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Bivalent Covid-19 Vaccines — A Cautionary Tale
Paul A. Offit, M.D.
doi : 10.1056/NEJMp2215780
February 9, 2023 Vol. 388 No. 6
A “Method of Use� to Prevent Generic and Biosimilar Market Entry
S. Sean Tu, Ph.D., J.D., and Ameet Sarpatwari, Ph.D., J.D.
doi : 10.1056/NEJMp2216020
Please Look at My Baby — When Clinicians Should Say the Word “Hospice�
Golda Grinberg, B.S.
doi : 10.1056/NEJMp2213031
Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer
Nasser Altorki, M.D., Xiaofei Wang, Ph.D, David Kozono, M.D., Ph.D., Colleen Watt, B.S., Rodney Landrenau, M.D., Dennis Wigle, M.D., Ph.D., Jeffrey Port, M.D., David R. Jones, M.D., Massimo Conti, M.D., Ahmad S. Ashrafi, M.D., Moishe Liberman, M.D., Ph.D., Kazuhiro Yasufuku, M.D., Ph.D., Stephen Yang, M.D., John D. Mitchell, M.D., Harvey Pass, M.D., Robert Keenan, M.D., Thomas Bauer, M.D., Daniel Miller, M.D., Leslie J. Kohman, M.D., Thomas E. Stinchcombe, M.D., and Everett Vokes, M.D.
doi : 10.1056/NEJMoa2212083
The increased detection of small-sized peripheral non–small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy.
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension
doi : 10.1056/NEJMoa2212663
Intravenous fluids and vasopressor agents are commonly used in early resuscitation of patients with sepsis, but comparative data for prioritizing their delivery are limited.
Phase 2 Trial of Difelikefalin in Notalgia Paresthetica
Brian S. Kim, M.D., M.T.R., Robert Bissonnette, M.D., Kristine Nograles, M.D., Catherine Munera, Ph.D., Nilam Shah, Pharm.D., Alia Jebara, M.D., Joshua Cirulli, Pharm.D., Joana Goncalves, M.D., and Mark Lebwohl, M.D. for the KOMFORT Trial Investigators*
doi : 10.1056/NEJMoa2210699
Notalgia paresthetica is a neuropathic disorder characterized by pruritus in a circumscribed region of the upper back. Difelikefalin, a selective kappa opioid receptor agonist, has shown efficacy in other chronic pruritic conditions and is being investigated for the treatment of notalgia paresthetica.
Early Treatment with Pegylated Interferon Lambda for Covid-19
Gilmar Reis, M.D., Ph.D., Eduardo A.S. Moreira Silva, M.D., Ph.D., Daniela C. Medeiros Silva, M.D., Ph.D., Lehana Thabane, Ph.D., Vitoria H.S. Campos, Thiago S. Ferreira, M.D., Castilho V.Q. Santos, Ana M.R. Nogueira, M.D., Ana P.F.G. Almeida, M.D., Leonardo C.M. Savassi, M.D., Ph.D., Adhemar D. Figueiredo-Neto, M.D., Ph.D., Ana C.F. Dias, Ph.D., Adelino M. Freire Júnior, M.D., Ph.D., Carina Bitarães, R.N., Aline C. Milagres, R.N., Eduardo D. Callegari, M.D., Maria I.C. Simplicio, B.Sc.Pharm., Luciene B. Ribeiro, R.N., M.P.H., Rosemary Oliveira, Ofir Harari, Ph.D., Lindsay A. Wilson, M.Sc., Jamie I. Forrest, Ph.D., M.P.H., Hinda Ruton, M.Sc., Sheila Sprague, Ph.D., Paula McKay, M.Sc., Christina M. Guo, B.Com., Eve H. Limbrick-Oldfield, Ph.D., Steve Kanters, Ph.D., Gordon H. Guyatt, M.D., Craig R. Rayner, Pharm.D., Christopher Kandel, M.D., Mia J. Biondi, Ph.D., Robert Kozak, Ph.D., Bettina Hansen, Ph.D., M. Atif Zahoor, Ph.D., Paul Arora, Ph.D., Colin Hislop, M.B., B.S., Ingrid Choong, Ph.D., Jordan J. Feld, M.D., M.P.H., Edward J. Mills, Ph.D., F.R.C.P., and Jeffrey S. Glenn, M.D., Ph.D. for the TOGETHER Investigators*
doi : 10.1056/NEJMoa2209760
The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms
Ellen M. Gravallese, M.D., and Gary S. Firestein, M.D.
doi : 10.1056/NEJMra2103726
Odontogenic Cutaneous Fistula
Jianqiu Jin, M.D., and Yuxing Zhang, M.D.
doi : 10.1056/NEJMicm2209259
Case 4-2023: A 56-Year-Old Man with Abnormal Results on Liver Testing
Irun Bhan, M.D., Esperance A. Schaefer, M.D., William R. Bradley, M.D., Josanna M. Rodriguez-Lopez, M.D., Jerome C. Crowley, M.D., and Bailey Hutchison, M.D.
doi : 10.1056/NEJMcpc2201249
Reviewers for the Journal, July–December 2022
Eric J. Rubin, M.D., Ph.D.
doi : 10.1056/NEJMe2300212
Initiating the Era of “Precision� Lung Cancer Surgery
Valerie W. Rusch, M.D.
doi : 10.1056/NEJMe2215647
Reconstructive Justice — Public Health Policy to End Mass Incarceration
Eric Reinhart, M.D.
doi : 10.1056/NEJMms2208239
