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Novel cognitive screening tests to address new clinical priorities and cultural diversity
Jordi A. Matias-Guiu, Alfonso Delgado-�lvarez
doi : 10.1111/ene.15653
Transcranial direct current stimulation and neurovascular modulation
Marom Bikson
doi : 10.1111/ene.15710
Brain-specific biomarkers: on the winding path to accessibility and clinical relevance
Radu Tanasescu, Didier Leys
doi : 10.1111/ene.15712
Performance validity tests in nonlitigant patients with functional motor disorder
Ilaria A. Di Vico, Jon Stone, Laura Mcwhirter, Marianna Riello, Maria Elisabetta Zanolin, Michela Colombari, Mirta Fiorio, Michele Tinazzi
doi : 10.1111/ene.15703
Clinical profiles and ethnic heterogeneity of sporadic fatal insomnia
Zhongyun Chen, Min Chu, Jing Zhang, Yu Kong, Kexin Xie, Yue Cui, Hong Ye, Li Liu, Junjie Li, Lin Wang, Liyong Wu
doi : 10.1111/ene.15676
This study was undertaken to elucidate the clinical profile of sporadic fatal insomnia (sFI), assess the similarities and differences between sFI and fatal familial insomnia (FFI), and evaluate the influence of ethnicity on the phenotype of sFI patients.
Analysis of co-medication in people with dementia
Raphael Wurm, Tandis Parvizi, Stella Goeschl, Helena Untersteiner, Sara Silvaieh, Tanja Stamm, Hakan Cetin, Berthold Reichardt, Elisabeth Stögmann
doi : 10.1111/ene.15675
Dementia prevalence is increasing, with numbers projected to double by 2050. Risk factors for its development include age and cardiovascular comorbidities, which are found more often in patients with dementia and should be treated properly to improve outcomes.
Chronic pain increases the risk of motoric cognitive risk syndrome at 4 years of follow-up: evidence from the China Health and Retirement Longitudinal Study
Haixu Liang, Ya Fang
doi : 10.1111/ene.15677
Slower gait speed and subjective cognitive concerns are characteristics of the motoric cognitive risk (MCR) syndrome. This study aimed to examine if changes in pain may be hallmarks of early MCR, through investigating the magnitude of the association of chronic pain and the risk of MCR at 4 years follow-up.
Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neuroinflammation processes in the Alzheimer's disease continuum
Caterina Motta, Martina Assogna, Chiara Giuseppina Bonomi, Francesco Di Lorenzo, Marzia Nuccetelli, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
doi : 10.1111/ene.15691
The locus coeruleus (LC) provides dopamine/noradrenaline (DA/NA) innervation throughout the brain and undergoes early degeneration in Alzheimer's disease (AD). We evaluated catecholaminergic enzyme levels in the cerebrospinal fluid (CSF) of a group of patients biologically defined as within the AD continuum (ADc) and explored their relationship with AD biomarkers and cytokine/growth factor levels to investigate their interplay with neurodegenerative and neuroinflammatory processes.
Cognitive phenotypes and factors associated with cognitive decline in a cohort of older patients with atrial fibrillation: The Strat-AF study
Emilia Salvadori, Eleonora Barucci, Carmen Barbato, Benedetta Formelli, Francesca Cesari, Stefano Chiti, Stefano Diciotti, Betti Giusti, Anna Maria Gori, Chiara Marzi, Francesca Pescini, Giovanni Pracucci, Enrico Fainardi, Rossella Marcucci, Anna Poggesi
doi : 10.1111/ene.15701
The multifactorial relationship between atrial fibrillation (AF) and cognitive impairment needs to be elucidated. The aim of this study was to assess, in AF patients on oral anticoagulants (OACs), the prevalence of cognitive impairment, defined according to clinical criteria or data-driven phenotypes, the prevalence of cognitive worsening, and factors associated with cognitive outcomes.
Characterizing SOD1 mutations in Spain: The impact of genotype, age and sex in the natural history of the disease
Juan F. Vázquez-Costa, Daniel Borrego-Hernández, Carmen Paradas, MarÃa Teresa Gómez-Caravaca, Ricardo Rojas-Garcia, Luis Varona, Mónica Povedano, Tania GarcÃa-Sobrino, Ivonne Jericó Pascual, Antonio Gutiérrez, Javier Riancho, Janina Turon-Sans, Abdelilah Assialioui, Jordi Pérez-Tur, Teresa Sevilla, Jesús Esteban Pérez, Alberto GarcÃa-Redondo, ALSGESCO
doi : 10.1111/ene.15661
The aim of this study was to describe the frequency and distribution of SOD1 mutations in Spain, and to explore factors contributing to their phenotype and prognosis.
Amyotrophic lateral sclerosis regional progression intervals change according to time of involvement of different body regions
Umberto Manera, Fabrizio D'Ovidio, Sara Cabras, Maria Claudia Torrieri, Antonio Canosa, Rosario Vasta, Francesca Palumbo, Maurizio Grassano, Fabiola De Marchi, Letizia Mazzini, Gabriele Mora, Cristina Moglia, Andrea Calvo, Adriano Chiò
doi : 10.1111/ene.15674
The prediction of disease course is one of the main targets of amyotrophic lateral sclerosis (ALS) research, particularly considering its wide phenotypic heterogeneity.
Repetitive transcranial magnetic stimulation for hypokinetic dysarthria in Parkinson's disease enhances white matter integrity of the auditory–motor loop
Lubos Brabenec, Patrik Simko, Alzbeta Sejnoha Minsterova, Milena Kostalova, Irena Rektorova
doi : 10.1111/ene.15665
In our previous study, repeated sessions of repetitive transcranial magnetic stimulation (rTMS) over the auditory feedback area were shown to improve hypokinetic dysarthria (HD) in Parkinson's disease (PD) and led to changes in functional connectivity within the left-sided articulatory networks.
Smartphone and custom-made software to assess the effect of botulinum toxin in essential blepharospasm: Initial results
Cristina Yabumoto, Midori H. Osaki, Gustavo R. Gameiro, Suzana Matayoshi, Mauro Campos, Tammy H. Osaki
doi : 10.1111/ene.15666
It is challenging to assess essential blepharospasm (EB) patients objectively because they exhibit chaotic patterns of abnormal eyelid movements. Previously employed objective approaches used systems with low levels of accuracy systems or were too complex to be applied in routine clinical practice.
Baseline free water within the visual processing system predicts future psychosis in Parkinson disease
Guanglu Li, Jiajia Zhu, Xingqi Wu, Tingting Liu, Panpan Hu, Yanghua Tian, Kai Wang
doi : 10.1111/ene.15668
As psychosis is associated with decreased quality of life, increased institutionalization, and mortality in Parkinson disease (PD), it is essential to identify individuals at risk for future psychosis.
European Society for the Study of Tourette Syndrome 2022 criteria for clinical diagnosis of functional tic-like behaviours: International consensus from experts in tic disorders
Tamara Pringsheim, Christos Ganos, Christelle Nilles, Andrea E. Cavanna, Donald L. Gilbert, Erica Greenberg, Andreas Hartmann, Tammy Hedderly, Isobel Heyman, Holan Liang, Irene Malaty, Osman Malik, Nanette Mol Debes, Kirsten Muller Vahl, Alexander Munchau, Tara Murphy, Peter Nagy, Tamsin Owen, Renata Rizzo, Liselotte Skov, Jeremy Stern, Natalia Szejko, Yulia Worbe, Davide Martino
doi : 10.1111/ene.15672
In 2020, health professionals witnessed a dramatic increase in referrals of young people with rapid onset of severe tic-like behaviours. We assembled a working group to develop criteria for the clinical diagnosis of functional tic-like behaviours (FTLBs) to help neurologists, pediatricians, psychiatrists, and psychologists recognize and diagnose this condition.
Independent effect of cardiometabolic syndromes and depression on dementia in Parkinson's disease: A 12-year longitudinal follow-up study of a nationwide cohort
Sung Hoon Kang, Yunjin Choi, Su Jin Chung, Chi Kyung Kim, Ji Hyun Kim, Kyungmi Oh, Joon Shik Yoon, Geum Joon Cho, Seong-Beom Koh
doi : 10.1111/ene.15689
We aimed to investigate the incidence rate of Parkinson's disease dementia (PDD) according to age and disease duration by sex. Furthermore, we explored the effect of each cardiometabolic syndrome and depression on the incidence of PDD.
White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative
Daniela Cristina Carvalho de Abreu, Frederico Pieruccini-Faria, Yanina Sarquis-Adamson, Alanna Black, Julia Fraser, Karen Van Ooteghem, Benjamin Cornish, David Grimes, Mandar Jog, Mario Masellis, Thomas Steeves, Nuwan Nanayakkara, Joel Ramirez, Christopher Scott, Melissa Holmes, Miracle Ozzoude, Courtney Berezuk, Sean Symons, Seyyed Mohammad Hassan Haddad, Stephen R. Arnott, Malcolm Binns, Stephen Strother, Derek Beaton, Kelly Sunderland, Athena Theyers, Brian Tan, Mojdeh Zamyadi, Brian Levine, Joseph B. Orange, Angela C. Roberts, Wendy Lou, Sujeevini Sujanthan, David P. Breen, Connie Marras, Donna Kwan, Sabrina Adamo, Alicia Peltsch, Angela K. Troyer, Sandra E. Black, Paula M. McLaughlin, Anthony E. Lang, William McIlroy, Robert Bartha, ONDRI Investigators, Manuel Montero-Odasso
doi : 10.1111/ene.15692
The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMHs) cognitive and motor impairments seem to be aggravated.
Mediterranean diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease/dementia with Lewy bodies: A longitudinal study
Maria I. Maraki, Mary Yannakoulia, Georgia Xiromerisiou, Leonidas Stefanis, Sokratis Charisis, Nikolaos Giagkou, Mary H. Kosmidis, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Maria Stamelou
doi : 10.1111/ene.15698
Lifestyle factors have been implicated in the long-lasting neurodegenerative process in prodromal Parkinson's disease (pPD). The aim was to investigate the associations between adherence to a Mediterranean diet (MeDi) and longitudinal changes of pPD probability and the development of Parkinson's disease (PD) or pPD in a Mediterranean older population.
The decline in stroke hospitalization due to COVID-19 is unrelated to COVID-19 intensity
Petra Sedova, Julia Anna Kent, Tomas Bryndziar, Jiri Jarkovsky, Ales Tomek, Martin Sramek, Ondrej Skoda, Tereza Sramkova, KateÅ™ina Pokorová, Simona Littnerova, Robert D. Brown Jr, Robert Mikulik
doi : 10.1111/ene.15664
During the coronavirus disease 2019 (COVID-19) pandemic many countries reported a decline in stroke volumes. The aim of this study was to analyze if the decline was related to the intensity of the COVID-19 pandemic.
Temporal trends and outcomes in acute ischaemic stroke patients with a current or historical diagnosis of cancer
Chi Peng, Fan Yang, Liwei Peng, Chenxu Zhang, Zhen Lin, Chenxin Chen, Huachen Gao, Jia He, Zhichao Jin
doi : 10.1111/ene.15699
The aim was to evaluate the temporal trends, characteristics and in-hospital outcomes of patients hospitalized with acute ischaemic stroke (AIS) between those with and without current or historical malignancies.
Intracranial carotid artery calcification morphology differs in patients with lacunar and nonlacunar acute ischemic strokes
Federico Mazzacane, Beatrice Del Bello, Federica Ferrari, Alessandra Persico, Elisa Rognone, Anna Pichiecchio, Alessandro Padovani, Anna Cavallini, Andrea Morotti, Francesco Arba
doi : 10.1111/ene.15704
Intracranial carotid artery calcifications (ICACs) are a common finding on noncontrast computed tomography (NCCT) and have been associated with an increased risk of ischemic stroke.
Quantitative muscle magnetic resonance imaging depicts microstructural abnormalities but no signs of inflammation or dystrophy in post-COVID-19 condition
Elena Enax-Krumova, Johannes Forsting, Marlena Rohm, Peter Schwenkreis, Martin Tegenthoff, Christine H. Meyer-Frießem, Lara Schlaffke
doi : 10.1111/ene.15709
Post-COVID-19 condition (PCC) has high impact on quality of life, with myalgia and fatigue affecting at least 25% of PCC patients. This case–control study aims to noninvasively assess muscular alterations via quantitative muscle magnetic resonance imaging (MRI) as possible mechanisms for ongoing musculoskeletal complaints and premature exhaustion in PCC.
Retinal ganglion cell loss is associated with future disability worsening in early relapsing–remitting multiple sclerosis
Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Mühlau, Tanja Schmitz-Hübsch, Claudia Chien, Achim Berthele, Alexander U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. Zimmermann, Benjamin Knier
doi : 10.1111/ene.15681
Thinning of the retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by optical coherence tomography (OCT) is a common finding in patients with multiple sclerosis. This study aimed to investigate whether a single retinal OCT analysis allows prediction of future disease activity after a first demyelinating event.
Sexual dysfunction in female and male people with multiple sclerosis: disability, depression and hormonal status matter
Franziska Di Pauli, Anne Zinganell, Bettina Böttcher, Janette Walde, Michael Auer, Robert Barket, Klaus Berek, Alexander Egger, Andrea Griesmacher, Natasa Sukalo, Florian Deisenhammer, Harald Hegen
doi : 10.1111/ene.15696
Sexual dysfunction (SD) in people with multiple sclerosis (pwMS) is common and an often underestimated issue in the care of pwMS. The objective of the study was to evaluate risk factors for SD in pwMS, correlate its prevalence with patient-reported measures (quality of life and physical activity) and analyse its association with hormonal status.
Observed associations between indicators of socioeconomic status and risk of multiple sclerosis in Sweden are explained by a few lifestyle-related factors
Lars Alfredsson, Jan Hillert, Tomas Olsson, Anna Karin Hedström
doi : 10.1111/ene.15705
The association between socioeconomic status (SES) and the risk of multiple sclerosis (MS) is unclear. The aim was to study whether a potential association between indicators of SES and MS risk in Sweden is explained by lifestyle/environmental factors.
Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis
Ibrahima Diouf, Charles B. Malpas, Sifat Sharmin, Izanne Roos, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Vahid Shaygannejad, Serkan Ozakbas, Guillermo Izquierdo, Sara Eichau, Marco Onofrj, Alessandra Lugaresi, Raed Alroughani, Alexandre Prat, Marc Girard, Pierre Duquette, Murat Terzi, Cavit Boz, Francois Grand'Maison, Sherif Hamdy, Patrizia Sola, Diana Ferraro, Pierre Grammond, Recai Turkoglu, Katherine Buzzard, Olga Skibina, Bassem Yamout, Ayse Altintas, Oliver Gerlach, Vincent van Pesch, Yolanda Blanco, Davide Maimone, Jeannette Lechner-Scott, Roberto Bergamaschi, Rana Karabudak, Gerardo Iuliano, Chris McGuigan, Elisabetta Cartechini, Michael Barnett, Stella Hughes, Maria José Sa, Claudio Solaro, Ludwig Kappos, Cristina Ramo-Tello, Edgardo Cristiano, Suzanne Hodgkinson, Daniele Spitaleri, Aysun Soysal, Thor Petersen, Mark Slee, Ernest Butler, Franco Granella, Koen de Gans, Pamela McCombe, Radek Ampapa, Bart Van Wijmeersch, Anneke van der Walt, Helmut Butzkueven, Julie Prevost, L. G. F. Sinnige, Jose Luis Sanchez-Menoyo, Steve Vucic, Guy Laureys, Liesbeth Van Hijfte, Dheeraj Khurana, Richard Macdonell, Riadh Gouider, Tamara Castillo-Triviño, Orla Gray, Eduardo Aguera-Morales, Abdullah Al-Asmi, Cameron Shaw, Norma Deri, Talal Al-Harbi, Yara Fragoso, Tunde Csepany, Angel Perez Sempere, Irene Trevino-Frenk, Jan Schepel, Fraser Moore, Tomas Kalincik
doi : 10.1111/ene.15706
This study assessed the effect of patient characteristics on the response to disease-modifying therapy (DMT) in multiple sclerosis (MS).
Retinal layer thickness predicts disability accumulation in early relapsing multiple sclerosis
Gabriel Bsteh, Harald Hegen, Patrick Altmann, Michael Auer, Klaus Berek, Franziska Di Pauli, Lukas Haider, Barbara Kornek, Nik Krajnc, Fritz Leutmezer, Stefan Macher, Paulus Rommer, Lisa-Maria Walchhofer, Karin Zebenholzer, Gudrun Zulehner, Florian Deisenhammer, Berthold Pemp, Thomas Berger
doi : 10.1111/ene.15718
This study was undertaken to investigate baseline peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) thickness for prediction of disability accumulation in early relapsing multiple sclerosis (RMS).
Sporadic Creutzfeldt–Jakob disease is associated with reorganization of metabolic connectivity in a pathological brain network
Tomaž Rus, Jernej Mlakar, Luka Ležaić, An Vo, Nha Nguyen, Chris Tang, Michele Fiorini, Elena Prieto, Gloria Marti-Andres, Javier Arbizu, David Eidelberg, Maja TroÅ¡t
doi : 10.1111/ene.15669
Although sporadic Creutzfeldt–Jakob disease (sCJD) is a rare cause of dementia, it is critical to understand its functional networks as the prion protein spread throughout the brain may share similar mechanisms with other more common neurodegenerative disorders. In this study, the metabolic brain network associated with sCJD was investigated and its internal network organization was explored.
Quantitative proteomic analysis of cerebrospinal fluid from patients with idiopathic facial nerve palsy
Ilias Masouris, Matthias Klein, Barbara Angele, Birgit Groß, Neha Goswami, Fathima Mashood, Manuela Gesell Salazar, Sören Schubert, Hans-Walter Pfister, Uwe Koedel, Frank Schmidt
doi : 10.1111/ene.15663
Idiopathic facial palsy (IFP) accounts for over 60% of peripheral facial palsy (FP) cases. The cause of IFP remains to be determined. Possible etiologies are nerve swelling due to inflammation and/or viral infection. In this study, we applied an integrative mass spectrometry approach to identify possibly altered protein patterns in the cerebrospinal fluid (CSF) of IFP patients.
Chronic inflammatory demyelinating polyradiculoneuropathy-associated tremor: Phenotype and pathogenesis
Matthew Silsby, Alessandro F. Fois, Con Yiannikas, Karl Ng, Matthew C. Kiernan, Victor S. C. Fung, Steve Vucic
doi : 10.1111/ene.15693
Tremor in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is underrecognized, and the pathophysiology remains incompletely understood.
Genotype–phenotype characteristics and baseline natural history of Chinese myelin protein zero gene related neuropathy patients
Liu Lei, Li Xiaobo, Lin Zhiqiang, Xie Yongzhi, Huang Shunxiang, Zhao Huadong, Tang Beisha, Zhang Ruxu
doi : 10.1111/ene.15700
The aim was to characterize the phenotypic and genotypic features of myelin protein zero (MPZ) related neuropathy and provide baseline data for longitudinal natural history studies or drug clinical trials.
Long-term favorable prognosis in late onset dominant distal titinopathy: Tibial muscular dystrophy
Victoria Lillback, Marco Savarese, Niina Sandholm, Peter Hackman, Bjarne Udd
doi : 10.1111/ene.15688
Tibial muscular dystrophy (TMD) is a dominant late onset distal titinopathy. It was first described in Finnish patients 3 decades ago. TMD patients with several other TTN mutations occur in many European populations. In this retrospective study, we were able to obtain longitudinal follow-up data of the disease progression over 15 years in 137 TMD patients.
Eptinezumab improved patient-reported outcomes and quality of life in patients with migraine and prior preventive treatment failures
Peter J. Goadsby, Piero Barbanti, Giorgio Lambru, Anders Ettrup, Cecilie Laurberg Christoffersen, Mette Krog Josiassen, Ravinder Phul, Bjørn Sperling
doi : 10.1111/ene.15670
In the phase 3b, randomized, double-blind, placebo-controlled DELIVER clinical trial, eptinezumab reduced migraine frequency and headache in adults with two to four prior preventive treatment failures. Here, the effect of eptinezumab on coinciding patient-reported outcomes is reported.
Response to erenumab assessed by Headache Impact Test-6 is modulated by genetic factors and arterial hypertension: An explorative cohort study
Chiara Zecca, Salvatore Terrazzino, Davide Para, Giovanna Campagna, Michele Viana, Christoph J. Schankin, Claudio Gobbi
doi : 10.1111/ene.15678
Response predictors to erenumab (ERE) in migraine patients would benefit their clinical management. We investigate associations between patients' clinical characteristics and polymorphisms at calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying protein 1 (RAMP1) genes and response to ERE treatment measured as clinically meaningful improvement on the Headache Impact Test-6 (HIT-6) score.
Economic burden of Huntington disease in Europe and the USA: Results from the Huntington's Disease Burden of Illness study
Idaira RodrÃguez-Santana, Tiago Mestre, Ferdinando Squitieri, Rosa Willock, Astri Arnesen, Alison Clarke, Barbara D'Alessio, Alex Fisher, Rebecca Fuller, Jamie L. Hamilton, Hayley Hubberstey, Cath Stanley, Louise Vetter, Michaela Winkelmann, Maria Doherty, Yunchou Wu, Alan Finnegan, Samuel Frank
doi : 10.1111/ene.15645
The prevalence of Huntington disease (HD) has increased over time; however, there is a lack of up-to-date evidence documenting the economic burden of HD by disease stage. This study provides an estimate of the annual direct medical, nonmedical, and indirect costs associated with HD from participants in the Huntington's Disease Burden of Illness (HDBOI) study in five European countries and the USA.
Comparative efficacy and safety of monoamine oxidase type B inhibitors plus channel blockers and monoamine oxidase type B inhibitors as adjuvant therapy to levodopa in the treatment of Parkinson's disease: a network meta-analysis of randomized controlled trials
Rui Yan, Huihui Cai, Yusha Cui, Dongning Su, Guoen Cai, Fabin Lin, Tao Feng
doi : 10.1111/ene.15651
The monoamine oxidase type B inhibitors plus channel blockers (MAO-BIs plus) are a new class of antiparkinsonian drug with additional mechanisms of action for their property as ion channel blockers. The present study aimed to compare the efficacy and safety of MAO-BIs plus and conventional MAO-BIs, as well as their corresponding doses, as adjuvant therapy to levodopa in the treatment of Parkinson's disease (PD).
Anti-neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia�a case report and review of the literature
Anina Schwarzwald, Anke Salmen, Alejandro Xavier León Betancourt, Lara Diem, Helly Hammer, Piotr Radojewski, Michael Rebsamen, Nicole Kamber, Andrew Chan, Robert Hoepner, Christoph Friedli
doi : 10.1111/ene.15648
Neuronal autoantibodies can support the diagnosis of primary autoimmune cerebellar ataxia (PACA). Knowledge of PACA is still sparce. This article aims to highlight the relevance of anti-neurochondrin antibodies and possible therapeutical consequences in people with PACA.
Ischaemic cerebral small vessel disease caused by adenosine deaminase 2 deficiency syndrome
Alessia Giossi, Silvia Clara Giliani, Massimo Gamba, Paola Toniati, Mauro Magoni, Alessandro Pezzini
doi : 10.1111/ene.15708
Only a small proportion of cerebral small vessel disease (cSVD), a frequent cause of stroke and cognitive or motor disability in adults, is attributable to monogenic conditions. The hereditary nature of a patient's cSVD may be masked by a mild or non-informative phenotype, as single-gene disorders have a variable mode of presentation, penetrance and disease severity.
Meningoencephalitis due to Mycobacterium lentiflavum in an immunocompromised patient: Case report
Javier Martinez-Poles, Ana Isabel Saldaña-DÃaz, Jaime Esteban, Mónica Lara-Almunia, Anthony Tito Vizarreta Figueroa, Leticia MartÃn-Gil, José Cebrián-Escudero, José Fernández-Ferro
doi : 10.1111/ene.15659
The first case of meningoencephalitis due to Mycobacterium lentiflavum in an immunocompromised patient is reported. Clinical and radiological characteristics are described, as well as the treatment and prognosis of the patient.
High-dose oral glutamine can reduce cerebrospinal fluid glutamate in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes without a beneficial clinical or cerebral tissue effect
Josef Finsterer, Sounira Mehri
doi : 10.1111/ene.15682
Reply: High-dose oral glutamine can reduce cerebrospinal fluid glutamate in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes without a beneficial clinical or cerebral tissue effect
MarÃÂa Paz Guerrero-Molina, Cristina DomÃÂnguez-González, Jesús González de la Aleja
doi : 10.1111/ene.15683
Autoantibody levels as biomarkers of disease activity in the management of myasthenia gravis
Hai-Feng Li, Feng Gao, Xiang-Jun Chen
doi : 10.1111/ene.15687
Reply to the Letter to the Editor in response to “Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal�
Andreas Meisel, Fulvio Baggi, Anthony Behin, Amelia Evoli, Anna Kostera-Pruszczyk, Renato Mantegazza, Raul Juntas Morales, Anna Rostedt Punga, Sabrina Sacconi, Michael Schroeter, Jan Verschuuren, Louise Crathorne, Kris Holmes, Maria-Isabel Leite
doi : 10.1111/ene.15690
