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The Stiffness-Sensitive Transcriptome of Human Tendon Stromal Cells (Adv. Healthcare Mater. 7/2023)
Amro A. Hussien, Barbara Niederoest, Maja Bollhalder, Nils Goedecke, Jess G. Snedeker
doi : 10.1002/adhm.202370031
Volume 12, Issue 7
Spatiotemporal Regulation of Injectable Heterogeneous Silk Gel Scaffolds for Accelerating Guided Vertebral Repair (Adv. Healthcare Mater. 7/2023)
Tianji Wang, Keyin Liu, Jing Wang, Geng Xiang, Xiaofan Hu, Hao Bai, Wei Lei, Tiger H. Tao, Yafei Feng
doi : 10.1002/adhm.202370032
Flexible Skin Patch Enabled Tumor Hybrid Thermophysical Therapy and Adaptive Antitumor Immune Response (Adv. Healthcare Mater. 7/2023)
Xuyang Sun, Tao Wu, Minghui Duan, Bo Yuan, Xiyu Zhu, Hongzhang Wang, Jing Liu
doi : 10.1002/adhm.202370034
Advances in Lipid-Based Codelivery Systems for Cancer and Inflammatory Diseases
Chinmay M. Jogdeo, Sudipta Panja, Shrey Kanvinde, Ekta Kapoor, Kasturi Siddhanta, David Oupický
doi : 10.1002/adhm.202202400
Combination therapy targeting multiple therapeutic targets is a favorable strategy to achieve better therapeutic outcomes in cancer and inflammatory diseases.
Application of Nanotechnology in Thrombus Therapy
Shuyin Zhou, Wenbo Zhao, Jinglei Hu, Chun Mao, Min Zhou
doi : 10.1002/adhm.202202578
A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow and causing clinical symptoms.
The Stiffness-Sensitive Transcriptome of Human Tendon Stromal Cells
Amro A. Hussien, Barbara Niederoest, Maja Bollhalder, Nils Goedecke, Jess G. Snedeker
doi : 10.1002/adhm.202101216
Extracellular matrix stiffness is a major regulator of cellular states. Stiffness-sensing investigations are typically performed using cells that have acquired “mechanical memoryâ€� through prolonged conditioning in rigid environments, e.g., tissue culture plastic (TCP).
Spatiotemporal Regulation of Injectable Heterogeneous Silk Gel Scaffolds for Accelerating Guided Vertebral Repair
Tianji Wang, Keyin Liu, Jing Wang, Geng Xiang, Xiaofan Hu, Hao Bai, Wei Lei, Tiger H. Tao, Yafei Feng
doi : 10.1002/adhm.202202210
Osteoporotic vertebral fracture is jeopardizing the health of the aged population around the world, while the hypoxia microenvironment and oxidative damage of bone defect make it difficult to perform effective tissue regeneration.
Flexible Skin Patch Enabled Tumor Hybrid Thermophysical Therapy and Adaptive Antitumor Immune Response
Xuyang Sun, Tao Wu, Minghui Duan, Bo Yuan, Xiyu Zhu, Hongzhang Wang, Jing Liu
doi : 10.1002/adhm.202202872
Innovations on materials and technologies have greatly promoted the rapid development of wearable electronics from disease diagnosis to therapeutics.
Peripheral Microneedle Patch for First-Aid Hemostasis
Jungho Lee, Sebin Park, Phuong Thao Le, Geunho Lee, Hyoun Wook Lee, Gaeun Yun, Juhyeong Jeon, Jeongwoo Park, Duy Tho Pham, Young Sook Park, Hoon Lim, Chulhong Kim, Tae Sik Hwang, Seung Whan Kim, Geunbae Lim
doi : 10.1002/adhm.202201697
Despite the minimized puncture sizes and high efficiency, microneedle (MN) patches have not been used to inject hemostatic drugs into bleeding wounds because they easily destroy capillaries when a tissue is pierced.
Delivery of Induced Neural Stem Cells Through Mechano-Tuned Silk–Collagen Hydrogels for the Recovery of Contused Spinal Cord in Rats
Ganchimeg Davaa, Jin Young Hong, Jung-Hwan Lee, Min Soo Kim, Jennifer O. Buitrago, Yu-Meng Li, Hae-Hyoung Lee, Dong Wook Han, Kam W. Leong, Jung Keun Hyun, Hae-Won Kim
doi : 10.1002/adhm.202201720
Neural stem cells (NSC) have tremendous potential for therapeutic regeneration of diseased or traumatized neural tissues, including injured spinal cord.
Amyloid-Based Albumin Hydrogels
Carolina Diaz, Dimitris Missirlis
doi : 10.1002/adhm.202201748
Amyloid fibrils may serve as building blocks for the preparation of novel hydrogel materials from abundant, low-cost, and biocompatible polypeptides. This work presents the formation of physically cross-linked, self-healing hydrogels based on bovine serum albumin at room temperature through a straightforward disulfide reduction step induced by tris (2-carboxyethyl) phosphine hydrochloride.
Diselenide-Based Dual-Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
Shu-Cheng Wan, Meng-Jie Ye, Qi-Chao Yang, Tian Zhang, Meng-Jie Zhang, Xian-Bin Ma, Ji-Ming Xu, Shuo Wang, Zhi-Zhong Wu, Lei-Lei Yang, Xue-Meng Shen, Zhigang Xu, Zhi-Jun Sun
doi : 10.1002/adhm.202202135
Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy.
Biomimetic Peridontium Patches for Functional Periodontal Regeneration
Yue Ma, Xueting Yang, Yan Chen, Jiumeng Zhang, Kuo Gai, Jinlong Chen, Fangjun Huo, Qiang Guo, Weihua Guo, Maling Gou, Bo Yang, Weidong Tian
doi : 10.1002/adhm.202202169
The unique structure of the periodontium, including the alveolar bone, cementum, and periodontal ligament (PDL), presents difficulties for the regeneration of its intricate organization.
Photothermal Enhanced and Tumor Microenvironment Responsive Nanozyme for Amplified Cascade Enzyme Catalytic Therapy
Yang Zhu, Yuanbo Pan, Zhengxi Guo, Duo Jin, Wenyu Wang, Manman Liu, Mingxi Zong, Xinwei Zheng, Yun Wu, Lulu Wang, Changlin Tian, Junjie Cheng, Yangzhong Liu
doi : 10.1002/adhm.202202198
Nanocatalysts, a class of nanomaterials with intrinsic enzyme-like activities, have been widely investigated for cancer catalytic therapy in recent years. However, precise construction of nanocatalysts with excellent enzyme catalytic activity and biosafety for tumor therapy still remains challenging.
Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation
Christina M. Tringides, Marjolaine Boulingre, Andrew Khalil, Tenzin Lungjangwa, Rudolf Jaenisch, David J. Mooney
doi : 10.1002/adhm.202202221
Multielectrode arrays would benefit from intimate engagement with neural cells, but typical arrays do not present a physical environment that mimics that of neural tissues.
Zwitterionic Polysaccharide-Based Hydrogel Dressing as a Stem Cell Carrier to Accelerate Burn Wound Healing
Qingyu Yu, Hong Sun, Zhiwei Yue, Chaojie Yu, Lijie Jiang, Xiaoru Dong, Mengmeng Yao, Mingyue Shi, Lei Liang, Yizao Wan, Hong Zhang, Fanglian Yao, Junjie Li
doi : 10.1002/adhm.202202309
Stem cell therapy integrated with hydrogels has shown promising potential in wound healing. However, the existing hydrogels usually cannot reach the desired therapeutic efficacy for burn wounds due to the inadaptability to wound shape and weak anti-infection ability.
Microneedle-Assisted Transdermal Delivery of 2D Bimetallic Metal–Organic Framework Nanosheet-Based Cascade Biocatalysts for Enhanced Catalytic Therapy of Melanoma
Jiajie Chen, Huicong Niu, Lei Guan, Zhibo Yang, Yuzhao He, Jinjin Zhao, Chengtie Wu, Yitong Wang, Kaili Lin, Yufang Zhu
doi : 10.1002/adhm.202202474
Current conventional treatments for malignant melanoma still face limitations, especially low therapeutic efficacy and serious side effects, and more effective strategies are urgently needed to develop them.
Functional Skeletal Muscle Regeneration Using Muscle Mimetic Tissue Fabricated by Microvalve-Assisted Coaxial 3D Bioprinting
Hanna Lee, Soon Hee Kim, Ji Seung Lee, Young Jin Lee, Ok Joo Lee, Olatunji Ajiteru, Md Tipu Sultan, Suk Woo Lee, Chan Hum Park
doi : 10.1002/adhm.202202664
3D-printed artificial skeletal muscle, which mimics the structural and functional characteristics of native skeletal muscle, is a promising treatment method for muscle reconstruction.
Dapagliflozin-Loaded Exosome Mimetics Facilitate Diabetic Wound Healing by HIF-1α-Mediated Enhancement of Angiogenesis
Weiyue Zhang, Lutong Wang, Haoyu Guo, Lulu Chen, Xin Huang
doi : 10.1002/adhm.202202751
Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) to facilitate diabetic wound healing.
