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Subretinal deposits in young patients treated with voretigene neparvovec-rzyl for RPE65-mediated retinal dystrophy
Jennifer Lopez, Mark Borchert, Thomas C Lee, Aaron Nagiel
doi : 10.1136/bjo-2022-321488
We report a series of three young patients (ages: 22 months, 2 years, and 5 years) who developed subretinal deposits at post-operative week one following subretinal voretigene neparvovec-rzyl treatment for RPE65-mediated retinal dystrophy. In the 5-year-old, subretinal deposits were also observed in the inferior periphery of both eyes.
Novel preloaded monocanalicular silicone stent for nasolacrimal duct intubation
Sarah Zwingelberg, Senmao Li, Alexandros Doulis, Michael Simon, Philomena A Wawer Matos, Alexander Christopher Rokohl, Ludwig M Heindl
doi : 10.1136/bjo-2022-321948
Clinical review of retinotopy
Jenny Nij Bijvank, Lucas Maillette de Buy Wenniger, Pim de Graaf, Axel Petzold
doi : 10.1136/bjophthalmol-2021-320563
Two observations made 29 years apart are the cornerstones of this review on the contributions of Dr Gordon T. Plant to understanding pathology affecting the optic nerve.
Intravitreal antivascular endothelial growth factor in diabetic macular oedema: scoping review of clinical practice guidelines recommendations
Manuel Vargas-Peirano, Catalina Verdejo, Laura Vergara-Merino, Cristóbal Loézar, Martin Hoehmann, Javier Pérez-Bracchiglione
doi : 10.1136/bjophthalmol-2021-319504
Background Diabetic macular oedema (DME) is a worldwide major cause of low vision and blindness. Intravitreal antivascular endothelial growth factor (anti-VEGF) constitutes an effective treatment. Clinical practice guidelines (CPGs) are synthesis documents that seek to improve patient care.
Immune checkpoint inhibitors for treatment of periorbital squamous cell carcinoma
Jeremy Allan Goldfarb, Renata Ferrarotto, Neil Gross, Ryan Goepfert, James Matthew Debnam, Brandon Gunn, Priyadharsini Nagarajan, Bita Esmaeli
doi : 10.1136/bjophthalmol-2021-319417
Purpose To report on the outcomes of immunotherapy in patients with locally advanced periorbital squamous cell carcinoma.
Intraepithelial growth pattern for eyelid sebaceous carcinoma: a cohort of 214 patients from a single institution
Chuandi Zhou, Peiwei Chai, Wenwen Xia, Jiang Li, Renbing Jia, Xianqun Fan
doi : 10.1136/bjophthalmol-2021-319789
Aims To determine the distribution of three different intraepithelial growth patterns (pagetoid, bowenoid and papillary) in eyelid sebaceous carcinoma (SC) and correlate them with the clinical characteristics and prognosis.
Differences in characteristics, aetiologies, isolated pathogens, and the efficacy of antibiotics in adult patients with preseptal cellulitis and orbital cellulitis between 2000–2009 and 2010–2019
En-Jie Shih, Jui-Kuang Chen, Pei-Jhen Tsai, Youn-Shen Bee
doi : 10.1136/bjophthalmol-2021-318986
Background/aims To understand whether the epidemiology, aetiologies, common pathogens and the antibiotic efficacy against the identified bacteria of periorbital cellulitis in adults have changed recently (2010–2019) compared with the past decade (2000–2009).
Time trends and heterogeneity in the disease burden of trachoma, 1990–2019: a global analysis
Jingxin He, Aiming Chen, Minjie Zou, Charlotte Aimee Young, Ling Jin, Danying Zheng, Guangming Jin, Nathan Congdon
doi : 10.1136/bjophthalmol-2021-319621
Purpose To evaluate the epidemiological trends and associated risk factors of disease burden due to trachoma.
Management of limbal stem cell deficiency by amnion-assisted conjunctival epithelial redirection using vacuum-dried amniotic membrane and fibrin glue
Harminder Singh Dua, Darren Shu Jeng Ting, Ahmed AlSaadi, Dalia G Said
doi : 10.1136/bjophthalmol-2020-318496
Purpose To study the outcome of a modified amnion-assisted conjunctival epithelial redirection (ACER) technique using vacuum-dried amnion (Omnigen) and fibrin glue for managing total limbal stem cell deficiency (LSCD).
Anterior segment biometric measurements explain misclassifications by a deep learning classifier for detecting gonioscopic angle closure
Alice Shen, Michael Chiang, Anmol A Pardeshi, Roberta McKean-Cowdin, Rohit Varma, Benjamin Y Xu
doi : 10.1136/bjophthalmol-2021-319058
Background/aims To identify biometric parameters that explain misclassifications by a deep learning classifier for detecting gonioscopic angle closure in anterior segment optical coherence tomography (AS-OCT) images.
Intermediate-term outcomes of the Aurolab aqueous drainage implant in neovascular glaucoma
Subathra Gnanavelu, George Varghese Puthuran, Kousalya Pavani Chiranjeevi, Hiruni Kaushalya Wijesinghe, Vishnuvardhan Reddy, Iswarya Mani, Subbaiah Ramasamy Krishnadas, Steven Jon Gedde
doi : 10.1136/bjophthalmol-2021-319999
Purpose To assess the outcomes of the non-valved Aurolab aqueous drainage implant (AADI) in neovascular glaucoma (NVG).
Relationship between vision impairment and employment
Yi Xuen Chai, Alfred Tau Liang Gan, Eva K Fenwick, Abraham Y Sui, Benjamin Kye Jyn Tan, Debra Q Y Quek, Chaoxu Qian, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux, Ryan Eyn Kidd Man
doi : 10.1136/bjophthalmol-2021-319655
Aims To examine the relationship between vision impairment (VI) and employment outcomes in a multiethnic Asian population.
Clinical and genetic features of retinoschisis in 120 families with RS1 mutations
Sainan Xiao, Wenmin Sun, Xueshan Xiao, Shiqiang Li, Hualei Luo, Xiaoyun Jia, Jiamin Ouyang, Xueqing Li, Yingwei Wang, Yi Jiang, Panfeng Wang, Qingjiong Zhang
doi : 10.1136/bjophthalmol-2021-319668
Background/aims X-linked retinoschisis (XLRS), associated with RS1, is the most common type of X-linked retinopathy in children. This study aimed to identify clinical and genetic features of retinoschisis in 120 families with RS1 variants in China.
Primary and secondary focal choroidal excavation morphologic phenotypes, associated ocular disorders and prognostic implications
Pamela Capellan, Luis A Gonzalez, M Abdallah Mahrous, Stephanie J Weiss, Benjamin Botsford, Tamara L Lenis, Michael Ryan, Anton Orlin, Thanos Papakostas, Szilard Kiss, Donald D'Amico, Kyle Kovacs
doi : 10.1136/bjophthalmol-2021-319569
Aims To characterise and classify the morphological, clinical and tomographic characteristics of focal choroidal excavation (FCE) lesions to determine their prognostic implications.
Effects of fetal haemoglobin on systemic oxygenation in preterm infants and the development of retinopathy of prematurity PacIFiHER Report No. 2
Kim Jiramongkolchai, Michael X Repka, Jing Tian, Sue W Aucott, Jennifer Shepard, Megan Collins, Julia Clemens, Mia Feller, Irina Burd, Marina Roizenblatt, Kerry Smith, J Fernando Arevalo, Peter L Gehlbach, James T Handa
doi : 10.1136/bjophthalmol-2021-319546
Background/aims Fetal haemoglobin (HbF) has an oxyhaemoglobin dissociation curve that may affect systemic oxygenation and the development of retinopathy of prematurity (ROP). The study aim is to characterise the effects of HbF levels on systemic oxygenation and ROP development.
Biosimilar SB11 versus reference ranibizumab in neovascular age-related macular degeneration: 1-year phase III randomised clinical trial outcomes
Neil M Bressler, Miroslav Veith, Jan Hamouz, Jan Ernest, Dominik Zalewski, Jan Studni�ka, Attila Vajas, András Papp, Gabor Vogt, James Luu, Veronika Matuskova, Young Hee Yoon, Tamás Pregun, Taehyung Kim, Donghoon Shin, Inkyung Oh, Hansol Jeong, Mercy Yeeun Kim, Se Joon Woo
doi : 10.1136/bjophthalmol-2021-319637
Background/Aims To provide longer-term data on efficacy, safety, immunogenicity and pharmacokinetics (PK) of ranibizumab biosimilar SB11 compared with the reference ranibizumab (RBZ) in patients with neovascular age-related macular degeneration (nAMD).
Six-year incidence of age-related macular degeneration and correlation to OCT-derived drusen volume measurements in a Chinese population
Anna CS Tan, Miao Li Chee, Beau J Fenner, Paul Mitchell, Yih Chung Tham, Tyler Rim, Kelvin Teo, Shaun S Sim, Ching Yu Cheng, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
doi : 10.1136/bjophthalmol-2021-319290
Aims To report the 6-year incidence of optical coherence tomography (OCT)-derived age-related changes in drusen volume and related systemic and ocular associations.
Morphological characteristics of eyes with neovascular age-related macular degeneration and good long-term visual outcomes after anti-VEGF therapy
Mengyuan Fang, Karntida Chanwimol, Jyotsna Maram, Ghazala A Datoo O'Keefe, Charles C Wykoff, David Sarraf, A’sha Brown, Shaun Ian Retief Lampen, Brenda Zhou, Alexander M Rusakevich, SriniVas Sadda
doi : 10.1136/bjophthalmol-2021-319602
Purpose To analyse the morphological characteristics of eyes with neovascular age-related macular degeneration (AMD) with good long-term visual acuity after anti-VEGF (vascular endothelial growth factor) therapy.
Incidence and mortality of uveal melanoma in Australia (1982–2014)
Aaron B Beasley, David B Preen, Samuel McLenachan, Elin S Gray, Fred K Chen
doi : 10.1136/bjophthalmol-2021-319700
Aims We aimed to estimate the incidence and mortality of uveal melanoma (UM) in Australia from 1982 to 2014.
Presumed incipient choroidal melanoma: proposed diagnostic criteria and management
Susanna Jouhi, Ranaa T Al-Jamal, Martin Täll, Sebastian Eskelin, Tero T Kivelä
doi : 10.1136/bjophthalmol-2020-318658
Aims To propose diagnostic criteria for a presumed incipient choroidal melanoma based on tumour growth rate and tumour doubling time (TDT) and to describe management of such tumours with transpupillary thermotherapy (TTT).
Evaluation of blood vessel network formation and visual field defect in optic disc melanocytoma
Jay Jiyong Kwak, Dong Hyun Lee, Sung Chul Lee, Christopher Seungkyu Lee
doi : 10.1136/bjophthalmol-2021-319630
Aim To investigate the association between visual field defects and blood vessel network (BVN) formation in optic disc melanocytomas (ODMs) using optical coherence tomography angiography (OCTA).
Therapeutic effect of modified double-dose photodynamic therapy in circumscribed choroidal haemangioma
Hyeong Ju Byeon, Ji Hwan Lee, Junwon Lee, Eun Young Choi, Yong Joon Kim, Sung Chul Lee, Christopher Seungkyu Lee
doi : 10.1136/bjophthalmol-2021-319832
Aims To retrospectively compare the therapeutic effect of modified double-dose photodynamic therapy (PDT) with standard-dose PDT in patients with circumscribed choroidal haemangioma (CCH).
Self-reported cataract surgery and 10-year all-cause and cause-specific mortality: findings from the National Health and Nutrition Examination Survey
Yifan Chen, Wei Wang, Huan Liao, Danli Shi, Zachary Tan, Xianwen Shang, Xueli Zhang, Yu Huang, Qingrong Deng, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu
doi : 10.1136/bjophthalmol-2021-319678
Purpose To investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample.
Burden of near vision loss in China: findings from the Global Burden of Disease Study 2019
Guangming Jin, Minjie Zou, Chi Liu, Aiming Chen, Yi Sun, Charlotte Aimee Young, Yi Li, Danying Zheng, Nathan Congdon, Xiaotong Han
doi : 10.1136/bjophthalmol-2021-319603
Purpose To investigate the burden of near vision loss (NVL) in China by year, age and gender from 1990 to 2019.
New insights into change of lens proteins’ stability with ageing under physiological conditions
Chenqi Luo, Jingjie Xu, Chenxi Fu, Ke Yao, Xiangjun Chen
doi : 10.1136/bjophthalmol-2021-319834
Background Age-related cataract, which presents as a cloudy lens, is the primary cause of vision impairment worldwide and can cause more than 80% senile blindness. Previous studies mainly explored the profile of lens proteins at a low concentration because of technical limitations, which could not reflect physiological status. This study focuses on protein stability changes with ageing under physiological conditions using a novel equipment, Unchained Labs (Uncle), to evaluate protein thermal stability.
