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Putative roles for homeostatic plasticity in epileptogenesis
Naoum P. Issa, Katherine C. Nunn, Shasha Wu, Hiba A. Haider, James X. Tao
doi : 10.1111/epi.17500
Homeostatic plasticity allows neural circuits to maintain an average activity level while preserving the ability to learn new associations and efficiently transmit information. This dynamic process usually protects the brain from excessive activity, like seizures.
Is the antiparasitic drug ivermectin a suitable candidate for the treatment of epilepsy?
Wolfgang Löscher
doi : 10.1111/epi.17511
There are only a few drugs that can seriously lay claim to the title of “wonder drug,� and ivermectin, the world's first endectocide and forerunner of a completely new class of antiparasitic agents, is among them.
Management of epilepsy in older adults: A critical review by the ILAE Task Force on Epilepsy in the elderly
Loretta Piccenna, Rebecca O'Dwyer, Ilo Leppik, Ettore Beghi, Giorgia Giussani, Cinzia Costa, Jacopo C. DiFrancesco, Monica B. Dhakar, Naoki Akamatsu, Benjamin Cretin, Günter Krämer, Edward Faught, Patrick Kwan
doi : 10.1111/epi.17426
Older adults represent a highly heterogeneous population, with multiple diverse subgroups. Therefore, an individualized approach to treatment is essential to meet the needs of each unique subgroup.
The epidemiology of epilepsy in older adults: A narrative review by the ILAE Task Force on Epilepsy in the Elderly
Ettore Beghi, Giorgia Giussani, Cinzia Costa, Jacopo C. DiFrancesco, Monica Dhakar, Ilo Leppik, Patrick Kwan, Naoki Akamatsu, Benjamin Cretin, Rebecca O'Dwyer, Guenter Kraemer, Loretta Piccenna, Edward Faught, the ILAE Task Force on Epilepsy in the Elderly (2017–2021)
doi : 10.1111/epi.17494
In an aging world, it is important to know the burden of epilepsy affecting populations of older persons. We performed a selective review of epidemiological studies that we considered to be most informative, trying to include data from all parts of the world.
Routine and sleep EEG: Minimum recording standards of the International Federation of Clinical Neurophysiology and the International League Against Epilepsy
Maria E. Peltola, Markus Leitinger, Jonathan J. Halford, Kollencheri Puthenveettil Vinayan, Katsuhiro Kobayashi, Ronit M. Pressler, Ioana Mindruta, Luis Carlos Mayor, Leena Lauronen, Sándor Beniczky
doi : 10.1111/epi.17448
This article provides recommendations on the minimum standards for recording routine (“standard�) and sleep electroencephalography (EEG).
Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies: Four-year results from the expanded access program
Jerzy P. Szaflarski, Orrin Devinsky, Merrick Lopez, Yong D. Park, Pilar Pichon Zentil, Anup D. Patel, Elizabeth A. Thiele, Robert T. Wechsler, Daniel Checketts, Farhad Sahebkar
doi : 10.1111/epi.17496
Cannabidiol (CBD) expanded access program, initiated in 2014, provided add-on CBD to patients with treatment-resistant epilepsies (TREs) at 35 US epilepsy centers. Prior publications reported results through December 2016; herein, we present efficacy and safety results through January 2019.
Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome
Iván Sánchez Fernández, Marta Amengual-Gual, Cristina Barcia Aguilar, Amanda Romeu, Tahir Sheikh, Alcy Torres, Jessica Chao, Rinat Jonas, Marina GaÃÂnza-Lein, Chellamani Harini, Laurie Douglass
doi : 10.1111/epi.17498
To describe the temporal trends in the cost and use of adrenocorticotropic hormone (ACTH), oral prednisolone, and vigabatrin, the first-line treatments for infantile epileptic spasms syndrome (IESS).
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions
Michael Tan, Samuel S. Allemann, Xiwen Simon Qin, Wendyl J. D'Souza
doi : 10.1111/epi.17502
Medication adherence is considered an important risk factor for sudden unexpected death in epilepsy (SUDEP), although measurement accuracy is difficult. Using prescription dispensations, this study aims to estimate antiseizure medication (ASM) adherence and identify adherence patterns that influence epilepsy mortality.
Ablation of apparent diffusion coefficient hyperintensity clusters in mesial temporal lobe epilepsy improves seizure outcomes after laser interstitial thermal therapy
Min Jae Kim, Brian Hwang, David Mampre, Serban Negoita, Yohannes Tsehay, Haris Sair, Joon Y. Kang, William S. Anderson
doi : 10.1111/epi.17432
Laser interstitial thermal therapy (LiTT) is a minimally invasive surgical procedure for intractable mesial temporal epilepsy (mTLE). LiTT is safe and effective, but seizure outcomes are highly variable due to patient variability, suboptimal targeting, and incomplete ablation of the epileptogenic zone.
Interictal HFO and FDG-PET correlation predicts surgical outcome following SEEG
Baotian Zhao, Aileen McGonigal, Wenhan Hu, Chao Zhang, Xiu Wang, Jiajie Mo, Xiaobin Zhao, Lin Ai, Xiaoqiu Shao, Kai Zhang, Jianguo Zhang
doi : 10.1111/epi.17485
This study aimed to investigate the quantitative relationship between interictal 18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) and interictal high-frequency oscillations (HFOs) from stereo-electroencephalography (SEEG) recordings in patients with refractory epilepsy.
How patients' psycho-social profiles contribute to decision-making in epilepsy surgery: A prospective study
Louisa Hohmann, Christian G. Bien, Martin Holtkamp, Philip Grewe
doi : 10.1111/epi.17499
Identifying factors associated with surgical decision-making is important to understand reasons for underutilization of epilepsy surgery.
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
doi : 10.1111/epi.17503
Epilepsy surgery fails to achieve seizure freedom in 30%–40% of cases. It is not fully understood why some surgeries are unsuccessful.
Visual outcomes after anterior temporal lobectomy and transsylvian selective amygdalohippocampectomy: A quantitative comparison of clinical and diffusion data
Philip Pruckner, Karl-Heinz Nenning, Florian Ph.S Fischmeister, Mehmet-Salih Yildirim, Michelle Schwarz, Andreas Reitner, Susanne Aull-Watschinger, Johannes Koren, Christoph Baumgartner, Daniela Prayer, Karl Rössler, Christian Dorfer, Thomas Czech, Ekaterina Pataraia, Gregor Kasprian, Silvia Bonelli
doi : 10.1111/epi.17490
Anterior temporal lobectomy (ATL) and transsylvian selective amygdalohippocampectomy (tsSAHE) are effective treatment strategies for intractable temporal lobe epilepsy but may cause visual field deficits (VFDs) by damaging the optic radiation (OpR).
Traumatic brain injury, stroke, and epilepsy: A mediation study in a Danish nationwide cohort
Kasper Lolk, Theis Lange, Felix Elwert, Julie W. Dreier, Jakob Christensen
doi : 10.1111/epi.17497
Traumatic brain injury (TBI) and stroke are well-known causes of acquired epilepsy. TBI is also a risk factor for stroke, and injury-induced stroke may indirectly convey a proportion of the epilepsy risk following TBI.
Establishing the cross-cultural applicability of a harmonized approach to cognitive diagnostics in epilepsy: Initial results of the International Classification of Cognitive Disorders in Epilepsy in a Spanish-speaking sample
Anny Reyes, Lilian Salinas, Bruce P. Hermann, Sallie Baxendale, Robyn M. Busch, William B. Barr, Carrie R. McDonald
doi : 10.1111/epi.17501
This study was undertaken to evaluate the cross-cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) to a cohort of Spanish-speaking patients with temporal lobe epilepsy (TLE) living in the United States.
A cross-sectional investigation of cognition and epileptiform discharges in juvenile absence epilepsy
Anita L. Dharan, Stephen C. Bowden, Andre Peterson, Alan Lai, Udaya Seneviratne, Gabriel Dabscheck, Ewan Nurse, Amy Loughman, Nicholas Parsons, Wendyl J. D'Souza
doi : 10.1111/epi.17505
Despite the prevalence of cognitive symptoms in the idiopathic generalized epilepsies (IGEs), cognitive dysfunction in juvenile absence epilepsy (JAE), a common yet understudied IGE subtype, remains poorly understood.
Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy
Erin C. Conrad, Andrew Y. Revell, Adam S. Greenblatt, Ryan S. Gallagher, Akash R. Pattnaik, Nicole Hartmann, James J. Gugger, Russell T. Shinohara, Brian Litt, Eric D. Marsh, Kathryn A. Davis
doi : 10.1111/epi.17482
Interictal spikes help localize seizure generators as part of surgical planning for drug-resistant epilepsy. However, there are often multiple spike populations whose frequencies change over time, influenced by brain state.
Attitudes toward persons with epilepsy as friends: Results of a factorial survey
Katrin Walther, Peter Kriwy, Jenny Stritzelberger, Wolfgang Graf, Stefanie Gollwitzer, Johannes D. Lang, Caroline Reindl, Stefan Schwab, Tamara M. Welte, Hajo. M. Hamer
doi : 10.1111/epi.17491
Discrimination against persons with epilepsy (PWEs) may persist. The aim of this study was to examine whether epilepsy is an obstacle to desired friendship.
Epilepsy severity mediates association between mutation type and ADHD symptoms in tuberous sclerosis complex
Charlotte Tye, Fiona S. McEwen, Holan Liang, Emma Woodhouse, Lisa Underwood, Elizabeth Shephard, Edward D. Barker, Fintan Sheerin, Nicholas Higgins, Juul Steenbruggen, Tuberous Sclerosis 2000 Study Group, Patrick F. Bolton
doi : 10.1111/epi.17507
The association between attention-deficit/hyperactivity disorder (ADHD) and tuberous sclerosis complex (TSC) is widely reported, with support for the role of epilepsy, yet the mechanisms underlying the association across development are unclear.
