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Choosing the Right Path toward Polio Eradication
Konstantin Chumakov, Ph.D., D.Sci., Christian Brechot, M.D., Ph.D., Robert C. Gallo, M.D., and Stanley Plotkin, M.D.
doi : 10.1056/NEJMp2215257
February 16, 2023 Vol. 388 No. 7
The Journey to RSV Vaccines — Heralding an Era of Structure-Based Design
Barney S. Graham, M.D., Ph.D.
doi : 10.1056/NEJMp2216358
Hunting for a Diagnosis
Leslie Chang, M.D., Debra Malina, Ph.D., Lisa Rosenbaum, M.D., Caren Solomon, M.D., M.P.H., and Timothy Vining
doi : 10.1056/NEJMp2301054
Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer
Ian H. Kunkler, M.B., B.Chir., Linda J. Williams, Ph.D., Wilma J.L. Jack, M.B., Ch.B., David A. Cameron, M.D., and J. Michael Dixon, M.D.
doi : 10.1056/NEJMoa2207586
Limited level 1 evidence is available on the omission of radiotherapy after breast-conserving surgery in older women with hormone receptor–positive early breast cancer receiving adjuvant endocrine therapy.
Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults
Alberto Papi, M.D., Michael G. Ison, M.D., Joanne M. Langley, M.D., Dong-Gun Lee, M.D., Ph.D., Isabel Leroux-Roels, M.D., Ph.D., Federico Martinon-Torres, M.D., Ph.D., Tino F. Schwarz, M.D., Ph.D., Richard N. van Zyl-Smit, M.D., Ph.D., Laura Campora, M.D., Nancy Dezutter, Ph.D., Nathalie de Schrevel, Ph.D., Laurence Fissette, M.S.,
doi : 10.1056/NEJMoa2209604
Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection.
Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults
Ann R. Falsey, M.D., Kristi Williams, Ph.D., Efi Gymnopoulou, Ph.D., Stephan Bart, M.D., John Ervin, M.D., Arangassery R. Bastian, Ph.D., Joris Menten, Ph.D., Els De Paepe, M.Sc., Sjouke Vandenberghe, Ph.D., Eric K.H. Chan, Ph.D., Jerald Sadoff, M.D., Macaya Douoguih, M.D.,
doi : 10.1056/NEJMoa2207566
Respiratory syncytial virus (RSV) can cause serious lower respiratory tract disease in older adults, but no licensed RSV vaccine currently exists. An adenovirus serotype 26 RSV vector encoding a prefusion F (preF) protein (Ad26.RSV.preF) in combination with RSV preF protein was previously shown to elicit humoral and cellular immunogenicity.
Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age
Flor M. Muñoz, M.D., Lawrence D. Sher, M.D., Charu Sabharwal, M.D., M.P.H., Alejandra Gurtman, M.D., Xia Xu, Ph.D., Nicholas Kitchin, M.D., Stephen Lockhart, D.M., Robert Riesenberg, M.D., Joanna M. Sexter, M.D., Hanna Czajka, M.D., Grant C. Paulsen, M.D., Yvonne Maldonado, M.D.,
doi : 10.1056/NEJMoa2211031
Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children.
Tuberculous Optochiasmatic Arachnoiditis
Carmen Amado, M.D., and Karlo J. Lizárraga, M.D.
doi : 10.1056/NEJMicm2205437
Case 5-2023: A 67-Year-Old Man with Interstitial Lung Disease, Fever, and Myalgias
Hemal N. Sampat, M.D., Amita Sharma, M.D., and E. Zachary Nussbaum, M.D.
doi : 10.1056/NEJMcpc2211364
Overcoming Resistance — Omission of Radiotherapy for Low-Risk Breast Cancer
Alice Y. Ho, M.D., and Jennifer R. Bellon, M.D.
doi : 10.1056/NEJMe2216133
Audio Interview: What to Expect from Covid-19 Vaccines
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Barney S. Graham, M.D., Ph.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2301645
Oral Vancomycin as Secondary Prophylaxis for Prevention of Recurrent Clostridioides difficile Infection
Leslie L. Chang, M.D., Jessica Allegretti, M.D., M.P.H., Andrew M. Skinner, M.D., and Erik R. Dubberke, M.D., M.S.P.H.
doi : 10.1056/NEJMclde2204692
Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1
doi : 10.1056/NEJMc2214314
Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer
doi : 10.1056/NEJMx220014
