Radiotherapy and Oncology




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Editorial Board

doi : 10.1016/S0167-8140(23)00008-7

Volume 178, January 2023, 109470

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Introducing article numbering to Radiotherapy and Oncology

doi : 10.1016/j.radonc.2023.109477

Volume 178, January 2023, 109477

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Sexual dysfunction in female patients with anal cancer treated with curative intent: A systematic review of the literature

Javier Mejia-Gomez a , Irina Petrovic b , Mary Doherty c , Erin Kennedy d,e,f , Wendy Wolfman g , Michelle Jacobson h , Christine Brezden i , Eleni Philippopoulos j , Jelena Lukovic

doi : 10.1016/j.radonc.2022.109437

Volume 178, January 2023, 109437

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Clues to address barriers for access to proton therapy in the Netherlands

Salina V. Thijssen a , Liesbeth J. Boersma a , Luca Heising a,b , Rachelle R. Swart a , Carol X. J. Ou b , Cheryl Roumen d , Maria J. G. Jacobs

doi : 10.1016/j.radonc.2022.11.021

Volume 178, January 2023, 109432

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Radiotherapy-specific quality indicators at national level: How to make it happen

Aude Vaandering a,b,⇑, Nicolas Jansen c , Caroline Weltens d , Luigi Moretti e , Karin Stellamans f , Frederik Vanhoutte g , Pierre Scalliet b , Vincent Remouchamps h , Yolande Lievens g , On behalf of the Belgian College for Physicians in Radiation Oncology

doi : 10.1016/j.radonc.2022.11.022

Volume 178, January 2023, 109433

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Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients

Jan Eulitz a,b , Esther G. C. Troost a,b,c,d,e , Lauritz Klünder f , Felix Raschke b , Christian Hahn a,c,f , Erik Schulz c , Annekatrin Seidlitz a,b,c,d,e , Justus Thiem a,b,c,d,e , Caroline Karpowitz a,b,c,d,e , Patricia Hahlbohm a,g , Arne Grey d,e,g , Kay Engellandt d,e,g , Steffen Löck a,b,c,d,e , Mechthild Krause a,b,c,d,e , Armin Lühr

doi : 10.1016/j.radonc.2022.11.011

Volume 178, January 2023, 109422

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Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer

Jelena Lukovic a,b,⇑, Ali Hosni a,b , Amy Liu c , Jasmine Chen a , Tony Tadic a,b , Tirth Patel d , Kecheng Li c , Kathy Han a,b , Patricia Lindsay a,b , Tim Craig a,b , James Brierley a,b , Aisling Barry a,b , Rebecca Wong a,b , Jolie Ringash a,b , Laura A. Dawson a,b , John J. Kim

doi : 10.1016/j.radonc.2022.11.018

Volume 178, January 2023, 109429

This study investigates the impact of dosimetric parameters on acute and late toxicity for patients with anal squamous cell carcinoma (SCC) treated with image-guided intensity modulated radiation therapy (IG-IMRT) and concurrent chemotherapy.

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The role of radiologic extranodal extension in predicting prognosis and chemotherapy benefit for T1-2 N1 nasopharyngeal carcinoma: A multicenter retrospective study

Yu-Jun Hu a,1 , Tian-Zhu Lu b,c,d,1 , Qiao-Juan Guo e,f,1 , Lin Zhang b,c,1 , You-Ping Xiao g , Shao-Jun Lin e,f , Han Zhou e , De-Chun Zheng g , Shi-Rong Ding a , Li-Zhi Liu h , Xiao-Chang Gong b,c,d , Jin-Gao Li b,c,d,⇑, Jian-Ji Pan e,f,⇑, Yun-Fei Xia a,⇑

doi : 10.1016/j.radonc.2022.11.025

Volume 178, January 2023, 109436

This multicenter retrospective study aimed to investigated the prognostic value of unequivocal radiologic extranodal extension (rENE) and the efficacy of chemotherapy for stage T1-2 N1 nasopharyngeal carcinoma (NPC) in the IMRT era.

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Comparison of induction chemotherapy combined with concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in Lymph-Node-Stage III nasopharyngeal carcinoma based on propensity score-matching

Zhi-Cheng Liu a,b , Ke-Hao Zeng b , Zhen-Bang Gu b , Run-Pu Chen b , Yi-Jing Luo b , Lin-Quan Tang c,d,e , Kai-Bin Zhu a,f,g , Yan Liu a,f,g , Xue-Song Sun c,d,e,⇑, Lei Zeng

doi : 10.1016/j.radonc.2022.11.010

Volume 178, January 2023, 109421

To explore the role of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients diagnosed with N3 nasopharyngeal carcinoma (NPC).

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The feasibility of reduced-dose radiotherapy in childhood nasopharyngeal carcinoma with favorable response to neoadjuvant chemotherapy

Ji-Jin Yao a,b,1 , Ya-Nan Jin b,1 , Yu-Jing Lin c,1 , Wang-Jian Zhang d , Tia Marks e , Ian Ryan e , Hong-Yu Zhang b,⇑, Liang-Ping Xia

doi : 10.1016/j.radonc.2022.11.003

Volume 178, January 2023, 109414

To assess the feasibility of adjusting radiation dose (RD) in childhood NPC with favorable tumor response after neoadjuvant chemotherapy (NAC).

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Post-irradiation sarcoma after definitive radiation therapy for nasopharyngeal carcinoma

Wan-Yu Chen a,b , Szu-Huai Lu a , Yu-Ming Wang c , Chun-Wei Wang a,d,e , Ku-Hao Fang f , Shih-Fan Lai a,b , Hsiang-Kuang Liang a,b , Bing-Shen Huang

doi : 10.1016/j.radonc.2022.11.012

Volume 178, January 2023, 109423

Postirradiation sarcoma (PIS) is a rare radiation-induced malignancy after nasopharyngeal carcinoma (NPC) treatment.

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Failure patterns for thymic carcinoma with completed resection and postoperative radiotherapy

Yan Gao a,b,1 , Xingwen Fan a,c,d,e,1,⇑, Chuanli Hua a,f,1 , Hong Zheng a,g , Yingshan Cui a,h , Yaqi Li a,c,d,e , Kailiang Wu a,c

doi : 10.1016/j.radonc.2022.109438

Volume 178, January 2023, 109438

We aimed to evaluate the pattern and risk factors of disease failure in patients with thymic carcinoma after complete resection and postoperative radiotherapy (PORT).

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Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study

Philipp Heumann a , Miguel E. Aguado-Barrera b,c , Barbara Avuzzi d , David Azria e , Erik Briers f , Renée Bultijnck g,h , Ananya Choudhury i , Dirk De Ruysscher j , Marie-Pierre Farcy-Jacquet k , Valérie Fonteyne g,h , Antonio Gómez Caamaño b,l , Irmgard Helmbold a , Kerstie Johnson m , Sarah L. Kerns n , Maarten Lambrecht o , Zoe Lingard i , Tiziana Rancati p , Barry S. Rosenstein q , Elena Sperk r , R. Paul Symonds m , Christopher Talbot m , Riccardo Valdagni d,s,t , Ana Vega b,c,u , Liv Veldeman g,h , Tim Ward v , Adam Webb m , Catharine M. West i , Jenny Chang-Claude a,w , Petra Seibold a,⇑, on behalf of the REQUITE Consortium

doi : 10.1016/j.radonc.2022.11.015

Volume 178, January 2023, 109426

Previous studies showed that healthcare professionals and patients had only moderate to low agreement on their assessment of treatment-related symptoms. We aimed to determine the levels of agreement in a large cohort of prostate cancer patients.

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Excellent treatment outcomes from low dose radiation therapy for primary cutaneous CD4+ small/medium T-Cell lymphoproliferative disorder

Jennifer Ward a,⇑, H. Miles Prince b,e , Chris McCormack c,e , Stephen Lade d , Odette Buelens b , Carrie van der Weyden b , Friyana Bhabha c , Belinda A. Campbell

doi : 10.1016/j.radonc.2022.11.019

Volume 178, January 2023, 109430

Primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a benign behaving condition, typically manifesting as solitary head or neck papules, frequently creating cosmetic concerns. Optimal management of this rare disease is unclear. Herein, patterns of care and treatment outcomes are described, with particular focus on low-dose RT.

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Prospective imaging comparison of anatomic delineation with rapid kV cone beam CT on a novel ring gantry radiotherapy device

Lauren E. Henke a , Benjamin W. Fischer-Valuck a , Soumon Rudra b , Leping Wan a , Pamela S. Samson a , Amar Srivastava a , Prashant Gabani a , Michael C. Roach c , Imran Zoberi a , Eric Laugeman a , Sasa Mutic a,e , Clifford G. Robinson a , Geoffrey D. Hugo a , Bin Cai d , Hyun Kim a,⇑

doi : 10.1016/j.radonc.2022.11.017

Volume 178, January 2023, 109428

A kV imager coupled to a novel, ring-gantry radiotherapy system offers improved on-board kV-cone-beam computed tomography (CBCT) acquisition time (17–40 seconds) and image quality, which may improve CT radiotherapy image-guidance and enable online adaptive radiotherapy.

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Brain metastases from NSCLC treated with stereotactic radiotherapy: prediction mismatch between two different radiomic platforms

Gianluca Carloni a,b,c,1,3 , Cristina Garibaldi d,1 , Giulia Marvaso a,e , Stefania Volpe a,e , Mattia Zaffaroni a,⇑, Matteo Pepa a,3 , Lars Johannes Isaksson a,e , Francesca Colombo a,e , Stefano Durante a , Giuliana Lo Presti f,3 , Sara Raimondi f , Lorenzo Spaggiari e,g , Filippo de Marinis h , Gaia Piperno a , Sabrina Vigorito i , Sara Gandini f , Marta Cremonesi d , Vincenzo Positano c,l,2 , Barbara Alicja Jereczek-Fossa

doi : 10.1016/j.radonc.2022.11.013

Volume 178, January 2023, 109424

Radiomics enables the mining of quantitative features from medical images. The influence of the radiomic feature extraction software on the final performance of models is still a poorly understood topic.

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Development and external validation of an MRI-based neural network for brain metastasis segmentation in the AURORA multicenter study

Josef A. Buchner a,1,⇑, Florian Kofler b,c,d,e,1 , Lucas Etzel a,f , Michael Mayinger g , Sebastian M. Christ g , Thomas B. Brunner h , Andrea Wittig i , Björn Menze b , Claus Zimmer c , Bernhard Meyer j , Matthias Guckenberger g , Nicolaus Andratschke g , Rami A. El Shafie k,l,m , Jürgen Debus k,l , Susanne Rogers n , Oliver Riesterer n , Katrin Schulze o , Horst J. Feldmann o , Oliver Blanck p , Constantinos Zamboglou q,r,s , Konstantinos Ferentinos s , Robert Wolff t,u , Kerstin A. Eitz a,f,v , Stephanie E. Combs a,f,v , Denise Bernhardt a,f , Benedikt Wiestler c,d,1 , Jan C. Peeken

doi : 10.1016/j.radonc.2022.11.014

Volume 178, January 2023, 109425

Stereotactic radiotherapy is a standard treatment option for patients with brain metastases. The planning target volume is based on gross tumor volume (GTV) segmentation. The aim of this work is to develop and validate a neural network for automatic GTV segmentation to accelerate clinical daily routine practice and minimize interobserver variability.

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External validation of a CT-based radiomics signature in oropharyngeal cancer: Assessing sources of variation

Philipp Guevorguian a,b , Tricia Chinnery a,b , Pencilla Lang c , Anthony Nichols d , Sarah A. Mattonen

doi : 10.1016/j.radonc.2022.11.023

Volume 178, January 2023, 109434

Radiomics is a high-throughput approach that allows for quantitative analysis of imaging data for prognostic applications. Medical images are used in oropharyngeal cancer (OPC) diagnosis and treatment planning and these images may contain prognostic information allowing for treatment personalization.

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Letter regarding “The clinical efficacy of low-dose whole-lung irradiation in moderate-to-severe COVID-19 pneumonia: RTMX-20 trial�

Zheng Li a,b,1 Yue Hu c,1 Qiang Li

doi : 10.1016/j.radonc.2022.11.009

Volume 178, January 2023, 109420

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In response to Topkan E. et al. letter (Radiother Oncol. 2022;174:132. https://doi.org/10.1016/j.radonc.2022.07.017)

Nicola Dinapoli Mariangela Massaccesi

doi : 10.1016/j.radonc.2022.11.016

Volume 178, January 2023, 109427

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Letter to the editor regarding “The dosimetric and clinical advantages of the GTV-CTV-PTV margins reduction by 6 mm in head and neck squamous cell carcinoma: Significant acute and late toxicity reduction�

Guang-ping ZengRui SunZhenguo Zhao

doi : 10.1016/j.radonc.2022.109442

Volume 178, January 2023, 109442

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