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Pyrolae herba: A review on its botany, traditional uses, phytochemistry, pharmacology and quality control
Chunjiao He a,1, Junyu Liu b,1, Tongwei Ke a, Yawen Luo a, Shaowu Zhang c, Ting Mao a, Zulun Li a, Xuhua Qin a,*, Shenrui Jin
doi : 10.1016/j.jep.2022.115584
Volume 298, 15 November 2022, 115584
Pyrolae herba is the dried whole plant of Pyrola calliantha H. Andres or Pyrola decorata H. Andres (Pyrolaceae). Pyrolae herba has a long history of medicinal use in China.
Traditional uses, phytochemistry, pharmacology, and toxicity of Eriobotrya japonica leaves: A summary
Xu Zhu a,1, Lin Wang b,1, Tie Zhao a, Qinghua Jiang
doi : 10.1016/j.jep.2022.115566
Volume 298, 15 November 2022, 115566
Eriobotrya japonica Lindl. has been included in “The Plant List” (http://www.theplantlist.org) and is the most widely researched species in its genus. E. japonica is a subtropical evergreen fruit tree belonging to the Rosaceae family.
Phytochemical and pharmacological review of diterpenoids from the genus Euphorbia Linn (2012–2021)
Huan Zhao b, Lei Sun b, ChuiHao Kong b, WenLi Mei a,c, HaoFu Dai a,c, FengQing Xu b,d,**, ShengZhuo Huang
doi : 10.1016/j.jep.2022.115574
Volume 298, 15 November 2022, 115574
Euphorbia is one of the major genera in angiosperms, which is widely distributed all over the world, including Asia, Africa and Central and South America. The roots or tubers of Euphorbia are famous for medicinal purposes, especially in China.
The effectiveness of miswak (Salvadora persica L. and Azadirachta indica A.Juss.) practices in reducing plaque and gingivitis among adults: A systematic review and meta-analysis
Haslinda Ramli a,f, Khairun Nain Nor Aripin b, Shahida Mohd Said c,*, Rohazila Mohamad Hanafiah d, Tuti Ningseh Mohd Dom
doi : 10.1016/j.jep.2022.115598
Volume 298, 15 November 2022, 115598
Salvadora persica L. and Azadirachtaindica A.Juss. are listed within the most common sources of miswak or chewing stick that widely used among Western Asia and Muslim populations worldwide.
The efficacy and toxicity of grayanoids as analgesics: A systematic review
Jian Yang 1, Jingyi Zhao 1, Jiquan Zhang
doi : 10.1016/j.jep.2022.115581
Volume 298, 15 November 2022, 115581
Grayanoids are natural diterpenoids that are mostly found in the Ericaceae family, such as Rhododendron molle (Blume) G. Don (Relevant herb: nao yang hua), Rhododendron micranthum Turcz (also known as: zhao shan bai), which have traditionally been used to treat abdominal pain, cephalgia, and rheumatoid arthritis.
Bidirectional effects and mechanisms of traditional Chinese medicine
Xiaonian Peng a,1, Fang Tang b,1, Yong Yang c, Tiandan Li a, Xiaochao Hu a, Sha Li a, Weihua Wu a,**, Kai He
doi : 10.1016/j.jep.2022.115578
Volume 298, 15 November 2022, 115578
The bidirectional property of traditional Chinese medicines (TCMs) was recorded in the classic work Medicine Origin (Yi Xue Qi Yuan) as early as the Jin and Yuan dynasties of ancient China.
Alternanthera sessilis: Uncovering the nutritional and medicinal values of an edible weed
Chia Shing Hwong a, Kok Hoong Leong b, Azlina Abdul Aziz a, Sarni Mat Junit a, Suzita Mohd Noor c, Kin Weng Kong a,*
doi : 10.1016/j.jep.2022.115608
Volume 298, 15 November 2022, 115608
Weeds are often considered undesirable as they interfere with the habitat of native plants, and therefore they are underestimated and underutilised. In fact, some edible weeds have beneficial nutritional and medicinal values.
Tubiechong：A review on ethnomedicinal uses, bioactive chemical constituents and pharmacological activities
Xiang Fu, Bing-Hao Shao, Xue Wei, Hui-Hui Wang, Xing Chen, Tian-tian Zhao, Chun-Mei Wang
doi : 10.1016/j.jep.2022.115642
Volume 298, 15 November 2022, 115642
Tubiechong comprises mainly Eupolyphaga and Steleophaga is widely distributed in China. It has been used in the traditional medicine systems in Asian countries specially in China，Japan and Singapore for thousand years.
Leaves, seeds and exocarp of Ginkgo biloba L. (Ginkgoaceae): A Comprehensive Review of Traditional Uses, phytochemistry, pharmacology, resource utilization and toxicity
Yanxia Liu a,1, Huawei Xin a,1, Yunchao Zhang a, Fengyuan Che b, Na Shen a,**, Yulei Cui a
doi : 10.1016/j.jep.2022.115645
Volume 298, 15 November 2022, 115645
Until now, there is no painstakingly summarized review on leaves, seeds and exocarp of G. biloba simultaneously. This review will systematically summarize and compare current knowledge of G. biloba.
A comprehensive review on ethnopharmacological, phytochemical, pharmacological and toxicological evaluation, and quality control of Pinellia ternata (Thunb.) Breit.
Jing Bai a, Jianbo Qi a, Li Yang b, Zhengtao Wang b, Rui Wang a,**, Yanhong Shi
doi : 10.1016/j.jep.2022.115650
Volume 298, 15 November 2022, 115650
Pinellia ternata tuber (PTT), the dried tuber of Pinellia ternata (Thunb.) Breit., has a long history of use in traditional Chinese medicine for drying dampness, resolving phlegm, down-bearing counterflow to check vomiting and dissipating masses.
Effects of okra (Abelmoschus esculentus (L.) Moench) on glycemic markers in animal models of diabetes: A systematic review
Aiane Benevide Sereno a,*, Carla Dayane Pinto a, Fabiana Antunes Andrade b,c, Michelli Aparecida Bertolazo da Silva a,e, Amanda Carvalho Garcia a, Cl �audia Carneiro Hecke Krüger d, Iara Jos �e de Messias Reason
doi : 10.1016/j.jep.2022.115544
Volume 298, 15 November 2022, 115544
Okra (Abelmoschus esculentus (L.) Moench) is traditionally used by different populations of Africa, América, Asia, and Europa to control diabetes. Although its action has been evaluated in several preclinical rodent trials, they have not been systematically analyzed.
Experimental and clinical trial investigations of phyto-extracts, phyto-chemicals and phyto-formulations against oral lichen planus: A systematic review
Alaka Sahoo *, Ajaya K. Jena, Maitreyee Panda
doi : 10.1016/j.jep.2022.115591
Volume 298, 15 November 2022, 115591
Bio-assay guided phytoextracts and derived phytoconstituents reported having multipotent biological activities and nearly 60–80% of the global population still using natural regimens as an alternative therapeutic source
Lichens: An update on their ethnopharmacological uses and potential as sources of drug leads
Olubukola Tolulope Adenubi a,*, Ibukun Michael Famuyide b, Lyndy Joy McGaw b, Jacobus Nicolaas Eloff
doi : 10.1016/j.jep.2022.115657
Volume 298, 15 November 2022, 115657
Lichens, a unique symbiotic association between an alga/cyanobacterium and a fungus, produce secondary metabolites that are a promising source of novel drug leads.
Carthamus tinctorius L.: A natural neuroprotective source for anti-Alzheimer's disease drugs
Yuanyuan Liang , Lin Wang
doi : 10.1016/j.jep.2022.115656
Volume 298, 15 November 2022, 115656
The aim of this review was to investigate published reports of C. tinctorius L. and its active constituents in AD treatment through a literature review.
Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review
Ibrahim Mssillou a,*, Meryem Bakour a, Meryem Slighoua b, Hassan Laaroussi a, Hamza Saghrouchni c, Fatima Ez-Zahra Amrati b, Badiaa Lyoussi a, Elhoussine Derwich
doi : 10.1016/j.jep.2022.115663
Volume 298, 15 November 2022, 115663
The human skin constitutes a biological barrier against external stress and wounds can reduce the role of its physiological structure. In medical sciences, wounds are considered a major problem that requires urgent intervention.
Anxiolytic effect of Anthemis nobilis L. (roman chamomile) and Citrus reticulata Blanco (tangerine) essential oils using the light-dark test in zebrafish (Danio rerio)
Virginia Silveira a, Karina Taciana Santos Rubio a, Maria Elvira Poleti Martucci
doi : 10.1016/j.jep.2022.115580
Volume 298, 15 November 2022, 115580
The anxiety disorders are the most prevalent mental health condition, and anxiety is considered the sixth cause of disability surpassing diabetes mellitus, chronic obstructive pulmonary disease, and osteoarthritis.
Tong-Qiao-Huo-Xue decoction activates PI3K/Akt/mTOR pathway to reduce BMECs autophagy after cerebral ischemia/reperfusion injury
Yaping Hua a,b,c,1, Yan Zhai a,b,c,1, Guangyun Wang a,b,c,d,**, Ning Wang a,b,c,*, Qian Wu a,b,d, Qi Huang a,b, Saiwang Seto e, Yan Wang
doi : 10.1016/j.jep.2022.115585
Volume 298, 15 November 2022, 115585
Tong-Qiao-Huo-Xue Decoction (TQHXD) is a traditional classic Chinese Medicinal Formula (CMF) used for clinical treatment of ischemic stroke. TQHXD leads to improvement in the symptoms of the acute period of cerebral infarction and recovery period after stroke.
Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways
Gaorui Wang a, Ziyu Chen a, Yingying Song a, Hui Wu a, Ming Chen b, Shusheng Lai b, Xiaojun Wu
doi : 10.1016/j.jep.2022.115592
Volume 298, 15 November 2022, 115592
In the long history of traditional Chinese medicine, Panax notoginseng has been used as a key herb for the treatment of blood diseases.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice
Huan He a, Jianling Deng a, Maochun Yang a, Linjing An a, Xiaoli Ye b,**, Xuegang Li
doi : 10.1016/j.jep.2022.115529
Volume 298, 15 November 2022, 115529
Obesity is closely related to diabetes. Jatrorrhizine (JAT) from Rhizoma Coptidis (RC) can reduce blood glucose and lipid levels. However, the molecular mechanisms for JAT's anti-obesity effect are still not clear.
Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways
Yu-Lei Ma a,1, Zi-Mei Wu a,b,1, Xiao Liu a,1, Jiang-Er Lan a, Wen-Jing Zai a, Xin Jin a, Hui Xie a, Qing Mu a,**, Hong-Rui Liu
doi : 10.1016/j.jep.2022.115560
Volume 298, 15 November 2022, 115560
Valeriana jatamansi Jones, a traditional medicine, is used for various medicinal purposes worldwide. This species is popular for its gastro-protective properties and has been verified to exert antidiarrheal effects.
Sub-chronic oral toxicity evaluation of herbo-metallic formulation Arshakuthar rasa in rats
Monika Kumari a,1, Shatrughna Madhukar Bajad a,b,1, Shripad Rajendra Kshirsagar a,b, Srinivas Chinde a, Andugulapati Sai Balaji a, M. Jerald Mahesh Kumar c, Saileshnath Saxena d, Srinivas Indu Kumari
doi : 10.1016/j.jep.2022.115306
Volume 298, 15 November 2022, 115306
Arshakuthar rasa (AR) is a mercury based Ayurvedic herbo-metallic formulation. The concerns are being raised about the probable toxicity of mercury after prolonged use of AR.
A systematic review: Botany, phytochemistry, traditional uses, pharmacology, toxicology, quality control and pharmacokinetics of Ilex rotunda Thunb.
Wei Zeng , Hui Cui , Weiqun Yang , Zhongxiang Zhao
doi : 10.1016/j.jep.2022.115419
Volume 298, 15 November 2022, 115419
Ilex rotunda Thunb. (I. rotunda) is an Ilex species of Aquifoliaceae, widely distributed in East Asia. Its dried bark is commonly used as a medicinal part in the field of traditional Chinese medicine (TCM), named Ilicis Rotundae Cortex.
Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer
Fan Gao a,1, Yuju Niu a,1, Luyao Sun a, Wenwen Li a, Haojie Xia a, Yaru Zhang a, Shengnan Geng b, Zhenzhen Guo a, Haihong Lin a,*, Gangjun Du
doi : 10.1016/j.jep.2022.115573
Volume 298, 15 November 2022, 115573
Mufangji decoction (MFJD), a famous traditional Chinese medicine formula in Synopsis of Golden Chamber (Jingui yaolue), has been utilized to treat cough and asthma and release chest pain over 2000 years in China.
Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat
Qian Lin a,1, Man Liu a,1, Famous Erhunmwunsee a, Bing Li b, Yanfang Mou b, Sen Wang a, Guimin Zhang b,**, Jun Tian
doi : 10.1016/j.jep.2022.115575
Volume 298, 15 November 2022, 115575
Shouhui tongbian capsule (SHTC) is a commercial Chinese patent medicine used in the treatment of constipation. However, its mechanism of action remains unclear.
Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro
Ndeye F. Kane , Bushra H. Kiani , Matthew R. Desrosiers , Melissa J. Towler , Pamela J. Weathers
doi : 10.1016/j.jep.2022.115587
Volume 298, 15 November 2022, 115587
The Chinese medicinal herb, Artemisia annua L., has been used for >2,000Â yr as traditional tea infusions to treat a variety of infectious diseases including malaria, and its use is spreading globally (along with A. afra Jacq. ex Willd.) mainly through grassroots efforts.
Efficacy and safety of Fuzheng Huayu tablet on persistent advanced liver fibrosis following 2 years entecavir treatment: A single arm clinical objective performance criteria trial
Zhi-Min Zhao a, Chuan-Wu Zhu b, Jia-Quan Huang c, Xiao-Dong Li d, Yu-Xi Zhang e, Jian Liang f, Wei Zhang g, Yong Zhang h, Xian-Gao Jiang i, Ya-Li Zong j, Ke-Jun Zhang k, Ke-Wei Sun l, Biao Zhang m, Yun-Hai Lv n, Hui-Chun Xing o, Qing Xie p, Ping Liu a,q,*, Cheng-Hai Liu
doi : 10.1016/j.jep.2022.115599
Volume 298, 15 November 2022, 115599
Antiviral therapy can alleviate liver fibrosis in chronic hepatitis B, but it has a limited effect on advanced liver fibrosis/cirrhosis.
Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera)
Anna Szurpnicka a,*, Anna Katarzyna Wro �nska b, Katarzyna Bus c, Aleksandra Kozi �nska d, Renata Jabłczy �nska a, Arkadiusz Szterk e,f, Katarzyna Lubelska
doi : 10.1016/j.jep.2022.115604
Volume 298, 15 November 2022, 115604
Viscum album L. (European mistletoe), a member of the Santalaceae, is a hemiparasitic, evergreen shrub growing on deciduous and coniferous trees.
Schisandra chinensis (Turcz.) Baill. Protects against DSS-induced colitis in mice: Involvement of TLR4/NF-κB/NLRP3 inflammasome pathway and gut microbiota
Zhenhua Bian a,b,1, Yuwen Qin a,1, Lin Li a,1, Lianlin Su a, Chenghao Fei a, Yu Li a, Minmin Hu b, Xiaowei Chen b, Wei Zhang a, Chunqin Mao a, Xiaohang Yuan b,**, Tulin Lu a,*, De Ji
doi : 10.1016/j.jep.2022.115570
Volume 298, 15 November 2022, 115570
the fruit of Schisandra chinensis (Turcz.) Baill. (SC) is an important traditional Chinese herbal medicine, which has been widely used in traditional Chinese medicine (TCM) for treating intestinal diseases.
The anti-inflammatory effects of Hedyotis diffusa Willd on SLE with STAT3 as a key target
Li Xu a,1, Ying Li a,1, Jinjun Ji a, Yahui Lai a, Jing Chen a, Tao Ding a, Haichang Li a, Bin Ding b,*, Weihong Ge
doi : 10.1016/j.jep.2022.115597
Volume 298, 15 November 2022, 115597
Hedyotis diffusa Willd, also named Scleromitrion diffusum (Willd.) R.J. Wang, is one medical herb, which has been traditionally used by the She nationality in China. And H. diffusa represents a beneficial effect on Systemic lupus erythematosus (SLE) treatment in clinic.
Metabolomics and integrated network pharmacology analysis reveal that ginkgolides act as potential active anticancer components by regulating one-carbon metabolism
Junyao Zhou a,b, Mingmin Qian a,c, Chenxi Li a,c, Wenbin Zhou a,b, Lan Yao a,b, Yanhua Chen a,c,*, Zeper Abliz
doi : 10.1016/j.jep.2022.115609
Volume 298, 15 November 2022, 115609
Ginkgo biloba L. is a rare tree species unique to China. Ginkgo biloba is a traditional Chinese medicinal with a long history, acting on the heart and lung meridians, and has been reported to have a significant effect on non-small cell lung cancer. However, the mechanism underlying this metabolic effect is poorly understood.
Dual effect of the herbal matcha green tea (Camellia sinensis L. kuntze) supplement in EA.hy926 endothelial cells and Artemia salina
Tuani Mendes Silva a, D �ebora Soligo Fracasso a, Ana Paula Vargas Visentin a, Carina Cassini a, Fernando Joel Scariot b, Sidineia Danetti c, Sergio Echeverrigaray b, Sidnei Moura c, Luciana Bavaresco Touguinha a, Catia Santos Branco a, Mirian Salvador
doi : 10.1016/j.jep.2022.115564
Volume 298, 15 November 2022, 115564
Matcha green tea (Camellia sinensis) based-supplements have been widely used since they present a greater content of phenolic compounds than traditional green tea, which is popularly used in the treatment of diabetes.
HPLC-MS/MS analysis of primary alkaloids in rat plasma after oral administration of “Nux vomica - Glycyrrhiza glabra decoction”: A pharmacokinetic study
Yuyan Guo a, Zejun Meng a, Yuanyuan Gu a, Weinan Li a, Shuang Sun a, Qiuhong Wang b,*, Haixue Kuang
doi : 10.1016/j.jep.2022.115588
Volume 298, 15 November 2022, 115588
Decoction is the most common form of administering traditional Chinese medicine (TCM). During the preparation of decoction, the high temperature and complex chemical environment result in the formation of complex and multiple phases.
Anti-inflammatory and anti-pruritic effects of Chi-Huang Solution in a murine model of allergic contact dermatitis
Hsiaoyu Yang a,1, Yuexiang Ming a,1, Weihsin Wang a, Yipeng Jin a, Zhihui Hao a,b, Gang Liu a, Di Zhang a,**, Jiahao Lin
doi : 10.1016/j.jep.2022.115543
Volume 298, 15 November 2022, 115543
In treating atopic dermatitis, multi-mode management is adopted, including trying to avoid the allergens, controlling and preventing secondary infections, and using drugs to control itching.
Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway
Jinfeng Yuan, Nuo Xu, Yanlin Tao, Xinyan Han, Liu Yang, Jinglei Liang, Haojieyin Jin, Xiaoxia Zhang, Hui Wu, Hailin Shi, Fei Huang, Xiaojun Wu
doi : 10.1016/j.jep.2022.115622
Volume 298, 15 November 2022, 115622
Radix Astragali is a traditional Chinese medicine with various pharmacological effects. Total astragalosides (TA), the main effective ingredients in Radix Astragali, exert properties including anti-oxidative stress, anti-neuroinflammation, and neuroprotection.
Co-existing polysaccharides affect the systemic exposure of major bioactive ingredients in Chang-Kang-Fang, a multi-herb prescription for treatment of irritable bowel syndrome
Ping Zhong a,b,1, Jing Zhou a,b,1, Yan-Ting Fan a,b, Meng-Fei Guo a,b, He Zhu b, Shan-Shan Zhou b, Jin-Hao Zhu b, Huan-Huan Zhang a,b, Gui-Rong Zhou c, Xing-Long Miao c, Song-Lin Li a,b,**, Qian Mao
doi : 10.1016/j.jep.2022.115601
Volume 298, 15 November 2022, 115601
Chang-Kang-Fang (CKF) is a traditional Chinese herbal formula used for treatment of irritable bowel syndrome (IBS) in China. Decoction is the administration form of CKF in clinical practice.
Discovery of Q-markers of Wenxin Formula based on a Chinmedomics strategy
Zong-wei Wang, Chang Liu, Ai-hua Zhang, Guang-li Yan, Hui Sun, Ying Han, Wei-tong Ma, Xi-jun Wang
doi : 10.1016/j.jep.2022.115576
Volume 298, 15 November 2022, 115576
Wenxin Formula (WXF) is a well-known prescription with a significant curative effect in the treatment of cardiac disease. However, the lack of quality control standards caused by unclear quality control components limits the development of new drugs.
Evaluation of the efficacy and safety of Unani Formulations in Pityriasis Versicolor: A randomized controlled trial
Bhoraniya Abdullah Ismail a, Mohammad Nawab a,*, Syeda Hajra Fatima b, Ahmed Minhajuddin c, Mohammed Abdul Rasheed Naikodi
doi : 10.1016/j.jep.2022.115603
Volume 298, 15 November 2022, 115603
Pityriasis Versicolor (PV) is a commonly encountered infection of the skin caused by Malassezia species. Despite effective conventional antifungal drugs, the prevention and treatment of PV remain a challenge.
Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers
Misato Ota a,b, Yasuhito Maki a,b, Ling-yu Xu a, Toshiaki Makino
doi : 10.1016/j.jep.2022.115625
Volume 298, 15 November 2022, 115625
Valeriana plant roots have traditionally been used to treat central nervous system-related disorders in European countries. Among this genus, the Japanese Pharmacopoeia registers the dried roots of V. fauriei Briq. (VF). However, insufficient pharmacological data are available for this species.
Integrated plasma pharmacochemistry and network pharmacology to explore the mechanism of Gerberae Piloselloidis Herba in treatment of allergic asthma
Kun Zhou a,c,1, Dingyan Lu a,1, Jingrui You a,c, Ting Liu b, Jia Sun b, Yuan Lu b, Jie Pan a, Yongjun Li a,**, Chunhua Liu
doi : 10.1016/j.jep.2022.115624
Volume 298, 15 November 2022, 115624
Gerberae Piloselloidis Herba (GPH), a commonly used traditional medicine in China, is derived from Gerbera piloselloides (Linn.) Cass. It is featured by its special bioactivities as antitussive, expectorant, anti-asthma, anti-bacterial, anti-tumor, uterine analgesia, and immunity-enhancing.
Screening and identification of anti-acetylcholinesterase ingredients from Tianzhi granule based on ultrafiltration combined with ultra-performance liquid chromatography-mass spectrometry and in silico analysis
Nan Zhao , Dan Liu , Yi Wang , Xiaozhe Zhang *, Lihua Zhang
doi : 10.1016/j.jep.2022.115641
Volume 298, 15 November 2022, 115641
Tianzhi granule (TZG) is a traditional Chinese formula that is widely used for the treatment of vascular dementia (VaD).
The antihypertensive and diuretic effect of crude root extract and saponins from Solanum sisymbriifolium Lam., in L-NAME-induced hypertension in rats
D.A. Ibarrola a,*, W. Arrua a, J.E. Gonzalez a, M.S. Soverina Escobar a, J. Centuri �on a, A.M. Campuzano Benitez a, F.M. Ovando Soria a, E.I. Rodas Gonz �alez a, K.G. Arrúa a, M.B. Acevedo Barrios a, O.Y. Heinichen a, Y. Montalbetti a, M.A. Campuzano-Bublitz a, M.L. Kennedy a, S.J. Figueredo Thiel c, N.L. Alvarenga b, M.C. Helli �on-Ibarrola
doi : 10.1016/j.jep.2022.115605
Volume 298, 15 November 2022, 115605
Solanum sisymbriifolium Lam., is used in Paraguayan folk medicine claiming antihypertensive and diuretic properties.
Rosa damascena together with brown sugar mitigate functional constipation in children over 12 months old: A double-blind randomized controlled trial
Mohammad Hadi Imanieh a, Naser Honar a, Abdolali Mohagheghzadeh b,c, Mahmood Haghighat a, Seyed Mohsen Dehghani a, Ghazaleh Mosleh d, Maryam Ataollahi a, Heidar Safarpour e,**, Behnaz Darban f, Fereshteh Karbasian f, Ali Reza Safarpour a, Amir Hossein Hassani g, Abbas Avazpour
doi : 10.1016/j.jep.2022.115582
Volume 298, 15 November 2022, 115582
Rosa × damascena Herrm., known as damask rose, is a bushy shrub that is found abundantly in Fars province, Iran.
Dendrobium nobile Lindl. Polysaccharides protect fibroblasts against UVA-induced photoaging via JNK/c-Jun/MMPs pathway
Wei Li a, Xingrui Mu a, Xingqian Wu a, Wenjie He a, Ye Liu a, Yiqiu Liu a, Junyu Deng a, Xuqiang Nie
doi : 10.1016/j.jep.2022.115590
Volume 298, 15 November 2022, 115590
Dendrobium nobile Lindl. is an orchid species that is found throughout Asia, including Thailand, Laos, Vietnam, and China. It has been used to treat tumors, hyperglycemia, hyperlipidemia, and neurological disorders caused by aging in recent decades.
Standardized phytopreparations and cucurbitacin IIb from Ibervillea sonorae (S. Watson) greene induce apoptosis in cervical cancer cells by Nrf2 inhibition
Max Vidal-Guti Ì�errez a,b, Heriberto Torres-Moreno c, VÃctor Arenas-Luna d, MarÃa Lilia Loredo-Mendoza d, Farid Tejeda-Dominguez d, Carlos Velazquez a, Wagner Vilegas b,e, Salom Ì�on Hern Ì�andez-Guti Ì�errez d,**, Ram Ì�on E. Robles-Zepeda
doi : 10.1016/j.jep.2022.115606
Volume 298, 15 November 2022, 115606
To evaluate the apoptotic and Nrf2 inhibition activity of the phytopreparations Acetison and Etanison from Ibervillea Sonorae in the HeLa cervical cancer cell line.
Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification
Yun Liu a, Shuo Li a, Dandan Liu a,c, Hong Wei a, Xingzhi Wang a, Fuling Yan
doi : 10.1016/j.jep.2022.115632
Volume 298, 15 November 2022, 115632
Explore the potential mechanism of Pushen capsule in vascular dementia (VaD) using network pharmacology analysis and experimental verification.
Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats
Armita Farid a, Mohammad Sheibani a,e, Asie Shojaii b,c, Mitra Noori d, Manijeh Motevalian a
doi : 10.1016/j.jep.2022.115595
Volume 298, 15 November 2022, 115595
Plantago major (P. major) has traditionally been used in Iranian Persian medicine to treat gastrointestinal ulcers and bleeding.
Dan-Lou tablets reduces inflammatory response via suppression of the MyD88/p38 MAPK/NF-κB signaling pathway in RAW 264.7 macrophages induced by ox-LDL
Zhu Li a,1, Qi Cheng a,1, Lu Yu a,1, Yuan-Yuan He a, Li-Na Gao b, Yue Wang a, Lin Li a, Yuan-Lu Cui a,**, Shan Gao a,***, Chun-Quan Yu
doi : 10.1016/j.jep.2022.115600
Volume 298, 15 November 2022, 115600
The anti-inflammatory effect of Dan-Lou tablets (DLT) have been reported; however, the signaling pathways involved and their role in foam cell formation remains unclear.
Marsdenia tenacissima extract disturbs the interaction between tumor-associated macrophages and non-small cell lung cancer cells by targeting HDGF
Jia-lei Fu 1, Hui-feng Hao 1, Shan Wang, Yan-na Jiao, Ping-ping Li **, Shu-yan Han
doi : 10.1016/j.jep.2022.115607
Volume 298, 15 November 2022, 115607
Marsdenia tenacissima (Roxb.) Wight et Arn. is a traditional Chinese herbal medicine, and its water-soluble ingredient Marsdenia tenacissima extract (MTE), was widely used for cancer treatment.
Integrating pharmacokinetics and network pharmacology to identify and validate targets of Guben Xiaozhen prescription for the treatment of chronic urticaria
Yayun Wu a,c,d,1, Yuanxin Ren a,b,1, Lijuan Liu a,d,1, Ya Zhao a,d, Yang Wang b, Ruizhi Zhao a,c,d,*, Chuanjian Lu a
doi : 10.1016/j.jep.2022.115628
Volume 298, 15 November 2022, 115628
Guben Xiaozhen prescription (GXP), a prescription of traditional Chinese medicine, has been used to treat skin diseases for a long history and achieved satisfactory therapeutic effects. However, its active ingredients and targets remain to be further elucidated.
Integrated systematic pharmacology analysis and experimental validation to reveal the mechanism of action of Semen aesculi on inflammatory bowel diseases
Min Li a,b, Fang Wang c, Ce Zhang b, Min-An Li b, Tian Wang b, Yu-Chen Li b, Feng-Hua Fu b,*
doi : 10.1016/j.jep.2022.115627
Volume 298, 15 November 2022, 115627
Semen aesculi (SA), a traditional Chinese herb, has been used in the treatment of gastrointestinal disease for thousands of years. The escin was the main components of SA.
Effect and mechanisms of Polygonatum kingianum (polygonati rhizome) on wound healing in diabetic rats
Qin Pan-Yue 1, Xu Ya-Jing 1, Zuo Xiang-Duo, Duan Jun-Hua , Qiu Bin, Li Xue-Fang, Li Jing-Ping *, Yu Jie
doi : 10.1016/j.jep.2022.115612
Volume 298, 15 November 2022, 115612
Diabetic dermatopathy is one of the most serious and common complications of diabetes. It has been found that high glucose can lead to abnormal glycometabolism.
Integrated network pharmacology and intestinal flora analysis to determine the protective effect of Xuanbai–Chengqi decoction on lung and gut injuries in influenza virus-infected mice
Jinlin Huo a,1, Ting Wang b,1, Bokai Wei a,1, Xunlong Shi b, Aidong Yang a, Daofeng Chen c,*, Jing Hu a,*, Haiyan Zhu
doi : 10.1016/j.jep.2022.115649
Volume 298, 15 November 2022, 115649
Xuanbai–Chengqi decoction (XBCQ) is a traditional Chinese medicine (TCM) compound used in the treatment of pulmonary infection in China. Despite the popular usage of XBCQ, its underlying protective roles and the associated molecular mechanisms with the gut-lung axis in influenza remain unclear.
Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-κB to alleviate LPS-induced ALI
Junnan Cai a,b,c,d, Yu-lian Wang a,b,c,d, Xiao-dong Sheng a,b,c,d, Lei Zhang a,b,c,d, Xiongwen Lv
doi : 10.1016/j.jep.2022.115661
Volume 298, 15 November 2022, 115661
Shufeng Jiedu capsule (SFJDC) is a pure form of traditional Chinese medicine (TCM) that contains eight medicinal plants. Known for its anti-inflammatory and antipyretic effects, it is mostly used to treat upper respiratory tract infections and other infectious diseases, such as colds, pharyngitis, laryngitis, and tonsillitis.
Zhen-Wu decoction and lactiflorin, an ingredient predicted by in silico modelling, alleviate uremia induced cardiac endothelial injury via Nrf2 activation
Xin Liu a,b,c, Yue Li a,b,c, Shi-Hao Ni a,b,c, Shu-Ning Sun a,b,c, Jian-Ping Deng a,b,c, Xiao-Lu Ou-Yang a,b,c, Yu-Sheng Huang a,b,c, Huan Li a,b,c, Zi-Xin Chen a,b,c, Wen-Jun Feng a, Zhi-Ming Lian d, Zhen-Kui Wang d, Shao-Xiang Xian a,b,c, Zhong-Qi Yang a,b,c, Xiao-Han Ye e,***, Ling-Jun Wang a,b,c,**, Lu Lu
doi : 10.1016/j.jep.2022.115579
Volume 298, 15 November 2022, 115579
Cardiorenal syndrome type 4 (CRS type 4), with high rates of morbidity and mortality, has become a social and economic problem worldwide over the last few decades.
Gastroprotective and gastric healing effects of the aqueous extract of Casearia sylvestris in rodents: Ultrasound, histological and biochemical analyzes
Beatriz Monteiro Magalh ̃aes de Oliveira a, PatrÃcia Zanotelli Serpa a, Maria Eduarda da Costa Zanatta b, Bruna Agnoatto Aires b, Amanda Maria Steffler b, Lincon Bordignon Somensi c, Benhur Judah Cury d, Ana Caroline dos Santos d, Larissa Venzon d, Thaise Boeing d, Luisa Mota da Silva d, Walter Antˆonio Roman Junior
doi : 10.1016/j.jep.2022.115660
Volume 298, 15 November 2022, 115660
This study evaluated the hypothesis that the aqueous extract a of C. sylvestris (AEC) prevents the gastric ulcers and accelerates the healing of ulcers already installed, by assessing ultrasound imaging, histological and biochemical analyses.
Network pharmacology-based prediction and verification of the active ingredients and potential targets of Huagan Decoction for reflux esophagitis
Yueying Zhao a,1, Yanfeng Cao a,1, Xueying Yang a, Mingxue Guo a, Changhai Wang a, Zekang Zhang a, Qing Zhang a, Xingyue Huang a, Meng Sun a, Cheng Xi a, Jakkree Tangthianchaichana b, Jie Bai a,*, Shouying Du a,**, Yang Lu
doi : 10.1016/j.jep.2022.115629
Volume 298, 15 November 2022, 115629
Huagan Decoction (HGD), a famous traditional Chinese medicine (TCM) formula, has been widely used in the treatment of reflux esophagitis (RE). However, its effective compounds, potential targets and molecular mechanism remain unclear.
Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb
Hai-Yan Jiang a,1, Hui-Yu Gao b,1, Jie Li a, Tian-Yu Zhou c, Shu-Ting Wang a, Jian-Bo Yang b, Rui-Rui Hao a, Fei Pang a, Feng Wei b, Zhi-Gang Liu d, Lian Kuang a, Shuang-Cheng Ma b,*, Jiu-Ming He e,g,**, Hong-Tao Jin
doi : 10.1016/j.jep.2022.115630
Volume 298, 15 November 2022, 115630
The liver toxicity of Reynoutria multiflora (Thunb.) Moldenke. (Polygonaceae) (Polygonum multiflorum Thunb, PM) has always attracted much attention, but the related toxicity materials and mechanisms have not been elucidated due to multi-component and multi-target characteristics.
Lianhuaqingwen capsule inhibits non-lethal doses of influenza virus-induced secondary Staphylococcus aureus infection in mice
Jian Song a,1, Jin Zhao a,1, Xuejun Cai a,1, Shengle Qin a,1, Zexin Chen a, Xiaodong Huang a, Runfeng Li a, Yutao Wang a,*, Xinhua Wang
doi : 10.1016/j.jep.2022.115653
Volume 298, 15 November 2022, 115653
Lianhuaqingwen capsule (LH-C) is a traditional Chinese medicine (TCM), consisting of two prescriptions, Ma-xing-shi-gan-tang (MXSGT) and Yinqiao San. It has been proven to have antiviral, antibacterial, and immunomodulatory effects in recent years.
Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway
Ming-Hui Li a,b,1, Jin Guan a,c,1, Zhe Chen c,1, Ju-Xian Mo a, Kai-Reng Wu c, Xu-Guang Hu b, Tian Lan a,*, Jiao Guo
doi : 10.1016/j.jep.2022.115644
Volume 298, 15 November 2022, 115644
Excessive serum uric acid (SUA) causes hyperuricemic nephropathy (HN), characterized by inflammatory infiltration and tubulointerstitial fibrosis. Most recently, we demonstrated that Fufang Zhenzhu Tiaozhi (FTZ) capsule attenuated diabetic nephropathy through inhibition of renal inflammation and fibrosis.
Phytochemical screening, cytotoxicity assessment and evaluation of in vitro antiplasmodial and in vivo antimalarial activities of Mentha spicata L. methanolic leaf extract
Aditi Chatterjee a,b,1, Nalini Singh a,1, Wahengbam Kabita Chanu c,1, Chingakham Brajakishor Singh c,**, Viswanathan Arun Nagaraj
doi : 10.1016/j.jep.2022.115636
Volume 298, 15 November 2022, 115636
Malaria causes extensive morbidity and mortality, and the decreasing efficacy of artemisinin and its partner drugs has posed a serious concern.
Phytochemical screening, cytotoxicity assessment and evaluation of in vitro antiplasmodial and in vivo antimalarial activities of Mentha spicata L. methanolic leaf extract
Aditi Chatterjee a,b,1, Nalini Singh a,1, Wahengbam Kabita Chanu c,1, Chingakham Brajakishor Singh c,**, Viswanathan Arun Nagaraj
doi : 10.1016/j.jep.2022.115636
Volume 298, 15 November 2022, 115636
Malaria causes extensive morbidity and mortality, and the decreasing efficacy of artemisinin and its partner drugs has posed a serious concern.
Target RNA expression omics approach to reveal the liver detoxification effect induced by Chinese medicine prescription Niu Huang Jie Du against realgar overexposure to mice
Juan Wu a,1, Dongqing Yang a,1, Ziwei Song b, Qin Qian c, Jianguo Dai d, Ju Dong
doi : 10.1016/j.jep.2022.115610
Volume 298, 15 November 2022, 115610
Niu Huang Jie Du prescription (NHJD) is a traditional Chinese medicine (TCM) widely used in patients suffering from excessive inner fire toxin (Huo Du Nei Sheng) syndrome, such as sore throat, gingival swelling, and pain, mouth and tongue sores, etc. This formula contains realgar (As4S4) which is one of the 28 toxic medicinal materials promulgated by the Chinese Ministry of Health.
Pharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L.
Jung-Hung Chen a, I-Hsin Lin a, Thomas Y. Hsueh b,c, Jeffrey W. Dalley d,e, Tung-Hu Tsai
doi : 10.1016/j.jep.2022.115623
Volume 298, 15 November 2022, 115623
Papaveris Pericarpium, which is the dried husk of Papaver somniferum L., has been used as a phytomedicine to relieve cough, diarrhea and pain.
Qingfei oral liquid alleviates RSV-induced lung inflammation by promoting fatty-acid-dependent M1/M2 macrophage polarization via the Akt signaling pathway
Li An a,b,1, Mengjiang Lu c,1, Weichen Xu a,b, Hui Chen a,b, Lu Feng a,b, Tong Xie a,b, Jinjun Shan a,b, Shouchuan Wang a,b,**, Lili Lin
doi : 10.1016/j.jep.2022.115637
Volume 298, 15 November 2022, 115637
Respiratory syncytial virus (RSV) is a common pathogen that causes lower respiratory tract disease in infants and the elderly, and no vaccination is presently available. Qingfei oral liquid (QF), a traditional Chinese medicine formula, has been shown in clinic to have anti-inflammatory properties.
Vitex trifolia L. modulates inflammatory mediators via down-regulation of the NF-κB signaling pathway in carrageenan-induced acute inflammation in experimental rats
Parvathi Annamalai *, Elden Berla Thangam
doi : 10.1016/j.jep.2022.115583
Volume 298, 15 November 2022, 115583
Vitex trifolia L. (V. trifolia L.), commonly known as the three-leaved chaste tree, is extensively employed in traditional Chinese medicine (TCM) to treat various conditions associated with inflammation.
Evaluation of the antimicrobial function of Ginkgo biloba exocarp extract against clinical bacteria and its effect on Staphylococcus haemolyticus by disrupting biofilms
Cong Wang b,1, Peng-Wei Wei a,1, Chao-Rong Song a, Xu Wang a, Gao-Feng Zhu b, Yong-Xin Yang a, Guo-Bo Xu b, Zu-Quan Hu a,d, Lei Tang b,**, Hong-Mei Liu a,***, Bing Wang
doi : 10.1016/j.jep.2022.115602
Volume 298, 15 November 2022, 115602
The fruit of Ginkgo biloba L. (Ginkgo nuts) has been used for a long time as a critical Chinese medicine material to treat cough and asthma, as well as a disinfectant. Similar records were written in the Compendium of Materia Medica (Ben Cao Gang Mu, pinyin in Chinese) and Sheng Nong's herbal classic (Shen Nong Ben Cao Jing, pinyin in Chinese).
Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity
Tingting Liu a,b,c,d,e,1, Guang Xu d,1,**, Yurong Li f,1, Wei Shi b,1, Lutong Ren b, Zhie Fang b, Longxin Liang b, Yan Wang b, Yuan Gao d, Xiaoyan Zhan b, Qiang Li b, Wenqing Mou b, Li Lin b, Ziying Wei b, Zhiyong Li b, Wenzhang Dai b, Jia Zhao b, Hui Li b, Jiabo Wang d, Yanling Zhao g,***, Xiaohe Xiao b,c,****, Zhaofang Bai
doi : 10.1016/j.jep.2022.115593
Volume 298, 15 November 2022, 115593
Psoralea corylifolia (P. corylifolia Linn.) is a traditional Chinese medicinal plant that exhibits significant aphrodisiac, diuretic, and anti-rheumatic effects. However, it has been reported to cause hepatic injury, but the precise mechanisms remain unclear.
The pharmacological validation of the Xiao-Jian-Zhong formula against ulcerative colitis by network pharmacology integrated with metabolomics
Wei Yu , Zhenghao Liang , Qi Li , Yanzhi Liu , Xincheng Liu , Lu Jiang , Chen Liu , Yijia Zhang , Cai Kang , Jing Yan
doi : 10.1016/j.jep.2022.115647
Volume 298, 15 November 2022, 115647
Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency and dysbiosis accompanied by persistent epithelial barrier dysfunction, and is divided into ulcerative colitis (UC) and Crohn's disease (CD).
Jieduquyuziyin prescription promotes the efficacy of prednisone via upregulating Nrf2 in MRL/lpr kidneys
Lijun Du 1, Yuxiang Feng 1, Chenxi Wang, Xiaowei Shi, Chengping Wen, Zhixing He **, Yun Zhang
doi : 10.1016/j.jep.2022.115643
Volume 298, 15 November 2022, 115643
The Jieduquyuziyin prescription (JP), a traditional Chinese medicine (TCM) formula, has been used as an approved hospital prescription to improve the efficacy of prednisone (Pred) in systemic lupus erythematosus (SLE) and lupus nephritis (LN) treatment. Although the synergistic effect of JP and Pred is prominent, the underlying mechanisms require further investigation.
Melaleuca rugulosa (Link) Craven Tannins: Appraisal of anti-inflammatory, radical scavenging activities, and molecular modeling studies
Hassan Y. Ebrahim a,1, Mohamed S. Mady a,*,1, Hanaa B. Atya b, Sahar A. Ali b, Heba E. Elsayed a, Fatma A. Moharram
doi : 10.1016/j.jep.2022.115596
Volume 298, 15 November 2022, 115596
Genus Melaleuca or tea tree species are well known to be an important source of biological active oils and extracts. The biological significance appears in their usage for treatment of several clinical disorder owing to their traditional uses as anti-inflammatory, antibacterial, antifungal, and cytotoxic activities.
Anti-inflammatory effects of Pikad Tri-phol-sa-mut-than remedy, consisting of dried fruits of Aegle marmelos (L.) Corrêa, Coriandrum sativum L., and Morinda citrifolia L.
Bing Tan a,b,c, Natthakarn Chiranthanut a,*, Sunee Chansakaow d, Seewaboon Sireeratawong a, Parirat Khonsung a, Wutigri Nimlamool a, Mingkwan Na Takuathung a, Nirush Lertprasertsuke
doi : 10.1016/j.jep.2022.115639
Volume 298, 15 November 2022, 115639
Inflammation has been known to possess some essential roles in many diseases, especially those with chronic or severe conditions. Pikad Tri-phol-sa-mut-than, a Thai traditional herbal remedy, has long been used to treat gastrointestinal sicknesses, fever, and severe illness caused by the deformities of Tridosha.
Investigation of the potential curative effects of Gui-Zhi-Jia-Ge-Gen decoction on wind-cold type of common cold using multidimensional analysis
Xinhao Wan a, Wenting Wu b, Zhenzhong Zang a, Kang Li a, Abid Naeem a, Yulu Zhu b, Lihua Chen a, Lingyun Zhong b, Weifeng Zhu a,*, Yongmei Guan a,
doi : 10.1016/j.jep.2022.115662
Volume 298, 15 November 2022, 115662
Gui-Zhi-Jia-Ge-Gen decoction (GJGD) is a classical Chinese medicine prescription that has been widely used in clinical practice for centuries. In recent times, TCM has received considerable attention for its potential efficacy in treating a wind-cold type of common cold.
Glycyrrhiza uralensis Fisch. alleviates dextran sulfate sodium-induced colitis in mice through inhibiting of NF-κB signaling pathways and modulating intestinal microbiota
Gaoxiang Shi a,b, Jinrong Kong a, Yunlai Wang a,c, Zihua Xuan a, Fan Xu
doi : 10.1016/j.jep.2022.115640
Volume 298, 15 November 2022, 115640
Licorice is widely used in traditional Chinese Medicine (TCM) for compound compatibility, which could reduce toxicity and increase efficacy of certain herbal medicine, and its active components prominently effects of inhibit of inflammation and regulate of immunity.
Essential oil of Ligusticum chuanxiong Hort. Regulated P-gp protein and tight junction protein to change pharmacokinetic parameters of temozolomide in blood, brain and tumor
Shu-yuan Shuai, Shan-shan Liu, Xiao-jin Liu, Guo-song Zhang, Qin Zheng, Peng-fei Yue, Ming Yang, Peng-yi Hu
doi : 10.1016/j.jep.2022.115646
Volume 298, 15 November 2022, 115646
The existence of the blood-brain barrier/blood tumor barrier (BBB/BTB) severely restricts the effectiveness of anti-tumor drugs, thus glioma is still an incurable disease with a high fatality rate.
Visual analysis and evaluation of clinical research on Traditional Chinese medicine compounds in treating insomnia of Yin deficiency syndrome
Qianyan Wu a, Xuan Chen b, Guoqing Gan c, Qingyuan Zhang a, Letian Yu a, Chunxiao Li a, Ying Zhang d,**, Meiying Ao
doi : 10.1016/j.jep.2022.115669
Volume 298, 15 November 2022, 115669
Insomnia is a common form of sleep disorder. Traditional Chinese medicine (TCM) compounds have definite curative effects and a low incidence of adverse reactions, which is recognized to be an effective intervention means for the treatment of insomnia.
In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae)
J. Mcebisi Mabuza a,b,*, Marcel Kaiser c,d, M. Johanna Bapela
doi : 10.1016/j.jep.2022.115659
Volume 298, 15 November 2022, 115659
The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms.
Digestive and gastroprotective effects of Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (syn. A. moschata Wulfen) (Asteraceae): From traditional uses to preclinical studies
Sara Vitalini a,b,c,*, Stefania Garzoli d, Francesca Sisto b,1, Raffaele Pezzani e,f,1, Maria Pia Argentieri g,1, Alessio Scarafoni a,1, Salvatore Ciappellano a,1, Maira Zorzan e, Jessica Capraro a, Daniela Collazuol e, Marcello Iriti b,c
doi : 10.1016/j.jep.2022.115670
Volume 298, 15 November 2022, 115670
Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson (syn. A. moschata Wulfen) (Asteraceae) is an alpine endemic plant whose aerial parts are harvested by the locals mainly for the digestive properties.
Ligustrazine mitigates chronic venous disease-induced pain hyperalgesia through desensitization of inflammation-associated TRPA1 activity in DRG
Mei Yu a,b,1, Fan Ye a,1, Chao Ma a,1, Xiang Jin a, Haiwang Ji a, Dijun Wang a, Yan Yang a, Chan Zhu a, Zongxiang Tang
doi : 10.1016/j.jep.2022.115667
Volume 298, 15 November 2022, 115667
Ligustrazine, an important active ingredient extracted from Ligusticum chuanxiong hort, has been widely used to cure cardiovascular diseases and exerts an analgesic effect.
Safety evaluation of aqueous extract from Eugenia uniflora leaves: Acute and subacute toxicity and genotoxicity in vivo assays
Magda Rhayanny Assunç ̃ao Ferreira a, Alessandra Daniele-Silva a, Lucas Ferreira de Almeida a,b, Ewelyn Cintya Felipe dos Santos a,b, Janaina Carla Barbosa Machado a,b, Alisson Mac Ì�ario de Oliveira c, Matheus de Freitas Fernandes Pedrosa d, PatrÃcia Maria Guedes Paiva c, Thiago Henrique Napole ̃ao c, Luiz Alberto Lira Soares
doi : 10.1016/j.jep.2022.115668
Volume 298, 15 November 2022, 115668
Eugenia uniflora Linn (Myrtaceae) is the native species of Brazil. The leaves of this species are used in folk medicine to treat different inflammatory and gastrointestinal disorders. However, research on the safety of using E. uniflora leaves has been poorly explored.
HuanglianGanjiang Tang alleviates DSS-induced colitis in mice by inhibiting necroptosis through vitamin D receptor
Xinyu Xiong a, Zhe Cheng a, Yi Zhou a, Fan Wu b, Linglin Xie c, Lauren Lawless c, Ruolan Dong a, Yan Zhao a, Lingling Yu b, Guang Chen
doi : 10.1016/j.jep.2022.115655
Volume 298, 15 November 2022, 115655
HuanglianGanjiang Tang (HGT) is a classic prescription of traditional Chinese medicine (TCM) recorded in Dan Xi Xin Fa, which was used to alleviate manifestations like diarrhea, abdominal pain and hemafecia. In current clinical practices, HGT is adopted for the treatment of ulcerative colitis (UC) and affords good curative effect. However, the underlying mechanism deserves further elucidation.
Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil
Donya Ziafatdoost Abed a, Sajjad Jabbari b, Zainul Amiruddin Zakaria c, Saeed Mohammadi
doi : 10.1016/j.jep.2022.115638
Volume 298, 15 November 2022, 115638
Descurainia sophia (L.)(Brassicaceae), popularly known as “Khaksheer�, is a native species widely distributed in Iran. The seeds and essential oil has been used in local traditional medicine (Persian folk ethnomedicine) to treat fever, inflammation, back pain, and headache.
Discovery and molecular elucidation of the anti-influenza material basis of Banlangen granules based on biological activities and ultra-high performance liquid chromatography coupled with quadrupole-orbitrap mass spectrometry
Xiu-yu Qian a,1, Li-xing Nie b,1, Hui Zhao b,*, Zhong Dai b, Shuang-cheng Ma b,**, Jin-mei Liu c, Yan-hui Kuang
doi : 10.1016/j.jep.2022.115683
Volume 298, 15 November 2022, 115683
Traditional Chinese medicine (TCM) has a wide range of applications, including human healthcare-associated treatments and bioactive compound discovery. However, complex chemical systems present a significant challenge for chemical-material-based research and quality control.
Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia
Qiang Li a,1, Peng Liu a,1, Chen Wu a, Lijie Bai a, Zhongyun Zhang a, Zilu Bao a, Min Zou a, Zhaoxiang Ren a, Lin Yuan a, Maochuan Liao a, Zhou Lan b, Shijin Yin a,**, Lvyi Chen
doi : 10.1016/j.jep.2022.115679
Volume 298, 15 November 2022, 115679
Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear.
Potential biomedical applications of Araucaria araucana as an antispasmodic, bronchodilator, vasodilator, and antiemetic: Involvement of calcium channels
Abdul Waheed Khan a,1, Zain ul Abidin b,1, Muhammad Umar Khayam Sahibzada c,**, Muhammad Faheem d, Neelam Gul Qazi d, Mahboob Alam e, Irfan Ullah f, Jalal Uddin g, Ajmal Khan h,*, Ahmed Al-Harrasi
doi : 10.1016/j.jep.2022.115651
Volume 298, 15 November 2022, 115651
Since pre-Columbian era, the resin of Araucaria araucana tree has been used traditionally for the treatment of ulcers and wounds.
Mechanisms of pancreatic tumor suppression mediated by Xiang-lian pill: An integrated in silico exploration and experimental validation
Juying Jiao a,b,1, Chien-shan Cheng a,b,1, Panling Xu c, Peiwen Yang a,b, Ke Zhang a,b, Yanhua Jing a,b, Zhen Chen
doi : 10.1016/j.jep.2022.115586
Volume 298, 15 November 2022, 115586
Xiang-lian pill, consisting of Coptis chinensis Franch. coprocessed with Tetradium ruticarpum (A.Juss.) T.G.Hartley (Yu-huang-lian) and Aucklandia lappa DC. (Mu-xiang), is traditionally used to relieve fever, abdominal pain, and gastrointestinal inflammatory symptoms observed in patients with malignancies of the gastrointestinal tract.
Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of Penthorum chinense Pursh against alcoholic liver injury
Yunbin Jiang a,*,1, Mei Zhong b,1, Hupo Zhan a, Xingbao Tao c, Yanfei Zhang d, Jingxin Mao a, Zhao Geng e,**, Bixing Gao
doi : 10.1016/j.jep.2022.115589
Volume 298, 15 November 2022, 115589
Penthorum chinense Pursh (PCP, Saxifragaceae) is an edible plant and frequently-used Chinese herbal medicine, and is commonly used as Miao medicine in China. It showed well effect on alcoholic liver injury (ALI), but studies on its active ingredients and mechanisms against ALI remain at the starting stage.
Identification of intrinsic hepatotoxic compounds in Polygonum multiflorum Thunb. using machine-learning methods
Xiaowen Hu a,1, Tingting Du b,1, Shengyun Dai a, Feng Wei a, Xiaoguang Chen b,*, Shuangcheng Ma
doi : 10.1016/j.jep.2022.115620
Volume 298, 15 November 2022, 115620
Polygonum multiflorum Thunb. (PM) is a herb, extracts of which have been used as Chinese medicine for years. Although it is believed to be beneficial to the liver, heart, and kidneys, it causes idiosyncratic drug-induced liver injury (DILI).
Anti-angiogenic effect of YuXueBi tablet in experimental rheumatoid arthritis by suppressing LOX/Ras/Raf-1 signaling
Xiaohui Su a, Bei Yuan c, Xueying Tao a, Wanyi Guo a, Xia Mao a, Anguo Wu b, Qian Wang c, Chunfang Liu a, Yanqiong Zhang a, Xiangying Kong a, Lan Han c,**, Na Lin
doi : 10.1016/j.jep.2022.115611
Volume 298, 15 November 2022, 115611
A Chinese patent medicine derived from a classical traditional Chinese medicine formula, Yu-Xue-Bi tablet (YXB) is widely used in the clinic to treat rheumatoid arthritis (RA).
Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata
Lu Yang a,1, Haiyan Lyu b,1, Ayixianmuguli Yiming c,1, Xiangzhen Xu b, Chunling Ma b, Shun Tu b, Binbin Chen b,***, Mingyuan Liu a,**, Caisheng Wu
doi : 10.1016/j.jep.2022.115648
Volume 298, 15 November 2022, 115648
Saussurea involucrata Kar.et Kir. (S.I.) has long been used as a precious national medicine and clinically proven to be an effective treatment for rheumatoid arthritis (RA) and cardiovascular diseases.
Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation
Fangjuan Deng a,1, Xiaofeng Li b,1, Cheng Tang c, Jinhong Chen a, Boya Fan a, Jiayu Liang a, Xin Zhen a, Rui Tao d, Shaoqiang Zhang b, Zidong Cong b, Wuxun Du b,*, Hucheng Zhao e,**, Liang Xu
doi : 10.1016/j.jep.2022.115631
Volume 298, 15 November 2022, 115631
Coronary heart disease (CHD) and depression are very common and often co-existing disorders. Xiong-Pi-Fang (XPF), a therapeutic classical traditional Chinese medicine (TCM) formula, has shown satisfactory efficacy in treating CHD associated with depression. However, its mechanism of action is still unknown.
Licorice: Resources, applications in ancient and modern times
Yiming Ding a, Eric Brand a, Wenquan Wang b, Zhongzhen Zhao a,c
doi : 10.1016/j.jep.2022.115594
Volume 298, 15 November 2022, 115594
Licorice has been widely used as a medicinal herb since ancient times. Licorice is also spelled as "liquorice" and it is known as "Glycyrrhizae Radix et Rhizoma" (Chinese:甘草 gan cao) in the Chinese Pharmacopoeia.
Analysis of international competitiveness of the China's licorice industry from the perspective of global trade
Zhi-Bin Yu a,c, Shu-Heng Dong a, Jia-Wei Zhang a, De-Yun Li b, Yan Liu c, Hui Li c, Shu-Shan Du
doi : 10.1016/j.jep.2022.115613
Volume 298, 15 November 2022, 115613
Licorice is a multi-purpose plant raw material, which is widely used in the pharmaceutical industry and food industry, cosmetic industry, etc. It has a wide application in various countries and regions around the world.
Corrigendum to “Discovery of the active compounds of Smilacis Glabrae Rhizoma by utilizing the relationship between the individual differences in blood drug concentration and the pharmacological effect in rats” [J. Ethnopharmacol. 258C (2020) 112886]
Gegentana a, Feng Xu a, Feng-Chun Li a, Yi-Fan Zhang a, Shu-Jie Shen a, Ping Yang a, Xin-Xin Yang a, Ming-Ying Shang a,**, Guang-Xue Liu a, Yao-Li Li a, Xuan Wang b, Shao-Qing Cai
doi : 10.1016/j.jep.2022.115664
Volume 298, 15 November 2022, 115664
Corrigendum to “De novo transcriptomic and proteomic analysis and potential toxin screening of Mesobuthus martensii samples from four different provinces” [J. Ethnopharmacol. 265 (20220) 113268]
Songyu Gao a,1, Hongyu Liang a,b,1, Zhaoyong Shou c,1, Yuzhe Yao d, Yang Lv a, Jing Shang d, Wei Lu e, Changliang Jia a, Qing Liu f, Haiyan Zhang g,**, Liang Xiao
doi : 10.1016/j.jep.2022.115665
Volume 298, 15 November 2022, 115665
Corrigendum to “Improving adjuvanticity of crude polysaccharides from cultivated Artemisia rupestris L. for influenza vaccine by promoting long-term immunity and TH1/TH2 response with dose-sparing effect� [J. Ethnopharmacol. 294 (2022) 115350]
Quanxiao Li 1, Xiang Weng 1, Peng Xiao, Yu Yang, Ailian Zhang
doi : 10.1016/j.jep.2022.115666
Volume 298, 15 November 2022, 115666
