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Facing the New Covid-19 Reality
Wafaa M. El-Sadr, M.D., M.P.H., M.P.A., Ashwin Vasan, M.D., Ph.D., and Ayman El-Mohandes, M.B., B.C.H., M.D., M.P.H.
doi : 10.1056/NEJMp2213920
February 2, 2023 Vol. 388 No. 5
Behind-the-Scenes Investment for Equity in Global Health Research
Jessica E. Haberer, M.D., and Yap Boum, II, Ph.D.
doi : 10.1056/NEJMp2213809
Malaria — Epidemiology, Treatment, and Prevention
Lindsey Baden, M.D., Flaminia Catteruccia, Ph.D., Abdoulaye Diabaté, Ph.D., Cristina Donini, Ph.D., François Nosten, Ph.D., Scott O’Neill, Ph.D., Faith Osier, M.D., Ph.D., Aung Pyae Phyo, Ph.D., and Nicholas White, Ph.D.
doi : 10.1056/NEJMp2216703
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension
Mason W. Freeman, M.D., Yuan-Di Halvorsen, Ph.D., William Marshall, M.D., Mackenzie Pater, Ph.D., Jon Isaacsohn, M.D., Catherine Pearce, D.H.Sc., Brian Murphy, M.D., M.P.H., Nicholas Alp, M.D., Ajay Srivastava, M.D., Deepak L. Bhatt, M.D., M.P.H., and Morris J. Brown, M.D. for the BrigHTN Investigators*
doi : 10.1056/NEJMoa2213169
Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase is essential but difficult to achieve because cortisol synthesis is catalyzed by another enzyme that shares 93% sequence similarity with aldosterone synthase.
VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19
Zhujun Cao, M.D., Ph.D., Weiyi Gao, M.D., Ph.D., Hong Bao, M.D., Ph.D., Haiyan Feng, M.D., Shuya Mei, M.D., Ph.D., Peizhan Chen, Ph.D., Yueqiu Gao, M.D., Ph.D., Zhilei Cui, M.D., Ph.D., Qin Zhang, M.D., Ph.D., Xianmin Meng, Ph.D., Honglian Gui, M.D., Ph.D., Weijing Wang, M.D., Ph.D., Yimei Jiang, M.D., Zijia Song, M.D., Ph.D., Yiqing Shi, M.D., Jing Sun, M.D., Ph.D., Yifei Zhang, M.D., Ph.D., Qing Xie, M.D., Ph.D., Yiping Xu, Ph.D., Guang Ning, M.D., Yuan Gao, M.D., Ph.D., and Ren Zhao, M.D., Ph.D.
doi : 10.1056/NEJMoa2208822
Nirmatrelvir–ritonavir has been authorized for emergency use by many countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply falls short of the global demand, which creates a need for more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Hypothermia or Machine Perfusion in Kidney Donors
Darren Malinoski, M.D., Christina Saunders, Ph.D., Sharon Swain, M.S.N., R.N., Tahnee Groat, M.P.H., Patrick R. Wood, M.D., Jeffrey Reese, M.D., Rachel Nelson, M.S., Jennifer Prinz, M.P.H.-H.P.A., B.S.N., Kate Kishish, R.N., Craig Van De Walker, M.S., P.J. Geraghty, M.B.A., Kristine Broglio, M.S., and Claus U. Niemann, M.D.
doi : 10.1056/NEJMoa2118265
Therapeutic hypothermia in brain-dead organ donors has been shown to reduce delayed graft function in kidney recipients after transplantation. Data are needed on the effect of hypothermia as compared with machine perfusion on outcomes after kidney transplantation.
Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children
Jesús Castilla, M.D., Ph.D., Manuel GarcÃa Cenoz, M.D., Ph.D., Raquel Abad, Ph.D., Laura Sánchez-Cambronero, M.D., Nicola Lorusso, M.D., Conchita Izquierdo, Ph.D., Soledad Cañellas Llabrés, M.D., Javier Roig, M.D., Alberto Malvar, M.D., Fernando González Carril, M.Sc., An L.D. Boone, M.D., Jaime Pérez MartÃn, M.D., M. Jesús RodrÃguez Recio, M.D., Antònia Galmés, M.D., Arturo Caballero, M.D., Amós GarcÃa Rojas, M.D., Felipe Juanas, M.D., Mercedes Nieto, M.D., Luis J. Viloria Raymundo, M.D., Eva MartÃnez Ochoa, M.D., Ana I. Rivas, M.D., Daniel Castrillejo, Ph.D., David Moreno Pérez, M.D., Ana MartÃnez, Ph.D., Eva Borrà s, Ph.D., Amaya Sánchez Gómez, Ph.D., Eliseo Pastor, M.D., Victoria Nartallo, M.D., José M. Arteagoitia, M.D., Blanca Ã�lvarez-Fernández, R.N., RocÃo GarcÃa Pina, M.D., Socorro Fernández Arribas, M.D., Joana Vanrell, M.D., Sara GarcÃa Hernández, R.N., Rita M. Mendoza, M.D., Manuel Méndez, M.D., M. Mar López-Tercero, M.D., Ã�ngela Fernández-RodrÃguez, Ph.D., Ã�ngela Blanco, M.D., F. Javier Carrillo de Albornoz, M.D., José Ruiz Olivares, M.D., Rafael Ruiz-Montero, M.P.H., Aurora Limia, M.D., Ph.D., José A. Navarro-Alonso, M.D., Julio A. Vázquez, Ph.D., and Aurelio Barricarte, M.D., Ph.D.
doi : 10.1056/NEJMoa2206433
In September 2015, the four-component, protein-based meningococcal serogroup B vaccine (4CMenB; Bexsero) became available for private purchase in Spain.
Humoral Innate Immunity and Acute-Phase Proteins
Alberto Mantovani, M.D., and Cecilia Garlanda, Ph.D.
doi : 10.1056/NEJMra2206346
Cerebral Alveolar Echinococcosis
Hu Ju, M.D., and Chuanchuan Liu, M.D., Ph.D.
doi : 10.1056/NEJMicm2202196
Cerebral Cystic Echinococcosis
Sumit Thakar, M.B., B.S., M.Ch., and Akhil Sunil, M.B., B.S., D.N.B.
doi : 10.1056/NEJMicm2208104
A Breathtaking Discovery
Jonathan Coraor Fried, M.D., John J. Ross, M.D., Zoe F. Weiss, M.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.
doi : 10.1056/NEJMcps2209057
Decreasing the Effects of Aldosterone in Resistant Hypertension — A Success Story
Michel Azizi, M.D., Ph.D.
doi : 10.1056/NEJMe2216143
Aldosterone and Treatment-Resistant Hypertension
Jane A. Leopold, M.D., and Julie R. Ingelfinger, M.D.
doi : 10.1056/NEJMe2213559
To Cool or Not to Cool — Organ-Preservation Strategies in Transplantation
Paulo N. Martins, M.D., Ph.D., and Winfred W. Williams, M.D.
doi : 10.1056/NEJMe2214715
Audio Interview: Updating and Standardizing Covid-19 Vaccines
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2301319
The Implications of the 2022 Election Outcome for Health Policy
Robert J. Blendon, Sc.D., and John M. Benson, M.A.
doi : 10.1056/NEJMsr2214949
Translational Challenges in Psychedelic Medicine
Robin L. Carhart-Harris, Ph.D.
doi : 10.1056/NEJMcibr2213109
Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke
doi : 10.1056/NEJMc2215148
Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke
doi : 10.1056/NEJMc2215907
