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How to Diagnose and Manage Cyclic Vomiting Syndrome?.
Lin, Lisa D. MD, MS 1; Chang, Lin MD 2,1
doi : 10.14309/ajg.0000000000002084
Volume 118(4) pgs. 579-760 April 2023
Tips for the Medical Management of Diverticulitis.
Strate, Lisa L. MD, MPH 1; Peery, Anne F. MD, MSCR 2
Why Has Screening and Surveillance for Barrett's Esophagus Fallen Short in Stemming the Rising Incidence of Esophageal Adenocarcinoma?.
Spechler, Stuart Jon MD 1; El-Serag, Hashem B. MD, MPH 2,3
Rupture Splenic Artery Aneurysm Caused by Pancreatic Cancer.
Hamada, Jun MD 1; Matsui, Yo MD 2; Yano, Takahiko MD 1; Inagaki, Daisuke MD, PhD 3
Severe Proctitis Associated With Mpox Virus.
Ramai, Daryl MD, MSc 1; Dubroff, Jason MD, MPH 1; Walker, Michael J. MD 1
Caught in the Act: Traditional Serrated Adenoma Arising From Sessile Serrated Lesion.
Zhang, Yu MD 1,2; Wang, Jingzhai MD 1,2; Tang, Ming MD 2,3; Guo, Qiang MD 1,2
Iatrogenic Portobiliary Fistula.
Chatterjee, Arjun MD 1; Singh, Amandeep MD 2; Gurajala, Ram MD 3; Chahal, Prabhleen MD 2
A Rare Cause of Melena Leading to an Even Rarer Diagnosis.
Stoskute, Monika BS 1; Ali, Saeed MD 1; El-Saied, Mohammad Usama MD 1; Boulay, Brian R. MD, MPH 1; Shuja, Asim MD 1
Magnet-Assisted Diverticuloplasty in the Treatment of a Large Epiphrenic Esophageal Diverticulum.
Liu, Ruide MD 1; Yuan, Xianglei MD 1; Zeng, Xianhui MD 1; Hu, Bing MD 1
Continuing Medical Education Questions: April 2023.
Haddad, Fady Georges MD
doi : 10.14309/ajg.0000000000002226
AB Article Title: Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (C) The American College of Gastroenterology 2023. All Rights Reserved.
Continuing Medical Education Questions: April 2023.
Han, Andrew J. MD
doi : 10.14309/ajg.0000000000002228
AB Article Title: What Every Gastroenterologist Should Know About Gastrointestinal NETs (C) The American College of Gastroenterology 2023. All Rights Reserved.
What Every Gastroenterologist Should Know About Gastrointestinal NETs.
Yang, Julie MD 1; Kim, Michelle Kang MD, PhD 2
doi : 10.14309/ajg.0000000000002107
AB Gastrointestinal neuroendocrine tumors are increasingly common. Practitioners should examine these lesions carefully found on routine endoscopy. Obtaining accurate neuroendocrine tumors stage and grade is critical to patient assessment and management, and assistance from advanced endoscopists may be needed. (C) The American College of Gastroenterology 2023. All Rights Reserved.
Applying Placebo and Nocebo Effects From Randomized Trials to Clinical Care and Future Studies.
Ma, Christopher MD, MPH 1,2,3
Conventional Antibiotics for Spontaneous Bacterial Peritonitis: Are They Still Effective?.
Avadhanam, Mahathi MBBS 1; Kulkarni, Anand V. MD, DM 1
Patient Knowledge, Risk Perception, and Barriers to Barrett's Esophagus Screening.
Kolb, Jennifer M. MD, MS 1; Chen, Mindy MD 2; Tavakkoli, Anna MD, MSc 3; Gallegos, Jazmyne BA 4; O'Hara, Jack BA 4; Tarter, Wyatt MS 5; Hochheimer, Camille J. PhD 5; Golubski, Bryan MD 6; Kopplin, Noa BS 3; Hennessey, Lilly BA 7; Kalluri, Anita BA 7; Devireddy, Shalika 4; Scott, Frank I. MD, MSCE 4; Falk, Gary W. MD, MS 7; Singal, Amit G. MD, MS 3; Vajravelu, Ravy K. MD, MSCE 8; Wani, Sachin MD 4
doi : 10.14309/ajg.0000000000002054
Most patients with esophageal adenocarcinoma (EAC) do not have a previous diagnosis of Barrett's esophagus (BE), demonstrating a failure of current screening practices.
Ten-Day Vonoprazan-Amoxicillin Dual Therapy as a First-Line Treatment of Helicobacter pylori Infection Compared With Bismuth-Containing Quadruple Therapy.
Qian, Hai-Sheng MD 1,2,*; Li, Wen-Jie MD 1,2,*; Dang, Yi-Ni MD, PhD 1,2,*; Li, Lu-Rong MD 1,2; Xu, Xiao-Bing MD 1,2; Yuan, Lin MD 1,2; Zhang, Wei-Feng MD 1,2; Yang, Zhen MD 1,2; Gao, Xin MD 1,2; Zhang, Min MD, PhD 1,2; Li, Xuan MD, PhD 1,2; Zhang, Guo-Xin MD, PhD 1,2
doi : 10.14309/ajg.0000000000002086
No study has investigated the efficacy and safety of vonoprazan-amoxicillin dual therapy compared with bismuth quadruple therapy (B-quadruple). This study aimed to evaluate the efficacy and safety of 10-day vonoprazan-amoxicillin dual therapy as a first-line treatment of Helicobacter pylori infection compared with B-quadruple and to explore the optimal dosage of amoxicillin in the dual therapy.
Cost-Effectiveness of Vonoprazan-Based and Rifabutin-Based vs Other Regimens as First-Line Treatment of Helicobacter pylori Infection in the United States.
Yunusa, Ismaeel PharmD, PhD 1,2; Love, Bryan L. PharmD, MPH 1,2
doi : 10.14309/ajg.0000000000002146
The economic and clinical implications of eradicating Helicobacter pylori (H. pylori) with vonoprazan-based and rifabutin-based regimens vs other existing prepackaged first-line treatment options in the United States are unknown.
Placebo Adverse Events in Non-alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants.
Tay, Phoebe Wen Lin MBBS 1,*; Ng, Cheng Han MBBS 1,*; Lin, Snow Yunni MBBS 1,*; Chin, Yip Han MBBS 1; Xiao, Jieling MBBS 1; Lim, Wen Hui MBBS 1; Lim, Sze Yinn MBBS 1; Fu, Clarissa Elysia MBBS 1; Chan, Kai En MBBS 1; Quek, Jingxuan MBBS 1; Tan, Darren Jun Hao MBBS 1; Chew, Nicholas MBBS 2; Syn, Nicholas MBBS 1; Keitoku, Taisei MD 3; Tamaki, Nobuharu MD 3; Siddiqui, Mohammad Shadab MD 4; Noureddin, Mazen MD 5; Muthiah, Mark MBBS, MRCP, MMed 1,6,7; Huang, Daniel Q. MBBS, MMed, MRCP 1,6,7,+; Loomba, Rohit MD 8,+
doi : 10.14309/ajg.0000000000002042
In the absence of an effective treatment for non-alcoholic steatohepatitis (NASH), a randomized, placebo-controlled trial (RCT) remains the current gold standard study design in NASH.
Response-Guided Therapy With Cefotaxime, Ceftriaxone, or Ciprofloxacin for Spontaneous Bacterial Peritonitis: A Randomized Trial: A Validation Study of 2021 AASLD Practice Guidance for SBP.
Yim, Hyung Joon MD, PhD 1,*; Kim, Tae Hyung MD, PhD 1,*; Suh, Sang Jun MD 1; Yim, Sun Young MD, PhD 1; Jung, Young Kul MD, PhD 1; Seo, Yeon Seok MD, PhD 1; Kang, Seong Hee MD, PhD 1,2,3; Kim, Moon Young MD, PhD 2; Baik, Soon Koo MD, PhD 2; Kim, Hong Soo MD, PhD 4; Kim, Young Seok MD, PhD 4; Park, Soo Young MD, PhD 5; Kim, Byung Ik MD, PhD 6; Park, Jun Yong MD, PhD 7; Heo, Jeong MD, PhD 8; Sohn, Joo Hyun MD, PhD 9; Heo, Nae-Yun MD, PhD 10; Han, Kwang-Hyub MD, PhD 7; Um, Soon Ho MD, PhD 1
doi : 10.14309/ajg.0000000000002126
For the treatment of spontaneous bacterial peritonitis (SBP), cefotaxime, ceftriaxone, and ciprofloxacin were used as first-line agents. However, considering the increasing rate of antibiotic resistance, it is unclear which of these drugs can be initially recommended.
COVID-19 Vaccine Effectiveness Against the Omicron Variant in a Veterans Affairs Cohort of Patients With Inflammatory Bowel Disease.
Khan, Nabeel MD 1,2; Mahmud, Nadim MD, MS, MPH, MSCE 1,2
doi : 10.14309/ajg.0000000000002071
With the advent of the Omicron variant, there are concerns about the efficacy of current vaccinations, especially among immunocompromised/immunosuppressed patients.
Real-World Evidence Comparing Vedolizumab and Ustekinumab in Antitumor Necrosis Factor-Experienced Patients With Crohn's Disease.
Kappelman, Michael D. MD, MPH 1; Adimadhyam, Sruthi PhD 2; Hou, Laura MS 2; Wolfe, Audrey E. MPH 2; Smith, Samantha BA 2; Simon, Andrew L. ScM 2; Moyneur, Erick MA 3; Reynolds, Juliane S. MPH 2; Toh, Sengwee ScD 2; Dobes, Angela MPH 4; Parlett, Lauren E. PhD 5; Haynes, Kevin PharmD, MSCE 5; Selvan, Mano PhD 6; Ma, Qianli MS 6; Nair, Vinit MS, RPh 6; Burris, Jessica MD 7; Dorand, Jennifer E. PhD 4; Dawwas, Ghadeer K. PhD 8; Lewis, James D. MD, MSCR 9; Long, Millie D. MD, MPH 1
doi : 10.14309/ajg.0000000000002068
Many patients with Crohn's disease (CD) lose response or become intolerant to antitumor necrosis factor (TNF) therapy and subsequently switch out of class.
Factors Associated With Placebo Treatment Response in Functional Dyspepsia Clinical Trials.
Jones, Michael P. PhD 1; Guthrie-Lyons, Liam MClin Psych 1; Sato, Yuri A. MD, MPH 2; Talley, Nicholas J. MD, PhD 2,3
doi : 10.14309/ajg.0000000000002097
Controlling for potential placebo effects is an important aspect of gaining an accurate estimate of how much the therapy alone changes patient symptoms or other end points.
Examining the Nocebo Effect in Trials of Neuromodulators for Use in Disorders of Gut-Brain Interaction.
Glissen Brown, Jeremy R. MD, MSc 1; Sanayei, Ava MD 2; Proctor, Samantha 3; Flanagan, Ryan MD, MPH 4; Ballou, Sarah PhD 3; Bain, Paul A. PhD 5; Nee, Judy MD 3
doi : 10.14309/ajg.0000000000002108
Nocebo effects are believed to influence the rate of reported adverse events (AE) and subject withdrawal in both the treatment and placebo groups of randomized clinical trials (RCT).
Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition.
Botteri, Edoardo PhD 1,2; Peveri, Giulia MSc 3,4; Berstad, Paula PhD 1; Bagnardi, Vincenzo PhD 5; Chen, Sairah L.F. MPhil 6; Sandanger, Torkjel M. PhD 6; Hoff, Geir MD, PhD 1,7; Dahm, Christina C. PhD 8; Antoniussen, Christian S. MSc 8; Tjonneland, Anne MD, PhD 9; Eriksen, Anne Kirstine PhD 9; Skeie, Guri PhD 6; Perez-Cornago, Aurora PhD 10; Huerta, Jose Maria PhD 11,12; Jakszyn, Paula PhD 13; Harlid, Sophia PhD 14; Sundstrom, Bjorn PhD 15; Barricarte, Aurelio PhD 12,16,17; Monninkhof, Evelyn M. PhD 18; Derksen, Jeroen W.G. PhD 18; Schulze, Matthias B. DrPH 19,20; Bueno-de-Mesquita, Bas MD, PhD 21; Sanchez, Maria-Jose MD, PhD 12,22,23,24; Cross, Amanda J. PhD 25; Tsilidis, Konstantinos K. PhD 25,26; De Magistris, Maria Santucci MSc 27; Kaaks, Rudolf PhD 28; Katzke, Verena PhD 28; Rothwell, Joseph A. PhD 29; Laouali, Nasser PhD 29; Severi, Gianluca PhD 29,30; Amiano, Pilar PhD 31,32,33; Contiero, Paolo PhD 34; Sacerdote, Carlotta PhD 35; Goldberg, Marcel MD, PhD 36; Touvier, Mathilde PhD 37,38; Freisling, Heinz PhD 39; Viallon, Vivian PhD 39; Weiderpass, Elisabete MD, PhD 39; Riboli, Elio MD, MSc 25; Gunter, Marc J. PhD 39; Jenab, Mazda PhD 39; Ferrari, Pietro PhD 39
doi : 10.14309/ajg.0000000000002065
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. METHODS: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development.
Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.
Botteri, Edoardo PhD 1,2; Peveri, Giulia MSc 3,4; Berstad, Paula PhD 1; Bagnardi, Vincenzo PhD 5; Chen, Sairah L.F. MPhil 6; Sandanger, Torkjel M. PhD 6; Hoff, Geir MD, PhD 1,7; Dahm, Christina C. PhD 8; Antoniussen, Christian S. MSc 8; Tjonneland, Anne MD, PhD 9; Eriksen, Anne Kirstine PhD 9; Skeie, Guri PhD 6; Perez-Cornago, Aurora PhD 10; Huerta, Jose Maria PhD 11,12; Jakszyn, Paula PhD 13; Harlid, Sophia PhD 14; Sundstrom, Bjorn PhD 15; Barricarte, Aurelio PhD 12,16,17; Monninkhof, Evelyn M. PhD 18; Derksen, Jeroen W.G. PhD 18; Schulze, Matthias B. DrPH 19,20; Bueno-de-Mesquita, Bas MD, PhD 21; Sanchez, Maria-Jose MD, PhD 12,22,23,24; Cross, Amanda J. PhD 25; Tsilidis, Konstantinos K. PhD 25,26; De Magistris, Maria Santucci MSc 27; Kaaks, Rudolf PhD 28; Katzke, Verena PhD 28; Rothwell, Joseph A. PhD 29; Laouali, Nasser PhD 29; Severi, Gianluca PhD 29,30; Amiano, Pilar PhD 31,32,33; Contiero, Paolo PhD 34; Sacerdote, Carlotta PhD 35; Goldberg, Marcel MD, PhD 36; Touvier, Mathilde PhD 37,38; Freisling, Heinz PhD 39; Viallon, Vivian PhD 39; Weiderpass, Elisabete MD, PhD 39; Riboli, Elio MD, MSc 25; Gunter, Marc J. PhD 39; Jenab, Mazda PhD 39; Ferrari, Pietro PhD 39
doi : 10.14309/ajg.0000000000002171
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. METHODS: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development.
Acute Pancreatitis Recurrences Augment Long-Term Pancreatic Cancer Risk.
Munigala, Satish MBBS, MPH, PhD 1; Almaskeen, Sami MD 2; Subramaniam, Divya S. PhD 3; Bandi, Sriya High School Diploma 4; Bowe, Benjamin MPH, PhD 5; Xian, Hong PhD 6; Sheth, Sunil G. MD 7; Burroughs, Thomas E. PhD 1; Agarwal, Banke MD 8
doi : 10.14309/ajg.0000000000002081
In animal models, inflammation caused by experimental acute pancreatitis (AP) promotes pancreatic carcinogenesis that is preventable by suppressing inflammation.
Rapid Immunochromatography on Fresh Intestinal Biopsy Is Highly Accurate in Detecting Intestinal Antitransglutaminase Antibodies.
Lega, Sara MD 1; De Leo, Luigina PhD 1; Ziberna, Fabiana PhD 1; Grigoletto, Veronica MD 2; Gaita, Bartolomea MSc 1; Giangreco, Manuela PhD 1; Villanacci, Vincenzo MD 3; Bramuzzo, Matteo MD 1; Di Leo, Grazia MD 1; Not, Tarcisio MD 1,2
doi : 10.14309/ajg.0000000000002105
Intestinal antitransglutaminase antibodies (I-anti-TG2) are a specific marker of celiac disease (CeD). The aim of this study was to evaluate the diagnostic accuracy of a novel application of an immunochromatographic assay referred to as Rapid_AntiTG2 to detect I-anti-TG2 on intestinal biopsy lysate.
Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis.
Hirano, Ikuo MD 1; Rothenberg, Marc E. MD, PhD 2,3; Zhang, Sandra PhD 4; de Oliveira, Claudia MD, PhD, MPH 4; Charriez, Christina M. PharmD, PhD 4; Coyne, Karin S. PhD, MPH 5; Bacci, Elizabeth Dansie PhD 6; Dellon, Evan S. MD, MPH 7
doi : 10.14309/ajg.0000000000002094
The aim of this study was to evaluate Dysphagia Days as a measure of symptom improvement in patients with eosinophilic esophagitis from the HEROES study.
Prevalence and Correlations of Gastrointestinal Symptoms With Endoscopic and Histologic Mucosal Healing in Crohn's Disease.
Tse, Chung Sang MD 1; Singh, Siddharth MD, MS 2; Valasek, Mark A. MD, PhD 3; Neill, Jennifer BS 2; Le, Helen BS 2; Collins, Angelina E. NP 2; Boland, Brigid Sweeney MD 2
doi : 10.14309/ajg.0000000000002122
AB To characterize the associations between clinical disease activity with endoscopic and histologic (endohistologic) mucosal healing in Crohn's disease, we performed a secondary analysis of prospectively collected data on 424 ileocolonoscopies from 258 unique adults at a tertiary referral center from 2014 to 2021.
Racial and Ethnic Disparities in Years of Potential Life Loss Among Patients With Cirrhosis During the COVID-19 Pandemic in the United States.
Zhao, Yunyu MD 1,*; Yeo, Yee Hui MD 2,*; Samaan, Jamil MD 2; Lv, Fan MD 3; He, Xinyuan MD 1; Liu, Jinli PhD 4; Li, Mei MD 1; Gao, Ning MD 1; Park, Justin MD 5; Yang, Ju Dong MD 2,6; Ayoub, Walid S. MD 2,6; Zhang, Lei PhD 4,7,8; Odden, Michelle C. PhD 9; Ji, Fanpu MD, PhD 1,10,11; Nguyen, Mindie H. MD, MAS 9,12
doi : 10.14309/ajg.0000000000002191
Our aim was to evaluate the impact of race/ethnicity on cirrhosis-related premature death during the COVID-19 pandemic. METHODS: We obtained cirrhosis-related death data (n = 872,965, January 1, 2012-December 31, 2021) from the US National Vital Statistic System to calculate age-standardized mortality rates and years of potential life lost (YPLL) for premature death aged 25-64 years.
Career and Race Are Associated With Cancer.
Jin, Tao MM 1; Huang, Mingxing PhD 2
Anemia-Resistant to Gluten-Free Diet in Patients With Celiac Disease: Is It Just a Malabsorption Problem?.
Seidita, Aurelio MD 1,*; Mansueto, Pasquale MD 1,*; Giuliano, Alessandra MD 2; Carroccio, Antonio MD 2,3
