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Looming Crisis of Financial Toxicity in Neurologic Drug Pricing: From Out-of-Pocket to Out-of-Community Costs.
Smith, A. Gordon MD, FAAN
doi : 10.1212/WNL.0000000000201725
Volume 100(9) pgs. 401-447,e884-e997 February 28, 2023
Excess Treatment Costs of Multiple Sclerosis: What Can We Learn From Longitudinal Population-Based Data?.
Bordea, Ekaterina MSc, PhD; Hunter, Rachael Maree MSc
Understanding the Role of the Choroid Plexus in Multiple Sclerosis as an MRI Biomarker of Disease Activity.
Muller, Jannis MD; Noteboom, Samantha MSc; Granziera, Cristina MD, PhD; Schoonheim, Menno M. PhD
Ralph L. Sacco, 65, Dies: Stroke Expert With a Talent for Architectural Design.
Avitzur, Orly MD, MBA
Costs and Utilization of New-to-Market Neurologic Medications.
Reynolds, Evan L. PhD; Gallagher, Gary MD; Hill, Chloe E. MD, MS; Banerjee, Mousumi PhD; Mante, Aristotle; Esper, Gregory J. MD, MBA; Callaghan, Brian C. MD, MS
doi : 10.1212/WNL.0000000000201627
The objective of this study was to compare the utilization and costs (total and out-of-pocket) of new-to-market neurologic medications with existing guideline-supported neurologic medications over time.
Direct Health Care Costs Associated With Multiple Sclerosis: A Population-Based Cohort Study in British Columbia, Canada, 2001-2020.
Khakban, Amir MSc; Rodriguez Llorian, Elisabet PhD; Michaux, Kristina D. MSc; Patten, Scott B. MD, PhD; Traboulsee, Anthony MD; Oh, Jiwon MD, PhD; Lynd, Larry D. PhD, FCAHS; on behalf of CanProCo Study Group
doi : 10.1212/WNL.0000000000201645
Multiple sclerosis (MS), a leading cause of nontraumatic neurologic disability in young adults, exerts a substantial economic burden on the health care system. The objective of this study was to quantify the excess health care costs of MS in British Columbia, Canada.
Association of Choroid Plexus Inflammation on MRI With Clinical Disability Progression Over 5 Years in Patients With Multiple Sclerosis.
Bergsland, Niels PhD; Dwyer, Michael G. PhD; Jakimovski, Dejan MD, PhD; Tavazzi, Eleonora MD; Benedict, Ralph H.B. PHD; Weinstock-Guttman, Bianca MD; Zivadinov, Robert MD, PhD
doi : 10.1212/WNL.0000000000201608
Inflammation of the choroid plexus (CP) has been reported in multiple sclerosis (MS). The AU1 association between CP inflammation and clinical disability progression is still under debate.
Handling Delayed or Missed Dose of Antiseizure Medications: A Model-Informed Individual Remedial Dosing.
Li, Zi-ran BSc; Wang, Chen-yu MSc; Lin, Wei-wei PhD; Chen, Yue-ting MSc; Liu, Xiao-qin PhD; Jiao, Zheng PhD
doi : 10.1212/WNL.0000000000201604
Delayed or missed antiseizure medications (ASMs) doses are common during long-term or lifelong antiepilepsy treatment. This study aims to explore optimal individualized remedial dosing regimens for delayed or missed doses of 11 commonly used ASMs.
Directionality of the Association Between Epilepsy and Depression: A Nationwide Register-Based Cohort Study.
Bolling-Ladegaard, Eva MD; Dreier, Julie Werenberg PhD; Kessing, Lars Vedel MD, DrMedSci; Budtz-Jorgensen, Esben MSc, DrSci; Lolk, Kasper MEc; Christensen, Jakob MD, DrMedSci
doi : 10.1212/WNL.0000000000201542
Epilepsy and depression share a bidirectional relationship; however, its magnitude and long-term temporal association remain to be elucidated. This study investigates the magnitude and long-term association between epilepsy and depression, comparing with the risks of the 2 disorders after another chronic medical illness (asthma).
Association of Peri-ictal MRI Abnormalities With Mortality, Antiseizure Medication Refractoriness, and Morbidity in Status Epilepticus.
Bonduelle, Thomas MD; Ollivier, Morgan MD; Trin, Kilian MD; Thomas, Benjamin MD; Daubigney, Antoine MD; Michel, Veronique MD; De Montaudouin, Marie MD; Marchal, Cecile MD; Aupy, Jerome MD, PhD
doi : 10.1212/WNL.0000000000201599
Status epilepticus (SE) is a life-threatening emergency requiring a prompt assessment of patient prognosis to guide management. MRI allows the identification of peri-ictal MRI abnormalities (PMAs) and provides insight into brain structural modifications induced by SE.
Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions: Results From the I-LAST Study.
Broocks, Gabriel MD; Meyer, Lukas MD; Elsayed, Sarah MD; McDonough, Rosalie MD; Bechstein, Matthias MD; Faizy, Tobias Djamsched MD, PhD; Sporns, Peter MD, MHBA; Schon, Gerhard MSc; Minnerup, Jens MD; Kniep, Helge C. MD, MHBA; Hanning, Uta MD, MHBA; Barow, Ewgenia MD; Schramm, Peter MD; Langner, Soenke MD; Nawabi, Jawed MD; Papanagiotou, Panagiotis MD; Wintermark, Max MD; Lansberg, Maarten G. MD, PhD; Albers, Gregory W. MD; Heit, Jeremy J. MD, PhD; Fiehler, Jens MD; Kemmling, Andre MD, MHBA; and the I-LAST Investigators
doi : 10.1212/WNL.0000000000201601
The effect of mechanical thrombectomy (MT) on functional outcome in patients with ischemic stroke with low ASPECTS is still uncertain. ASPECTS rating is based on the presence of ischemic hypoattenuation relative to normal; however, the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered an imaging biomarker in stroke triage.
Associations of Olfaction With Longitudinal Trajectories of Brain Volumes and Neuropsychological Function in Older Adults.
Tian, Qu PhD, MS; An, Yang MS; Kitner-Triolo, Melissa H. PhD; Davatzikos, Christos PhD; Studenski, Stephanie A. MD, MPH; Ferrucci, Luigi MD, PhD; Resnick, Susan M. PhD
doi : 10.1212/WNL.0000000000201646
Olfactory function declines with aging, and olfactory deficits are one of the earliest features of neurodegenerative diseases, such as Parkinson disease and Alzheimer disease.
Longitudinal Assessment of Creatine Kinase, Creatine/Creatinineratio, and Myostatin as Monitoring Biomarkers in Becker Muscular Dystrophy.
van de Velde, Nienke M. MD; Koeks, Zaida MD; Signorelli, Mirko PhD; Verwey, Nisha MSc; Overzier, Maurice BSc; Bakker, Jaap A. PhD; Sajeev, Gautam ScD; Signorovitch, James PhD; Ricotti, Valeria MD; Verschuuren, Jan MD, PhD; Brown, Kristy PhD; Spitali, Pietro PhD *; Niks, Erik H. MD, PhD *
doi : 10.1212/WNL.0000000000201609
The slow and variable disease progression of Becker muscular dystrophy (BMD) urges the development of biomarkers to facilitate clinical trials.
Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder.
Pizzolato Umeton, Raffaella MD; Waltz, Michael MAS; Aaen, Gregory S. MD; Benson, Leslie MD; Gorman, Mark MD; Goyal, Manu MD; Graves, Jennifer S. MD, PhD, MAS; Harris, Yolanda PhD, MSN, CRNP, CPNP-AC; Krupp, Lauren MD; Lotze, Timothy E. MD; Shukla, Nikita M. MD; Mar, Soe MD; Ness, Jayne MD; Rensel, Mary MD; Schreiner, Teri MD; Tillema, Jan-Mendelt MD; Roalstad, Shelly MS; Rodriguez, Moses MD; Rose, John MD; Waubant, Emmanuelle MD, PhD; Weinstock-Guttman, Bianca MD; Casper, Charles PhD; Chitnis, Tanuja MD; on behalf of the US Network of Pediatric MS Centers
doi : 10.1212/WNL.0000000000201625
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition, which can lead to significant disability, and up to 3%-5% of the cases have a pediatric onset. There are limited studies to guide physicians in disease-modifying treatment (DMT) choices for children with NMOSD.
Academic Neurology and the COVID-19 Pandemic: Resilience, Hope, and Solutions.
Schor, Nina F. MD, PhD; Cudkowicz, Merit E. MD; Banwell, Brenda MD
doi : 10.1212/WNL.0000000000201571
AB The SARS-CoV-2 (COVID-19) viral pandemic dramatically affected human health, health care delivery, health care workers, and health care research worldwide. The field of academic neurology was no exception.
Reversible Diffusion-Weighted Imaging High Intensity Signal in Wilson Disease.
Cai, Naiqing MD; Lin, Jie MD; Zhu, Jiting MD
Pearls & Oy-sters: Sequential Bilateral Hearing and Vision Loss With Optic Disc Swelling Due to Sphenoid Bone Craniofacial Fibrous Dysplasia.
Handley, Joel D. MBBCh, MSc, MRCP (UK); Mathur, Sachin MRCP, FRCR; Chhetri, Suresh K. MBBS, MD, MRCP (Neurology), FHEA, FRCP
doi : 10.1212/WNL.0000000000201663
AB Bilateral optic disc swelling is a common finding but rarely associated with multiple cranial neuropathies. In this case, an 18-year-old man presented with subacute sequential hearing loss followed by subacute sequential visual loss. Clinical examination revealed bilateral optic disc swelling.
Teaching NeuroImage: Intraventricular Fetus-in-Fetu With Extensive De Novo Gain in Genetic Copy Number.
Li, Zongze MD; Ma, Li MD, PhD; Zhao, Yuanli MD, PhD; Li, Chunde MD
Epilepsy and Depression: How Are They Related?.
Karceski, Steven MD
Editors' Note: Acute Arterial Ischemic Stroke Following COVID-19 Vaccination: A Systematic Review and Meta-analysis.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: Acute Arterial Ischemic Stroke Following COVID-19 Vaccination: A Systematic Review and Meta-analysis.
Du, Lixin; Li, Zhigang; Zhao, Yunhui
Author Response: Acute Arterial Ischemic Stroke Following COVID-19 Vaccination: A Systematic Review and Meta-analysis.
Stefanou, Maria Ioanna; Palaiodimou, Lina; Tsivgoulis, Georgios
