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Transcriptomic and Cellular Content Analysis of Colorectal Cancer by Combining Multiple Independent Cohorts.
Kothalawala, William Jayasekara MD, BSc 1; Gyorffy, Balazs MD, PhD, DSc, MAE 2,3,4
doi : 10.14309/ctg.0000000000000517
By linking cellular content and molecular subtypes of colorectal cancer (CRC), we aim to uncover novel features useful for targeted therapy. Our first goal was to evaluate gene expression alterations linked to CRC pathogenesis, and then, we aimed to evaluate the cellular composition differences between normal colon mucosa and tumor and between different colon cancer molecular subtypes.
Pancreatitis and the Risk of Developing Gastric Neuromuscular Dysfunction.
Pasricha, Trisha S. MD, MPH 1,2; Staller, Kyle MD, MPH 1,2; Kuo, Braden MD 1,2
doi : 10.14309/ctg.0000000000000562
Most gastroparesis and functional dyspepsia cases (collectively, gastric neuromuscular dysfunction [GND]) remain idiopathic. It is believed that some idiopathic cases of GND may be triggered by an inflammatory insult to the gastrointestinal tract.
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial.
Swanson, Garth R. MD, MS 1,2; Biglin, Mary MD 1; Raff, Hannah BS 1; Chouhan, Vijit MD 1; Jochum, Sarah MD 1; Shaikh, Maliha MS 1,2; Francey, Lauren PhD 3; Bishehsari, Faraz MD, PhD 1,2; Hogenesch, John PhD 3; Keshavarzian, Ali MD 1,2
doi : 10.14309/ctg.0000000000000549
Chronotherapy is the timing of medication according to biological rhythms of the host to optimize drug efficacy and minimize toxicity. Efficacy and myelosuppression of azathioprine/6-mercaptopurine (AZA/6-MP) are correlated with the metabolite 6-thioguanine, while the metabolite 6-methylmercaptopurine correlates with hepatotoxicity.
Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models.
He, Siyi MS 1,*; Sun, Dianqin MS 1,*; Li, He MS 1; Cao, Maomao MS 1; Yu, Xinyang MS 1; Lei, Lin MS 2; Peng, Ji PhD 2; Li, Jiang PhD 1; Li, Ni PhD 1; Chen, Wanqing PhD 1
doi : 10.14309/ctg.0000000000000546
Some gastric cancer prediction models have been published. Still, the value of these models for application in real-world practice remains unclear. We aim to summarize and appraise modeling studies for gastric cancer risk prediction and identify potential barriers to real-world use.
Disproportionately Low Albumin and High Neutrophil-to-Lymphocyte Ratio in Small Bowel Adenocarcinoma Patients With Long-Duration Crohn's Disease.
Veisman, Ido MD 1,2,*; Oppenheim, Amit MD 2,3,*; Sub laban, Zuheir MD 2,3; Kenig, Ariel MD 4,5; Ukashi, Offir MD 1,2,3; Shacham-Shmueli, Einat MD 2,6; Engel, Tal MD 1,2; Kopylov, Uri MD 1,2; Ben-Horin, Shomron MD 1,2; Lang, Alon MD 1,2
doi : 10.14309/ctg.0000000000000553
Although Crohn's disease (CD) is a known risk factor of small bowel adenocarcinoma (SBA), early diagnosis remains a significant clinical challenge. Identification of biomarkers for SBA may lead to early detection.
Pathogen-Specific Alterations in the Gut Microbiota Predict Outcomes in Flare of Inflammatory Bowel Disease Complicated by Gastrointestinal Infection.
Axelrad, Jordan E. MD, MPH 1; Chen, Ze BS 2,3; Devlin, Joseph PhD 2,3; Ruggles, Kelly V. PhD 3,4; Cadwell, Ken PhD 1,2
doi : 10.14309/ctg.0000000000000550
Enteric infection with Clostridioides difficile, Escherichia coli subtypes, and norovirus is commonly detected in flares of inflammatory bowel disease (IBD). We associated the gut microbiome during flare complicated by a gastrointestinal pathogen with outcomes of IBD.
Automated In Vivo High-Resolution Imaging to Detect Human Papillomavirus-Associated Anal Precancer in Persons Living With HIV.
Brenes, David BS 1; Kortum, Alex MS 1; Carns, Jennifer PhD 1; Mutetwa, Tinaye MSc 2; Schwarz, Richard PhD 1; Liu, Yuxin MD, PhD 3; Sigel, Keith MD, PhD, MPH 2; Richards-Kortum, Rebecca PhD 1; Anandasabapathy, Sharmila MD 4; Gaisa, Michael MD, PhD 2; Chiao, Elizabeth MD, MPH 5,6
doi : 10.14309/ctg.0000000000000558
In the United States, the effectiveness of anal cancer screening programs has been limited by a lack of trained professionals proficient in high-resolution anoscopy (HRA) and a high patient lost-to-follow-up rate between diagnosis and treatment.
