CKJ: Clinical Kidney Journal




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Renal artery stenting in the correct patients with atherosclerotic renovascular disease: time for a proper renal and cardiovascular outcome study?

Marieta P Theodorakopoulou, Artemios G Karagiannidis, Charles J Ferro, Alberto Ortiz, Pantelis A Sarafidis

doi : 10.1093/ckj/sfac140

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 201–204

Atherosclerotic renovascular disease (ARVD) represents the most common type of renal artery stenosis.

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Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification

Armando Luis Negri

doi : 10.1093/ckj/sfac224

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 205–209

Morbidity and mortality of chronic kidney disease (CKD) patients are largely associated with vascular calcification, an actively regulated process in which vascular smooth muscle cells (VSMCs) change into cells similar to osteocytes/chondrocytes, known as trans-differentiation.

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Peritoneal dialysis for acute kidney injury: back on the front-line

Brett Cullis

doi : 10.1093/ckj/sfac201

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 210–217

Peritoneal dialysis (PD) for acute kidney injury (AKI) has been available for nearly 80 years and has been through periods of use and disuse largely determined by availability of other modalities of kidney replacement therapy and the relative enthusiasm of clinicians

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PoCUS in nephrology: a new tool to improve our diagnostic skills

Gregorio Romero-González, Joaquin Manrique, María F Slon-Roblero, Faeq Husain-Syed, Rafael De la Espriella, Fiorenza Ferrari, Jordi Bover, Alberto Ortiz, Claudio Ronco

doi : 10.1093/ckj/sfac203

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 218–229

Point-of-Care Ultrasonography (PoCUS) aims to include a fifth pillar (insonation) in the classical physical examination in order to obtain images to answer specific questions by the clinician at the patient's bedside, allowing rapid identification of structural or functional abnormalities, enabling more accurate volume assessment and supporting diagnosis, as well as guiding procedures.

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Novel strategies in nephrology: what to expect from the future?

Sidar Copur, Cem Tanriover, Furkan Yavuz, Maria J Soler, Alberto Ortiz, Adrian Covic, Mehmet Kanbay

doi : 10.1093/ckj/sfac212

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 230–244

Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically.

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Age and the eGFR-dependent risk for adverse clinical outcomes

Ping Liu, Pietro Ravani

doi : 10.1093/ckj/sfac213

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 245–253

Although the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller.

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Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival

Mehmet Kanbay, Sidar Copur, Duygu Ucku, Carmine Zoccali

doi : 10.1093/ckj/sfac216

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 254–261

The effect of donor obesity on kidney transplantation success has long been an overlooked clinical research area. Even though there is no strict guideline in most countries prohibiting donation from obese individuals, most candidates with a body mass index >35–40 kg/m2 are rejected due to concerns regarding long-term renal functional deterioration in the donor.

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Hypoxia during maintenance hemodialysis—the critical role of pH

Scott McGuire, Nithya Krishnan, Abdul R Malik, Alex Waddell, Sophie L Russell, Francesca Denton, Stuart Ennis, Elizabeth Horton, Djordje Jakovljevic, Gordon McGregor

doi : 10.1093/ckj/sfac191

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 262–271

The impact and management of subclinical hypoxia during hemodialysis is a significant medical challenge. As key determinants of O2 availability and delivery, proposed mechanisms contributing to hypoxia include ischemia, alkalemia and pulmonary leukocyte sequestration

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Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury

Ander Vergara, Kaiming Wang, Daniele Colombo, Mahmoud Gheblawi, Jaslyn Rasmuson, Rupasri Mandal, Franca Del Nonno, Brian Chiu, James W Scholey, María José Soler, David S Wishart, Gavin Y Oudit

doi : 10.1093/ckj/sfac215

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 272–284

Angiotensin-converting enzyme 2 (ACE2), the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed in the kidneys.

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A prospective study on serum citrate levels and clinical correlations in patients receiving regional citrate anticoagulation

Harmony H M To, Arthur M C Kwan, Natalie Y Y Leung, W M Chan, C W Ngai, Alfred S K Wong, Polly N W Tsai, Tammy S K Ma, Irene Yam, Pauline Yeung Ng, Desmond Y H Yap

doi : 10.1093/ckj/sfac223

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 285–292

Current ways to diagnose citrate accumulation (CA) in patients receiving regional citrate anticoagulation (RCA) continuous renal replacement therapy (CRRT) are confounded by various clinical factors.

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A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease

Rajiv Agarwal, Bertram Pitt, Biff F Palmer, Csaba P Kovesdy, Ellen Burgess, Gerasimos Filippatos, Jolanta Małyszko, Luis M Ruilope, Patrick Rossignol, Peter Rossing, Roberto Pecoits-Filho, Stefan D Anker, Amer Joseph, Robert Lawatscheck, Daniel Wilson, Martin Gebel, George L Bakris

doi : 10.1093/ckj/sfac234

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 293–302

Mineralocorticoid receptor antagonists (MRAs) reduce systolic blood pressure (SBP) and increase serum potassium concentration ([K+]). This indirect comparison investigated any differences in SBP-lowering and hyperkalemia risk between finerenone, a nonsteroidal MRA, and the steroidal MRA spironolactone ± a potassium binder.

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Prevalence of anaemia in adults with chronic kidney disease in a representative sample of the United States population: analysis of the 1999–2018 National Health and Nutrition Examination Survey

Csaba P Kovesdy, Jill R Davis, Ian Duling, Dustin J Little

doi : 10.1093/ckj/sfac240

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 303–311

Population-based estimates of anaemia prevalence in patients with chronic kidney disease (CKD) vary, and data on the prevalence of severe anaemia of CKD are limited. This study examined the prevalence of anaemia and anaemia eligible for erythropoiesis-stimulating agent (ESA) treatment in patients with CKD in the USA.

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Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019

Yang Li, Yichun Ning, Bo Shen, Yiqin Shi, Nana Song, Yi Fang, Xiaoqiang Ding

doi : 10.1093/ckj/sfac218

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 312–321

This study aimed to characterize the temporal trends of chronic kidney disease (CKD) burden in China during 1990–2019, evaluate their age, period and cohort effects, and predict the disease burden for the next 10 years.

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2009 CKD-EPI glomerular filtration rate estimation in Black individuals outside the United States: a systematic review and meta-analysis

Carolina Pires Zingano, Gustavo Monteiro Escott, Bruna Martins Rocha, Indianara Franciele Porgere, Candice Cristine Moro, Pierre Delanaye, Sandra Pinho Silveiro

doi : 10.1093/ckj/sfac238

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 322–330

The 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is the most used equation to estimate glomerular filtration rate (GFR), with race being a factor thereof, increasing GFR by 16% in self-identified Black persons compared with non-Black persons.

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Collaboration between local nephrologists and the transplant centre ensures good outcomes in post-transplant care

Yves L Kaufmann, Seraina von Moos, Tahm Spitznagel, Laurenz S Matter, Thomas F Mueller, Thomas Schachtner

doi : 10.1093/ckj/sfac232

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 331–341

Despite substantial improvements in short-term kidney allograft survival, median long-term survival remains at a standstill. It is unclear whether and to what extent a transplant centre’s post-transplant care influences long-term outcomes.

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Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization

Benjamin M Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J Ferro, Thomas A Jackson, Adnan Sharif

doi : 10.1093/ckj/sfac241

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 342–354

Frailty and depression are highly prevalent in haemodialysis recipients, exhibit a reciprocal relationship, and are associated with increased mortality and hospitalization, and lower quality of life.

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The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait

Hamad Ali, Medhat Naim, Sarah R Senum, Ali AlSahow, Yousif Bahbahani, Mohamed Abu-Farha, Jehad Abubaker, Anwar Mohammad, Adel Al-Hunayan, Akram M Asbeutah, Mohamed Zayed, Sriraman Devarajan, Naser Hussain, Sumi Elsa John, Arshad Channanath, Thangavel Alphonse Thanaraj, Mohammad Al-Ali, Mustafa AlMousawi, Fahd Al-Mulla, Peter C Harris

doi : 10.1093/ckj/sfac236

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 355–366

Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disease, characterized by bilateral accumulation of renal fluid-filled cysts leading to progressive renal volume enlargement and gradual impairment of kidney function, often resulting in end-stage renal disease.

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Renal arcuate vein thrombosis–induced acute kidney injury: a rare multiple-Hit–mediated disease

Clara Pardinhas, Rui Filipe, Paul Vergnaud, Mathilde Grapin, Elsa Ferrière, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Pérot, Olivia Boyer, Marion Rabant, Jean-Paul Duong Van Huyen, Pierre Isnard

doi : 10.1093/ckj/sfac244

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 367–373

Renal arcuate vein thrombosis (RAVT) is a rare and recently recognized cause of acute kidney injury (AKI) in young adults. However, the precise incidence and underlying pathophysiologic mechanisms leading to AKI in these patients remain elusive.

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Acute and chronic kidney disease and risk of hospital mortality during COVID-19 pandemic waves in the pre-vaccination era

José Portolés, Paula López-Sánchez, Leyre Martin-Rodríguez, María Luisa Serrano-Salazar, Maria Valdenebro-Recio, Antonio Ramos, Rosa María Malo, Felipe Zalamea, Juan Manuel Martin-Giner, María Marques, Alberto Ortiz

doi : 10.1093/ckj/sfac239

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 374–383

Chronic kidney disease (CKD) is a risk factor for death from coronavirus disease 2019 (COVID-19), and COVID-19 may cause acute kidney injury (AKI) which also influences outcomes.

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Microvascular perfusion, perfused boundary region and glycocalyx shedding in patients with autosomal dominant polycystic kidney disease: results from the GlycoScore III study

Alexander Fuchs, Jennifer Dederichs, Sita Arjune, Polina Todorova, Fabian Wöstmann, Philipp Antczak, Anja Illerhaus, Birgit Gathof, Franziska Grundmann, Roman-Ulrich Müller, Thorsten Annecke

doi : 10.1093/ckj/sfac229

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 384–393

Vascular abnormalities and endothelial dysfunction are part of the spectrum of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms behind these manifestations, including potential effects on the endothelial surface layer (ESL) and glycocalyx integrity, remain unknown.

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Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections

Chau Wei Ling, Kamal Sud, Rahul P Patel, Gregory M Peterson, Ronald L Castelino

doi : 10.1093/ckj/sfac131

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 394–395

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Reply to ‘Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections’

David W Johnson, Simon Wai Yin So, Philip Kam-Tao Li

doi : 10.1093/ckj/sfac132

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Page 396

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Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C?

Viola D'Ambrosio, Pietro Manuel Ferraro, Valeria Guglielmino, Marco Luigetti

doi : 10.1093/ckj/sfac156

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 397–398

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Reply to ‘Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C?’

Justine Solignac, Noémie Jourde-Chiche

doi : 10.1093/ckj/sfac157

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Page 399

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No difference in mortality after three different kidney replacement therapy initiation strategies in acute kidney injury

Jia-Jin Chen, George Kuo, Tao Han Lee, Chih-Hsiang Chang

doi : 10.1093/ckj/sfac231

Clinical Kidney Journal, Volume 16, Issue 2, February 2023, Pages 400–402

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