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Machine learning powers biobank-driven drug discovery
Michael EisensteinÂÂ
Monkeypox response relies on three vaccine suppliers
Charlotte HarrisonÂÂ
Decentralized investor communities gain traction in biotech
Laura DeFrancesco & Ariel KleveczÂ
HSV-1’s contribution as a vector for gene therapy
Alberto L. EpsteinÂÂ
Arthur D. Riggs 1939–2022
Gerd P. Pfeifer, Judith Singer-Sam & Keiichi ItakuraÂ
Brand-name market exclusivity for nebulizer therapy to treat asthma and COPD
William B. Feldman, Doni Bloomfield, Reed F. Beall & Aaron S. KesselheimÂ
Phage therapy suppresses gut inflammation in IBD
Eleni KotsilitiÂÂ
A new route to vaccines using PROTACs
Brad Gilbertson & Kanta SubbaraoÂ
Haplotype-resolved assembly of diploid genomes without parental data
Haoyu Cheng, Erich D. Jarvis, Olivier Fedrigo, Klaus-Peter Koepfli, Lara Urban, Neil J. Gemmell & Heng LiÂ
doi : 10.1038/s41587-022-01261-x
Routine haplotype-resolved genome assembly from single samples remains an unresolved problem. Here we describe an algorithm that combines PacBio HiFi reads and Hi-C chromatin interaction data to produce a haplotype-resolved assembly without the sequencing of parents.
Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants
Jason Z. Zhang, Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N. Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, Lauren Carter, Rashmi Ravichandran, Mark H. Wener, Lance Stewart, David Veesler, Michael S. Diamond, Alexander L. Greninger, David M. Koelle & David BakerÂ
doi : 10.1038/s41587-022-01280-8
We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum.
A genome and gene catalog of glacier microbiomes
Yongqin Liu, Mukan Ji, Tao Yu, Julian Zaugg, Alexandre M. Anesio, Zhihao Zhang, Songnian Hu, Philip Hugenholtz, Keshao Liu, Pengfei Liu, Yuying Chen, Yingfeng Luo & Tandong YaoÂ
doi : 10.1038/s41587-022-01367-2
Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming.
Spatially informed cell-type deconvolution for spatial transcriptomics
Ying Ma & Xiang ZhouÂ
doi : 10.1038/s41587-022-01273-7
Many spatially resolved transcriptomic technologies do not have single-cell resolution but measure the average gene expression for each spot from a mixture of cells of potentially heterogeneous cell types.
DestVI identifies continuums of cell types in spatial transcriptomics data
Romain Lopez, Baoguo Li, Hadas Keren-Shaul, Pierre Boyeau, Merav Kedmi, David Pilzer, Adam Jelinski, Ido Yofe, Eyal David, Allon Wagner, Can Ergen, Yoseph Addadi, Ofra Golani, Franca Ronchese, Michael I. Jordan, Ido Amit & Nir YosefÂ
doi : 10.1038/s41587-022-01272-8
Most spatial transcriptomics technologies are limited by their resolution, with spot sizes larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can alleviate this problem, current methods are limited to assessing discrete cell types, revealing the proportion of cell types inside each spot.
Generation of a live attenuated influenza A vaccine by proteolysis targeting
Longlong Si, Quan Shen, Jing Li, Li Chen, Jinying Shen, Xue Xiao, Haiqing Bai, Tang Feng, Adam Yongxin Ye, Le Li, Chunhe Zhang, Zhen Li, Ping Wang, Crystal Yuri Oh, Atiq Nurani, Siwen Niu, Chengxin Zhang, Xiaoqiong Wei, Wanqiong Yuan, Hao Liao, Xiaojie Huang, Ning Wang, Wen-xia Tian, Hongwei Tian, …Roberto PlebaniÂ
doi : 10.1038/s41587-022-01381-4
The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes and techniques. Here we describe the generation of a live attenuated influenza A virus vaccine using proteolysis-targeting chimeric (PROTAC) technology to degrade viral proteins via the endogenous ubiquitin–proteasome system of host cells.
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA
Beverly Y. Mok, Anna V. Kotrys, Aditya Raguram, Tony P. Huang, Vamsi K. Mootha & David R. LiuÂ
doi : 10.1038/s41587-022-01256-8
The all-protein cytosine base editor DdCBE uses TALE proteins and a double-stranded DNA-specific cytidine deaminase (DddA) to mediate targeted C•G-to-T•A editing.
A split prime editor with untethered reverse transcriptase and circular RNA template
Bin Liu, Xiaolong Dong, Haoyang Cheng, Chunwei Zheng, Zexiang Chen, Tomás C. RodrÃÂguez, Shun-Qing Liang, Wen Xue & Erik J. SontheimerÂ
doi : 10.1038/s41587-022-01255-9
Delivery and optimization of prime editors (PEs) have been hampered by their large size and complexity. Although split versions of genome-editing tools can reduce construct size, they require special engineering to tether the binding and catalytic domains.
An engineered prime editor with enhanced editing efficiency in plants
Yuan Zong, Yijing Liu, Chenxiao Xue, Boshu Li, Xiangyang Li, Yanpeng Wang, Ji Li, Guanwen Liu, Xingxu Huang, Xiaofeng Cao & Caixia GaoÂ
doi : 10.1038/s41587-022-01254-w
Prime editing is a versatile genome-editing technology, but it suffers from low editing efficiency. In the present study, we introduce optimized prime editors with substantially improved editing efficiency.
Targeting a gene regulatory element enhances rice grain yield by decoupling panicle number and size
Xiaoguang Song, Xiangbing Meng, Hongyan Guo, Qiao Cheng, Yanhui Jing, Mingjiang Chen, Guifu Liu, Bing Wang, Yonghong Wang, Jiayang Li & Hong YuÂ
doi : 10.1038/s41587-022-01281-7
Crop genetic improvement requires balancing complex tradeoffs caused by gene pleiotropy and linkage drags, as exemplified by IPA1 (Ideal Plant Architecture 1), a typical pleiotropic gene in rice that increases grains per panicle but reduces tillers.
Author Correction: An engineered prime editor with enhanced editing efficiency in plants
Yuan Zong, Yijing Liu, Chenxiao Xue, Boshu Li, Xiangyang Li, Yanpeng Wang, Ji Li, Guanwen Liu, Xingxu Huang, Xiaofeng Cao & Caixia GaoÂ
Author Correction: A highly photostable and bright green fluorescent protein
Masahiko Hirano, Ryoko Ando, Satoshi Shimozono, Mayu Sugiyama, Noriyo Takeda, Hiroshi Kurokawa, Ryusaku Deguchi, Kazuki Endo, Kei Haga, Reiko Takai-Todaka, Shunsuke Inaura, Yuta Matsumura, Hiroshi Hama, Yasushi Okada, Takahiro Fujiwara, Takuya Morimoto, Kazuhiko Katayama & Atsushi MiyawakiÂ
How researchers can join the race to develop new ways of making meat
Seren L. KellÂÂ
