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Nonstenotic intracranial atherosclerosis as an emerging mechanism in cryptogenic cerebral embolism
James E. Siegler
doi : 10.1111/ene.15662
Physical activity and brain health in patients with atrial fibrillation
Elena Herber, Stefanie Aeschbacher, Michael Coslovsky, Fabian Schwendinger, Elisa Hennings, Andreas Gasser, Marcello Di Valentino, Elia Rigamonti, Tobias Reichlin, Nicolas Rodondi, Seraina Netzer, Juerg H. Beer, Annina Stauber, Andreas Müller, Peter Ammann, Tim Sinnecker, Marco Duering, Jens Wuerfel, David Conen, Michael Kühne, Stefan Osswald, Leo H. Bonati, for the SWISS-AF Investigators
doi : 10.1111/ene.15660
Vascular brain lesions, such as ischemic infarcts, are common among patients with atrial fibrillation (AF) and are associated with impaired cognitive function. The role of physical activity (PA) in the prevalence of brain lesions and cognition in AF has not been investigated.
Validity of the Brief Assessment of Impaired Cognition case-finding instrument for identification of dementia subgroups and staging of dementia
Kasper Jørgensen, Thomas Rune Nielsen, Ann Nielsen, Frans Boch Waldorff, Peter Høgh, Hanne Gottrup, Karsten Vestergaard, Anne-Britt Oxbøll, Gunhild Waldemar
doi : 10.1111/ene.15636
The aims of this study were to examine the psychometric properties of the Brief Assessment of Impaired Cognition (BASIC) case-finding instrument in clinical settings focusing on (i) test–retest reliability, (ii) the discriminative validity of BASIC and its components for identification of Alzheimer disease (AD) dementia and non-AD dementia, and (iii) the association of expert clinical rating of cognitive status with BASIC performance.
Effect of APOE ε4 genotype on amyloid-β, glucose metabolism, and gray matter volume in cognitively normal individuals and amnestic mild cognitive impairment
Weihua Li, Runtian Li, Shaozhen Yan, Zhilian Zhao, Yi Shan, Zhigang Qi, Jie Lu, for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1111/ene.15656
The presence of apolipoprotein E ε4 (APOE ε4) is associated with an increased risk of developing Alzheimer disease (AD). The aim of this study was to assess the effects of APOE ε4 on amyloid-β (Aβ) pathology, glucose metabolism, and gray matter (GM) volume and their longitudinal changes in healthy control (HC) and amnestic mild cognitive impairment (aMCI).
The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset
Gonzalo Forno, Jose Contador, Agnès Pérez-Millan, Nuria Guillen, Neus Falgà s, Jordi Sarto, Adrià Tort-Merino, Magdalena CastellvÃ, Beatriz Bosch, Guadalupe Fernández-Villullas, Mircea Balasa, Anna Antonell, Roser Sala- Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Lladó … See fewer authors
doi : 10.1111/ene.15657
How the APOE genotype can differentially affect cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease (AD) was assessed.
Prevalence and determinants of language impairment in non-demented amyotrophic lateral sclerosis patients
Federica Solca, Edoardo Nicolò Aiello, Silvia Torre, Laura Carelli, Roberta Ferrucci, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Alessia Monti, Barbara Poletti
doi : 10.1111/ene.15652
This study aimed at estimating the prevalence of language impairment (LI) in a large, clinic-based cohort of non-demented amyotrophic lateral sclerosis (ALS) patients and assessing its underpinnings at motor and non-motor levels.
Unraveling the role of relative telomere length and CAG expansion on initial symptoms of juvenile Huntington disease
Adriana PerezGrovas-Saltijeral, Adriana Ochoa-Morales, Aurelio Jara-Prado, Rafael Velázquez-Cruz, Berenice Rivera-Paredez, David Dávila-OrtizdeMontellano, Edmar O. BenÃtez-Alonso, Mónica SantamarÃa-Olmedo, Rosalba Sevilla-Montoya, Ernesto Marfil-MarÃn, Margarita Valdés-Flores, Leticia MartÃnez-Ruano, Alejandra Camacho-Molina, Alberto Hidalgo-Bravo
doi : 10.1111/ene.15644
Juvenile-onset Huntington disease (JHD) is defined when symptoms initiate before 20 years of age. Mechanisms explaining differences between juvenile and adult onset are not fully understood.
I spy with my little eye: The detection of changes in emotional faces and the influence of facial feedback in Parkinson disease
Maria Kuehne, Laura Polotzek, Aiden Haghikia, Tino Zaehle, Janek S. Lobmaier
doi : 10.1111/ene.15647
Longitudinal study of clinical and neurophysiological features in essential tremor
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
doi : 10.1111/ene.15650
Essential tremor (ET) is a common and heterogeneous disorder characterized by postural/kinetic tremor of the upper limbs and other body segments and by non-motor symptoms, including cognitive and psychiatric abnormalities.
Sex differences in imaging and clinical characteristics of patients from the WAKE-UP trial
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Götz Thomalla, Robin Lemmens
doi : 10.1111/ene.15629
Sex-based differences in acute ischemic stroke are a well-known phenomenon. We aimed to explore these differences between women and men in the Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke (WAKE-UP) trial.
Vulnerable plaque of the petrous internal carotid artery in embolic stroke of undetermined source
Lin Tao, Yi-Han Wang, Zi-Yang Shang, Ben-Qiang Yang, Hui-Sheng Chen
doi : 10.1111/ene.15655
The association between nonstenotic plaque at the petrous internal carotid artery (ICA) and embolic stroke of undetermined source (ESUS) remains unknown. We aimed to test the hypothesis that the presence of a larger build-up of petrous plaque is more prevalent in the ipsilateral versus the contralateral side among ESUS patients without plaque in the intracranial and proximal ICA.
Comparing radiographic scores for prediction of complications and outcome of aneurysmal subarachnoid hemorrhage: Which performs best?
Maryam Said, Svenja Odensass, Meltem Gümüs, Jan Rodemerk, Mehdi Chihi, Laurèl Rauschenbach, Thiemo Florin Dinger, Marvin Darkwah Oppong, Philipp Dammann, Karsten Henning Wrede, Ulrich Sure, Ramazan Jabbarli
doi : 10.1111/ene.15634
Aneurysmal subarachnoid hemorrhage (aSAH) is characterized by high morbidity and mortality proceeding from the initial severity and following complications of aSAH. Various scores have been developed to predict these risks. We aimed to analyze the clinical value of different radiographic scores for prognostication of aSAH outcome.
Clinical outcomes of delayed mechanical thrombectomy: Descriptive analysis and development of a screening tool
Alexander Berry-Noronha, Daniel Myall, Jae Beom Hong, Wayne Collecutt, Martin Krauss, John Fink, Susan Weggery, Animesh Chatterjee, Sam Bartholomew, Mark Smith, Campbell Le Heron, Wendy Busby, Stefan Brew, Peter Alan Barber, Teddy Y. Wu, Duncan Wilson
doi : 10.1111/ene.15658
Limited data guide the selection of patients with large vessel occlusion ischaemic stroke who may benefit from referral to a distant tertiary centre for mechanical thrombectomy (MT). We aimed to characterize this population, describe clinical outcomes and develop a screening system to identify patients most likely to benfit from delayed mechanical thrombectomy (MT).
Functional disorders as a common motor manifestation of COVID-19 infection or vaccination
Wilson K. W. Fung, Qais Sa'di, Hans Katzberg, Robert Chen, Anthony E. Lang, Angela M. Cheung, Alfonso Fasano
doi : 10.1111/ene.15630
There have been over 500 million confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), across the globe.
CCR5-�32 polymorphism�a possible protective factor from gait impairment amongst post-stroke patients
Jeremy Molad, Hen Hallevi, Estelle Seyman, Ofer Rotschild, Natan M. Bornstein, Oren Tene, Nir Giladi, Jeffrey M. Hausdorff, Anat Mirelman, Einor Ben Assayag
doi : 10.1111/ene.15637
Stroke and small vessel disease cause gait disturbances and falls. The naturally occurring loss-of-function mutation in the C-C chemokine receptor 5 gene (CCR5-�32) has recently been reported as a protective factor in post-stroke motor and cognitive recovery. We sought to examine whether it also influences gait and balance measures up to 2 years after stroke.
Cerebrospinal fluid analysis in emergency patients with suspected infection of the central nervous system
Stefanie Völk, Fabian Dobler, Uwe Koedel, Hans-Walter Pfister, Mathias Bruegel, Sören Schubert, Matthias Klein
doi : 10.1111/ene.15638
Meningitis and encephalitis are potentially life-threatening diseases that require fast and accurate diagnostics and therapy. The value of polymerase chain reaction (PCR) multiplex testing in clinical practice is still a matter of debate. This study aims to evaluate its benefits and limitations in emergency patients.
Frequency, entity and determinants of fatigue in Charcot–Marie–Tooth disease
Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Yuri Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson, for the Italian CMT Network
doi : 10.1111/ene.15643
Fatigue, a disabling symptom in many neuromuscular disorders, has been reported also in Charcot–Marie–Tooth disease (CMT). The presence of fatigue and its correlations in CMT was investigated.
Skin biopsy reveals generalized small fibre neuropathy in hypermobile Ehlers–Danlos syndromes
Denver Igharo, Joana C. Thiel, Roman Rolke, Merve Akkaya, Joachim Weis, Istvan Katona, Jörg B. Schulz, Andrea Maier
doi : 10.1111/ene.15649
Ehlers–Danlos syndromes are hereditary disorders of connective tissue that are characterized by joint hypermobility, skin hyperextensibility and tissue fragility. The most common subtype is the hypermobile type.
Brain-specific biomarkers in urine as a non-invasive approach to monitor neuronal and glial damage
Konstantin Kohlhase, Franziska Frank, Christian Wilmes, Kimberly Koerbel, Martin A. Schaller-Paule, Martha Miles, Christoph Betz, Helmuth Steinmetz, Christian Foerch
doi : 10.1111/ene.15641
This study evaluates the quantitative measurability of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and total tau (t-tau) in urine of patients with acute cerebral damage.
Lyme neuroborreliosis with antibodies in cerebrospinal fluid but not in serum
Tizza P. Zomer, Reitze Bruinsma, Anusha van Samkar, Yolande M. Vermeeren, Renske G. Wieberdink, Barend van Kooten, Thomas van Bemmel
doi : 10.1111/ene.15631
To diagnose Lyme neuroborreliosis (LNB), cerebrospinal fluid (CSF)Â is tested for pleocytosis and intrathecal antibody production. The Dutch guideline for Lyme borreliosis indicates a lumbar puncture in the case of positive Borrelia serology or a strong clinical suspicion of LNB.
Systemic light chain amyloidosis myopathy responsive to daratumumab monotherapy
Diana Maria Chitimus, Edouard Berling, Laurent Garderet, Nadia Venturelli, Edoardo Malfatti, François Jérôme Authier, Guillaume Nicolas, Pascal Laforêt, Claire Lefeuvre
doi : 10.1111/ene.15640
Amyloid myopathy is a rare and severe manifestation of systemic light chain (AL) amyloidosis. Early diagnosis and staging are mandatory for optimal therapy, given the rapid progression of muscle weakness. Despite the efficacy of bortezomib-based treatment regimens, there is a lack of therapeutic alternatives in non-responsive patients.
Cost-effectiveness of surgical treatment compared to medical treatment in patients with drug-refractory epilepsy: AÂ systematic review
Anne Kitschen, Milda AleknonytÄ—-Resch, Gabija SakalytÄ—, Freya Diederich
doi : 10.1111/ene.15632
Approximately 30% of epilepsy patients develop a drug-refractory epilepsy, that is, seizures cannot be controlled with antiepileptic drugs. Surgery has been evaluated as an effective but costly form of treatment. The aim of this systematic review is to synthesize the available evidence on the cost-effectiveness of surgical treatment compared to medical treatment for these patients.
Efficacy and safety of non-ergot dopamine-receptor agonists as an adjunct to levodopa in advanced Parkinson's disease: AÂ network meta-analysis
Xiang-Ting Chen, Qian Zhang, Si-Yuan Wen, Fei-Fei Chen, Chang-Qing Zhou
doi : 10.1111/ene.15635
Non-ergot dopamine agonists (NEDAs) have been used as an adjunct therapy to levodopa in advanced Parkinson's disease (PD) for many years. However, there is no strong evidence that a given NEDA is more potent than another.
Cerebellar involvement associated with immune checkpoint inhibitors: A systematic review
Alessandro Dinoto, Elisa Mantovani, Sergio Ferrari, Sara Mariotto, Stefano Tamburin
doi : 10.1111/ene.15624
Immune checkpoint inhibitors (ICIs) targeting programmed death receptor 1 (PD-1), cytotoxic T-lymphocyte-associated-4 (CTLA-4) and programmed cell death ligand 1 can be associated with immune-related adverse events (iRAEs). Amongst neurological iRAEs, cerebellar involvement seems to be rare and currently lacks a proper characterization. The aim of this study was to phenotype cerebellar iRAEs.
Bilateral dural arteriovenous fistula diagnosed with neurovascular ultrasonography
Klearchos Psychogios, Magoufis Georgios, Apostolos Safouris, Odysseas Kargiotis, Andrikopoulou Athina, Lina Palaiodimou, Maria Chondrogianni, Eleni Bakola, Georgios Tsivgoulis
doi : 10.1111/ene.15627
Intracranial dural arteriovenous fistulas (dAVFs) are pathological anastomoses between meningeal arteries and dural venous sinuses or cortical veins. Diagnosis of dAVFs can be challenging due to their broad range of clinical manifestations and the lack of specificity in their symptoms.
Lyme neuroborreliosis: An unusual case with extensive (peri)vasculitis of the middle cerebral artery
Carla Palleis, Robert Forbrig, Louisa Lehner, Stefanie Quach, Nathalie L. Albert, Matthias Brendel, Florian Schöberl, Andreas Straube
doi : 10.1111/ene.15633
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi sensu latu. Neuroborreliosis is reported in approximately 10% of patients with Lyme disease. We report a patient with central nervous system (CNS) large vessel vasculitis, ischemic stroke, and tumefactive contrast-enhancing brain lesions, an unusual complication of neuroborreliosis.
