New England Journal of Medicine




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Investing in National HIV PrEP Preparedness

Jeremiah Johnson, M.P.H., Amy Killelea, J.D., and Kenyon Farrow

doi : 10.1056/NEJMp2216100

Vol. 388 No. 9

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Health Care Reform and Equity for Undocumented Immigrants — When Crisis Meets Opportunity

Patricia Mae G. Santos, M.D., Kanan Shah, M.D., Francesca M. Gany, M.D., and Fumiko Chino, M.D.

doi : 10.1056/NEJMp2213751

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The Injury Equity Framework — Establishing a Unified Approach for Addressing Inequities

Sadiqa Kendi, M.D., M.P.H., and Michelle L. Macy, M.D.

doi : 10.1056/NEJMp2212378

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Aligning Quality Measures across CMS — The Universal Foundation

Douglas B. Jacobs, M.D., M.P.H., Michelle Schreiber, M.D., Meena Seshamani, M.D., Ph.D., Daniel Tsai, B.A., Elizabeth Fowler, Ph.D., J.D., and Lee A. Fleisher, M.D.

doi : 10.1056/NEJMp2215539

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Hard to Swallow

Debra Malina, Ph.D., Mridula Nadamuni, M.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining

doi : 10.1056/NEJMp2301652

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Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence

Nasser A. Dhayat, M.D., Olivier Bonny, M.D., Ph.D., Beat Roth, M.D., Andreas Christe, M.D., Alexander Ritter, M.D., Nilufar Mohebbi, M.D., Nicolas Faller, M.D., Ph.D., Lisa Pellegrini, M.D., Giulia Bedino, M.D., Reto M. Venzin, M.D., Philipp Grosse, M.D., Carina Hüsler, M.D., Irene Koneth, M.D., Christian Bucher, M.D., Rosaria Del Giorno, M.D., Luca Gabutti, M.D., Michael Mayr, M.D., Urs Odermatt, M.D., Florian Buchkremer, M.D., Thomas Ernandez, M.D., Catherine Stoermann-Chopard, M.D., Daniel Teta, M.D., Bruno Vogt, M.D., Marie Roumet, Ph.D., Luca Tamò, Ph.D., Grazia M. Cereghetti, Ph.D., Sven Trelle, M.D., and Daniel G. Fuster, M.D.

doi : 10.1056/NEJMoa2209275

Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose–response data are also limited.

Buy The Package and View The Article Online


Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus

George M. Varghese, M.D., Divya Dayanand, M.P.H., Karthik Gunasekaran, M.D., Debasree Kundu, Ph.D., Mukta Wyawahare, M.D., Navneet Sharma, M.D., Dhruva Chaudhry, D.M., Sanjay K. Mahajan, M.D., Kavitha Saravu, M.D., Blessed W. Aruldhas, M.D., Binu S. Mathew, M.D., Roshini G. Nair, M.P.H.,

doi : 10.1056/NEJMoa2208449

The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.

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Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Nicholas C. Allen, M.P.H., Andrew J. Martin, Ph.D., Victoria A. Snaidr, F.R.A.C.G.P., Renee Eggins, M.Biostat., Alvin H. Chong, F.A.C.D., Pablo Fernandéz-Peñas, Ph.D., Douglas Gin, F.A.C.D., Shireen Sidhu, F.R.C.P., F.A.C.D., Vanessa L. Paddon, F.A.C.D., Leith A. Banney, F.A.C.D., Adrian Lim, F.A.C.D., Edward Upjohn, F.A.C.D., Helmut Schaider, F.A.C.D., Aparna D. Ganhewa, M.S., Jennifer Nguyen, M.P.H., Catriona A. McKenzie, F.R.C.P.A., Saurabh Prakash, F.R.C.P.A., Catriona McLean, F.R.C.P.A., Alistair Lochhead, F.R.C.P.A., Jan Ibbetson, F.R.C.P.A., Andrew Dettrick, F.R.C.P.A., Anthony Landgren, F.R.C.P.A., Katherine J. Allnutt, M.B., B.S., Clare Allison, M.B., Ch.B., Rachael B. Davenport, M.B., B.S., Blake P. Mumford, M.B., B.S., Brittany Wong, M.B., B.S., Brendan Stagg, M.B., B.S., Alexander Tedman, M.B., B.S., Hannah Gribbin, M.D., Harrison A. Edwards, M.Clin.Epi., Nicholas De Rosa, M.Sci.(Med.), Thomas Stewart, M.Med., Brent J. Doolan, M.B., B.S., Yonatan Kok, M.D., Kate Simpson, M.B., B.S., Zhi M. Low, M.B., B.S., Tom Kovitwanichkanont, M.P.H., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, Ph.D., Steven J. Chadban, Ph.D., David G. Bowen, Ph.D., Andrew C. Chen, Ph.D., and Diona L. Damian, Ph.D.

doi : 10.1056/NEJMoa2203086

Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation–induced DNA damage, reduces the cutaneous immunosuppressive effects of UV radiation, and reduces the incidence of keratinocyte cancers (including squamous-cell and basal-cell carcinomas) and actinic keratoses among high-risk immunocompetent patients.

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Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma

Sapna P. Patel, M.D., Megan Othus, Ph.D., Yuanbin Chen, M.D., Ph.D., G. Paul Wright, Jr., M.D., Kathleen J. Yost, M.D., John R. Hyngstrom, M.D., Siwen Hu-Lieskovan, M.D., Ph.D., Christopher D. Lao, M.D., M.P.H., Leslie A. Fecher, M.D., Thach-Giao Truong, M.D., Jennifer L. Eisenstein, M.D., Sunandana Chandra, M.D.,

doi : 10.1056/NEJMoa2211437

Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.

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Cancer Screening after the Adoption of Paid-Sick-Leave Mandates

Kevin Callison, Ph.D., Michael F. Pesko, Ph.D., Serena Phillips, Dr.P.H., and Julie A. Sosa, M.D.

doi : 10.1056/NEJMsa2209197

By the end of 2022, nearly 20 million workers in the United States have gained paid-sick-leave coverage from mandates that require employers to provide benefits to qualified workers, including paid time off for the use of preventive services.

Buy The Package and View The Article Online


Encapsulating Peritoneal Sclerosis

Xiaojing Tang, M.D., and Lijun Sun, M.D.

doi : 10.1056/NEJMicm2206513

Buy The Package and View The Article Online


Pseudoxanthoma Elasticum–like Syndrome

Manish Kumar, M.B., B.S., M.D., and Abdul R. Saifudeen, M.B., B.S., M.D.

doi : 10.1056/NEJMicm2024743

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A Rocky Resurgence

John W. Ostrominski, M.D., Thomas E. Clancy, M.D., Lynn Bry, M.D., Ph.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2107002

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Do Thiazides Reduce the Risk of Kidney-Stone Recurrence?

R. Todd Alexander, M.D., Ph.D.

doi : 10.1056/NEJMe2300120

Buy The Package and View The Article Online


Progress in Treating a Neglected Tropical Disease

David H. Walker, M.D., and Lucas S. Blanton, M.D.

doi : 10.1056/NEJMe2300113

Buy The Package and View The Article Online


Skin-Cancer Chemoprevention in Transplant Recipients

David M. Miller, M.D., Ph.D., and Kevin S. Emerick, M.D.

doi : 10.1056/NEJMe2214930

Buy The Package and View The Article Online


Audio Interview: The Path Forward for Covid-19 Therapeutics

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2302292

Buy The Package and View The Article Online


Health Care in U.S. Correctional Facilities — A Limited and Threatened Constitutional Right

Marcella Alsan, M.D., Ph.D., M.P.H., Crystal S. Yang, J.D., Ph.D., James R. Jolin, Lucy Tu, and Josiah D. Rich, M.D., M.P.H.

doi : 10.1056/NEJMms2211252

Buy The Package and View The Article Online


Antivenom for Severe Scorpion Envenomation in Arizona

doi : 10.1056/NEJMc2029813

Buy The Package and View The Article Online


Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine

doi : 10.1056/NEJMc2214916

Buy The Package and View The Article Online


Investing in National HIV PrEP Preparedness

Jeremiah Johnson, M.P.H., Amy Killelea, J.D., and Kenyon Farrow

doi : 10.1056/NEJMp2216100

Vol. 388 No. 9

Buy The Package and View The Article Online


Health Care Reform and Equity for Undocumented Immigrants — When Crisis Meets Opportunity

Patricia Mae G. Santos, M.D., Kanan Shah, M.D., Francesca M. Gany, M.D., and Fumiko Chino, M.D.

doi : 10.1056/NEJMp2213751

Buy The Package and View The Article Online


The Injury Equity Framework — Establishing a Unified Approach for Addressing Inequities

Sadiqa Kendi, M.D., M.P.H., and Michelle L. Macy, M.D.

doi : 10.1056/NEJMp2212378

Buy The Package and View The Article Online


Aligning Quality Measures across CMS — The Universal Foundation

Douglas B. Jacobs, M.D., M.P.H., Michelle Schreiber, M.D., Meena Seshamani, M.D., Ph.D., Daniel Tsai, B.A., Elizabeth Fowler, Ph.D., J.D., and Lee A. Fleisher, M.D.

doi : 10.1056/NEJMp2215539

Buy The Package and View The Article Online


Hard to Swallow

Debra Malina, Ph.D., Mridula Nadamuni, M.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining

doi : 10.1056/NEJMp2301652

Buy The Package and View The Article Online


Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence

Nasser A. Dhayat, M.D., Olivier Bonny, M.D., Ph.D., Beat Roth, M.D., Andreas Christe, M.D., Alexander Ritter, M.D., Nilufar Mohebbi, M.D., Nicolas Faller, M.D., Ph.D., Lisa Pellegrini, M.D., Giulia Bedino, M.D., Reto M. Venzin, M.D., Philipp Grosse, M.D., Carina Hüsler, M.D., Irene Koneth, M.D., Christian Bucher, M.D., Rosaria Del Giorno, M.D., Luca Gabutti, M.D., Michael Mayr, M.D., Urs Odermatt, M.D., Florian Buchkremer, M.D., Thomas Ernandez, M.D., Catherine Stoermann-Chopard, M.D., Daniel Teta, M.D., Bruno Vogt, M.D., Marie Roumet, Ph.D., Luca Tamò, Ph.D., Grazia M. Cereghetti, Ph.D., Sven Trelle, M.D., and Daniel G. Fuster, M.D.

doi : 10.1056/NEJMoa2209275

Nephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose–response data are also limited.

Buy The Package and View The Article Online


Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus

George M. Varghese, M.D., Divya Dayanand, M.P.H., Karthik Gunasekaran, M.D., Debasree Kundu, Ph.D., Mukta Wyawahare, M.D., Navneet Sharma, M.D., Dhruva Chaudhry, D.M., Sanjay K. Mahajan, M.D., Kavitha Saravu, M.D., Blessed W. Aruldhas, M.D., Binu S. Mathew, M.D., Roshini G. Nair, M.P.H.,

doi : 10.1056/NEJMoa2208449

The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.

Buy The Package and View The Article Online


Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

Nicholas C. Allen, M.P.H., Andrew J. Martin, Ph.D., Victoria A. Snaidr, F.R.A.C.G.P., Renee Eggins, M.Biostat., Alvin H. Chong, F.A.C.D., Pablo Fernandéz-Peñas, Ph.D., Douglas Gin, F.A.C.D., Shireen Sidhu, F.R.C.P., F.A.C.D., Vanessa L. Paddon, F.A.C.D., Leith A. Banney, F.A.C.D., Adrian Lim, F.A.C.D., Edward Upjohn, F.A.C.D., Helmut Schaider, F.A.C.D., Aparna D. Ganhewa, M.S., Jennifer Nguyen, M.P.H., Catriona A. McKenzie, F.R.C.P.A., Saurabh Prakash, F.R.C.P.A., Catriona McLean, F.R.C.P.A., Alistair Lochhead, F.R.C.P.A., Jan Ibbetson, F.R.C.P.A., Andrew Dettrick, F.R.C.P.A., Anthony Landgren, F.R.C.P.A., Katherine J. Allnutt, M.B., B.S., Clare Allison, M.B., Ch.B., Rachael B. Davenport, M.B., B.S., Blake P. Mumford, M.B., B.S., Brittany Wong, M.B., B.S., Brendan Stagg, M.B., B.S., Alexander Tedman, M.B., B.S., Hannah Gribbin, M.D., Harrison A. Edwards, M.Clin.Epi., Nicholas De Rosa, M.Sci.(Med.), Thomas Stewart, M.Med., Brent J. Doolan, M.B., B.S., Yonatan Kok, M.D., Kate Simpson, M.B., B.S., Zhi M. Low, M.B., B.S., Tom Kovitwanichkanont, M.P.H., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, Ph.D., Steven J. Chadban, Ph.D., David G. Bowen, Ph.D., Andrew C. Chen, Ph.D., and Diona L. Damian, Ph.D.

doi : 10.1056/NEJMoa2203086

Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation–induced DNA damage, reduces the cutaneous immunosuppressive effects of UV radiation, and reduces the incidence of keratinocyte cancers (including squamous-cell and basal-cell carcinomas) and actinic keratoses among high-risk immunocompetent patients.

Buy The Package and View The Article Online


Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma

Sapna P. Patel, M.D., Megan Othus, Ph.D., Yuanbin Chen, M.D., Ph.D., G. Paul Wright, Jr., M.D., Kathleen J. Yost, M.D., John R. Hyngstrom, M.D., Siwen Hu-Lieskovan, M.D., Ph.D., Christopher D. Lao, M.D., M.P.H., Leslie A. Fecher, M.D., Thach-Giao Truong, M.D., Jennifer L. Eisenstein, M.D., Sunandana Chandra, M.D.,

doi : 10.1056/NEJMoa2211437

Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable stage III or IV melanoma is unknown.

Buy The Package and View The Article Online


Cancer Screening after the Adoption of Paid-Sick-Leave Mandates

Kevin Callison, Ph.D., Michael F. Pesko, Ph.D., Serena Phillips, Dr.P.H., and Julie A. Sosa, M.D.

doi : 10.1056/NEJMsa2209197

By the end of 2022, nearly 20 million workers in the United States have gained paid-sick-leave coverage from mandates that require employers to provide benefits to qualified workers, including paid time off for the use of preventive services.

Buy The Package and View The Article Online


Encapsulating Peritoneal Sclerosis

Xiaojing Tang, M.D., and Lijun Sun, M.D.

doi : 10.1056/NEJMicm2206513

Buy The Package and View The Article Online


Pseudoxanthoma Elasticum–like Syndrome

Manish Kumar, M.B., B.S., M.D., and Abdul R. Saifudeen, M.B., B.S., M.D.

doi : 10.1056/NEJMicm2024743

Buy The Package and View The Article Online


A Rocky Resurgence

John W. Ostrominski, M.D., Thomas E. Clancy, M.D., Lynn Bry, M.D., Ph.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2107002

Buy The Package and View The Article Online


Do Thiazides Reduce the Risk of Kidney-Stone Recurrence?

R. Todd Alexander, M.D., Ph.D.

doi : 10.1056/NEJMe2300120

Buy The Package and View The Article Online


Progress in Treating a Neglected Tropical Disease

David H. Walker, M.D., and Lucas S. Blanton, M.D.

doi : 10.1056/NEJMe2300113

Buy The Package and View The Article Online


Skin-Cancer Chemoprevention in Transplant Recipients

David M. Miller, M.D., Ph.D., and Kevin S. Emerick, M.D.

doi : 10.1056/NEJMe2214930

Buy The Package and View The Article Online


Audio Interview: The Path Forward for Covid-19 Therapeutics

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2302292

Buy The Package and View The Article Online


Health Care in U.S. Correctional Facilities — A Limited and Threatened Constitutional Right

Marcella Alsan, M.D., Ph.D., M.P.H., Crystal S. Yang, J.D., Ph.D., James R. Jolin, Lucy Tu, and Josiah D. Rich, M.D., M.P.H.

doi : 10.1056/NEJMms2211252

Buy The Package and View The Article Online


Antivenom for Severe Scorpion Envenomation in Arizona

doi : 10.1056/NEJMc2029813

Buy The Package and View The Article Online


Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine

doi : 10.1056/NEJMc2214916

Buy The Package and View The Article Online


Immunogenicity of a Fourth Homologous Dose of NVX-CoV2373

doi : 10.1056/NEJMc2215509

Buy The Package and View The Article Online


Tumor-Infiltrating Lymphocyte Therapy in Advanced Melanoma

doi : 10.1056/NEJMc2300132

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Defibrillation Strategies for Refractory Ventricular Fibrillation

doi : 10.1056/NEJMc2216382

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Aren’t You the Valet? Tales of Black American Surgeons

Orlando Kirton, M.D., M.B.A., and Selwyn O. Rogers, Jr., M.D., M.P.H.

doi : 10.1056/NEJMpv2301016

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