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Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline
Ghada El-Hajj Fuleihan, Gregory A Clines, Mimi I Hu, Claudio Marcocci, M Hassan Murad, Thomas Piggott, Catherine Van Poznak, Joy Y Wu, Matthew T Drake
doi : 10.1210/clinem/dgac621
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Hypercalcemia of malignancy (HCM) is the most common metabolic complication of malignancies, but its incidence may be declining due to potent chemotherapeutic agents.
Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline
Anthony L McCall, David C Lieb, Roma Gianchandani, Heidemarie MacMaster, Gregory A Maynard, M Hassan Murad, Elizabeth Seaquist, Joseph I Wolfsdorf, Robin Fein Wright, Wojtek Wiercioch
doi : 10.1210/clinem/dgac596
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Hypoglycemia in people with diabetes is common, especially in those taking medications such as insulin and sulfonylureas (SU) that place them at higher risk. Hypoglycemia is associated with distress in those with diabetes and their families, medication nonadherence, and disruption of life and work, and it leads to costly emergency department visits and hospitalizations, morbidity, and mortality.
Patient and Physician Decisional Factors Regarding Hypercalcemia of Malignancy Treatment: A Novel Mixed-Methods Study
Aya Bassatne, Mohammad H Murad, Thomas Piggott, Matthew T Drake, Maya Rahme, Ghada El-Hajj Fuleihan
doi : 10.1210/clinem/dgac630
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Integrating shared decision making between patients and physicians and incorporating their values and preferences in the development of clinical practice guidelines (CPGs) is of critical importance to optimize CPG implementation and treatment adherence. This applies to many debilitating diseases, including hypercalcemia of malignancy (HCM).
A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on the Treatment of Hypercalcemia of Malignancy in Adults
Mohamed O Seisa, Tarek Nayfeh, Bashar Hasan, Mohammed Firwana, Samer Saadi, Ahmed Mushannen, Sahrish H Shah, Noora S Rajjoub, Magdoleen H Farah, Larry J Prokop, Zhen Wang, Ghada El-Hajj Fuleihan, Matthew T Drake, Mohammad Hassan Murad
doi : 10.1210/clinem/dgac631
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Hypercalcemia is a common complication of malignancy that is associated with high morbidity and mortality.
A Systematic Review Supporting the Endocrine Society Guidelines: Management of Diabetes and High Risk of Hypoglycemia
Victor D Torres Roldan, Meritxell Urtecho, Tarek Nayfeh, Mohammed Firwana, Kalpana Muthusamy, Bashar Hasan, Rami Abd-Rabu, Andrea Maraboto, Amjad Qoubaitary, Larry Prokop, David C Lieb, Anthony L McCall, Zhen Wang, Mohammad Hassan Murad
doi : 10.1210/clinem/dgac601
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Interventions targeting hypoglycemia in people with diabetes are important for improving quality of life and reducing morbidity and mortality.
DNA Methylation in Autoimmune Thyroid Disease
Nicole Lafontaine, Scott G Wilson, John P Walsh
doi : 10.1210/clinem/dgac664
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Graves disease and Hashimoto disease form part of the spectrum of autoimmune thyroid disease (AITD), to which genetic and environmental factors are recognized contributors. Epigenetics provides a potential link between environmental influences, gene expression, and thyroid autoimmunity.
Pancreas Transplantation: Current Challenges, Considerations, and Controversies
Jonathan A Fridell, Robert J Stratta, Angelika C Gruessner
doi : 10.1210/clinem/dgac644
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Pancreas transplantation (PTx) reestablishes an autoregulating source of endogenous insulin responsive to normal feedback controls. In addition to achieving complete β-cell replacement that frees the patient with diabetes from the need to monitor serum glucose and administer exogenous insulin, successful PTx provides counterregulatory hormone secretion and exocrine function.
Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
doi : 10.1210/clinem/dgac649
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Primary aldosteronism (PA) patients have a higher degree of arterial stiffness, which can be reversed after adrenalectomy.
Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas
Meng-si Liu, Zhao-yang Tian, Zhou Zhang, Fan Yang, Yuan Lou, Yi-jie Wang, Yang-jie Zeng, Zi-wei Zhang, Da-long Zhu, Ping Li
doi : 10.1210/clinem/dgac603
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Glucocorticoids have potent effects on the central nervous system. However, while patients with Cushing syndrome frequently report impairments in cognitive function, studies investigating cognitive function in patients with autonomous cortisol secretion (ACS) in adrenal incidentalomas (AIs) are scarce.
Tracking and Cumulative Lifetime Exposure to IGF-I in 6459 Healthy Individuals and in SGA Children Treated With GH
Anna Sophie L Kjaer, Rikke Beck Jensen, Jørgen H Petersen, Allan Linneberg, Line Lund Kårhus, Louise Scheutz Henriksen, Trine Holm Johannsen, Katharina M Main, Andrew R Hoffman, Anders Juul
doi : 10.1210/clinem/dgac605
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance
Morten Lyng Høgild, Astrid Johannesson Hjelholt, Jakob Hansen, Steen Bønløkke Pedersen, Niels Møller, Jørgen F P Wojtaszewski, Mogens Johannsen, Niels Jessen, Jens Otto Lunde Jørgensen
doi : 10.1210/clinem/dgac595
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain.
Low Gestational Weight Gain in Women With Gestational Diabetes Is Safe With Better Metabolic Profile Postpartum
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
doi : 10.1210/clinem/dgac599
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
More data are needed on the potential benefits and risks of gestational weight gain (GWG) less than recommended and excessive GWG in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT) during pregnancy.
Hyperinsulinemic Hypoglycemia Diagnosed in Childhood Can Be Monogenic
Jasmin J Hopkins, Alexandra J Childs, Jayne A L Houghton, Thomas I Hewat, Navoda Atapattu, Matthew B Johnson, Kashyap A Patel, Thomas W Laver, Sarah E Flanagan
doi : 10.1210/clinem/dgac604
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Congenital hyperinsulinism (HI) is characterized by inappropriate insulin secretion despite low blood glucose. Persistent HI is often monogenic, with the majority of cases diagnosed in infancy. Less is known about the contribution of monogenic forms of disease in those presenting in childhood.
Risk Modeling to Reduce Monitoring of an Autoantibody-Positive Population to Prevent DKA at Type 1 Diabetes Diagnosis
Colin O’Rourke, Alyssa Ylescupidez, Henry T Bahnson, Christine Bender, Cate Speake, Sandra Lord, Carla J Greenbaum
doi : 10.1210/clinem/dgac594
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 688–696
The presence of islet autoimmunity identifies individuals likely to progress to clinical type 1 diabetes (T1D). In clinical research studies, autoantibody screening followed by regular metabolic monitoring every 6 months reduces incidence of diabetic ketoacidosis (DKA) at diagnosis.
Implications of an HbA1c-based Diabetes Screening on Prevalence and Effect of Dysglycemia in Patients With COVID-19
Lukas Van Baal, Johanna Reinold, Sven Benson, Anke Diehl, Oliver Witzke, Dagmar Fuehrer, Susanne Tan
doi : 10.1210/clinem/dgac590
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 697–705
In patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%.
Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With PCOS in the United States
Katherine VanHise, Jessica L Chan, Sahar Wertheimer, Roy G Handelsman, Ekaterina Clark, Rae Buttle, Erica T Wang, Ricardo Azziz, Margareta D Pisarska
doi : 10.1210/clinem/dgac515
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Ongoing research is needed to determine geo-epidemiologic differences of polycystic ovary syndrome (PCOS).
Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China
Yiwen Liu, Fan Ping, Jie Yu, Lu Lv, Yuan Zhao, Mengya Qi, Wei Li, Lingling Xu, Miao Yu, Ming Li, Huabing Zhang, Yuxiu Li
doi : 10.1210/clinem/dgac578
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 713–717
Exogenous insulin antibody syndrome (EIAS) can lead to unexpected and potentially life-threatening recurrent hypoglycemia.
Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19
Marie E McDonnell, Rajesh Garg, Geetha Gopalakrishnan, Joanna Mitri, Ruth S Weinstock, Margaret Greenfield, Sai Katta, Jasmin Lebastchi, Nadine E Palermo, Ramya Radhakrishnan, Gregory P Westcott, Matthew Johnson, Donald C Simonson
doi : 10.1210/clinem/dgac587
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Diabetes or hyperglycemia at admission are established risk factors for adverse outcomes during hospitalization for COVID-19, but the impact of prior glycemic control is not clear.
Treatment of Cushing Disease With Pituitary-Targeting Seliciclib
Ning-Ai Liu, Anat Ben-Shlomo, John D Carmichael, Christina Wang, Ronald S Swerdloff, Anthony P Heaney, Garni Barkhoudarian, Daniel Kelly, Mazen Noureddin, Lin Lu, Manish Desai, Yana Stolyarov, Kevin Yuen, Adam N Mamelak, James Mirocha, Mourad Tighiouart, Shlomo Melmed
doi : 10.1210/clinem/dgac588
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 726–735
Preclinical studies show seliciclib (R-roscovitine) suppresses neoplastic corticotroph proliferation and pituitary adrenocorticotrophic hormone (ACTH) production.
Association of Complement C3 With Incident Type 2 Diabetes and the Mediating Role of BMI: A 10-Year Follow-Up Study
Jing Jiang, Hao Wang, Kang Liu, Shiqi He, Zhaoyang Li, Yu Yuan, Kuai Yu, Pinpin Long, Jing Wang, Tingyue Diao, Xiaomin Zhang, Meian He, Huan Guo, Tangchun Wu
doi : 10.1210/clinem/dgac586
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 736–744
Impairment of immune and inflammatory homeostasis is reported to be one of the causal factors of diabetes. However, the association of complement C3 levels with incident diabetes in humans remains unclear.
General Comorbidity Indicators Contribute to Fracture Risk Independent of FRAX: Registry-Based Cohort Study
Gregory A Kline, Suzanne N Morin, Lisa M Lix, Eugene V McCloskey, Helena Johansson, Nicholas C Harvey, John A Kanis, William D Leslie
doi : 10.1210/clinem/dgac582
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages 745–754
FRAX® estimates 10-year fracture probability from osteoporosis-specific risk factors. Medical comorbidity indicators are associated with fracture risk but whether these are independent from those in FRAX is uncertain.
Efficacy and Safety of Tyrosine Kinase Inhibitors in Patients with Metastatic Pheochromocytomas/Paragangliomas
Yue Zhou, Yunying Cui, Dingding Zhang, Anli Tong
doi : 10.1210/clinem/dgac657
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Tyrosine kinase inhibitors (TKIs) can be used to treat locally unresectable or distantly metastatic pheochromocytomas/paragangliomas (PPGLs), such as sunitinib, according to the National Comprehensive Cancer Network guidelines in 2022. However, the precise effect of different TKIs in metastatic PPGLs is still unclear.
Reduced Intestinal Calcium Absorption Correlates With Bone Loss After Sleeve Gastrectomy: Implications for Clinical Care
Claudia Gagnon
doi : 10.1210/clinem/dgac681
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages e32–e33
New Hope for a Tumor-Directed Therapy for Cushing Disease
Nicholas A Tritos
doi : 10.1210/clinem/dgac666
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages e34–e35
Metabolomics to Assess Thyroid Hormone Status?
Heleen I Jansen, Eveline Bruinstroop, Paul M Yen
doi : 10.1210/clinem/dgac655
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages e36–e37
Screening for Adverse Metabolic Consequences in Women With Idiopathic Hirsutism—Is it Relevant?
Anastasia Dimakopoulou, Sophie A Clarke, Channa N Jayasena
doi : 10.1210/clinem/dgac652
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023
Letter to the Editor From Sumi et al.: “Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compared to European Patients Receiving Hemodialysis�
Hirofumi Sumi, Kazuhiro Shiizaki, Naoto Tominaga
doi : 10.1210/clinem/dgac696
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages e40–e41
Response to Letter to the Editor From Sumi et al: “Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compared to European Patients Receiving Hemodialysis�
Hanne Skou Jørgensen, Pieter Evenepoel, Hirotaka Komaba, Sandro Mazzaferro, Marc Vervloet, Etienne Cavalier, Masafumi Fukagawa
doi : 10.1210/clinem/dgac698
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Pages e42–e43,
Correction to: “Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline�
doi : 10.1210/clinem/dgac737
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Page e44
Correction to “Clinical, Endocrine and Neuroimaging Findings in Girls With Central Precocious Puberty�
doi : 10.1210/clinem/dgac710
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Page e45
Correction to “Understanding Pathogenesis Intersects With Effective Treatment for Thyroid Eye Disease�
doi : 10.1210/clinem/dgac711
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Page e46
Correction to “Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism�
doi : 10.1210/clinem/dgac712
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 3, March 2023, Page e47,
