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Regulatory RNAs in rheumatology: From pathogenesis to potential therapy
Ming-Chi Lu
doi : 10.1111/1756-185X.14615
Amitriptyline for fibromyalgia: Off-label treatment, but non-inferior to approved medication
Cheng Hsien Hung, Yung-Heng Lee, James Cheng-Chung Wei
doi : 10.1111/1756-185X.14618
Calprotectin in spondyloarthritis and gut inflammation, is it clinically meaningful?
Kuan-Kai Tung, Shih-Tien Chen, Cheng-Hung Lee, Chun-Fang Tung, James Cheng-Chung Wei
doi : 10.1111/1756-185X.14619
The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis
Tao Wang, Zhandong Wang, Wenxia Qi, Ganggang Jiang, Gang Wang
doi : 10.1111/1756-185X.14560
Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis and pannus formation as the basic pathological changes. T-lymphocyte infiltration is the key to its pathogenesis.
Impact of targeted therapies on the risk of cardiovascular events in patients with psoriasis and psoriatic arthritis: AÂ systematic review and aggregate data meta-analysis of randomized controlled trials
Ruyi Cai, Yinji Jin, Beidi Chen, Jinxia Zhao, Jiayu Zhai, Lin Zeng, Rong Mu
doi : 10.1111/1756-185X.14603
We aimed to investigate the effect of targeted therapies on cardiovascular risk in psoriasis (PsO) and psoriatic arthritis (PsA) via a meta-analysis of randomized controlled trials (RCTs).
Long non-coding RNA telomerase RNA elements improve glucocorticoid-induced osteoporosis by EZH2 to regulate DKK1
He Hu, Xiaodong Guo, Tingting Mu, Huifang Song
doi : 10.1111/1756-185X.14567
Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis, which increases the risk of fracture. Long non-coding RNA telomerase RNA elements (TERC) has been proven to be closely related to osteoporosis. However, the role of TERC in glucocorticoid-induced osteoporosis and its underlying molecular mechanism remains unclear.
CCL26 in primary biliary cholangitis – Is it a novel disease mediator?
Xiaochuan Sun, Yihan Cao, Li Wang, Hua Chen, Fengchun Zhang
doi : 10.1111/1756-185X.14578
To verify the role of CX3C chemokine ligand 1 - CX3C chemokine receptor 1 (CX3CL1-CX3CR1) pathway in the pathogenesis of primary biliary cholangitis (PBC). To explore whether CCL26, a novel functional ligand to CX3CR1, participates in the immunological mechanism of PBC.
Acute stroke in familial Mediterranean fever: An analysis of 23 new cases and systematic review of the literature
Mehmet Akif Topcuoglu, Cansu Ayvacioglu-Cagan, Ethem Murat Arsava, Pınar Acar-Ozen, Umut Kalyoncu, Rahsan Gocmen, Tayfun Hilmi Akbaba, Banu Balcı-Peynircioğlu, Meryem Aslı Tuncer
doi : 10.1111/1756-185X.14588
The nature of neurovascular involvement in cases of familial Mediterranean fever (FMF) has not been adequately clarified.
Performance of systemic lupus erythematosus responder index for detecting clinician-rated responders in patients with active systemic lupus erythematosus
Pornsawan Leosuthamas, Pongthorn Narongroeknawin, Sumapa Chaiamnuay, Paijit Asavatanabodee, Rattapol Pakchotanon
doi : 10.1111/1756-185X.14606
Disease activity measures in systemic lupus erythematosus (SLE) are critical tools for trial endpoints. We aimed to evaluate the performance of current treatment outcome measures in SLE.
Association between serum uric acid levels of patients with gout and their complications and examination fees: A cross-sectional analysis
Wantai Dang, Ling Zhao, Jing Wang, Dan Xu, Jian Liu, Lanlan You
doi : 10.1111/1756-185X.14609
Correlation influence factor analysis of gout patients' serum uric acid (SUA) levels, their examination fees, and various complications were explored.
Assessing prognostic factors correlating with response to nintedanib for connective tissue disease-associated interstitial lung disease: A real-world single-center study
Hiraku Kokubu, Saki Takeuchi, Takahisa Tozawa, Satoko Hisada, Yoshihiro Yamada, Yumi Itoh, Masanari Kodera
doi : 10.1111/1756-185X.14611
For patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), early medical intervention would be desirable. This study analyzed the real-world, single-center use of nintedanib for CTD-ILD patients.
Paradigm guiding to tapering or discontinuation of biologic and targeted synthetic disease-modifying antirheumatic drugs in the treatment of patients with rheumatoid arthritis: Results from a local prospective study
Nedim Kaban, Halil Harman
doi : 10.1111/1756-185X.14616
We prospectively conduct the current study to figure out predicting factors whether biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) can be discontinued or tapered in patients with rheumatoid arthritis (RA).
MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5
Rongrong Ni, Heting Liu, Guojing Song, Xiaohong Fu, Bingqian Deng, Zhizhen Xu, Shuangshuang Dai, Gang Huang
doi : 10.1111/1756-185X.14622
Dual-specificity phosphatase 5 (DUSP5) is a novel anti-inflammatory modulator in many inflammatory diseases. However, the role of DUSP5 in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) remains unknown.
Genetic predisposition between coronavirus disease 2019 and rheumatic diseases: A 2-sample Mendelian randomization study
Liuliu Quan, Jiangshan Tan, Lu Hua, Xin You
doi : 10.1111/1756-185X.14624
The causalities between the coronavirus disease 2019 (COVID-19) and the risk of rheumatic diseases remain unclear. The purpose of this study was to investigate the causal effect of COVID-19 on rheumatic disease occurrence.
Dasatinib, a selective tyrosine kinase inhibitor, prevents joint destruction in rheumatoid arthritis animal model
Hong Ki Min, Se Hee Kim, Ji-Yeon Won, Kyoung-Woon Kim, Ji-Yeon Lee, Sang-Heon Lee, Hae-Rim Kim
doi : 10.1111/1756-185X.14627
We aimed to evaluate the preventive role of the tyrosine kinase inhibitor dasatinib in an animal model of rheumatoid arthritis (RA).
Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study
Samuel Katsuyuki Shinjo, Minchul Kim, Leonardo Santos Hoff, Rafael Giovani Missé, Parikshit Sen, R. Naveen, Jessica Day, Rafael Alves Cordeiro, Jucier Gonçalves Júnior, Tulika Chatterjee, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Marcin Milchert, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Elena Nikiphorou, Ashima Makol, Ai Lyn Tan, Lorenzo Cavagna, Miguel A. Saavedra, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Arvind Nune, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, COVAD Study Group
doi : 10.1111/1756-185X.14636
To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs).
Efficacy of PF-06651600 in alleviating the pro-inflammatory capacity of CD4+ T cells in rheumatoid arthritis patients
Talar Ahmad Merza Mohammad
doi : 10.1111/1756-185X.14643
PF-06651600 is a highly specific inhibitor of Janus-activated kinase 3 and the Tec family of kinases. Regarding its dual function in the inhibition of both γc cytokine receptors and T cell receptor signaling, the present study aimed at evaluating the impact of PF-06651600 on the status of T-helper cells (Th) as the central game players in the pathogenesis of rheumatoid arthritis (RA).
Attitudes and factors affecting decision-making regarding COVID-19 vaccination among autoimmune rheumatic disease patients
Orathai Wantha, Ajanee Mahakkanukrauh, Kwankaew Tuydaung, Walailuk Donsrichan, Kannikar Yingyaun, Sumalee Kaewmeun, Siraphop Suwannaroj, Chingching Foocharoen
doi : 10.1111/1756-185X.14644
Coronavirus disease-2019 (COVID-19) vaccine hesitancy is a significant threat to the success of COVID-19 vaccination programs.
Progressive interstitial lung disease in hypomyopathic dermatomyositis in the COVID-19 pandemic: A case report
Shenqi Wang, Yi Lyu, Ling Xu, Wenmei Zhang
doi : 10.1111/1756-185X.14498
Clinically amyopathic dermatomyositis (CADM) is characterized by typical skin lesions with no (amyopathic) or subclinical (hypomyopathic) evidence of muscle involvement. Patients with CADM may also develop rapidly progressive interstitial lung disease (ILD), and have a poor prognosis.
Adult case of chronic granulomatous disease mimicking granulomatosis with polyangiitis
Åžerife Åžeyda Zengin AcemoÄŸlu, Ä°pek Türk, Sevil Özsoy, Mustafa Yavuz Köker, Bulut Sat
doi : 10.1111/1756-185X.14507
This article presents a patient who was initially diagnosed as having granulomatosis with polyangiitis (GPA), and was later diagnosed as having chronic granulomatous disease (CGD) in adulthood. We aimed to raise awareness of CGD, which can be confused with rheumatic diseases.
Visceral leishmaniasis in a patient with systemic lupus erythematosus: Dilemma in diagnosis and management
Gamze Akkuzu, Selvinaz Ozkara, Duygu Sevinc Ozgur, Bilgin Karaalioglu, Fatih Yıldırım, Mesut Ayer, Cemal Bes
doi : 10.1111/1756-185X.14510
Patients with systemic lupus erythemasus (SLE) have an increased risk of bacterial, viral, fungal or parasitic infections, especially if they are receiving immunosuppressive therapy.
Prolonged peripheral seronegative spondyloarthritis following BioNTech coronavirus disease 2019 vaccination: A case report
Shu-Yi Koh, Hui-Ming Chen, Chung-Yuan Hsu
doi : 10.1111/1756-185X.14512
A female 17-year-old diagnosed with seronegative spondyloarthritis (SpA) following the first jab of the BioNTech162b2 (BNT162b2) vaccine presented with recurrent swelling and painful knee accompanied by posterior heel tenderness over the past 1.5Â months.
Coexistence of 3q29 microdeletion syndrome and Takayasu arteritis: A case report
Cansu Coşkun, Rıza Can Kardaş, Hamit Küçük
doi : 10.1111/1756-185X.14515
Takayasu arteritis (TAK) is a rare type of large and medial vessel systemic vasculitis. A variety of factors are thought to play a role in the occurrence and development of TAK such as human leukocyte antigen-B52, autoimmunity, inflammation and environmental factors.
Tofacitinib treatment in anti-glycyl-tRNA synthetase antibody interstitial lung disease – A case report
Chih-Wei Tseng
doi : 10.1111/1756-185X.14516
Anti-aminoacyl-transfer-RNA synthetase syndrome (ASS) related interstitial lung disease (ILD) is rarely presented initially alongside acute respiratory distress syndrome (ARDS), which in and of itself is a severe condition with a high mortality rate
Intrathecal injection of methotrexate combined with dexamethasone for Cogan's syndrome with neurological involvement: A case report and literature review
Jiarui Hu, Hongjia Du, Jiang Su, Tong Wu, Rui Wu, Jing Zhu
doi : 10.1111/1756-185X.14518
Cogan's syndrome (CS) is a rare autoimmune disease in which approximately 10%–13% of people with the condition develop neurological symptoms.
Edema localized to the lips as a novel manifestation of myositis
Hayakazu Sumida, Yoshihide Asano, Jun Shimizu, Shinichi Sato
doi : 10.1111/1756-185X.14543
lymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies with presumed autoimmune pathogenesis, characterized by the features of proximal skeletal muscle weakness and evidence of muscle inflammation.
Visceral extra-abdominal panniculitis after COVID19
Cristina AusÃÂn-GarcÃÂa, Eva Cervilla-Muñoz, Pablo Demelo-RodrÃÂguez, MarÃÂa Victoria Villalba-GarcÃÂa, Luis A. Alvarez-Sala Walther
doi : 10.1111/1756-185X.14544
“Retractile mesenteritis� was the first name given to a rare, benign, inflammatory disease that affects the adipose tissue of the intestinal mesentery and less frequently other locations. Now labeled as mesenteric panniculitis, the pathogenic mechanism remains unclear.
Complex regional pain syndrome with progressive dystonia
Banwari Sharma
doi : 10.1111/1756-185X.14561
A remarkable case of active spondyloarthritis
Fadi Kharouf, Yusef Azraq
doi : 10.1111/1756-185X.14566
Thromboangiitis obliterans and foot necrosis: A case of successful treatment with alprostadil
Susana P. Silva, Sofia Ferreira Azevedo, Gisela Eugénio, Anabela Barcelos
doi : 10.1111/1756-185X.14573
Superior mesenteric artery thrombosis after the messenger RNA-1273 vaccine
Chen-Wei Chen, Wen-Yee Chen, Renin Chang, Chih-Hsiang Kao
doi : 10.1111/1756-185X.14614
A rare cause of dermatomyositis: Large cell neuroendocrine tumor of the lung
Reşit Yıldırım, Mustafa Dinler, Bahattin Erdoğan, Emine Dündar, Nazife Şule Yaşar Bilge, Timuçin Kaşifoğlu
doi : 10.1111/1756-185X.14635
Progressive cognitive dysfunction with subdural polycystic hygroma and systemic inflammation under immunosuppressive therapy
Masato Tarumi, Nobuya Abe, Tatsuya Atsumi
doi : 10.1111/1756-185X.14649
Juvenile idiopathic arthritis in an adult Filipino female: A case report
Cristina A. Dorado, Evan S. Vista
doi : 10.1111/1756-185X.14579
Juvenile idiopathic arthritis (JIA) is a family of arthritic conditions that occurs in childhood. If untreated, the disease may result in poor quality of life and complications, such as long-term joint damage, that may affect patients their entire lives.
