clinical recurrence in APS patients: a longitudinal study

Giuseppe Barilaro, Alexandra Esteves, Carlo Della Rocca, Albert Perez-Isidro, Olga Araujo, Gilberto Pires da Rosa, Estibaliz Ruiz-Ortiz, Dolors Tàssies Penella, Odette Viñas, Joan Carles Reverter, Ricard Cervera, Gerard Espinosa

doi : 10.1093/rheumatology/keac485

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1576–1585

To assess the effect of the average adjusted global APS score (aGAPSS) over time on recurrence of clinical manifestations in APS patients through a retrospective longitudinal study.

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Predicting lymphoma in Sjögren’s syndrome and the pathogenetic role of parotid microenvironment through precise parotid swelling recording

Salvatore De Vita, Miriam Isola, Chiara Baldini, Andreas V Goules, Loukas G Chatzis, Luca Quartuccio, Alen Zabotti, Ivan Giovannini, Valentina Donati, Francesco Ferro, Maria Teresa Rizzo, Valeria Manfrè, Enrico Pegolo, Michael Voulgarelis, Francesco Zaja, Renato Fanin, Christos Masaoutis, Dimitra Rontogianni, Dimitrios I Fotiadis, Maurilio Ponzoni, Athanasios G Tzioufas

doi : 10.1093/rheumatology/keac470

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1586–1593

Parotid swelling (PSW) is a major predictor of non-Hodgkin’s lymphoma (NHL) in primary SS (pSS). However, since detailed information on the time of onset and duration of PSW is scarce, this was investigated to verify whether it may lead to further improved prediction. NHL localization was concomitantly studied to evaluate the role of the parotid gland microenvironment in pSS-related lymphomagenesis.

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JAK inhibitors in difficult-to-treat adult-onset Still’s disease and systemic-onset juvenile idiopathic arthritis

Louise Gillard, Jacques Pouchot, Fleur Cohen-Aubart, Isabelle Koné-Paut, Gaël Mouterde, Martin Michaud, Héloïse Reumaux, Léa Savey, Alexandre Belot, Bruno Fautrel, Stéphane Mitrovic on behalf of the CRI (Club Rhumatismes et Inflammation)

doi : 10.1093/rheumatology/keac440

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1594–1604,

Excessive and inappropriate production of pro-inflammatory cytokines plays a key role in Still’s disease. Janus kinase inhibitor (JAKi) agents mainly block pro-inflammatory cytokine pathways, notably IL-6 and IFN. The objective was to assess the efficacy and safety of JAKi agents in difficult-to-treat systemic JIA or adult-onset Still’s disease (AOSD).

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Standardized nailfold capillaroscopy in children with rheumatic diseases: a worldwide study

Karin Melsens, Maurizio Cutolo, Dieneke Schonenberg-Meinema, Ivan Foeldvari, Maria C Leone, Yora Mostmans, Valérie Badot, Rolando Cimaz, Joke Dehoorne, Ellen Deschepper, Tracy Frech, Johanna Hernandez-Zapata, Francesca Ingegnoli, Archana Khan, Dorota Krasowska, Hartwig Lehmann, Ashima Makol, Miguel A Mesa-Navas, Malgorzata Michalska-Jakubus, Ulf Müller-Ladner, Laura Nuño-Nuño, Rebecca Overbury, Carmen Pizzorni, Mislav Radic, Divya Ramadoss, Angelo Ravelli, Silvia Rosina, Clara Udaondo, Merlijn J van den Berg, Ariane L Herrick, Alberto Sulli, Vanessa Smith, for the EULAR Study Group on Microcirculation in Rheumatic Diseases

doi : 10.1093/rheumatology/keac487

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1605–1615

To standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs).

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Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: results from the CAPRI Registry

Jonathan Park, Michelle Batthish, Roberta A Berard, Gaëlle Chédeville, Jean-Philippe Proulx-Gauthier, Dax G Rumsey, Lori B Tucker, Stephanie Wong, Jaime Guzman, for the CAPRI Registry Investigators

doi : 10.1093/rheumatology/keac468

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1616–1620

To identify differences between baseline Canadian JIA practices and the 2019 ACR guidelines for JIA.

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Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Sinead Maguire, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, Suleman Bhana, Anic Branimir, Inita Bulina, Megan Clowse, Karina Cogo, Iris Colunga, Claire Cook, Karen J Cortez, Kathryn Dao, Milena Gianfrancesco, Monique Gore-Massey, Laure Gossec, Rebecca Grainger, Jonathon Hausman, Tiffany Y T Hsu, Kimme Hyrich, Carolina Isnardi, Yumeko Kawano, Rachael Kilding, Daria A Kusevich, Saskia Lawson-Tovey, Jean Liew, Eoghan McCarthy, Anna Montgumery, Sebastian Moyano, Noreen Nasir, Ivan Padjen, Charalampos Papagoras, Naomi J Patel, Mariana Pera, Cecilia Pisoni, Guillermo Pons-Estel, Antonio L Quiambao, Rosana Quintana, Eric Ruderman, Sebastian Sattui, Veronica Savio, Savino Sciascia, Marieta Sencarova, Rosa Serrano Morales, Faizah Siddique, Emily Sirotich, Jeffrey Sparks, Anja Strangfeld, Paul Sufka, Helen Tanner, Yohana Tissera, Zachary Wallace, Marina L Werner, Leanna Wise, Angus B Worthing, JoAnn Zell, Julija Zepa, Pedro M Machado, Jinoos Yazdany, Philip Robinson, Richard Conway on behalf of the COVID-19 Global Rheumatology Alliance

doi : 10.1093/rheumatology/keac534

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1621–1626

To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.

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Seroconversion after a third COVID-19 vaccine is affected by rituximab dose but persistence is not in patients with rheumatoid arthritis

Céleste J T van der Togt, David F Ten Cate, Bart J F van den Bemt, Janette Rahamat-Langendoen, Nathan den Broeder, Alfons A den Broeder

doi : 10.1093/rheumatology/keac486

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1627–1630

In patients with RA treated with (ultra-)low-dose rituximab (RTX), we investigated the association of dosing and timing of RTX on seroconversion after a third coronavirus disease 2019 (COVID-19) vaccination and the persistence of humoral response after a two-dose vaccination.

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Comparing MRI and conventional radiography for the detection of structural changes indicative of axial spondyloarthritis in the ASAS cohort

Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M Machado, Robert G Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Østergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P Maksymowych, Denis Poddubnyy

doi : 10.1093/rheumatology/keac432

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1631–1635

To compare MRI and conventional radiography of SI joints for detection of structural lesions typical for axial spondyloarthritis (axSpA).

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AOSD endotypes based on immune cell profiles: patient stratification with hierarchical clustering analysis

Ruru Guo, Xuesong Liu, Yixuan Li, Xinyu Meng, Rui Li, Xiaoxiang Chen, Liangjing Lu

doi : 10.1093/rheumatology/keac439

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1636–1644,

This study aimed to analyse the immune cell profiles of adult-onset Still’s disease (AOSD) and to stratify disease-associated endotypes.

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Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis

Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z Lim, Graeme Jones, Catherine L Hill, Anita E Wluka, Andrew Tonkin, Changhai Ding, Flavia M Cicuttini

doi : 10.1093/rheumatology/keac469

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1645–1651

There is increasing evidence for the involvement of vascular disease in the pathogenesis of knee OA. Popliteal artery wall thickness can be used as a surrogate marker of atherosclerosis. We examined the association between popliteal artery wall thickness and knee cartilage volume in individuals with symptomatic knee OA.

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Metformin attenuates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes

Delong Li, Guangfeng Ruan, Yan Zhang, Yang Zhao, Zhaohua Zhu, Qianhua Ou, Hong Huang, Jieli Chen, Weiyu Han, Su’an Tang, Jia Li, Liang Wang, Tianyu Chen, Xiaochun Bai, Daozhang Cai, Changhai Ding

doi : 10.1093/rheumatology/keac467

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1652–1661

To investigate the therapeutic effect and mechanism of metformin on knee OA in normal diet (ND) mice or high-fat diet (HFD)-induced obese mice.

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Longitudinal global transcriptomic profiling of preclinical systemic sclerosis reveals molecular changes associated with disease progression

Chiara Bellocchi, Lorenzo Beretta, Xuan Wang, Marka A Lyons, Maurizio Marchini, Maurizio Lorini, Vincenzo Carbonelli, Nicola Montano, Shervin Assassi

doi : 10.1093/rheumatology/keac492

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1662–1668

To investigate peripheral blood cell (PBCs) global gene expression profile of SSc at its preclinical stage (PreSSc) and to characterize the molecular changes associated with progression to a definite disease over time.

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Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis

Rodrigo Coutinho de Almeida, Margo Tuerlings, Yolande Ramos, Wouter Den Hollander, Eka Suchiman, Nico Lakenberg, Rob G H H Nelissen, Hailiang Mei, Ingrid Meulenbelt

doi : 10.1093/rheumatology/keac498

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1669–1676

To present an unbiased approach to identify positional transcript single nucleotide polymorphisms (SNPs) of osteoarthritis (OA) risk loci by allelic expression imbalance (AEI) analyses using RNA sequencing of articular cartilage and subchondral bone from OA patients.

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A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients

Didac Llop, Daiana Ibarretxe, Núria Plana, Roser Rosales, Delia Taverner, Lluís Masana, Joan Carles Vallvé, Silvia Paredes

doi : 10.1093/rheumatology/keac483

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1677–1686

Patients with RA present increased risk of cardiovascular (CV) disease compared with the general population. Moreover, CV risk factors that have a causal relationship with atherosclerosis do not seem to fully explain the accelerated process that they exhibit.

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Dendritic cells drive profibrotic inflammation and aberrant T cell polarization in systemic sclerosis

José Alberto Choreño-Parra, Diana Cervantes-Rosete, Luis Armando Jiménez-�lvarez, Gustavo Ramírez-Martínez, José Eduardo Márquez-García, Alfredo Cruz-Lagunas, Ana Yelli Magaña-Sánchez, Guadalupe Lima, Humberto López-Maldonado, Emanuel Gaytán-Guzmán, Adrian Caballero, Rosario Fernández-Plata, Janette Furuzawa-Carballeda, Criselda Mendoza-Milla, Maria del Carmen Navarro-González, Luis Llorente, Joaquín Zúñiga, Tatiana Sofía Rodríguez-Reyna

doi : 10.1093/rheumatology/keac489

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1687–1698

SSc is a devastating autoimmune disease characterized by fibrosis and obliterative vasculopathy affecting the skin and visceral organs. While the processes mediating excessive extracellular matrix deposition and fibroblast proliferation are clear, the exact link between autoimmunity and fibrosis remains elusive.

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Novel mutation and expanding phenotype in IRF2BP2 deficiency

Julia Körholz, Anastasia Gabrielyan, Henrike Lisa Sczakiel, Livia Schulze, Manuela Rejzek, Martin W Laass, Nicolai Leuchten, Oliver Tiebel, Diana Aust, Karsten Conrad, Nadja Röber, Eva-Maria Jacobsen, Nadja Ehmke, Reinhard Berner, Nadja Lucas, Minae A Lee-Kirsch, Ralf Wiedemuth, Joachim Roesler, Axel Roers, Timm Amendt, Catharina Schuetz

doi : 10.1093/rheumatology/keac575

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1699–1705

Inborn errors of immunity manifest with susceptibility to infection but may also present with immune dysregulation only. According to the European Society for Immunodeficiencies Registry about 50% of inborn errors of immunity are classified as common variable immunodeficiencies (CVID).

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Similar effect of co-administration of methotrexate and folic acid for the treatment of arthritis compared to separate administration

Elisa Dalix, Mathieu Maalouf, Sylvie Peyroche, Arnaud Vanden-Bossche, Charles-Antoine Arthaud, Sophie Hodin, Rüdiger B Müller, Hubert Marotte

doi : 10.1093/rheumatology/keac579

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1706–1710

MTX is the recommended first-line treatment for RA associated with folic acid (FA) to reduce side effects related to MTX. Here, we proposed to test a co-administration of MTX with FA in the rat adjuvant-induced arthritis (AIA) on efficacy.

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Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study

Nadège Cordel, Benoît Dechelotte, Fabienne Jouen, Janine A Lamb, Hector Chinoy, Paul New, Jiri Vencovsky, Herman Mann, Angeles S Galindo-Feria, Lara Dani, Albert Selva-O’Callaghan, Victoria P Werth, Adarsh Ravishankar, Océane Landon-Cardinal, Benoit Tressières, Olivier Boyer

doi : 10.1093/rheumatology/keac577

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1711–1715

To assess the role of the anti-TIF1γ auto-antibody (aAb) IgG2 isotype as a biomarker of cancer in anti-TIF1γ aAb-positive adult DM.

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Obituary: Professor Justin Charles Mason

Taryn Youngstein, Dorian Haskard

doi : 10.1093/rheumatology/keac699

Rheumatology, Volume 62, Issue 4, April 2023, Pages 1716–1717

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Correction to: Ruxolitinib inhibits IFNγ-stimulated Sjögren’s salivary gland MSC HLA-DR expression and chemokine-dependent T cell migration

doi : 10.1093/rheumatology/keac588

Rheumatology, Volume 62, Issue 4, April 2023, Page 1718

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Correction to: Which inflamed tissues explain a positive metatarsophalangeal squeeze test? A large imaging study to clarify a common diagnostic procedure

doi : 10.1093/rheumatology/keac516

Rheumatology, Volume 62, Issue 4, April 2023, Page 1719

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British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids

Mark D Russell, Mrinalini Dey, Julia Flint, Philippa Davie, Alexander Allen, Amy Crossley, Margreta Frishman, Mary Gayed, Kenneth Hodson, Munther Khamashta, Louise Moore, Sonia Panchal, Madeleine Piper, Clare Reid, Katherine Saxby, Karen Schreiber, Naz Senvar, Sofia Tosounidou, Maud van de Venne, Louise Warburton, David Williams, Chee-Seng Yee, Caroline Gordon, Ian Giles, BSR Standards, Audit and Guidelines Working Group

doi : 10.1093/rheumatology/keac551

Rheumatology, Volume 62, Issue 4, April 2023, Pages e48–e88

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British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice

Karen Schreiber, Margreta Frishman, Mark D Russell, Mrinalini Dey, Julia Flint, Alexander Allen, Amy Crossley, Mary Gayed, Kenneth Hodson, Munther Khamashta, Louise Moore, Sonia Panchal, Madeleine Piper, Clare Reid, Katherine Saxby, Naz Senvar, Sofia Tosounidou, Maud van de Venne, Louise Warburton, David Williams, Chee-Seng Yee, Caroline Gordon, Ian Giles, BSR Standards, Audit and Guidelines Working Group

doi : 10.1093/rheumatology/keac552

Rheumatology, Volume 62, Issue 4, April 2023, Pages e89–e104

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Correlation between soluble TREM2 and anti-GluN2 antibody in lupus patients with diffuse psychiatric and neuropsychological syndromes

Yoshiyuki Arinuma, Yasuhiro Hasegawa, Tomoki Tanaka, Yu Matsueda, Tatsuhiko Wada, Kenji Oku, Kunihiro Yamaoka

doi : 10.1093/rheumatology/keac488

Rheumatology, Volume 62, Issue 4, April 2023, Pages e105–e106

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Is there a gender gap in global rheumatology leadership?

Tayyeba Khursheed, Ghita Harifi, Pavel V Ovseiko, Harish G Shekar, Humeira Badsha, Latika Gupta

doi : 10.1093/rheumatology/keac499

Rheumatology, Volume 62, Issue 4, April 2023, Pages e107–e108

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Procalcitonin can increase during activation of adult-onset Still’s disease (AOSD) in the absence of an ınfection focus

Reşit Yıldırım, Sedanur Oğuzman, Döndü Üsküdar Cansu, Mustafa Dinler, Cengiz Korkmaz

doi : 10.1093/rheumatology/keac511

Rheumatology, Volume 62, Issue 4, April 2023, Pages e109–e110

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Elevated serum levels of soluble T cell immunoglobulin and mucin-containing-molecule-3 in patients with idiopathic inflammatory myopathy

Yueyuan Zhou, Sheng Ye, Leiyi Yang, Geng Yin, Qibing Xie

doi : 10.1093/rheumatology/keac510

Rheumatology, Volume 62, Issue 4, April 2023, Pages e111–e113

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Absence of overexpression of KIR3DL2 on CD4+ T cells and NK cells in patients with axial spondyloarthritis

Guillaume Larid, Sophie Trijau, Clothilde Barral, Pierre Lafforgue, Thao Pham

doi : 10.1093/rheumatology/keac546

Rheumatology, Volume 62, Issue 4, April 2023, Pages e114

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Sulfasalazine induced leukocytoclastic vasculitis resulting in gangrene

Laith Alamlih, Layth AL-Karaja, Dana Amro, Mutaz Alnatsheh

doi : 10.1093/rheumatology/keac490

Rheumatology, Volume 62, Issue 4, April 2023, Pages e117–e118

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DWI scalp dot sign: superficial temporal artery restricted diffusion in giant cell arteritis

Eleanor Taylor, Francesca Tona, Victoria Singh-Curry, Marius Venter, Maresa Carulli, Colin Tench, Taryn Youngstein, Luke Dixon

doi : 10.1093/rheumatology/keac502

Rheumatology, Volume 62, Issue 4, April 2023, Pages e119–e121

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Atypical polyarticular juvenile idiopathic arthritis revealing multicentric reticulohistiocytosis with pulmonary involvement

Anna Gaussem, Perrine Dusser, Van Huynh, Caroline Galeotti, Adrien Schvartz, Léa Jaume, Linda Rossi-Semerano, Isabelle Koné-Paut, Charlotte Borocco

doi : 10.1093/rheumatology/keac480

Rheumatology, Volume 62, Issue 4, April 2023, Pages e122–e123

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The bias in the nomenclature of large-vessel vasculitis

Chetan B Mukhtyar

doi : 10.1093/rheumatology/keac527

Rheumatology, Volume 62, Issue 4, April 2023, Pages e124–e126

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Transient osteoporosis of the hip: a novel vascular manifestation of COVID-19?

Jacopo Ciaffi, Elena Vanni, Giancarlo Facchini, Marco Miceli, Francesco Ursini

doi : 10.1093/rheumatology/keac537

Rheumatology, Volume 62, Issue 4, April 2023, Pages e127–e128

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Comment on: Efficacy and safety of tocilizumab in Behçet’s syndrome with refractory arterial lesions: a single-centre observational cohort study in China

Rıza Can Kardaş, Hamit Küçük

doi : 10.1093/rheumatology/keac493

Rheumatology, Volume 62, Issue 4, April 2023, Pages e129–e130

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Comment on: Efficacy and safety of tocilizumab in Behçet’s syndrome with refractory arterial lesions: a single-centre observational cohort study in China: reply

Hua Zhong, Tian Liu

doi : 10.1093/rheumatology/keac494

Rheumatology, Volume 62, Issue 4, April 2023, Page e131

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Comment on: Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen

Rubén Queiro-Silva

doi : 10.1093/rheumatology/keac554

Rheumatology, Volume 62, Issue 4, April 2023, Pages e132–e133,

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Comment on: Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen: reply

Telma Thrastardottir, Elana Meer, Arna Hauksdottir, Bjorn Gudbjornsson, Sigurdur Yngvi Kristinsson, Alexis Ogdie, Thorvardur Jon Love

doi : 10.1093/rheumatology/keac555

Rheumatology, Volume 62, Issue 4, April 2023, Pages e134–e135

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Granulomatosis with polyangiitis presenting as obstructive uropathy and vasculitic myopathy

Bradly A Kimbrough, Elie Naddaf, Kenneth J Warrington, Rafael E Jimenez, Matthew J Koster

doi : 10.1093/rheumatology/keac506

Rheumatology, Volume 62, Issue 4, April 2023, Pages e136–e137

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Flare-up of mucocutaneous leishmaniasis following infliximab discontinuation and antiparasitic therapy in a patient with juvenile idiopathic arthritis

Florent Amatore, Floriane Lebas, Aurélie Haffner, Emmanuel Delaporte

doi : 10.1093/rheumatology/keac513

Rheumatology, Volume 62, Issue 4, April 2023, Pages e138–e139

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