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Uncovering how the GnRH pulse generator is controlled in female mice
Claire Greenhill
doi : 10.1038/s41574-022-00795-z
Volume 19 Issue 2, February 2023
Genomics suggest role for IGF1 resistance in T2DM
Shimona StarlingÂÂ
Gene-edited organoids enable sensitive assessment of peptide hormone variation
Olivia TysoeÂÂ
A mitochondrial trigger for beige adipocyte development
Shimona StarlingÂÂ
Co-agonist therapeutics come of age for obesity
Tricia M.-M. TanÂÂ
A spectacular year for islet and stem cell transplantation
A. M. James Shapiro & Kevin VerhoeffÂ
Energy intake at the intersection of the clock and ageing
Kristin Eckel-MahanÂÂ
Translational perspectives from TSHR, MCT8 and TRα research
Lars C. MoellerÂÂ
Approaches to addressing the rise in obesity levels
Caroline M. Apovian, Xi-Rong Guo, John A. Hawley, Shahzeer Karmali, Ruth J. F. Loos & Wilma E. WaterlanderÂ
doi : 10.1038/s41574-022-00777-1
Levels of obesity and overweight are increasing globally, with affected individuals often experiencing health issues and reduced quality of life. The pathogenesis of obesity is complex and multifactorial, and effective solutions have been elusive.
The role of insufficient sleep and circadian misalignment in obesity
Jean-Philippe Chaput, Andrew W. McHill, Rebecca C. Cox, Josiane L. Broussard, Caroline Dutil, Bruno G. G. da Costa, Hugues Sampasa-Kanyinga & Kenneth P. Wright JrÂ
doi : 10.1038/s41574-022-00747-7
Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activity, cannot fully explain the high prevalence of these conditions. Insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain and have received increased research attention in the past 10 years.
Exercise in adults with type 1 diabetes mellitus
Michael C. Riddell & Anne L. PetersÂ
doi : 10.1038/s41574-022-00756-6
Regular physical activity improves cardiometabolic and musculoskeletal health, helps with weight management, improves cognitive and psychosocial functioning, and is associated with reduced mortality related to cancer and diabetes mellitus.
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
Kerri Devine, Elisa Villalobos, Catriona J. Kyle, Ruth Andrew, Rebecca M. Reynolds, Roland H. Stimson, Mark Nixon & Brian R. WalkerÂ
doi : 10.1038/s41574-022-00745-9
Responses to hormones that act through nuclear receptors are controlled by modulating hormone concentrations not only in the circulation but also within target tissues. The role of enzymes that amplify or reduce local hormone concentrations is well established for glucocorticoid and other lipophilic hormones; moreover, transmembrane transporters have proven critical in determining tissue responses to thyroid hormones.
