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Occupational inhalants, genetics and the respiratory mucosal paradigm for ACPA-positive rheumatoid arthritis
Vanessa L Kronzer, Jeffrey A Sparks
doi : 10.1136/ard-2022-223286
March 2023 - Volume 82 - 3
From real-world electronic health record data to real-world results using artificial intelligence
Rachel Knevel, Katherine P Liao
doi : 10.1136/ard-2022-222626
With the worldwide digitalisation of medical records, electronic health records (EHRs) have become an increasingly important source of real-world data (RWD). RWD can complement traditional study designs because it captures almost the complete variety of patients, leading to more generalisable results.
Matching researchers’ needs and patients’ contributions: practical tips for meaningful patient engagement from the field of rheumatology
Casper G Schoemaker, Dawn P Richards, Maarten de Wit
doi : 10.1136/ard-2022-223561
There is an increasing recognition of the importance of patient engagement and involvement in health research, specifically within the field of rheumatology. In general, researchers in this specialty appreciate the value of patients as partners in research. In practice, however, the majority of researchers does not involve patients on their research teams.
Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking
Bowen Tang, Qianwen Liu, Anna Ilar, Pernilla Wiebert, Sara Hägg, Leonid Padyukov, Lars Klareskog, Lars Alfredsson, Xia Jiang
doi : 10.1136/ard-2022-223134
Objectives To assess the effects of occupational inhalable exposures on rheumatoid arthritis (RA) development and their interactions with smoking and RA-risk genes, stratifying by presence of anticitrullinated protein antibodies (ACPA).
Reducing cardiovascular risk with immunomodulators: a randomised active comparator trial among patients with rheumatoid arthritis
Daniel H Solomon, Jon T Giles, Katherine P Liao, Paul M Ridker, Pamela M Rist, Robert J Glynn, Rachel Broderick, Fengxin Lu, Meredith T Murray, Kathleen Vanni, Leah M Santacroce, Shady Abohashem, Philip M Robson, Zahi Fayad, Venkatesh Mani, Ahmed Tawakol, Joan Bathon
doi : 10.1136/ard-2022-223302
Objective Recent large-scale randomised trials demonstrate that immunomodulators reduce cardiovascular (CV) events among the general population. However, it is uncertain whether these effects apply to rheumatoid arthritis (RA) and if certain treatment strategies in RA reduce CV risk to a greater extent.
Malignancy risk with tofacitinib versus TNF inhibitors in rheumatoid arthritis: results from the open-label, randomised controlled ORAL Surveillance trial
Jeffrey R Curtis1, Kunihiro Yamaoka2, Yi-Hsing Chen3, Deepak L Bhatt4, Levent M Gunay5, Naonobu Sugiyama6, Carol A Connell7, Cunshan Wang7, Joseph Wu7, Sujatha Menon7, Ivana Vranic8, Juan J Gómez-Reino9
doi : 10.1136/ard-2022-222543
Objectives To evaluate malignancies and their associations with baseline risk factors and cardiovascular risk scores with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in patients with rheumatoid arthritis (RA).
Tenderness and radiographic progression in rheumatoid arthritis and psoriatic arthritis
Irina Gessl, Claudia A Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S Smolen, Daniel Aletaha, Peter Mandl
doi : 10.1136/ard-2022-222787
Objective The aim of this study was to assess the predictive value of tenderness in the absence of swelling with consideration of other potential risk factors for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
doi : 10.1136/ard-2022-223035
Objectives To quantify global, regional and country-specific estimates of epidemiology of systemic lupus erythematosus (SLE).
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis
Julia Z Adamska, Amin Zia, Michelle S Bloom, Leslie J Crofford, Daniel E Furst, Ellen Goldmuntz, Lynette Keyes-Elstein, Maureen D Mayes, Peter McSweeney, Richard A Nash, Ashley Pinckney, Beverly Welch, Zelda Z Love, Keith M Sullivan, William Robinson
doi : 10.1136/ard-2021-221925
Objectives Myeloablative autologous haematopoietic stem cell transplant (HSCT) was recently demonstrated to provide significant benefit over cyclophosphamide (CYC) in the treatment of diffuse cutaneous systemic sclerosis (dcSSc) in the Scleroderma: Cyclophosphamide or Transplantation (SCOT) trial. As dysregulation of the B cell compartment has previously been described in dcSSc, we sought to gain insight into the effects of myeloablative autologous HSCT as compared with CYC.
Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis
Sébastien Sanges, Lisa Rice, Ly Tu, Eleanor Valenzi, Jean-Luc Cracowski, David Montani, Julio C Mantero, Camille Ternynck, Guillemette Marot, Andreea M Bujor, Eric Hachulla, David Launay, Marc Humbert, Christophe Guignabert, Robert Lafyatis
doi : 10.1136/ard-2022-223237
Objectives To mine the serum proteome of patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and to detect biomarkers that may assist in earlier and more effective diagnosis and treatment.
Deciphering the role of cDC2s in Sjögren’s syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity
Ana P Lopes, Maarten R Hillen, Anneline C Hinrichs, Sofie LM Blokland, Cornelis PJ Bekker, Aridaman Pandit, Aike A Kruize, Timothy RDJ Radstake, Joel A van Roon
doi : 10.1136/ard-2022-222728
Objective Type 2 conventional dendritic cells (cDC2s) are key orchestrators of inflammatory responses, linking innate and adaptative immunity. Here we explored the regulation of immunological pathways in cDC2s from patients with primary Sjögren’s syndrome (pSS).
Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement
Cecilie Henkel, Unnur Styrkársdóttir, Gudmar Thorleifsson, Lilja Stefánsdóttir, Gyda Björnsdóttir, Karina Banasik, Søren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar René Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, DBDS Genomic Consortium, Thorgeir E Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kári Stefánsson, Anders Troelsen
doi : 10.1136/ard-2022-223199
Objectives Osteoarthritis is a common and severe, multifactorial disease with a well-established genetic component. However, little is known about how genetics affect disease progression, and thereby the need for joint placement. Therefore, we aimed to investigate whether the genetic associations of knee and hip osteoarthritis differ between patients treated with joint replacement and patients without joint replacement.
Stage-specific and location-specific cartilage calcification in osteoarthritis development
Xiaozhao Wang, Qin Wu, Ru Zhang, Zhang Fan, Wenyue Li, Renwei Mao, Zihao Du, Xudong Yao, Yuanzhu Ma, Yiyang Yan, Wei Sun, Hongwei Wu, Wei Wei, Yejun Hu, Yi Hong, Huan Hu, Yi Wen Koh, Wangping Duan, Xiao Chen, Hongwei Ouyang
doi : 10.1136/ard-2022-222944
Objectives This study investigated the stage-specific and location-specific deposition and characteristics of minerals in human osteoarthritis (OA) cartilages via multiple nano-analytical technologies.
Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus
Hannah Swahn, Kun Li, Tomas Duffy, Merissa Olmer, Darryl D D'Lima, Tony S Mondala, Padmaja Natarajan, Steven R Head, Martin K Lotz
doi : 10.1136/ard-2022-223227
Objectives Single-cell level analysis of articular cartilage and meniscus tissues from human healthy and osteoarthritis (OA) knees.
Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment
HanLin Xu, Bohan Zhang, Yaxin Chen, Fengzhen Zeng, Wenjuan Wang, Ziyi Chen, Ling Cao, Jun Shi, Jun Chen, Xiaoxia Zhu, Yu Xue, Rui He, MinBiao Ji, YingHui Hua
doi : 10.1136/ard-2022-222764
Objective Increasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since the relationship between cartilage matrix protein and gout flares remains unclear, we investigated its role in monosodium urate (MSU) crystallisation and following inflammation.
Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Fraser L Collins, Anke J Roelofs, Rebecca A Symons, Karolina Kania, Ewan Campbell, Elaina S R Collie-duguid, Anna H K Riemen, Susan M Clark, Cosimo De Bari
doi : 10.1136/ard-2021-221682
Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin and relationship with adult progenitors.
Database of synovial T cell repertoire of rheumatoid arthritis patients identifies cross-reactive potential against pathogens including unencountered SARS-CoV-2
Zihan Zheng, Ling Chang, Jie Mu, Qingshan Ni, Zhong Bing, Qing-Hua Zou, Ying Wan, Yuzhang Wu, Jingyi Li, Liyun Zou
doi : 10.1136/ard-2022-222763
Expression of interleukin-6 in synovial tissue of patients with polymyalgia rheumatica
William F Jiemy, Anqi Zhang, Annemieke M H Boots, Peter Heeringa, Maria Sandovici, Arjan Diepstra, Sandra Hein, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis SM van der Geest
doi : 10.1136/ard-2022-222873
Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)
Christopher John Redmond, Moses M Kitakule, Aran Son, McKella Sylvester, Keith Sacco, Ottavia Delmonte, Francesco Licciardi, Riccardo Castagnoli, M Cecilia Poli, Yasmin Espinoza, Camila Astudillo, Sarah E Weber, Gina A Montealegre Sanchez, Karyl S Barron, Mary Magliocco, Kerry Dobbs, Yu Zhang, Helen Matthews, Cihan Oguz, Helen C Su, Luigi D Notarangelo, Pamela Frischmeyer-Guerrerio, Daniella M Schwartz
doi : 10.1136/ard-2022-223269
Genetically proxied TYK2 inhibition is associated with reduced sarcoidosis susceptibility
Sizheng Steven Zhao, Anne Barton, John Bowes
doi : 10.1136/ard-2022-223513
Correspondence on: ‘EULAR definition of difficult-to-treat rheumatoid arthritis
Marta Novella-Navarro, Chamaida Plasencia-RodrÃguez, Carolina Tornero, Victoria Navarro-Compán, José Luis Cabrera-Alarcón, Diana Peiteado, Laura Nuño, Irene Monjo, Karen Franco-Gómez, Alejandro Villalba, Alejandro Balsa
Response to: ‘Correspondence on ‘EULAR definition of difficult-to-treat rheumatoid arthritis’’ by Novella-Navarro et al
Nadia M T Roodenrijs, Paco M J Welsing, Marlies C van der Goes, Johannes WG Jacobs, Désirée van der Heijde, Jacob M van Laar, György Nagy
Correspondence on ‘Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?’
Socrates Angelides, Nicholas Manolios
Response to: ‘Correspondence on “Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?’ by Angelides and Manolios
Gabriel Herrero-Beaumont, Raquel Largo
Correspondence on ‘Jan Gösta Waldenström and rheumatology’
Haralampos M Moutsopoulos
Response to: ‘Correspondence on ‘Jan Gösta Waldenströmand rheumatology’’ by Moutsopoulos
Frank A Wollheim
Correspondence on ‘Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis
Satoshi Takanashi
Response to: ‘Correspondence on ‘Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis’’ by Takanashi et al
Iago Pinal-Fernandez, Maria Casal-Dominguez, Jose Cesar Milisenda, Andrew Lee Mammen
Correspondence on ‘What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern
Samy Hakroush, Björn Tampe
Response to: ‘Correspondence on ‘What comes after the lockdown? Clustering of ANCA-associated vasculitis: single-centre observation of a spatiotemporal pattern’’ by Hakroush and Tampe
Philipp Gauckler, Andreas Kronbichler
Correspondence on ‘Haemodynamic phenotypes and survival in patients with systemic sclerosis: the impact of the new definition of pulmonary arterial hypertension
Michele Iudici, Danièle Allali, Raphaël Porcher
Response to: ‘ Correspondence on ‘Haemodynamic phenotypes and survival in patients with systemic sclerosis: the impact of the new definition of pulmonary arterial hypertension’’ by Iudici et al
Ekkehard Grünig, Nicola Benjamin, Panagiota Xanthouli, Suzana Jordan, Nicklas Milde, Alberto Marra, Norbert Blank, Benjamin Egenlauf, Matthias Gorenflo, Satenik Harutyunova, Hanns-Martin Lorenz, Christian Nagel, Vivienne Theobald, Mona Lichtblau, Charlotte Berlier, Silvia Ulrich, Oliver Distler
Correspondence on ‘Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial
Bin Wang, Shiju Chen, Jingxiu Xuan, Yan Li, Qing Zheng, Xinwei Zhang, Yuan Liu, Guixiu Shi
Response to: ‘Correspondence on ‘Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial’’ by Wang et al
Renaud Felten, Jacques-Eric Gottenberg
Correspondence on ‘Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases
Sibel Zehra Aydin, Elliot Hepworth, Peter Tugwell
Response to: ‘Correspondence on ‘Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases’’ by Aydin et al
Dalifer Dayanira Freites Nuñez, Leticia Leon, Arkaitz Mucientes, Luis Rodriguez-Rodriguez, Judit Font Urgelles, Alfredo Madrid GarcÃa, Jose Ignacio Colomer, Juan A Jover, BenjamÃn Fernandez-Gutierrez, Lydia Abasolo
Correspondence on ‘Preliminary predictive criteria for COVID-19 cytokine storm
Desiree Tampe, Martin S Winkler, Peter Korsten, Samy Hakroush, Onnen Moerer, Björn Tampe
Response to: ‘Correspondence on ‘Preliminary predictive criteria for COVID-19 cytokine storm’’ by Tampe et al
Roberto Caricchio, Marcello Gallucci, Chandra Dass, Xinyan Zhang, Stefania Gallucci, David Fleece, Michael Bromberg, Gerard J Criner
Systemic lupus erythematosus and COVID-19: what we know so far
Giuseppe A. Ramirez, Luca Moroni, Emanuel Della-Torre, Maria Gerosa, Lorenzo Beretta, Enrica P. Bozzolo, Lorenzo Dagna
Repeated false-negative tests delayed diagnosis of COVID-19 in a case with granulomatosis with polyangiitis under maintenance therapy with rituximab and concomitant influenza pneumonia
Samy Hakroush, Jonas Franz, Jörg Larsen, Peter Korsten, Martin Sebastian Winkler, Björn Tampe
Comment on: ‘Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry’ by Gianfrancesco et al
Samet Karahan, Ali Cetinkaya, Kaniye Aydin, Hatice Aslan Sirakaya
Correction: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
