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2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases
Anne R. Bass, Eliza Chakravarty, Elie A. Akl, Clifton O. Bingham, Leonard Calabrese, Laura C. Cappelli, Sindhu R. Johnson, Lisa F. Imundo, Kevin L. Winthrop, Reuben J. Arasaratnam, Lindsey R. Baden, Roberta Berard, S. Louis Bridges Jr., Jonathan T. L. Cheah, Jeffrey R. Curtis, Polly J. Ferguson, Ida Hakkarinen, Karen B. Onel, Grayson Schultz, Vidya Sivaraman, Benjamin J. Smith, Jeffrey A. Sparks, Tiphanie P. Vogel, Eleanor Anderson Williams, Cassandra Calabrese, Joanne S. Cunha, Joann Fontanarosa, Miriah C. Gillispie-Taylor, Elena Gkrouzman, Priyanka Iyer, Kimberly S. Lakin, Alexandra Legge, Mindy S. Lo, Megan M. Lockwood, Rebecca E. Sadun, Namrata Singh, Nancy Sullivan, Herman Tam, Marat Turgunbaev, Amy S. Turner, James Reston
doi : 10.1002/art.42386
To provide evidence-based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs).
I Kappa B-Kliev-ε That the Inhibitor of NF-κB Kinase Subunit ε (IKBKε) May Hold the Key to Treating NPSLE!
Carla M. Cuda
doi : 10.1002/art.42371
Role of Human Mesenchymal Stem Cells and Derived Extracellular Vesicles in Reducing Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis
Minji Ai, William E. Hotham, Luke A. Pattison, Qingxi Ma, Frances M.D. Henson, Ewan St. John Smith
doi : 10.1002/art.42353
Mesenchymal stem/stromal cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) have been reported to alleviate pain in patients with knee osteoarthritis (OA). We undertook this study to determine whether MSCs and/or MSC-EVs reduce OA pain through influencing sensory neuron excitability in OA joints.
Targeting CD38 to Suppress Osteoarthritis Development and Associated Pain After Joint Injury in Mice
Paulo Gil Alabarse, Liang-Yu Chen, Patricia Oliveira, Huaping Qin, Ru Liu-Bryan
doi : 10.1002/art.42351
This study was undertaken to determine the role of CD38, which can function as an enzyme to degrade NAD+, in osteoarthritis (OA) development.
R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis
Anne Gigout, Daniela Werkmann, Stephanie Menges, Christian Brenneis, Frances Henson, Kyra J. Cowan, Djordje Musil, Christian S. Thudium, Hans Gühring, Martin Michaelis, Kerstin Kleinschmidt-Doerr
doi : 10.1002/art.42343
To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug.
HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis
Shiyao Liao, Qiangqiang Zheng, Haotian Shen, Guang Yang, Yuzi Xu, Xiaolei Zhang, Hongwei Ouyang, Zongyou Pan
doi : 10.1002/art.42369
Osteoarthritis (OA) is one of the most common degenerative joint diseases and is associated with autophagy suppression. However, the molecular mechanism of autophagy regulation in the context of OA is not fully understood. In this study, we sought to determine the role that HECTD1 plays in the pathogenesis of OA.
Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With Long-Term Clinical Outcomes: A Five-Year Prospective Study
Kathryn Connelly, Rangi Kandane-Rathnayake, Alberta Hoi, Worawit Louthrenoo, Laniyati Hamijoyo, Shue Fen Luo, Yeong-Jian Jan Wu, Jiacai Cho, Aisha Lateef, CS Lau, Yi-Hsing Chen, Sandra Navarra, Leonid Zamora, Zhanguo Li, Yuan An, Sargunan Sockalingam, Yanjie Hao, Zhuoli Zhang, Madelynn Chan, Yasuhiro Katsumata, Masayoshi Harigai, Shereen Oon, Sang-Cheol Bae, Sean O'Neill, Kathryn A. Gibson, BMDB Basnayake, Jun Kikuchi, Tsutomu Takeuchi, Kristine Pek Ling Ng, Nicola Tugnet, Sunil Kumar, Fiona Goldblatt, Annie Law, Michael Tee, Cherica Tee, Yoshiya Tanaka, Naoaki Ohkubo, Jin Yu Tan, Chetan S. Karyekar, Mandana Nikpour, Vera Golder, Eric F. Morand
doi : 10.1002/art.42350
In trials of systemic lupus erythematosus (SLE), the SLE Responder Index (SRI) is the most commonly used primary efficacy end point but has limited validation against long-term outcomes. We aimed to investigate associations of attainment of a modified version of the SRI (mSRI) with key clinical outcomes in SLE patients with up to 5 years of follow-up.
Inhibitor of NF-κB Kinase Subunit ε Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation
Kohei Karino, Michihito Kono, Shuhei Takeyama, Yuki Kudo, Masatoshi Kanda, Nobuya Abe, Kuniyuki Aso, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Olga Amengual, Tatsuya Atsumi
doi : 10.1002/art.42352
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiorgan dysfunction. Neuropsychiatric SLE (NPSLE) occurs in 30–40% of lupus patients and is the most severe presentation of SLE, frequently resulting in limitation of daily life.
Proteomics Landscape Mapping of Organ-Resolved Behçet's Disease Using In-Depth Plasma Proteomics for Identifying Hyaluronic Binding Protein 2 Expression Associated With Vascular Involvement
Linlin Cheng, Dongxue Wang, Zhimian Wang, Haolong Li, Guibin Wang, Ziyan Wu, Meng Xu, Songxin Yan, Haoting Zhan, Hongye Wang, Xiaomei Zhang, Te Liang, Chundi Wei, Fengchun Zhang, Wenjie Zheng, Xiaobo Yu, Yongzhe Li
doi : 10.1002/art.42348
This study was undertaken to elucidate the pathogenesis and heterogeneity of Behçet's disease (BD) involving different organs using in-depth proteomics to identify the biomarkers for clinical assessment and treatment of patients with BD.
Critical Role of LMCD1 in Promoting Profibrotic Characteristics of Lung Myofibroblasts in Experimental and Scleroderma-Associated Lung Fibrosis
Galina S. Bogatkevich, Ilia Atanelishvili, Andrew M. Bogatkevich, Richard M. Silver
doi : 10.1002/art.42344
Interstitial lung disease (ILD) is a serious complication and leading cause of mortality in patients with systemic sclerosis (SSc). In this study, we explored the role of LIM and cysteine-rich domains protein 1 (LMCD1) as a novel factor in the pathogenesis of SSc-related ILD (SSc-ILD).
Dynamic Prediction of Pulmonary Hypertension in Systemic Sclerosis Using Landmark Analysis
Svetlana I. Nihtyanova, Benjamin E. Schreiber, Voon H. Ong, Athol U. Wells, John G. Coghlan, Christopher P. Denton
doi : 10.1002/art.42349
Pulmonary hypertension (PH) is a serious complication of systemic sclerosis (SSc). In this study, we explored the prediction of short-term risk for PH using serial pulmonary function tests (PFTs) and other disease features.
Efficacy and Safety of Botulinum Toxin in Adults with Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Patricia Senet, Hervé Maillard, Elisabeth Diot, Isabelle Lazareth, Sophie Blaise, Jean-Philippe Arnault, Marc-Antoine Pistorius, Carine Boulon, Olivier Cogrel, Ursula Warzocha, Sébastien Rivière, Julie Malloizel-Delaunay, Amélie Servettaz, Bruno Sassolas, Manuelle Viguier, Jean-Benoit Monfort, Solène Janique, Eric Vicaut, on behalf of the BRASS collaborators
doi : 10.1002/art.42342
To determine whether a single session of botulinum toxin type A (BTA) injections into both hands more effectively decreases the frequency of systemic sclerosis–associated Raynaud's phenomenon (SSc-RP) episodes than placebo.
De Novo Gain-Of-Function Variations in LYN Associated With an Early-Onset Systemic Autoinflammatory Disorder
Camille Louvrier, Elma El Khouri, Martine Grall Lerosey, Pierre Quartier, Anne-Marie Guerrot, Brigitte Bader Meunier, Julie Chican, Malaïka Mohammad, Eman Assrawi, Aphrodite Daskalopoulou, Angela Arenas Garcia, Bruno Copin, William Piterboth, Florence Dastot Le Moal, Sonia A. Karabina, Serge Amselem, Irina Giurgea
doi : 10.1002/art.42354
To identify the molecular basis of a severe systemic autoinflammatory disorder (SAID) and define its main phenotypic features, and to functionally assess the sequence variations identified in LYN, a gene encoding a nonreceptor tyrosine kinase.
Risk of Arrhythmia Among New Users of Hydroxychloroquine in Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Population-Based Study
M. Rashedul Hoque, Leo Lu, Narsis Daftarian, John M. Esdaile, Hui Xie, J. Antonio Aviña-Zubieta
doi : 10.1002/art.42337
We assessed the association between hydroxychloroquine (HCQ) initiation and risk of arrhythmia among patients with incident rheumatoid arthritis (RA) or with incident systemic lupus erythematosus (SLE).
Seronegative palindromic rheumatism: what are we talking about? Comment on the article by Yang et al
Raimon Sanmarti, Beatriz Frade-Sosa, Rosa Morlà , Juan D. Cañete
doi : 10.1002/art.42387
Botulinum toxin for Raynaud's phenomenon associated with systemic sclerosis: comment on the article by Senet et al
Hanlin Yin, Bei Liu, Qianqian Li, Qingran Yan, Liangjing Lu
doi : 10.1002/art.42379
Clinical Images: Impending cardiac tamponade and coated aorta in Erdheim-Chester disease
Sho Fukui, Satoshi Kobayashi, Mitsumasa Kishimoto
doi : 10.1002/art.42385
