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"Time Shall Unfold[horizontal ellipsis]": The Clinical Value of Grading Mammary Angiosarcoma.
Hoda, Syed A. MD *; Hoda, Raza S. MD +
doi : 10.1097/PAS.0000000000002015
Volume 47(3) pgs. 279-419 March 2023
Lymphoid Interstitial Pneumonia (LIP) Revisited: A Critical Reappraisal of the Histologic Spectrum of "Radiologic" and "Pathologic" LIP in the Context of Diffuse Benign Lymphoid Proliferations of the Lung.
Fraune, Christoph MD *; Churg, Andrew MD +; Yi, Eunhee S. MD ++; Khoor, Andras MD, PhD [S]; Kelemen, Katalin MD, PhD [//]; Larsen, Brandon T. MD, PhD [//]; Butt, Yasmeen M. MD [//]; Smith, Maxwell L. MD [//]; Gotway, Michael B. MD [P]; Ryu, Jay H. MD #; Tazelaar, Henry D. MD [//]
doi : 10.1097/PAS.0000000000002014
AB The use of lymphoid interstitial pneumonia (LIP) as a diagnostic term has changed considerably since its introduction. Utilizing a multi-institutional collection of 201 cases from the last 20 years that demonstrate features associated with the LIP rubric, we compared cases meeting strict histologic criteria of LIP per American Thoracic Society (ATS)/European Respiratory Society (ERS) consensus ("pathologic LIP"; n=62) with cystic cases fulfilling radiologic ATS/ERS criteria ("radiologic LIP"; n=33) and with other diffuse benign lymphoid proliferations.
Angiomyxoma of the Breast: A Clinicopathologic Analysis of 40 Cases.
Baranov, Esther MD; Alston, Erin L.J. MD; Lester, Susan C. MD, PhD; Fletcher, Christopher D.M. MD; Doyle, Leona A. MD
doi : 10.1097/PAS.0000000000001989
AB Superficial angiomyxoma is an uncommon benign mesenchymal neoplasm that usually arises in dermis/subcutis of the extremities or trunk. Some tumors are associated with Carney complex.
Histopathologic Grading Is of Prognostic Significance in Primary Angiosarcoma of Breast: Proposal of a Simplified 2-tier Grading System.
Kuba, Maria G. MD *; Dermawan, Josephine K. MD, PhD *; Xu, Bin MD, PhD *; Singer, Samuel MD +; Plitas, George MD ++; Tap, William D. MD ++; D'Angelo, Sandra P. MD ++,[S]; Rosenbaum, Evan MD ++; Brogi, Edi MD, PhD *; Antonescu, Cristina R. MD *
doi : 10.1097/PAS.0000000000001998
AB Despite a wide spectrum of clinical presentations, including primary or secondary, most angiosarcomas are considered high grade. One exception is primary breast angiosarcoma, where historically, histologic grading has shown to predict outcome using the Rosen 3-tier system.
Next-generation Sequencing as a Potential Diagnostic Adjunct in Distinguishing Between Desmoplastic Melanocytic Neoplasms.
Roth, Andrew BS *; Boutko, Anastasiya MS *; Lampley, Nathaniel III BS *; Dhillon, Soneet BA *; Hagstrom, Michael BA *; Olivares, Shantel BA *; Dittman, David MS +; Jennings, Lawrence MD +; Santana dos Santos, Lucas PhD +; Busam, Klaus MD ++; Gerami, Pedram MD *,[S]
doi : 10.1097/PAS.0000000000001999
AB Desmoplastic melanomas (DMs) are often challenging to diagnose and ancillary tests, such as immunohistochemistry, have limitations. One challenge is distinguishing DM from benign desmoplastic melanocytic neoplasms.
Molecular Characterization of Multifocal Granular Cell Tumors.
Dehner, Carina A. MD, PhD *; Schroeder, Molly C. PhD *; Lyu, Yang PhD +; Bell, Robert MD *; Borcherding, Dana C. PhD +; Moon, Tyler MD ++; Hirbe, Angela MD, PhD +; Chrisinger, John S.A. MD *
doi : 10.1097/PAS.0000000000001992
AB Granular cell tumors (GrCT) were recently found to be driven by inactivating mutations in vacuolar H+-ATPase (V-ATPase) genes, most frequently ATP6AP1 and ATP6AP2. Multifocal presentation is present in ~10% of cases; however, the relationship between multifocal tumors in a given patient has not been elucidated.
Recurrent IDH2 Mutations in Salivary Gland Striated Duct Adenoma Define an Expanded Histologic Spectrum Distinct From Canalicular Adenoma.
Rooper, Lisa M. MD *,+; Agaimy, Abbas MD ++; Assaad, Adel MD [S]; Bal, Munita MD [//]; Eugene, Henrietta BS *; Gagan, Jeffrey MD, PhD [P]; Nonogaki, Hiro MS *; Palsgrove, Doreen N. MD [P]; Shah, Akeesha MD #; Stelow, Edward MD **; Stoehr, Robert PhD ++; Thompson, Lester D.R. MD ++; Weinreb, Ilan MD ++++,[S][S]; Bishop, Justin A. MD [P]
doi : 10.1097/PAS.0000000000002004
AB Striated duct adenoma (SDA) is a rare salivary gland neoplasm defined by histologic similarity to normal striated ducts. However, doubt persists about whether SDA represents a genuine entity distinct from canalicular adenoma and if a malignant counterpart exists.
Overlapping Features of Primary Cutaneous Marginal Zone Lymphoproliferative Disorder and Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder: A Diagnostic Challenge Examined by Genomic Analysis.
Obiorah, Ifeyinwa E. MD, PhD *; Karrs, Jeremiah DO *; Brown, Laura MD +; Wang, Hao-Wei MD, PhD *; Karai, Laszlo J. MD, PhD ++; Pham, Trinh Hoc-Tran BS *; Pham, Thu Anh BS *; Xi, Liqiang PhD *; Pittaluga, Stefania MD, PhD *; Raffeld, Mark MD *; Jaffe, Elaine S. MD *
doi : 10.1097/PAS.0000000000001984
AB Primary cutaneous marginal zone lymphoproliferative disorder (PCMZL) and primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4+ TLPD) are indolent lymphoproliferative disorders.
Primary Clear Cell Sarcoma of Bone: Clinicopathologic Study of a Rare Presentation.
Odintsov, Igor MD *; Jagannathan, Jyothi P. MD +; Al-Ibraheemi, Alyaa MD ++; Selig, Martin K. BA [S]; Newman, Erik T. MD [//]; Fletcher, Christopher D.M. MD *; Nielsen, Gunnlaugur P. MD [S]; Hornick, Jason L. MD, PhD *
doi : 10.1097/PAS.0000000000001988
AB Clear cell sarcoma (CCS) is an uncommon malignant mesenchymal neoplasm of young adults with a predilection for tendons and aponeuroses of distal extremities, a distinctive nested growth pattern, melanocytic differentiation, and usually an EWSR1::ATF1 fusion. Distinction from melanoma can be challenging but is critical for clinical management.
Recurrent EWSR1: COLCA2 Fusions Define a Novel Sarcoma With Spindle/Round Cell Morphology and Strong Predilection for the Sinonasal Tract.
Agaimy, Abbas MD *; Baneckova, Martina MD +,++; De Almeida, John MD [S]; Dickson, Brendan C. MD, MSc [//],[P]; Dimmler, Arno MD #; Hartmann, Wolfgang MD **,++; Lae, Marick MD, PhD ++++; Pablik, Jessica MD [S][S]; Schubart, Christoph PhD *; Skalova, Alena MD, PhD +,++; Stoehr, Robert PhD *; Trautmann, Marcel PhD **,++; Wardelmann, Eva MD **; Wassef, Michel MD [//][//]; Weinreb, Ilan MD [P][P]
doi : 10.1097/PAS.0000000000002000
AB The last 2 decades have attended a dynamic evolution in the nosology of poorly differentiated sinonasal tract malignancies, with several new molecularly defined entities having been described in addition to delineation of the genetic driver/s of some established older entities.
The Distinctive Nature of Thyroid MALT Lymphomas Including IRTA1 Expression.
Carlsen, Eric D. MD, PhD *; Davis, Adam R. MD +; Cook, James R. MD, PhD ++; Swerdlow, Steven H. MD +,[S]
doi : 10.1097/PAS.0000000000002005
AB Mucosa-associated lymphoid tissue (MALT) lymphomas often express IgM and IRTA1 with only a minority demonstrating plasmacytic differentiation. However, like primary cutaneous marginal zone lymphoproliferative disorders (PCMZLPD), thyroid MALT lymphomas (T-MALT-L) frequently show plasmacytic differentiation and IgG positivity.
Acinar Cystic Transformation of the Pancreas: Histomorphology and Molecular Analysis to Unravel its Heterogeneous Nature.
Luchini, Claudio MD, PhD *,+; Mattiolo, Paola MD *; Basturk, Olca MD ++; Mafficini, Andrea PhD *,+; Ozcan, Kerem MD ++; Lawlor, Rita T. PhD *,+; Hong, Seung-Mo MD, PhD [S]; Brosens, Lodewijk A. MD, PhD [//]; Marchegiani, Giovanni MD, PhD [P]; Pea, Antonio MD, PhD [P]; Manfrin, Erminia MD *; Sciacca, Giuseppe MS *; Zampieri, Federica MD *; Polati, Rita MD *; De Robertis, Riccardo MD, PhD #; Milella, Michele MD **; D'Onofrio, Mirko MD #; Malleo, Giuseppe MD, PhD [P]; Salvia, Roberto MD, PhD [P]; Adsay, Volkan MD ++; Scarpa, Aldo MD, PhD *,+
doi : 10.1097/PAS.0000000000002017
AB Acinar cystic transformation (ACT) of the pancreas, previously called acinar cell cystadenoma, is a poorly understood and rare entity among pancreatic cystic lesions. This study aims to clarify its real nature
Lymph Nodes With Increased IgG4-positive Plasma Cells and Patterns Suspicious for IgG4-related Disease: Can Lymph Nodes Be the Only Site of Disease?.
Chen, Ying-Ren MD *; Yu, Shan-Chi MD +; Wang, Ren-Ching MD ++; Lee, Chih-Ling MD [S]; Song, Hsiang-Lin MD [//]; Medeiros, L. Jeffrey MD [P]; Yue, Chung-Tai MD, PhD #; Chang, Kung-Chao MD, PhD **,++,++++
doi : 10.1097/PAS.0000000000002007
AB Lymphadenopathy with increased immunoglobulin (Ig) G4+ plasma cells can be a nonspecific finding or a manifestation of immunoglobulin G4-related disease (IgG4-RD).
Intact Chorionic Vesicle in Very Early Products of Conception Specimens: Clinicopathologic Features of 26 Cases That May Mimic Complete Hydatidiform Mole.
Kayraklioglu, Neslihan MD, PhD *; Gasper, Cynthia MD *; Cho, Soo Jin MD, PhD *; Lage, Janice MD +; Rabban, Joseph T. MD, MPH *
Follicle Center Lymphoma (FCL) of the Lower Female Genital Tract (LFGT): A Novel Variant of Primary Cutaneous Follicle Center Lymphoma (PCFCL).
Saksena, Annapurna MD *; Jain, Ashish PhD +,++; Pack, Svetlana D. PhD *; Kim, Jung PhD *; Lee, Ina MD, PhD *; Tyagi, Manoj PhD *; Xi, Liqiang MD *; Pittaluga, Stefania MD, PhD *; Raffeld, Mark MD *; Jaffe, Elaine S. MD *
doi : 10.1097/PAS.0000000000002003
AB Primary cutaneous follicle center lymphoma has been distinguished from nodal follicular lymphoma (FL) based on genomic and clinical features. The nature of other extranodal FLs is not well defined. We report 15 cases of follicle center lymphoma involving the lower female genital tract.
