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Phase Contrast Spine MRI for the Evaluation of CSF Leak, and Why It Matters.
Carroll, Ian MD, MS; Callen, Andrew MD
doi : 10.1212/WNL.0000000000201694
Volume 100(7) pgs. 313-356,e651-e763 February 14, 2023
Pregnancy and Use of Antiseizure Medication: What Do We Know About the Long-term Cognitive Risks for the Child?.
Dreier, Julie Werenberg PhD; Meador, Kimford J. MD; Christensen, Jakob MD, PhD, DrMedSci
CSF Flow and Spinal Cord Motion in Patients With Spontaneous Intracranial Hypotension: A Phase Contrast MRI Study.
Wolf, Katharina MD; Luetzen, Niklas MD; Mast, Hansjoerg; Kremers, Nico MD; Reisert, Marco PhD; Beltran, Saul; Fung, Christian MD; Beck, Jurgen MD; Urbach, Horst MD
doi : 10.1212/WNL.0000000000201527
Spontaneous intracranial hypotension (SIH) is characterized by loss of CSF volume. We hypothesize that in this situation of low volume, a larger CSF flow and spinal cord motion at the upper spine can be measured by noninvasive phase contrast MRI.
Ten-Year Follow-up of Internal Neurofibroma Growth Behavior in Adult Patients With Neurofibromatosis Type 1 Using Whole-Body MRI.
Ly, K. Ina MD; Merker, Vanessa L. PhD; Cai, Wenli PhD; Bredella, Miriam A. MD; Muzikansky, Alona MA; Thalheimer, Raquel D. MSc; Da, Jennifer Liwei BA; Orr, Christina C. MSN; Herr, Hamilton P. MA; Morris, Mary E. MD, PhD; Chang, Connie Y. MD; Harris, Gordon J. PhD; Plotkin, Scott R. MD, PhD *; Jordan, Justin T. MD, MPH *
doi : 10.1212/WNL.0000000000201535
Internal neurofibromas, including plexiform neurofibromas (PNF), can cause significant morbidity in patients with neurofibromatosis type 1 (NF1). PNF growth is most pronounced in children and young adults, with more rapid growth thought to occur in a subset of PNF termed distinct nodular lesions (DNL).
Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis.
Bril, Vera MD; Szczudlik, Andrzej MD; Vaitkus, Antanas MD, PhD; Rozsa, Csilla MD; Kostera-Pruszczyk, Anna MD, PhD; Hon, Petr MD; Bednarik, Josef MD; Tyblova, Michaela MD, PhD; Kohler, Wolfgang MD; Toomsoo, Toomas MD, PhD; Nowak, Richard J. MD; Mozaffar, Tahseen MD; Freimer, Miriam L. MD; Nicolle, Michael W. MD, DPhil; Magnus, Tim MD; Pulley, Michael T. MD, PhD; Rivner, Michael MD; Dimachkie, Mazen M. MD; Distad, B. Jane MD; Pascuzzi, Robert M. MD; Babiar, Donna BA; Lin, Jiang PhD; Querolt Coll, Montse MS; Griffin, Rhonda MS; Mondou, Elsa MD
doi : 10.1212/WNL.0000000000201501
Myasthenia gravis (MG) is an autoimmune disease characterized by dysfunction at the neuromuscular junction. Treatment frequently includes corticosteroids (CSs) and IV immunoglobulin (IVIG).
Plasma Phosphorylated Tau at Threonine 181 and Neuropsychiatric Symptoms in Preclinical and Prodromal Alzheimer Disease.
Ghahremani, Maryam PhD; Wang, Meng MSc; Chen, Hung-Yu PhD; Zetterberg, Henrik MD, PhD; Smith, Eric MD, MPH; Ismail, Zahinoor MD; for the Alzheimer's Disease Neuroimaging Initiative*
doi : 10.1212/WNL.0000000000201517
Plasma phosphorylated tau at threonine 181 (p-tau181), a well-validated marker of Alzheimer disease (AD) pathologic change, could be a more efficient way to diagnose AD than invasive or expensive biomarkers requiring CSF or PET.
Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities.
Holland, Thomas Monroe MD, MS; Agarwal, Puja PhD; Wang, Yamin PhD; Dhana, Klodian MD, PhD; Leurgans, Sue E. PhD; Shea, Kyla PhD; Booth, Sarah L. PhD; Rajan, Kumar B. PhD; Schneider, Julie A. MD, MS; Barnes, Lisa L. PhD
doi : 10.1212/WNL.0000000000201541
Previous research has examined the association between cognition and flavonoids: bioactives found in foods, known to possess anti-inflammatory and antioxidant properties.
Impact of White Adipose Tissue on Brain Structure, Perfusion, and Cognitive Function in Patients With Severe Obesity: The BARICO Study.
Vreeken, Debby MSc *; Seidel, Florine MSc *; de La Roij, Guido MSc; Vening, Wouter MD; den Hengst, Willem A. MD, PhD; Verschuren, Lars PhD; Ozsezen, Serdar Msc; Kessels, Roy P.C. PhD; Duering, Marco MD, PhD; Mutsaerts, Henk J.M.M. MD, PhD; Kleemann, Robert PhD; Wiesmann, Maximilian PhD; Hazebroek, Eric J. MD, PhD +; Kiliaan, Amanda J. PhD +
doi : 10.1212/WNL.0000000000201538
While underlying pathophysiology linking obesity to brain health is not completely understood, white adipose tissue (WAT) is considered a key player. In obesity, WAT becomes dysregulated, showing hyperplasia, hypertrophy, and eventually inflammation.
Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques.
Arredondo, Kristen H. MD; Ahrens, Stephanie M. DO; Bagic, Anto I. MD, PhD; Bai, Shasha PhD; Chapman, Kevin E. MD; Ciliberto, Michael A. MD; Clarke, Dave F. MD; Eisner, Mariah MS; Fountain, Nathan B. MD; Gavvala, Jay R. MD; Perry, M. Scott MD; Rossi, Kyle C. MD; Wong-Kisiel, Lily C. MD; Herman, Susan T. MD; Ostendorf, Adam P. MD; on behalf of the NAEC Center Director Study Group
doi : 10.1212/WNL.0000000000201526
early one-third of persons with epilepsy will continue having seizures despite trialing multiple antiseizure medications. Epilepsy surgery may be beneficial in these cases, and evaluation at a comprehensive epilepsy center is recommended.
Prenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study.
Ren, Tai MD; Lee, Priscilla Ming Yi PhD; Li, Fei MD, PhD *; Li, Jiong MD, PhD *
doi : 10.1212/WNL.0000000000201529
To investigate whether children born to mothers who used carbamazepine during pregnancy had worse academic performance in adolescence
Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.
Marto, Joao Pedro MD *; Strambo, Davide MD *; Ntaios, George MD; Nguyen, Thanh N. MD, FRCPC; Herzig, Roman MD, PhD; Czlonkowska, Anna MD, PhD; Demeestere, Jelle MD; Mansour, Ossama Yassin MD, PhD; Salerno, Alexander MD; Wegener, Susanne MD; Baumgartner, Philipp MD; Cereda, Carlo W. MD; Bianco, Giovanni MD; Beyeler, Morin MD; Arnold, Marcel MD; Carrera, Emmanuel MD; Machi, Paolo MD; Altersberger, Valerian MD; Bonati, Leo MD;
doi : 10.1212/WNL.0000000000201537
COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS).
Endovascular vs Medical Management for Late Anterior Large Vessel Occlusion With Prestroke Disability: Analysis of CLEAR and RESCUE-Japan.
Siegler, James E. MD; Qureshi, Muhammad M. MBBS, MPH; Nogueira, Raul G. MD; Tanaka, Kanta MD, PhD; Nagel, Simon MD; Michel, Patrik MD; Vigilante, Nicholas BS; Ribo, Marc MD; Yamagami, Hiroshi MD, PhD; Yoshimura, Shinichi MD, PhD; Abdalkader, Mohamad MD; Haussen, Diogo C. MD; Mohammaden, Mahmoud H. MD; Nannoni, Stefania MD PhD; Mohlenbruch, Markus A. MD; Henon, Hilde MD, PhD; Sheth, Sunil A. MD; Ortega-Gutierrez, Santiago MD MS; Olive-Gadea, Marta MD; Caparros, Francois MD; Seker, Fatih MD; Zaidi, Syed MD; Castonguay, Alicia C. PhD; Uchida, Kazutaka MD, PhD; Sakai, Nobuyuki MD; Puri, Ajit S. MD; Farooqui, Mudassir MD, MPH; Toyoda, Kazunori MD, PhD; Salazar-Marioni, Sergio MD; Takeuchi, Masataka MD, PhD; Farzin, Behzad MD; Masoud, Hesham E. MD; Kuhn, Anna Luisa MD, PhD; Rana, Ameena MD; Morimoto, Masafumi MD, PhD; Shibata, Masunari MD, PhD; Nonaka, Tadashi MD, PhD; Klein, Piers MA; Sathya, Anvitha BA; Kiley, Nicole L. PA-C; Cordonnier, Charlotte MD, PhD; Strambo, Davide MD; Demeestere, Jelle MD; Ringleb, Peter A. MD; Roy, Daniel MD; Zaidat, Osama O. MD; Jovin, Tudor G. MD; Kaesmacher, Johannes MD, PhD; Fischer, Urs MD, MSc; Raymond, Jean MD; Nguyen, Thanh N. MD, FRCPC
doi : 10.1212/WNL.0000000000201543
Current guidelines do not address recommendations for mechanical thrombectomy (MT) in the extended time window (>6 hours after time last seen well [TLSW]) for large vessel occlusion (LVO) patients with preexisting modified Rankin Scale (mRS) > 1.
Clinical, Imaging, and Laboratory Findings in Patients With GATA2 Deficiency Presenting With Early-Onset Ischemic Stroke.
Bierman-Chow, Shaia BA; Holland, Steven M. MD; Hsu, Amy P. BA; Palmer, Cindy RN; Lynch, John DO; Mina, Yair MD; Joo (Sophie) Cho, Hyun MD
doi : 10.1212/WNL.0000000000201569
The purpose of this study was to characterize the clinical, laboratory, and imaging findings of 10 patients with GATA2 deficiency who presented with early-onset ischemic stroke.
Primary Melanocytoma Arising From Trigeminal Nerve.
Liu, Jun MD *; Zhang, Wenjun MD *; Ye, Xinyun MD; Zhang, Si MD +; Jiang, Qiuhua MD +
Clinical Reasoning: Rapidly Progressive Dementia in a Man With HIV Infection and Undetectable Plasma Viral Load.
Chishimba, Lorraine Chishimba MMED; Chomba, Mashina MBChB MMed; Zimba, Stanley MMED, STP; Asukile, Melody Tunsubilege MBChB, MMed, FC Neurol(SA); Makai, Obrie MMED; Saylor, Deanna R. MD, MHS
doi : 10.1212/WNL.0000000000201576
AB Neurocognitive decline associated with HIV infection remains prevalent even in the antiretroviral therapy (ART) era, albeit usually in less severe forms
Right Brain: Oriented to Self.
Geczi, Kristin BA
doi : 10.1212/WNL.0000000000201602
AB In medical school, students learn to view the world through a biomedical lens. While necessary clinically, this lens can be impersonal. For example, the mental status examination (MSE) evaluates cognitive function through a brief assessment of alertness and orientation to person, place, time, and situation.
Teaching Video NeuroImage: Delayed Radiation-Induced Unilateral Myokymia of the Tongue.
Senerchia, Gianmaria MD; Iuzzolino, Valentina Virginia MD; Zoccolella, Stefano MD; Ugga, Lorenzo MD, PhD; Iodice, Rosa MD; Manganelli, Fiore MD; Dubbioso, Raffaele MD, PhD
Editors' Note: Prospective Natural History Study in 24 Adult Patients With LGMDR12 Over 2 Years of Follow-up: Quantitative MRI and Clinical Outcome Measures.
Siegler, James E. MD; Galetta, Steven MD
Reader Response: Prospective Natural History Study in 24 Adult Patients With LGMDR12 Over 2 Years of Follow-up: Quantitative MRI and Clinical Outcome Measures.
Kawada, Tomoyuki
Author Response: Prospective Natural History Study in 24 Adult Patients With LGMDR12 Over 2 Years of Follow-up: Quantitative MRI and Clinical Outcome Measures.
De Wel, Bram; Claeys, Kristl G.
Editors' Note: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.
Siegler, James E. MD; Galetta, Steven MD
Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.
Piantino, Juan A.; Iliff, Jeffrey J.; Lim, Miranda M.; Levendovszky, Swati Rane
Author Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.
Siow, Tiing Yee; Toh, Cheng Hong; Hsu, Jung-Lung; Liu, Geng-Hao; Lee, Shwu-Hua; Chen, Ning-Hung; Fu, Changjui James; Castillo, Mauricio; Fang, Ji-Tseng
