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Chronic Intramural Dissection Creating a Management Challenge in Eosinophilic Esophagitis: Endoscopic Septotomy to the Rescue
Andrew Canakis, Erin Causey, Osman Ali & Raymond E. Kim
New Insight into Endoscopic Work-Related Musculoskeletal Disorders (WRMD): Why Repeated Motions Damage
Dariush Shahsavari & Zain A. Sobani
Speaking Their Language: Gastrointestinal Testing in Patients with Limited English Proficiency
Christopher Vélez, Christopher Kirwan & Walter W. Chan
Precision HCC Surveillance: It Is All in the Number (Needed)
Amit G. Singal, Neehar D. Parikh & Yujin Hoshida
Acid Test: MELD-Lactate Enhances Prediction in Patients with Variceal Hemorrhage
Fernando H. Calmet & Paul Martin
Broadening Horizons: Why Gastroenterologists Should Consider a Career in Obesity Medicine
Albert Do & Jin Xu
Racial Disparities in Endoscopy Cancellations During the COVID-19 Pandemic
Connie W. Wang, Richard Mclean I, Yao-Wen Cheng, Stephanie Kim, Jonathan Terdiman, Priya Kathpalia & Kendall R. Beck
doi : 10.1007/s10620-022-07575-9
The coronavirus disease 19 (COVID-19) pandemic has disrupted healthcare delivery including elective endoscopy. We aimed to determine the prevalence of endoscopy cancellations in the COVID-19 era and identify patient characteristics associated with cancellation due to the pandemic.
Patient Factors Affect Ergonomic Strain of Endoscopists During Colonoscopy
Alexander Shiang, Jean S. Wang, Daniel H. Cho, Bradley Kushner, Ali K. Panahi & Michael M. Awad
doi : 10.1007/s10620-022-07721-3
Endoscopic procedures place a great deal of muscular strain on providers, especially over the span of their careers. In this study we quantitatively analyzed the effects of patient factors such as age, body mass index, and sex on the ergonomics of endoscopists performing colonoscopies.
Evidence-Based Cognitive Endoscopy Simulators: Do They Exist? A Systematic Search and Evaluation of Existing Platforms
Raj Shah, Michael Kurin, Sagarika Satyavada, Mayada Ismail, Zachary Smith, Perica Davitkov, Gerard Isenberg, Raju Gottumukkala, Ashley Faulx, Yngve Falck-Ytter & Amitabh Chak
Results of Anorectal Physiological Testing in Patients with Limited English Proficiency
Jean C. Fox, Aoife M. Feighery, Jeffrey R. Fetzer & David O. Prichard
doi : 10.1007/s10620-022-07732-0
Patients with limited English proficiency (LEP) experience barriers to healthcare. These include language barriers and difficulty accessing medical subspecialties. Consequently, patients with LEP may be underrepresented, and may be more likely to have abnormal results, among individuals referred for anorectal testing.
Missed Opportunities for Screening or Surveillance Among Patients with Newly Diagnosed Non-cardia Gastric Adenocarcinoma
Mimi C. Tan, Niharika Mallepally, Theresa H. Nguyen, Tariq Hammad, Debora K. Kim, Mohamed O. Othman, Hashem B. El-Serag & Aaron P. Thrift
doi : 10.1007/s10620-022-07587-5
Screening for gastric cancer is not recommended despite rising rates in certain U.S. populations. We determined possible missed opportunities for the detection and surveillance of preneoplastic lesions among gastric cancer patients in a VA hospital.
Hepatocellular Carcinoma Risk Scores Predict Patients Under Surveillance at Low Risk of Benefit and High Risk of Harm
Chris Curran, Matthew Priest, Shouren Datta, Ewan H. Forrest, Adrian J. Stanley & Stephen T. Barclay
doi : 10.1007/s10620-022-07731-1
Surveillance for hepatocellular carcinoma (HCC) is recommended for patients with cirrhosis. Multiple risk scores aim to stratify HCC risk, potentially allowing individualized surveillance strategies. We sought to validate four risk scores and quantify the consequences of surveillance via the calculation of numbers needed to benefit (NNB) and harm (NNH) according to classification by risk score strata.
CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor Binding Protein 5 Through EZH2 in Ulcerative Colitis
Dan Gu, Ting Cao, Shijie Yi, Ya Liu & Chao Fan
doi : 10.1007/s10620-022-07566-w
Ulcerative colitis (UC) features chronic, non-infectious inflammation of the colon. Insulin-like growth factor binding protein 5 (IGFBP5) has been indicated to be related to various inflammation-related diseases. However, its association with UC remains largely unclear.
CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes for Patients with Gastric Cancer
Bei Ji, Lili Qiao & Wei Zhai
doi : 10.1007/s10620-022-07513-9
Gastric cancer (GC) seriously threatens people’s health and life quality worldwide.
Lymphatic Drainage System and Lymphatic Metastasis of Cancer Cells in the Mouse Esophagus
Yahui Li, Qing Cheng, Zhaohui Xiong, Chorlada Paiboonrungruang, Timothy Adekoya, Yong Li & Xiaoxin Chen
doi : 10.1007/s10620-022-07586-6
Lymphatic metastasis is commonly seen in patients with esophageal squamous cell carcinoma (ESCC). Both lymphatic metastasis and the number of involved nodes are prognostic for post-operative survival. To better understand lymphatic metastasis of ESCC, there is a need to develop proper animal models.
Comprehensive Analysis of microRNA Expression During the Progression of Colorectal Tumors
Tamotsu Sugai, Ryo Sugimoto, Makoto Eizuka, Mitsumasa Osakabe, Shun Yamada, Naoki Yanagawa, Takayuki Matsumoto & Hiromu Suzuki
doi : 10.1007/s10620-022-07576-8
No effective early diagnostic biomarkers are available for colorectal cancer (CRC). Therefore, we sought to identify new biomarkers that could identify CRC from progression as a pre-cancerous lesion to its invasive form. Recent studies have shown that microRNAs (miRs) are associated with the onset of cancer invasion and progression.
Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores
Ruoxin Xu, Siming Xie, Ju Gong, Wei Chen, Yakang Jin & Jian Huang
doi : 10.1007/s10620-022-07585-7
B7-H5 is an important ligand which is deeply involved in the immune response in various diseases. However, its clinical usefulness as an early indicator in acute pancreatitis (AP) remains unclear.
Wilms Tumor 1-Associated Protein Expression Is Linked to a T-Cell-Inflamed Phenotype in Pancreatic Cancer
Ji-li XuÂ
doi : 10.1007/s10620-022-07620-7
The molecular driving forces of anti-tumor immunity in pancreatic ductal adenocarcinoma (PDAC) remain unclear, which causing great difficulty in identifying an appropriate treatment strategy.
Targeting CXCL5 in Pancreatic Cancer Cells Inhibits Cancer Xenograft Growth by Reducing Proliferation and Inhibiting EMT Progression
Zheng-zheng Wang, Xiao-ting Li, Qing-jun Li & Jin-xue Zhou
doi : 10.1007/s10620-022-07529-1
Pancreatic cancer (PC) is the most lethal malignant tumor, with average survival period of about 10 months. C-X-C ligand 5 (CXCL5), an important chemokine for immune cell accumulation in tumor tissues, has been reported to be involved in a variety of human cancers. However, the exact role of CXCL5 in PC progression has not been well defined.
Direct Percutaneous Endoscopic Gastrostomy Versus Radiological Gastrostomy in Patients Unable to Undergo Transoral Endoscopic Pull Gastrostomy
Divyanshoo R. Kohli, Craig Smith, Omer Chaudhry, Madhav Desai, Dion DePaolis & Prateek Sharma
doi : 10.1007/s10620-022-07569-7
A subset of patients needing long-term enteral access are unable to undergo a conventional transoral “pull� percutaneous endoscopic gastrostomy (PEG). We assessed the safety and efficacy of an introducer-style endoscopic direct PEG (DPEG) and an interventional radiologist guided gastrostomy (IRG) among patients unable to undergo a pull PEG.
Celiac Disease Presenting in a Community-Based Gastroenterology Practice: Obesity and Bone Disease Are Common
Giovanni A. Roldan, Sehrish Jamot, Krzysztof Kopec, Amber Charoen, Daniel Leffler, Edward R. Feller & Samir A. Shah
doi : 10.1007/s10620-022-07521-9
The description of the clinical presentation of celiac disease (CeD) has usually come from studies at referral centers. Data about CeD presentation in the community are sparse.
Taking Oral Sulfate Tablets with Simethicone for Bowel Preparation Leads to Higher Adenoma Detection Rate than Polyethylene Glycol: A Propensity Score Analysis
Seung Eun Lee, Dong Jun Oh, Ji Hyung Nam, Hyeki Cho, Jae Hak Kim, Jun Kyu Lee, Yun Jeong Lim, Moon Soo Koh & Sang Hoon Kim
doi : 10.1007/s10620-022-07611-8
Efficient bowel preparation is essential for preventing colorectal cancer by improving endoscopic adenoma detection. Tablet for bowel preparation containing sulfate salts, OSTs (oral sulfate tablets), has been developed and it is gaining more popularity.
Early Anti-Tumor-Necrosis-Factor Therapy for Crohn’s Disease-Related Abdominal Abscesses and Phlegmon in Children
Brad D. Constant, Edwin F. de Zoeten, Jason P. Weinman, Lindsey Albenberg & Frank I. Scott
doi : 10.1007/s10620-022-07604-7
Internally penetrating Crohn’s Disease complications, including abscesses and phlegmon, represent a high-risk Crohn’s Disease phenotype. Anti-tumor-necrosis-factor-α (Anti-TNF) therapies are effective in treating penetrating Crohn’s Disease and early initiation has shown unique benefits.
Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease
Alex Barnes, Soong-Yuan J. Ooi, Kate D. Lynch, Nina Parthasarathy, Maria Bishara, Michael Gounder, Rachel Grafton, Peta Leach, Peter Bampton, Alexandra Sechi, Watson Ng, Susan Connor, Daniel van Langenberg, Réme Mountifield & Jane M. Andrews
doi : 10.1007/s10620-022-07556-y
The thiopurine medications are well established in the treatment of inflammatory bowel disease (IBD). There is significant variation in levels of toxic and therapeutic metabolites. Current data from small or short-term studies support therapeutic drug monitoring (TDM) in assessing azathioprine (AZA) and 6-mercaptopurine (6MP).
Serum Cytomegalovirus Polymerase Chain Reaction Test Is a Valuable Negative Predictor of Infection in Acute Severe Ulcerative Colitis
Nathaniel A. Cohen, Maryam Zafer, Namrata Setia, Michael J. Anderson, Atsushi Sakuraba, Sushila Dalal, Joel Pekow, Russell D. Cohen, David T. Rubin & Dejan Micic
doi : 10.1007/s10620-022-07607-4
Diagnosis of cytomegalovirus (CMV) colitis in the setting of severe ulcerative colitis (UC) remains a clinical challenge. This study aimed to determine the utility of serum CMV polymerase chain reaction (PCR) as a non-invasive test for the diagnosis of CMV superinfection in patients hospitalized with UC.
Cardiovascular Risk Factors and Physical Fitness Among Subjects with Asymptomatic Colonic Diverticulosis
Offir Ukashi, Barak Pflantzer, Yiftach Barash, Eyal Klang, Shlomo Segev, David J. Ozeri, Ido Veisman, Adi Lahat, Ido Laish, Uri Kopylov & Amit Oppenheim
doi : 10.1007/s10620-022-07572-y
The association between diverticular disease and atherosclerotic cardiovascular disease (ASCVD) has been demonstrated previously, mainly in symptomatic subjects.
Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review
Elisa Reitano, Elisa Francone, Elisa Bona, Antonia Follenzi & Sergio Gentilli
doi : 10.1007/s10620-022-07600-x
Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries.
Recto-anal Pressures in Constipated Men and Women Undergoing High-Resolution Anorectal Manometry
David O. Prichard & Jeffrey Fetzer
doi : 10.1007/s10620-022-07590-w
In constipated individuals, high-resolution anorectal manometry (HRM) may suggest the presence of a defecatory disorder. Despite known physiological differences between men and women, our understanding of functional anorectal pathophysiology is based upon predominantly female cohorts. Results are generalized to men.
Liver Cirrhosis Increases the Risk of Developing Advanced Colon Polyps
Maxine Kugelmas, Isain Zapata, Jose Tawil, Annelisa Pessetto, Michael Taglienti & Marcelo Kugelmas
doi : 10.1007/s10620-022-07561-1
To analyze our experience with adenoma detection rates in patients with liver cirrhosis in a community setting.
Efficacy and Safety of Fluoroscopy-Guided Self-Expandable Metal Stent Placement for Treatment of Malignant Colorectal Obstruction
Zhaofei Zeng, Yang Liu, Ketong Wu, Dan Li, Haiyang Lai & Bo Zhang
doi : 10.1007/s10620-022-07557-x
To investigate long-term outcomes after SEMS insertion in patients with malignant colorectal obstruction and to identify the risk factors for complications.
Apheresis Technique for Acute Hyperlipidemic Pancreatitis: A Systemic Review and Meta-Analysis
You-Fei Lin, Yan Yao, Yuan Xu & Hui-Bin Huang
doi : 10.1007/s10620-022-07545-1
The apheresis technique is increasingly used in patients with hypertriglyceridemia-induced pancreatitis (HTGP), while its role in this context is still not well established. Thus, we aimed to evaluate the clinical outcomes of an apheresis therapy compared to usual care in such a patient population.
Combination Topical Epinephrine and Non-steroidal Inflammatory Drugs in the Prevention of Post-ERCP Pancreatitis: A Systematic Review
Nabil El Hage Chehade, Sara Ghoneim, Sagar Shah, Anastasia Chahine, Abdulfatah Issak, Alyssa Y. Choi, Zain Moosvi, Kenneth J. Chang & Jason B. Samarasena
doi : 10.1007/s10620-022-07518-4
The utility of combination rectal NSAID and topical epinephrine (EI) or rectal NSAID and normal saline (SI) sprayed on duodenal papilla in the prevention of post-ERCP pancreatitis (PEP) has been studied but results have been conflicting.
Effect of Synbiotics in Reducing the Systemic Inflammatory Response and Septic Complications in Moderately Severe and Severe Acute Pancreatitis: A Prospective Parallel-Arm Double-Blind Randomized Trial
Gorrepati Rohith, Sathasivam Sureshkumar, Amaranathan Anandhi, Vikram Kate, B. S. Rajesh, K. M. Abdulbasith, Nivedita Nanda, Chinnakali Palanivel & Chellappa Vijayakumar
doi : 10.1007/s10620-022-07618-1
This study aimed at evaluating the efficacy of synbiotics in reducing septic complications in moderately severe and severe acute pancreatitis.
High Triglyceride–Glucose Index Is Associated with Poor Prognosis in Patients with Acute Pancreatitis
Wei Yimin & Guo Jianqiang
doi : 10.1007/s10620-022-07567-9
Acute pancreatitis (AP) is a common gastrointestinal disease worldwide. Severe acute pancreatitis (SAP) is characterized as persistent organ failure with a mortality rate as high as 20–30%.
Deep Venous Thrombosis in Acute Pancreatitis Is Associated with High Mortality: A Prospective Study
Terence Susngi, Jimil Shah, Harish Bhujade, Vaneet Jearth, Anupam K. Singh, Harshal S. Mandavdhare, Vishal Sharma, Rajesh Gupta, Surinder Rana & Usha Dutta
doi : 10.1007/s10620-022-07617-2
Incidence and risk factors for the development of extremity deep vein thrombosis (eDVT) in admitted patients of acute pancreatitis have been rarely explored.
Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis
Marlyn J. Mayo, Elizabeth Carey, Helen T. Smith, Andrea R. Mospan, Megan McLaughlin, April Thompson, Heather L. Morris, Robert Sandefur, W. Ray Kim, Christopher Bowlus on behalf of the TARGET-PBC Investigators & Cynthia Levy
doi : 10.1007/s10620-022-07581-x
Patients with primary biliary cholangitis (PBC) often suffer with pruritus. We describe the impact of pruritus on quality of life and how it is managed in a real-world cohort.
Crohn’s Disease Is Associated with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
Manik Aggarwal, Rajat Garg, Gopanandan Parthasarthy, Amy S. Nowacki, Ruthvik Padival, Arthur McCullough, Taha Qazi, Benjamin Click, Florian Rieder & Benjamin L. Cohen
doi : 10.1007/s10620-022-07562-0
Chronic inflammation in IBD is postulated to drive NAFLD progression from steatosis to fibrosis.
Compensated Advanced Chronic Liver Disease in Nonalcoholic Fatty Liver Disease: Two-Step Strategy is Better than Baveno Criteria
Anshuman Elhence, Abhinav Anand, Sagnik Biswas, Manas Vaishnav, Rajni Yadav, Prasenjit Das, Rajesh Panwar, Sandeep Agarwal, Shivanand Gamanagatti, Ramesh Kumar & Shalimar
doi : 10.1007/s10620-022-07579-5
Advanced fibrosis and cirrhosis (compensated advanced chronic liver disease [cACLD]) are clinically indistinguishable and increase risk of developing clinically significant portal hypertension. Baveno VII recommends using elastography to rule out and diagnose cACLD with liver stiffness measurement (LSM) cut-offs of 10/15Â kPa.
Association of Previous Gastric Bypass Surgery and Patient Outcomes in Alcohol-Associated Cirrhosis Hospitalizations
Pradeep Yarra, Winston Dunn, Zobair Younossi, Yong-Fang Kuo & Ashwani K. Singal
doi : 10.1007/s10620-022-07591-9
Roux-En-Y gastric bypass (RYGB) is associated with risk of alcohol use disorder. The impact of RYGB among patients with alcohol-associated liver disease (ALD) remains unknown.
Intragastric Balloon in Obese Compensated Nonalcoholic Steatohepatitis Cirrhosis Patients Is Safe and Achieves Significant Weight Reduction at 6-Months
Rajan Vijayaraghavan, Shiv K. Sarin, Ankit Bharadwaj, Lovkesh Anand, Rakhi Maiwall, Ashok Choudhury, Jaya Benjamin, Uma Kanal & Kapil Dev Jamwal
doi : 10.1007/s10620-022-07596-4
Weight reduction is the mainstay treatment for Nonalcoholic steatohepatitis (NASH). intragastric balloon (IGB) placement has proven benefit in terms of weight reduction. The aim of the present study is to assess the safety and efficacy of IGB placement in compensated NASH cirrhosis.
MELD-Lactate Predicts Poor Outcome in Variceal Bleeding in Cirrhosis
Thomas Horvatits, Nadim Mahmud, Marina Serper, Oliver Seiz, Dominik Reher, Andreas Drolz, Naveed Sarnast, Wenyi Gu, Hans Peter Erasmus, Gabriel Allo, Phillip Ferstl, Sebastian Wittmann, Felix Piecha, Stefan Groth, Stefan Zeuzem, Christoph Schramm, Samuel Huber, Thomas Rösch, Ansgar W. Lohse, Jonel Trebicka, Gerald Ogola, Sumeet K. Asrani & Johannes Kluwe
doi : 10.1007/s10620-022-07744-w
Predictors of poor outcome associated with variceal bleeding remain suboptimal. In patients with cirrhosis, serum lactate combined with Model for End-Stage Liver Disease (MELD-LA) improved prediction across heterogeneous populations. However, prognostic properties have not yet been assessed in the context of variceal bleeding.
Physical Activity and Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Kara DiJoseph, Audrey Thorp, Alex Harrington, Kathryn H. Schmitz, Vernon M. Chinchilli & Jonathan G. Stine
doi : 10.1007/s10620-022-07601-w
Physical activity offers promise to protect against multiple non-hepatic primary cancers. We performed a systematic review to quantify the association between physical activity and hepatocellular carcinoma (HCC) risk.
Clinical Course and Outcomes of Patients with Nonalcoholic Fatty Liver Disease-Related Hepatocellular Cancer (NAFLD-HCC)Â
Jinna Chu, George Cholankeril, Xian Yu, Abbas Rana, Yamini Natarajan, Hashem B. El-Serag, Jennifer Kramer & Fasiha Kanwal
doi : 10.1007/s10620-022-07565-x
Among etiologies for hepatocellular (HCC), nonalcoholic fatty liver disease (NAFLD) carries a high risk of competing non-cancer mortality. The effect of cancer and non-cancer factors on risk of death after NAFLD-HCC diagnosis remains unclear. We aimed to evaluate the role of non-cancer mortality with NAFLD-HCC.
Ileal Desmoid Tumor in Ileal Crohn’s: Coincidence or Connection?
Scott Friedberg, Ira Hanan, Neil Hyman, Gustavo Rubio, Aarti Sharma & David T. Rubin
doi : 10.1007/s10620-022-07583-9
Desmoid tumors, also called aggressive fibromatoses, are rare fibroblastic/myofibroblastic neoplasms that infiltrate muscles and tendons. They are benign tumors, but can be locally destructive.
