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The Heart’s Pacemaker Mimics Brain Cytoarchitecture and Function: Novel Interstitial Cells Expose Complexity of the SAN
Rostislav Bychkov, P HD, a Magdalena Juhaszova, PHD, a Miguel Calvo-Rubio Barrera, P HD, b Lorenzo A.H. Donald, BS, a Christopher Coletta, MS,c Chad Shumaker, BS, a Kayla Moorman, BS, a Syevda Tagirova Sirenko, PHD, a Alexander V. Maltsev, BS, a Steven J. Sollott, MD, a Edward G. Lakatta, MD
doi : 10.1016/j.jacep.2022.07.003
Volume 8, Issue 10, October 2022, Pages 1191-1215
The sinoatrial node (SAN) of the heart produces rhythmic action potentials, generated via calcium signaling within and among pacemaker cells.
The Central Brain of the Heart: The Sinoatrial Node∗
Nathan Grainger, PH D, a L. Fernando Santana, P HD
doi : 10.1016/j.jacep.2022.08.016
Volume 8, Issue 10, October 2022, Pages 1216-1218
Attenuation of the Heartbeat-Evoked Potential in Patients With Atrial Fibrillation
Deniz Kumral, PH D, a,b,c Esra Al, P HD, a,d,e Elena Cesnaite, MS C,a Jelena Kornej, MD, f,g Christian Sander, PHD, g,h Tilman Hensch, PHD, g,h,i Samira Zeynalova, P HD, g Sandra Tautenhahn, MD, j Andreas Hagendorf, MD,j Ulrich Laufs, MD, j Rolf Wachter, MD, j Vadim Nikulin, PHD, a,k Arno Villringer, MD a,d
doi : 10.1016/j.jacep.2022.06.019
Volume 8, Issue 10, October 2022, Pages 1219-1230
The heartbeat-evoked potential (HEP) is a brain response to each heartbeat, which is thought to reflect cardiac signaling to central autonomic areas and suggested to be a marker of internal body awareness (eg, interoception).
Atrial Fibrillation as a Disorder of Heart-Brain Communication∗
Sahib S. Khalsa, MD, PHD, a,b Charles Verdonk, MD, PH D
doi : 10.1016/j.jacep.2022.07.021
Volume 8, Issue 10, October 2022, Pages 1231-1233
Ventricular Arrhythmia Substrate Distribution and Its Relation to Sympathetic Innervation in Nonischemic Cardiomyopathy Patients
H. Sophia Chen, MD,a,b, * Christiane Jungen, MD, PHD, a,c, * Yoshitaka Kimura, MD, PH D, a Petra Dibbets-Schneider, MS C,d Sebastiaan R. Piers, MD, PHD, a Alexander F.A. Androulakis, MD, a Rob J. van der Geest, PH D, d Lioe-Fee de Geus-Oei, MD, PHD, d Arthur J.H.A. Scholte, MD, P HD, a Hildo J. Lamb, MD, PH D, d Monique R.M. Jongbloed, MD, PHD, a,b Katja Zeppenfeld, MD, P HD
doi : 10.1016/j.jacep.2022.07.006
Volume 8, Issue 10, October 2022, Pages 1234-1245
Nonischemic cardiomyopathy patients referred for catheter ablation of ventricular arrhythmias (VAs) typically have either inferolateral (ILS) or anteroseptal (ASS) VA substrate locations, with poorer outcomes for ASS. Sympathetic denervation is an important determinant of arrhythmogenicity.
Neuroimaging of Cardiac Sympathetic Innervation in Patients Undergoing Catheter Ablation of Ventricular Tachycardia∗
Robert Lemery, MD, MA
doi : 10.1016/j.jacep.2022.08.007
Volume 8, Issue 10, October 2022, Pages 1246-1248
Association Between Device-Detected Sleep-Disordered Breathing and Implantable Defibrillator Therapy in Patients With Heart Failure
Andrea Mazza, MD,a Maria Grazia Bendini, MD,a Valter Bianchi, MD,b Cristina Esposito, MD, c Leonardo Calò, MD,d Chiara Andreoli, MD, e Vincenzo Ezio Santobuono, MD,f Antonio Dello Russo, MD, g Miguel Viscusi, MD,h Carmelo La Greca, MD,i Claudia Baiocchi, MD,j Antonello Talarico, MD,k Raimondo Calvanese, MD, l Giuseppe Arena, MD, m Giovanna Giubilato, MD, n Matteo Ziacchi, MD, o Antonio Rapacciuolo, MD, p Monica Campari, MS C,d Sergio Valsecchi, PHD, q Giuseppe Boriani, MD, P HD
doi : 10.1016/j.jacep.2022.07.017
Volume 8, Issue 10, October 2022, Pages 1249-1256
Sleep-disordered breathing is highly prevalent in heart failure (HF) and has been suggested as a risk factor for malignant ventricular arrhythmias. The Respiratory Disturbance Index (RDI) computed by an implantable cardioverter-defibrillator (ICD) algorithm accurately identifies severe sleep apnea.
Heart Failure, Sleep-Disordered Breathing, and Ventricular Arrhythmias: Insights From and Implications of Thoracic Impedance Monitoring∗
Konstantinos C. Siontis, MD, Virend K. Somers, MD, P HD
doi : 10.1016/j.jacep.2022.08.014
Volume 8, Issue 10, October 2022, Pages 1257-1259
Survivors of Sudden Cardiac Arrest Presenting With Pulseless Electrical Activity: Clinical Substrate, Triggers, Long-Term Prognosis
Lauri Holmstrom, MD, a,b, * Shiva Salmasi, MD, a, * Harpriya Chugh, BE, a Audrey Uy-Evanado, MD,a Chad Sorenson, BS, a Ziana Bhanji, BS, a Madison Seifer, BA, a Arayik Sargsyan, MD, MPH,a Angelo Salvucci, MD, c Jonathan Jui, MD, MPH,d Kyndaron Reinier, PH D, MPH,a Sumeet S. Chugh, MD
doi : 10.1016/j.jacep.2022.06.022
Volume 8, Issue 10, October 2022, Pages 1260-1270
The proportion of sudden cardiac arrest (SCA) presenting as pulseless electrical activity (PEA) is rising, and survival remains low. The pathophysiology of PEA-SCA is poorly understood, and current clinical practice lacks specific options for the management of survivors.
New Insights Into Cardiac Arrest From Pulseless Electrical Activity∗
Henry R. Halperin, MD, MA, a,b,c Daniel I. Ambinder, MD,a Matt T. Oberdier, PHD
doi : 10.1016/j.jacep.2022.07.019
Volume 8, Issue 10, October 2022, Pages 1271-1273
Lipomatous Metaplasia Enables Ventricular Tachycardia by Reducing Current Loss Within the Protected Corridor
Lingyu Xu, MD, PH D, a Mirmilad Khoshknab, MD, a Ronald D. Berger, MD, P HD, b,c Jonathan Chrispin, MD,b,c Sanjay Dixit, MD, a Pasquale Santangeli, MD, P HD, a David Callans, MD,a Francis E. Marchlinski, MD, a Stefan L. Zimmerman, MD,d Yuchi Han, MD, a Natalia Trayanova, PH D, b Benoit Desjardins, MD, P HD, e Saman Nazarian, MD, PH D
doi : 10.1016/j.jacep.2022.07.005
Volume 8, Issue 10, October 2022, Pages 1274-1285
Post–myocardial infarction ventricular tachycardia (VT) is due to re-entry through surviving conductive myocardial corridors across infarcted tissue. However, not all conductive corridors participate in re-entry.
Ventricular Tachycardia Corridors and Fat∗
William G. Stevenson, MD, Travis D. Richardson, MD, Arvindh N. Kanagasundram, MD
doi : 10.1016/j.jacep.2022.08.005
Volume 8, Issue 10, October 2022, Pages 1286-1288
Last Entrainment Sequence: A Novel Diagnostic Technique for Atrial Tachycardia Mimicking Other Supraventricular Tachycardias
Mitsunori Maruyama, MD, PHD, a Hiroshige Yamabe, MD, P HD, b Seiji Takatsuki, MD, P HD, c Yuta Seki, MD,c Shunsuke Uetake, MD, PH D, d Tsuyoshi Nohara, MD, a Ippei Tsuboi, MD, PHD, a Shiro Ishihara, MD, a Yasushi Miyauchi, MD, P HD, d Wataru Shimizu, MD, PHD
doi : 10.1016/j.jacep.2022.07.007
Volume 8, Issue 10, October 2022, Pages 1289-1300
Adenosine-sensitive re-entrant atrial tachycardia (AT) originating from near the atrioventricular (AV) node or AV annulus resembles other supraventricular tachycardias (SVTs), and the differential diagnosis is sometimes challenging.
Last Entrainment Sequence: The Last Word in Perinodal Atrial Tachycardia Diagnosis?∗
Vadivelu R. Mandharam, MD, DM,a Yash Y. Lokhandwala, MD, DM
doi : 10.1016/j.jacep.2022.08.020
Volume 8, Issue 10, October 2022, Pages 1301-1303
Sex Differences in Outcomes of Tetralogy of Fallot Patients With Implantable Cardioverter-Defibrillators
Victor Waldmann, MD, P HD, a,b,c Abdeslam Bouzeman, MD, d Guillaume Duthoit, MD, e Linda Koutbi, MD, f Francis Bessière, MD, PHD, g Fabien Labombarda, MD, h Christelle Marquié, MD, i Jean-Baptiste Gourraud, MD, PHD, j Pierre Mondoly, MD, k Jean Marc Sellal, MD, l Pierre Bordachar, MD, PH D, m Alexis Hermida, MD, n Alain Al Arnaout, MD,o Frédéric Anselme, MD, PHD, p Caroline Audinet, MD,q Yvette Bernard, MD, r Serge Boveda, MD,s Sok Sithikun Bun, MD,t Morgane Chassignolle, PHD, a Gaël Clerici, MD, u Antoine Da Costa, MD, PHD, v Maxime de Guillebon, MD,w Pascal Defaye, MD, x Nathalie Elbaz, MD,y Romain Eschalier, MD, PH D, z Rodrigue Garcia, MD, aa Charles Guenancia, MD, bb Benoit Guy-Moyat, MD,cc Franck Halimi, MD, d Didier Irles, MD,dd Laurence Iserin, MD,b François Jourda, MD, ee Magalie Ladouceur, MD, PH D, a,b Philippe Lagrange, MD,ff Mikael Laredo, MD, e Jacques Mansourati, MD, PH D, gg Grégoire Massoulié, MD, z Amel Mathiron, MD, n Philippe Maury, MD, k Anne Messali, MD, hh Kumar Narayanan, MD, a Cédric Nguyen, MD, ii Sandro Ninni, MD, i Marie-Cécile Perier, MSC ,a Bertrand Pierre, MD, jj Penelope Pujadas, MD, kk Frédéric Sacher, MD, P HD, m Pascal Sagnol, MD, ii Ardalan Sharifzadehgan, MD, MPH,a,c Camille Walton, MD,g Pierre Winum, MD, ll Cyril Zakine, MD, mm Laurent Fauchier, MD, P HD, jj Raphaël Martins, MD, P HD, nn Jean-Luc Pasquié, MD, PHD, oo Jean-Benoit Thambo, MD, PHD, m Xavier Jouven, MD, P HD, a,c Nicolas Combes, MD, s Eloi Marijon, MD, PHD
doi : 10.1016/j.jacep.2022.06.024
Volume 8, Issue 10, October 2022, Pages 1304-1314
Women with congenital heart disease at high risk for sudden cardiac death have been poorly studied thus far.
Are We Underutilizing ICDs in Women With Tetralogy of Fallot?∗
Chalese Richardson, MD,a Maully J. Shah, MBBS
doi : 10.1016/j.jacep.2022.07.023
Volume 8, Issue 10, October 2022, Pages 1315-1316
Catheter Ablation of Atrial Fibrillation in Patients With Partial Anomalous Pulmonary Venous Return
Andrea Demarchi, MD *Angelo Auricchio, MD, PhD Serge Boveda, MD, PhD Hamed Bourenane, MD Pascal Dafaye, MD Adrien Carabelli, MD Dhiraj Gupta, MD Nikola Kozhuharov, MD Catherine Klersy, MD, MscEpid Giulio Conte, MD, PhD
doi : 10.1016/j.jacep.2022.05.014
Volume 8, Issue 10, October 2022, Pages 1317-1319
Device Pocket Antibiotic Irrigation Provides No CIED-Pocket Infection Prophylaxis Advantage Compared to Normal Saline
Daniel Rodriguez, MD Clinton J. Thurber, MD Jorge E. Romero, MD William H. Sauer, MD Sunil Kapur, MD Thomas M. Tadros, MD *Bruce A. Koplan, MD, MPH
doi : 10.1016/j.jacep.2022.05.018
Volume 8, Issue 10, October 2022, Pages 1319-1320
Noninducibility as an Ablation Strategy for Atrial Tachycardia After First-Time Persistent AF Ablation
Louisa O’Neill, MD, PhD Mattias Duytschaever, MD, PhD Jean-Benoit Le Polain De Waroux, MD, PhD Torsten Konrad, MD Thomas Rostock, MD, PhD Nicolas Derval, MD, PhD Thomas Pambrun, MD Anne Rollin, MD Philippe Maury, MD Sebastien Knecht, MD, PhD
doi : 10.1016/j.jacep.2022.05.015
Volume 8, Issue 10, October 2022, Pages 1320-1322
Pulmonary Vein Stenosis—Balloon Angioplasty Versus Stenting: A Systematic Review and Meta-Analysis
Abdul Hakim Almakadma, MD, a, * Dhruv Sarma, MD,b, * Leslie Hassett, MLS, c William Miranda, MD,a Mohamad Alkhouli, MD, a Guy S. Reeder, MD,a Thomas M. Munger, MD,a Douglas L. Packer, MD, a Trevor Simard, MD,a David R. Holmes, J R, MD
doi : 10.1016/j.jacep.2022.08.008
Volume 8, Issue 10, October 2022, Pages 1323-1333
Pulmonary vein stenosis (PVS) may arise from a variety of conditions and result in major morbidity and mortality. In some patients, pharmacologic therapy may help, but more often in advanced stages, mechanical treatment must be considered. Transcatheter approaches, both balloon angioplasty (BA) and stent implantation, have been applied. Although both are effective, they continue to be limited by restenosis.
Multifocal Ectopic Purkinje-Related Premature Contractions Syndrome in R222Q-SCN5A Gene Mutation Carriers Treated With Flecainide
Paolo Basile, MD, Gianluigi Napoli, MD, Matteo Anaclerio, MD, Cinzia Forleo, MD, P HD, Andrea Igoren Guaricci, MD, PHD
doi : 10.1016/j.jacep.2022.07.008
Volume 8, Issue 10, October 2022, Pages 1334-1336
An Unusual Incessant Narrow-Wide Complex Polymorphic Tachycardia: Electrophysiological Phenotype Due to an Allelic Variant
Hao Chen, MD,a Junpeng Liu, MD, a Dapeng Dai, P HD, b Jiefu Yang, MD, a Haifeng Shi, MD
doi : 10.1016/j.jacep.2022.06.005
Volume 8, Issue 10, October 2022, Pages 1337-1339
