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Exploring GI Diseases Across the Lifespan.
Bajaj, Jasmohan S. MD, MS, FACG 1; Long, Millie D. MD, MPH, FACG 2
doi : 10.14309/ajg.0000000000002208
Volume 118(3) pgs. 381-578 March 2023
Diagnosis and Management of Celiac Disease.
Jansson-Knodell, Claire L. MD 1; Adams, Dawn MD 2; Rubio-Tapia, Alberto MD 1
De-escalate Don't Escalate: Essential Steps to Effectively Recognize and Manage the Patient Who Is Angry and Disruptive.
Lacy, Brian E. MD, PhD, FACG 1; Keefer, Laurie PhD 2; Drossman, Douglas A. MD, MACG 3
Tangible Resources for Multidisciplinary Treatment of Patients With Nonalcoholic Fatty Liver Disease.
Abbas, Daniyal MD 1; Fix, Oren K. MD, MSc 2; Evon, Donna M. PhD 2; Barritt, A. Sidney IV MD, MSCR 2
Multiple Ileal Inflammatory Fibroid Polyps or Vanek Tumors in a 30-Year-Old Woman.
Manzotti, Cristina MD 1; Albertini Petroni, Guglielmo MD 1; Borsotti, Edoardo MD 2; Lagoussis, Pavlos MD 2,3
Rare Cause of Dyschezia in a Man: Cholecystocolic Fistula With Huge Gallstone Migrated to the Rectum.
Chen, Lei MD 1,*; Ni, Xiufan MD 1,*; Yin, Jian MD 1; Zhu, Zhen MD 1
When Endoscopy Is Needed for a "Stone Heart".
Singh, Anupam Kumar MD, DM 1; Neelam, Pardhu Bharath MD 1; Abuji, Kishore MS 2; Jena, Anuraag MD, DM 1; Shah, Jimil MD, DM 1; Sakaray, Yashwant Raj MS 2; Dutta, Usha MD, DM 1
Lynch Syndrome Affecting[horizontal ellipsis]the Esophagus? A Polypoid Lesion Arising From a Gastric Inlet Patch.
Soriano, Christopher T. MD 1; Ruggiero, Francesca MD 2; Levenick, John M. MD 1
Familial Adenomatous Polyposis With Concomitant Celiac Disease: An Unexpected Finding on Capsule Endoscopy With a Panoramic View.
Wiedbrauck, Damian MD 1,2; Rymaszewska, Julia E. MD 2; Hollerbach, Stephan MD 1; Wiedbrauck, Felix MD 1
Gastrointestinal Bleeding in a Child: Is It a Meckel Diverticulum?.
Liu, Jun MD 1; Yu, Yanbo MD 1; Ji, Rui MD 1; Zuo, Xiuli MD, PhD 1
Continuing Medical Education Questions: March 2023.
Dirweesh, Ahmed M. MD
doi : 10.14309/ajg.0000000000002200
AB Article Title: ACG Clinical Guideline-Diagnosis and Management of Biliary Strictures (C) The American College of Gastroenterology 2023. All Rights Reserved.
Continuing Medical Education Questions: March 2023.
Grover, Shilpa MD, MPH
doi : 10.14309/ajg.0000000000002199
AB Article Title: Fecal Microbiota Transplantation Across the Lifespan- Balancing Efficacy, Safety, and Innovation (C) The American College of Gastroenterology 2023. All Rights Reserved.
ACG Clinical Guideline: Diagnosis and Management of Biliary Strictures.
Elmunzer, B. Joseph MD, MSc 1; Maranki, Jennifer L. MD, MSc 2; Gomez, Victoria MD 3; Tavakkoli, Anna MD, MSc 4,5; Sauer, Bryan G. MD, MSc, FACG 6; Limketkai, Berkeley N. MD, PhD, FACG 7; Brennan, Emily A. MLIS 8; Attridge, Elaine M. MLS 9; Brigham, Tara J. MLIS, AHIP 10; Wang, Andrew Y. MD 6
doi : 10.14309/ajg.0000000000002190
AB A biliary stricture is an abnormal narrowing in the ductal drainage system of the liver that can result in clinically and physiologically relevant obstruction to the flow of bile. The most common and ominous etiology is malignancy, underscoring the importance of a high index of suspicion in the evaluation of this condition.
When to Stop Screening-Liver Cancer.
Taddei, Tamar H. MD 1,*; Jou, Janice H. MD 2,*
Surveillance for Colorectal Neoplasia in Inflammatory Bowel Disease: When to Stop.
Axelrad, Jordan E. MD, MPH 1; Cross, Raymond K. MD, MS 2
Colon Cancer Screening and the End of Life: Is Age Just a Number?.
Reinink, Andrew R. MD 1,2; Malhotra, Ashish MD 3,4; Shaukat, Aasma MD, MPH, FACG 3,5
doi : 10.14309/ajg.0000000000002174
AB Age is the strongest risk factor for colorectal cancer. Although there is updated guidance for the age at which to start screening, there is little guidance for individuals or their medical teams on how to decide when to stop. Current recommendations from the US Preventive Services Task Force and other societies focus primarily on age.
Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation.
Gulati, Ajay S. MD 1,2; Nicholson, Maribeth R. MD, MPH 3; Khoruts, Alexander MD 4; Kahn, Stacy A. MD 5
doi : 10.14309/ajg.0000000000002167
AB Fecal microbiota transplantation (FMT) is a rapidly growing therapy aimed at reconstituting the dysbiotic microbiota of a patient with the beneficial stool microbiota of a healthy individual.
When to Stop Surveillance: Pancreatic Cysts.
Petrov, Maxim S. MD, MPH, PhD 1
doi : 10.14309/ajg.0000000000002178
AB Surveillance of mucinous pancreatic cysts is a key to reducing pancreatic cancer risk and detecting malignancy early. However, while the management of cysts with high-risk and worrisome features is fairly straightforward, surveillance of patients with low-risk branch-duct intraductal papillary mucinous neoplasms has long presented gastroenterologists with the challenging question of discontinuation of surveillance.
Pediatric-to-Adult Transfer of Care in Patients With Pancreas Disease: Recommendations for Care and Research Opportunities.
Gariepy, Cheryl E. MD 1; Lara, Luis F. MD 2; Easler, Jeffrey J. MD 3; Shaikhkhalil, Ala MD 1; Uc, Aliye MD 4
doi : 10.14309/ajg.0000000000001910
AB Young adults who have experienced recurrent acute pancreatitis and chronic pancreatitis as children or adolescents are vulnerable to poor follow-up and disease management during the transfer from the pediatric to adult healthcare system.
Gastroesophageal Reflux Treatment in Infancy Through Young Adulthood.
Rosen, Rachel MD, MPH 1
doi : 10.14309/ajg.0000000000002160
AB Gastroesophageal reflux treatment varies greatly across the pediatric age spectrum. Infant reflux treatments rely heavily on nutritional interventions, whereas reflux in older children is treated more commonly with medications.
Gastric Peroral Endoscopic Pyloromyotomy for Infants With Congenital Hypertrophic Pyloric Stenosis: Ready for Prime Time?.
Mamula, Petar MD 1; Coe, Alexander MD 1
Taking a "Second Look" at the Incidence of Pediatric Celiac Disease.
Egberg, Matthew D. MD, MPH, MMSc
Getting to the Bottom of It: Reducing the Burden of Congenital Anorectal Malformation Diagnostic Testing.
Bar, Nir MD 1; Velez, Christopher MD 2
Gastric Peroral Endoscopic Pyloromyotomy for Infants With Congenital Hypertrophic Pyloric Stenosis.
Zhang, Hanhua MD 1,*; Liu, Zuqiang PhD 2,*; Ma, Liyun MD 2,*; Li, Quanlin MD 2,3; Huang, Ying MD, PhD 4; Dong, Kuiran PhD 4; Ye, Hong MD 5; Liu, Jiangbin MD, PhD 6; Liu, Haifeng MD, PhD 7; Ren, Xiaoxia MD 1; Yang, Hongbin MD 1; Hou, Chongzhi MD 8; Ge, Kuku MD 1; Wang, Hua MD 1; Zhou, Pinghong MD, PhD, FASGE 2,3; Fang, Ying MD 1,9
doi : 10.14309/ajg.0000000000001973
Congenital hypertrophic pyloric stenosis (CHPS), the most common infantile disease requiring surgical intervention, is routinely treated with open or laparoscopic pyloromyotomy.
Dementia Frequently Coexists With Hepatic Encephalopathy but Not Other Cirrhosis Complications in US Veterans.
Adejumo, Adeyinka MD 1,*; Noll, Alan MD 1,*; Rogal, Shari S. MD 1,2; Yakovchenko, Vera PhD 2; Chia, Linda PharmD 3; Spoutz, Patrick PharmD 4; Morgan, Timothy R. MD 5; Bajaj, Jasmohan S. MD 6,7
doi : 10.14309/ajg.0000000000002189
Hepatic encephalopathy (HE) is a common decompensating event in patients with cirrhosis. Because of the aging population of patients with cirrhosis, differentiating HE from nonhepatic etiologies of cognitive impairment, such as dementia, is increasingly important.
Medicare Patients Face High Out-of-Pocket Costs for Specialty Inflammatory Bowel Disease Medications.
Dong, Jeffrey MD 1; Ladonne, Michelle MA 2; Feuerstein, Joseph D. MD 2
doi : 10.14309/ajg.0000000000002057
Medicare patients in the United States may face high out-of-pocket (OOP) costs for specialty inflammatory bowel disease (IBD) medications. METHODS: We conducted a study of Medicare OOP costs for specialty IBD medications between 2020 and 2022 and compared them to incomes of typical Medicare beneficiaries.
Higher Postinduction Infliximab Concentrations Are Associated With Favorable Clinical Outcomes in Pediatric Crohn's Disease: A Post Hoc Analysis of the REACH Trial.
Cheifetz, Adam S. MD 1,*; Vande Casteele, Niels PharmD, PhD 2,3,*; Wang, Zhongya 3; Dubinsky, Marla C. MD 4; Papamichael, Konstantinos MD, PhD 1
doi : 10.14309/ajg.0000000000002096
Exposure-outcome relationship data show that higher infliximab concentrations are associated with better outcomes in patients with Crohn's disease (CD). However, most of these data were derived from adult patients on maintenance therapy.
Maternal Inflammatory Bowel Disease During Pregnancy and Infectious Disease in Offspring Younger Than 5 Years: A Population-Based Cohort Study.
Ren, Tai MD 1; Yu, Yongfu PhD 2,3; Wang, Hui PhD 1; Li, Fei MD, PhD 4; Zhang, Jun MD, PhD 1; Li, Jiong MD, PhD 3
doi : 10.14309/ajg.0000000000002179
Maternal inflammatory bowel disease (IBD) during pregnancy may be associated with increased susceptibility to infection in offspring. We aimed to assess this association, taking into consideration the mediating role of anti-tumor necrosis factor [alpha] (anti-TNF[alpha]) agents and adverse birth outcomes.
Has the Incidence of Inflammatory Bowel Disease Peaked? Evidence From the Population-Based NorDIBD Cohort 1978-2020.
Larsen, Lone MD, PhD 1,2; Karachalia Sandri, Anastasia PhD 2; Fallingborg, Jan MD, DMSc 1; Jacobsen, Bent Ascanius MD 1; Jacobsen, Henrik Albaek MD 1,2; Bogsted, Martin PhD 2,3; Drewes, Asbjorn Mohr MD, PhD, DMSc 1,3; Jess, Tine MD, DMSc 1,2
doi : 10.14309/ajg.0000000000002187
While the incidence of inflammatory bowel disease (IBD) is rising globally, it has been suggested to stabilize in westernized countries, but this has not yet been shown in exhaustive and large cohorts.
The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study.
Sun, Yuhao MBBS 1,2,*; Yuan, Shuai PhD 1,3,*; Chen, Xuejie MBBS 2,4,*; Sun, Jing PhD 1; Kalla, Rahul PhD 5; Yu, Lili MBBS 1; Wang, Lijuan PhD 1,6; Zhou, Xuan PhD 1; Kong, Xiangxing PhD 7; Hesketh, Therese PhD 2,8; Ho, Gwo-tzer PhD 9; Ding, Kefeng PhD 7; Dunlop, Malcolm PhD 10; Larsson, Susanna C. PhD 3,11; Satsangi, Jack PhD 12; Chen, Jie PhD 2,4; Wang, Xiaoyan PhD 4; Li, Xue PhD 1; Theodoratou, Evropi PhD 6,10,+; Giovannucci, Edward L. PhD 13,14,+
doi : 10.14309/ajg.0000000000002180
The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. METHODS: Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into high, intermediate, and low genetic risk categories.
Physician Decision-Making About Surveillance in Older Adults With Prior Adenomas: Results From a National Survey.
Schoenborn, Nancy L. MD, MHS 1; Pollack, Craig E. MD, MHS 2; Gupta, Samir MD, MSCS 3,4; Boyd, Cynthia M. MD, MPH 1
doi : 10.14309/ajg.0000000000002193
There is no clear guidance on when surveillance colonoscopies should stop in older adults with prior adenomas. We aimed to examine physicians' decision-making regarding surveillance colonoscopies in older adults.
Effects of Bowel Training and Defecation Posture on Chronic Constipation in Older Adults With Dementia: A Randomized Controlled Trial.
Naito, Tomoyoshi RN, MSN 1; Nakamura, Mieko MD, PhD 2; Suzuki, Mizue RN, PhD 1; Ojima, Toshiyuki MD, PhD 2
Incidence of Pediatric Celiac Disease Varies by Region.
Stahl, Marisa MD 1; Li, Qian PhD 2; Lynch, Kristian PhD 3; Koletzko, Sibylle MD 4,5; Mehta, Pooja MD 1; Gragert, Loren PhD 6; Norris, Jill M. PhD 7; Andren Aronsson, Carin PhD 8; Lindfors, Katri PhD 9; Kurppa, Kalle MD, PhD 9,10; Ilonen, Jorma MD, PhD 11; Krischer, Jeffrey PhD 3; Alkolkar, Beena PhD 12,13; Ziegler, Anette-G MD 14; Toppari, Jorma MD, PhD 15; Rewers, Marian J. MD, PhD 16; Agardh, Daniel MD, PhD 17; Hagopian, William MD, PhD 18; Liu, Edwin MD 1; the TEDDY Study Group
doi : 10.14309/ajg.0000000000002056
The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol.
Diagnosing Mild Forms of Anorectal Malformation With Anorectal Manometry: A Prospective Study.
den Hollander, Venla E.C. BSc 1; Gerritsen, Steffie BSc 1; van Dijk, Tonnis H. MD 2; Trzpis, Monika PhD 1; Broens, Paul M.A. MD, PhD 1,2
doi : 10.14309/ajg.0000000000002121
Rectoperineal congenital anorectal malformations (CARMs) are diagnosed by examining the perineum, combined with electric stimulation (ES) of the anal sphincter performed under anesthesia.
A Randomized, Double-Blind, Controlled Trial of Percutaneous Tibial Nerve Stimulation With Pelvic Floor Exercises in the Treatment of Childhood Constipation.
Yu, Zheng-tong MD 1; Song, Jun-Min MD 2,*; Qiao, Lei MD 3,*; Wang, Yang MD 1; Chen, Ying MD 1; Wang, En-Hui MD 1; Zhang, Shu-Cheng MD 1
Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial.
Takeda, Tsutomu MD, PhD 1; Asaoka, Daisuke MD, PhD 2; Nojiri, Shuko PhD 3; Yanagisawa, Naotake PhD 3; Nishizaki, Yuji PhD 3; Osada, Taro MD, PhD 4; Koido, Shigeo MD, PhD 5; Nagahara, Akihito MD, PhweD 1; Katsumata, Noriko 6; Odamaki, Toshitaka PhD 6,7; Xiao, Jin-Zhong PhD 6,7; Ohkusa, Toshifumi MD, PhD, AGAF 5,7; Sato, Nobuhiro MD, PhD, AGAF 7
doi : 10.14309/ajg.0000000000002028
Few reports exist regarding the therapeutic effects of probiotics on chronic constipation in elderly individuals. This study evaluated the effects of Bifidobacterium longum BB536 in elderly individuals with chronic constipation.
Association of Accelerometer-Measured Sedentary Behavior Patterns With Nonalcoholic Fatty Liver Disease Among Older Adults: The MIND-China Study.
Han, Qi MD 1,*; Han, Xiaolei MD, PhD 1,2,*; Wang, Xiaojie MD 1; Wang, Chaoqun MD 1; Mao, Ming MD 1; Tang, Shi MD, PhD 2; Cong, Lin MD, PhD 2; Hou, Tingting MD, PhD 2; Liu, Cuicui MD 2; Wang, Yongxiang MD, PhD 2; Du, Yifeng MD, PhD 1,2,+; Qiu, Chengxuan PhD 1,3,+
doi : 10.14309/ajg.0000000000002135
The relationships between sedentary behavior patterns and nonalcoholic fatty liver disease (NAFLD) in older adults are not well investigated. METHODS: This population-based study included 1,899 rural-dwelling adults (aged 60 years or older).
Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.
Valitutti, Francesco MD 1,2; Leonard, Maureen M. MD 3,4; Kenyon, Victoria MS 3,4; Montuori, Monica MD 5; Piemontese, Pasqua MD 6; Francavilla, Ruggiero MD 7; Malamisura, Basilio MD 8; Norsa, Lorenzo MD 9; Calvi, Angela MD 10; Lionetti, Maria Elena MD 11; Baldassarre, Mariella MD 12; Trovato, Chiara Maria MD 13; Perrone, Michela MD 6; Passaro, Tiziana MD 8; Sansotta, Naire MD 9; Crocco, Marco MD 10; Morelli, Annalisa MD 14; Raguseo, Lidia Celeste MD 7; Malerba, Federica MD 10; Elli, Luca MD 15; Cristofori, Fernanda MD 7; Catassi, Carlo MD 11; Fasano, Alessio MD 2,3,4; CD-GEMM Team
doi : 10.14309/ajg.0000000000002192
The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).
