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Overcoming Challenges of Deceased Organ Donation in Indian Private Hospitals.
Seth, Avnish Kumar MBBS, MD, DM 1; Pandit, Rahul MBBS, MD, FCICM 2; Gopashetty, Mahesh MBBS, MS, MRCS 3; Rajarathinam, Buddhan MBBS, MD, EDIC, IDCCM 4; Saseedharan, Sanjith MBBS, EDIC, DA, MD 5; Prakash, Om MBBS, DA 1; Chauhan, Munish MBBS, MD, FNB, EDIC 1; Sharma, Gauri Shankar MBBS, MD, FRCP 6; Sircar, Mrinal MBBS, MD, DNB, EDIC, EDARM 7; Paliwal, Yashesh MBBS, MD, FRCA, EDIC 8; Gore, Sudhir B. MBBS, DA, IDCCM 9; Mahay, Harjit Singh MBBS, MD, EDIC 10; Joad, Shabbar H.K. MBBS, MD, FNB-CCM, IDCCM 11; Dhir, Jasrita BA, MBA, AMPH 12; Lal, Sukhvinder BA, MSW 1; Singh, Twinkle BSc, MBA 1
doi : 10.1097/TP.0000000000004229
Volume 107(2) pgs. 283-547,e45-e73 February 2023
Research Highlights.
Atallah, Nora MSc 1; Beckett, Joseph MBiol 1; Issa, Fadi DPhil, FRCS (Plast) 1
Acute Inflammatory Recovery-A Matter of Sophisticated Interaction of Two Cell Populations?.
Heim, Christian MD 1; Ensminger, Stephan MD, DPhil 2
Achieving Equity in Organ Transplantation: Recommendations for Action Based on the National Academies of Sciences, Engineering, and Medicine Report.
Dageforde, Leigh Anne MD, MPH 1,2; English, Rebecca A. MPH 3; Kizer, Kenneth W. MD, MPH 4
doi : 10.1097/TP.0000000000004464
AB The United States organ transplantation system has recently reached a historic milestone of a cumulative 1 million transplants. Despite this considerable success in providing life-saving organ transplants to patients with end organ failure, there are ample opportunities for improvement, particularly with regard to achieving equity.
The Destiny of Articles When Pairing "Traditional"-With Open Access Sibling Journals.
van den Berg, Tamar A.J. MD 1; Benjamens, Stan MD, PhD 1,2; Bakker, Stephan J.L. MD, PhD 3; Chapman, Jeremy R. MD, PhD 4; Geissler, Edward K. MD, PhD 5; Pol, Robert A. MD, PhD 1
Monkeypox a Concern for Donor-derived Infection?.
Boan, Peter MBBS, FRACP, FRCPA 1,2
Intragraft B Cells, Just Not Like the Others.
Zorn, Emmanuel PhD 1
Commentary on "Lung Transplantation for COVID-19 Pulmonary Sequelae": Beautiful Story, Already History?.
Zappella, Nathalie MD 1; Montravers, Philippe MD, PhD 1,2
Replacing the Endomyocardial Biopsy: Easier Said Than Done.
Baran, David A. MD 1
Amelioration of Diabetes and Neuropathy After Pancreas Transplantation: Measurable Differences in Vibration Perception Thresholds Impact Outcomes.
Parsons, Ronald F. MD 1
In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Determination Death: Organ Utilization, Outcomes, and Elusiveness of a Randomized Clinical Trial.
Hessheimer, Amelia J. MD, PhD 1
Current Status of ABO-incompatible Liver Transplantation.
Egawa, Hiroto MD, PhD 1; Ohdan, Hideki MD, PhD 2; Saito, Kazuhide MD, PhD 3
doi : 10.1097/TP.0000000000004250
AB By 2014, strategies to prevent antibody-mediated rejection (AMR) after ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) were established in Japan and expanded primarily to Asia, where LDLT is now the predominant form of LT owing to the scarcity of brain-dead donors.
Abdominal Organ Preservation Solutions in the Age of Machine Perfusion.
Ramos, Pedro MD 1; Williams, Paul MD 2; Salinas, Javier MD, PhD 1,3; Vengohechea, Jordi BS 3,4; Lodge, J. Peter A. MD, PhD 2; Fondevila, Constantino MD, PhD 1,3,5; Hessheimer, Amelia J. MD, PhD 1,3,5
doi : 10.1097/TP.0000000000004269
AB The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs. Perfusion is dynamic and offers several advantages in comparison with static cold storage.
Biomarkers for Chronic Lung Allograft Dysfunction: Ready for Prime Time?.
Verleden, Stijn E. PhD 1,2,3; Hendriks, Jeroen M.H. MD, PhD 1,2; Lauwers, Patrick MD 1,2; Yogeswaran, Suresh Krishan MD 1,2; Verplancke, Veronique MD 3; Kwakkel-Van-Erp, Johanna M. MD, PhD 3,4
doi : 10.1097/TP.0000000000004270
AB Chronic lung allograft dysfunction (CLAD) remains a major hurdle impairing lung transplant outcome. Parallel to the better clinical identification and characterization of CLAD and CLAD phenotypes, there is an increasing urge to find adequate biomarkers that could assist in the earlier detection and differential diagnosis of CLAD phenotypes, as well as disease prognostication.
Desensitization in Crossmatch-positive Kidney Transplant Candidates.
Noble, Johan MD 1,2; Jouve, Thomas MD, PhD 1,2; Malvezzi, Paolo MD 1; Rostaing, Lionel MD, PhD 1,2,3
doi : 10.1097/TP.0000000000004279
AB Access to kidney transplantation is limited by HLA-specific sensitization. Desensitization strategies enable crossmatch-positive kidney transplantation. In this review, we describe clinical experience gained over the last 20 y using desensitization strategies before kidney transplantation and describe the different tools used (both drugs and apheresis options), including IVIg, rituximab, apheresis techniques, interleukin-6 interference, proteasome inhibition, enzymatic degradation of HLA antibodies, complement inhibition, and B cytokine interference. Although access to transplantation for highly sensitized kidney transplantation candidates has been vastly improved by desensitization strategies, it remains, however, limited by the recurrence of HLA antibodies after transplantation and the occurrence of antibody-mediated rejection. Copyright (C) 2023 Wolters Kluwer Health, Inc. All rights reserved.
Heart Transplantation From DCD Donors in Australia: Lessons Learned From the First 74 Cases.
Joshi, Yashutosh MBBS 1,2,3; Scheuer, Sarah MD 1,2,3; Chew, Hong PhD 1,2,3; Ru Qiu, Min PhD 3,4; Soto, Claudio MSc 1,5; Villanueva, Jeanette PhD 2; Gao, Ling PhD 2; Doyle, Aoife MSc 2; Takahara, Shingo PhD 1; Jenkinson, Charles MBBS 1; Vaidhya, Nikunj MS 1; Matsumoto, Yorihiko MD 1; Hwang, Bridget BMed, MD 3; Zhao, Christine MD 3; Iyer, Arjun PhD 1,2,3; Connellan, Mark MBBS 1; Watson, Alasdair PhD 1; Granger, Emily MBBS 1; Muthiah, Kavitha PhD 1; Jabbour, Andrew PhD 1; Kotlyar, Eugene PhD 1; Keogh, Anne MD 1; Bart, Nicole K. PhD 1,2,3; Hayward, Chris MD 1; Dhital, Kumud PhD 1,2,3; Jansz, Paul PhD 1,2; Macdonald, Peter S. PhD 1,2,3
doi : 10.1097/TP.0000000000004294
AB Heart transplantation from donation after circulatory death (DCD) donors has the potential to substantially increase overall heart transplant activity. The aim of this report is to review the first 8 y of our clinical heart transplant program at St Vincent's Hospital Sydney, to describe how our program has evolved and to report the impact that changes to our retrieval protocols have had on posttransplant outcomes.
TIGIT-Fc Prolongs Corneal Allograft Survival in Mice by Upregulating TIGIT/CD226 Expression and the Proportion of Helios+Foxp3+ Treg Cells.
Li, Shang MD, PhD 1; Zhang, Peng BSMed 1; Li, Ao BSMed 1; Bao, Jiayu DS, PhD 1; Pan, Zhiqiang MD, PhD 1; Jie, Ying MD, PhD 1
doi : 10.1097/TP.0000000000004257
AB Background. Reduction of graft rejection remains key issue for supporting long-term graft retention after corneal transplantation. The relevance of Treg in reduction of corneal allografts rejection has been demonstrated.
P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients.
Udomkarnjananun, Suwasin MD 1,2,3; Francke, Marith I. BSc 1,2; Dieterich, Marjolein BSc 1; van De Velde, Daan BSc 4; Litjens, Nicolle H.R. PhD 1,2; Boer, Karin PhD 1,2; De Winter, Brenda C.M. PharmD, PhD 2,4; Baan, Carla C. PhD 1,2; Hesselink, Dennis A. MD, PhD 1,2
doi : 10.1097/TP.0000000000004287
Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0.
The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice.
Zou, Zhimiao MD 1,2,3,4; Shang, Runshi MS 1,2,3,4; Zhou, Liang MS 1,2,3,4; Du, Dunfeng PhD 1,2,3,4; Yang, Yang MD 1,2,3,4; Xie, Yalong MD 1,2,3,4; Li, Zeyang MD 1,2,3,4; Zhao, Minghui MS 1,2,3,4; Jiang, Fengchao PhD 5; Zhang, Limin PhD 1,2,3,4; Zhou, Ping PhD 1,2,3,4
doi : 10.1097/TP.0000000000004317
With the development of medical technology and increased surgical experience, the number of patients receiving liver transplants has increased. However, restoration of liver function in patients is limited by the occurrence of hepatic ischemia-reperfusion injury (IRI).
Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation.
Zhang, Hengcheng MD, PhD 1; Cavazzoni, Cecilia B. PhD 1; Hanson, Benjamin L. 1; Bechu, Elsa D. 1; Podesta, Manuel A. MD 1,2; Azzi, Jamil MD 1; Blazar, Bruce R. MD 3; Chong, Anita S. PhD 4; Kreisel, Daniel MD, PhD 5; Alessandrini, Alessandro PhD 6; Sage, Peter T. PhD 1
doi : 10.1097/TP.0000000000004398
Following allogeneic kidney transplantation, a substantial proportion of graft loss is attributed to the formation of donor-specific antibodies and antibody-mediated rejection.
Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome.
Kwong, Allison J. MD, MS 1; Kim, W. Ray MD 1,2; Lake, John MD 2,3; Stock, Peter G. MD, PhD 2,4; Wang, Connie J. MD 5; Wetmore, James B. MD, MS 5; Melcher, Marc L. MD, PhD 6; Wey, Andrew PhD 2; Salkowski, Nicholas PhD 2; Snyder, Jon J. PhD, MS 2,7; Israni, Ajay K. MD, MS 2,5,7
doi : 10.1097/TP.0000000000004291
The Scientific Registry of Transplant Recipients (SRTR) had not traditionally considered biopsy results in risk-adjustment models, yet biopsy results may influence outcomes and thus decisions regarding organ acceptance.
Nodular Regenerative Hyperplasia Is Not a Rare Condition After Liver Transplantation: Incidence, Predictive Factors, and Impact on Survival.
Kounis, Ilias MD 1,2,3,4; Sebagh, Mylene MD 2,3,4,5; Evain, Manon MD 1; Cailliez, Valerie 1,2,3,4; Roche, Bruno MD 1,2,3,4; De Martin, Eleonora MD, PhD 1,2,3,4; Sobesky, Rodolphe MD, PhD 1,2,3,4; Guettier, Catherine MD, PhD 2,3,4,5; Allard, Marc Antoine MD, PhD 1,2,3,4; Golse, Nicolas MD, PhD 1,2,3,4; Azoulay, Daniel MD, PhD 1,2,3,4; Vibert, Eric MD, PhD 1,2,3,4; Duclos Vallee, Jean Charles MD, PhD 1,2,3,4; Feray, Cyrille MD, PhD 1,2,3,4; Samuel, Didier MD, PhD 1,2,3,4; Coilly, Audrey MD, PhD 1,2,3,4
Personality Traits in Patients With Cirrhosis Are Different From Those of the General Population and Impact Likelihood of Liver Transplantation.
Thuluvath, Avesh J. MD 1,2; Siddiqui, Osama BS 1; Lai, Jennifer C. MD, MBA 3; Peipert, John PhD 1,4; Levitsky, Josh MD, MS 2; Daud, Amna MBBS, MPH 1; Mazumder, Nikhilesh R. MD, MPH 1,2; Flores, Anne-Marie PT, PhD 1; Borja-Cacho, Daniel MD 1,5; Caicedo, Juan C. MD 1,5; Loftus, Corinne BS 1; Wong, Randi BS 3; Mroczek, Dan PhD 4,6; Ladner, Daniela P. MD, MPH 1,4,5
doi : 10.1097/TP.0000000000004304
Personality traits influence clinical outcomes in chronic diseases, but their impact in cirrhosis is unknown. We studied the personality of patients with cirrhosis undergoing liver transplant (LT) evaluation and determined their correlation to clinical outcomes.
The Conundrum of Patients With Compensated Cirrhosis Requiring Kidney Transplantation; Kidney Alone or Simultaneous Liver Kidney Transplantation.
Dodge, Jennifer L. MPH 1,2; Lee, Brian T. MD 3; Kassem, Ali Casey Z. MD 4; Biggins, Scott W. MD 5; Rana, Prachi A. MD 3; Nadim, Mitra K. MD 6; Asrani, Sumeet K. MD, MS 4; Fong, Tse-Ling MD 1,7
doi : 10.1097/TP.0000000000004311
Patients with compensated cirrhosis and chronic kidney disease are increasing along with demand for simultaneous liver kidney transplant (SLKT) and shortages of organs for transplantation.
Improved Organ Utilization and Better Transplant Outcomes With In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Death.
Oniscu, Gabriel C. MD 1,,2; Mehew, Jennifer PhD 3; Butler, Andrew J. MChir 4,,5; Sutherland, Andrew DPhil 1,,2; Gaurav, Rohit MS 5; Hogg, Rachel MSc 3; Currie, Ian PhD 1,,2; Jones, Mark MSc 3; Watson, Christopher J.E. MD 4,,5
doi : 10.1097/TP.0000000000004280
We evaluated whether the use of normothermic regional perfusion (NRP) was associated with increased organ recovery and improved transplant outcomes from controlled donation after circulatory death (cDCD).
Lung Transplantation for COVID-19 Pulmonary Sequelae.
Kehara, Hiromu MD, PhD 1; Mangukia, Chirantan MD 1; Sunagawa, Gengo MD 1; Iturra, Sebastian A. MD 1; Yanagida, Roh MD, PhD 1; Kashem, Mohammed MD, PhD 1; Persidsky, Yuri MD, PhD 2; Shenoy, Kartik MD 3; Mamary, Albert J. MD 3; Marchetti, Nathaniel DO 3; Cordova, Francis MD 3; Criner, Gerard J. MD 3; Toyoda, Yoshiya MD, PhD 1; Shigemura, Norihisa MD, PhD 1,3
doi : 10.1097/TP.0000000000004428
The role of lung transplantation for coronavirus disease 2019 (COVID-19)-related lung failure is evolving as the pandemic persists. Methods. From January 2021 to April 2022, 20 patients (median age 62 y; range 31-77) underwent lung transplantation for COVID-related lung failure at our institution. We reviewed their clinical and intraoperative characteristics and early outcomes including postoperative complications.
Dynamics of Humoral and Cellular Responses in Renal Transplant Recipients Receiving 3 Doses of SARS-CoV-2 mRNA Vaccine.
Arias-Cabrales, Carlos PhD 1; Folgueiras, Montserrat BS 1; Faura, Anna BSN 1; Eguia, Jorge BPharm 2; Padilla, Eduardo BPharm 2; Hurtado, Sara MD 3; Ribera, Laura MD 3; Echeverria-Esnal, Daniel PhD 4; Perez-Saez, Maria Jose PhD 1; Redondo-Pachon, Dolores PhD 1; Burballa, Carla PhD 1; Buxeda, Anna MD 1; Llinas-Mallol, Laura PhD 1; Cao, Higini MD 1; Barbosa, Francesc MD 1; Rovira, Xavier DTech 5; Cima, Florencia MD 6; Pascual, Julio PhD 7; Crespo, Marta PhD 1
doi : 10.1097/TP.0000000000004433
The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity after 2 doses in KT.
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients.
Perez-Carrillo, Lorena PhD 1; Gimenez-Escamilla, Isaac PhD 1; Sanchez-Lazaro, Ignacio MD 1,2; Trivino, Juan Carlos PhD 3; Feijoo-Bandin, Sandra PhD 4; Lago, Francisca PhD 4; Gonzalez-Juanatey, Jose Ramon MD 4; Martinez-Dolz, Luis MD 1,2; Portoles, Manuel PhD 1; Tarazon, Estefania PhD 1; Rosello-Lleti, Esther PhD 1
doi : 10.1097/TP.0000000000004273
Given the central role of sarcomeric dysfunction in cardiomyocyte biology and sarcomere alterations described in endomyocardial biopsies of transplant patients with rejection, we hypothesized that the serum expression levels of genes encoding sarcomeric proteins were altered in acute cellular rejection (ACR).
Diabetic Neuropathy Is Independently Associated With Worse Graft Outcomes and Incident Cardiovascular Disease After Pancreas Transplantation: A Retrospective Cohort Study in Type 1 Diabetes.
Boswell, Laura MD 1,2; Ventura-Aguiar, Pedro MD, PhD 3,4; Alejaldre, Aida MD, PhD 5; Navarro-Otano, Judith MD, PhD 5; Cofan, Frederic MD, PhD 3,4; Seres-Noriega, Tonet MD 1; Pane, Adriana MD 1; Montagud-Marrahi, Enrique MD 3; Molina-Andujar, Alicia MD 3; Ruiz, Montserrat RN 1; Cucchiari, David MD, PhD 3; Musquera, Mireia MD, PhD 6; Ferrer-Fabrega, Joana MD, PhD 7; Diekmann, Fritz MD, PhD 3,4,8; Esmatjes, Enric MD, PhD 9,10; Amor, Antonio J. MD, PhD 1
doi : 10.1097/TP.0000000000004275
Information about the impact of diabetic neuropathy (DN) on outcomes after pancreas transplantation (PT) is scarce. We assessed the independent relationship between DN markers with both graft survival and incident cardiovascular disease (CVD) after transplantation.
The Molecular Diagnosis Might Be Clinically Useful in Discrepant Kidney Allograft Biopsy Findings: An Analysis of Clinical Outcomes.
Schachtner, Thomas MD 1; von Moos, Seraina MD 1; Kokkonen, Sanna M. BSc 1; Helmchen, Birgit MD 2; Gaspert, Ariana MD 2; Mackova, Martina PhD 3; Halloran, Philip F. MD, PhD 3; Mueller, Thomas F. MD 1
doi : 10.1097/TP.0000000000004284
The Molecular Microscope Diagnostic System (MMDx) may overcome histology shortcomings. Previous studies have simply examined discrepant findings but have not attempted to determine clinical endpoints.
Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena.
Borski, Anita MD 1; Eskandary, Farsad MD, PhD 1; Haindl, Susanne BSc 1; Doberer, Konstantin MD 1; Muhlbacher, Jakob MD, PhD 2; Mayer, Katharina A. MD 1; Budde, Klemens MD 3; Halloran, Philip F. MD, PhD 4; Chong, Edward MD 5; Jilma, Bernd MD 6; Bohmig, Georg A. MD 1; Wahrmann, Markus PhD 1
doi : 10.1097/TP.0000000000004285
Blockade of interleukin-6 (IL-6) has emerged as a promising therapeutic option for antibody-mediated rejection. Subtherapeutic anti-IL-6 antibody level or treatment cessation following prolonged cytokine neutralization may result in proinflammatory rebound phenomena via accumulation of IL-6 and/or modulated gene expression of major components of the IL-6/IL-6 receptor (IL-6R) axis.
Apheresis of Deceased Donors as a New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance.
Sosa, Rebecca A. PhD 1,,2; Mone, Thomas MS 3; Naini, Bita V. MD 1; Kohn, Donald B. MD 4,5,6; Reed, Elaine F. PhD 1,2; Wheeler, Kristina BSN 3; Campo-Fernandez, Beatriz PhD 4; Davila, Alejandra BS 4; Chaffin, Donald J. MD 7; DiNorcia, Joseph MD 8; Kaldas, Fady M. MD 8; Cohen, Aaron MS 3; Lum, Erik L. MD 9; Veale, Jeffrey L. MD 10; Kogut, Neil M. MD 10
doi : 10.1097/TP.0000000000004288
Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure; however, recipients must remain on lifelong immunosuppression, leaving them susceptible to infections and cancer.
Dynamics of Human Anelloviruses in Plasma and Clinical Outcomes Following Kidney Transplantation.
Forque, Lorena PharmD 1,2; Fernandez-Ruiz, Mario MD, PhD 2,3,4; Albert, Eliseo PharmD 1,2; Gimenez, Estela PhD 1,2; Monzo, Carolina MSc 5; Chaves, Javier PhD 5; Redondo, Natalia PhD 2,3; Rodriguez-Goncer, Isabel MD, PhD 2,3; Ruiz-Merlo, Tamara BSN 2,3; Parra, Patricia CLS 2,3; Andres, Amado MD, PhD 4,6; Aguado, Jose Maria MD, PhD 2-4; Navarro, David MD, PhD 1,2,7
doi : 10.1097/TP.0000000000004292
Torque teno virus, the major member of the genus Alphatorquevirus, is an emerging biomarker of the net state of immunosuppression after kidney transplantation. Genetic diversity constitutes a main feature of the Anelloviridae family, although its posttransplant dynamics and clinical correlates are largely unknown.
Recipient and Graft Outcomes in Simultaneous Kidney and Pancreas Transplantation With Steroid Avoidance in the United States.
Cerise, Adam MD 1; Shaker, Tamer MD 1; LeNguyen, Phuoc MD 1; Dinesh, Anant MD 1; Jackson, Scott MS 2; Kandaswamy, Raja MD 1; Riad, Samy MD, MS 3,4
doi : 10.1097/TP.0000000000004295
Steroid avoidance in kidney transplantation has been proven noninferior. Long-term outcome data on steroid avoidance in simultaneous pancreas-kidney (SPK) remains scant. Methods.
Transplantation of Organs From DCD and DBD Donors Who Died After Ligature Asphyxiation.
Trotter, Patrick B. PhD 1,2,3; Dark, John FRCS 2,4; Fisher, Andrew J. FRCP 2,4; Robb, Matthew PhD 2,3; Watson, Christopher MD 2,5; Neuberger, James DM 6
doi : 10.1097/TP.0000000000004296
The United Kingdom transplant registry data demonstrated similar transplant outcomes for recipients of kidneys from donors who died following ligature asphyxiation and those who received organs from donors dying from other causes.
Analysis of Native Kidney Function Recovery With Renal Scintigraphy Following Simultaneous Liver-Kidney Transplantation.
Werneburg, Glenn T. MD, PhD 1; Hettel, Daniel R. MD 1; Mahajan, Paresh MD 3; Goldfarb, David A. MD 1,2; Fatica, Richard A. MD 1,2; Eltemamy, Mohamed MD 1,2; Menon, K.V. Narayanan MD 4; Lindenmeyer, Christina C. MD 4; Krishnamurthi, Venkatesh MD 1,2; Wee, Alvin MD 1,2
doi : 10.1097/TP.0000000000004310
Patients undergoing simultaneous liver-kidney transplantation (SLK) have impaired native kidney function. The relative contribution of allograft versus native function after SLK is unknown.
Kidney Transplant Patients Generate Varicella Zoster-Reactive T-cell and Humoral Immunity Following Protein-based Varicella Zoster Vaccination.
Roch, Toralf PhD 1,2; Wehler, Patrizia PhD 1,2; Blazquez-Navarro, Arturo PhD 2; Bachmann, Friederike MD 3; Neumann, Isabel E. BSc 2; Kaliszczyk, Sviatlana 2; Thieme, Constantin J. MD, PhD 2; Anft, Moritz PhD 1; Stervbo, Ulrik PhD 1,2; Westhoff, Timm H. MD 1; Babel, Nina MD 1,2; Choi, Mira MD 3
COVID-19 Outcomes in Solid Organ Transplant Recipients Who Received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab Treatment in a Nurse-driven Monoclonal Antibody Program During the Omicron Surge.
Cochran, Willa MSN, CRNP 1; Salto-Alejandre, Sonsoles MD 2; Barker, Lindsay CRNP 1; Langlee, Julie CRNP 1; Freed, Kristin CRNP 1; Carter, Debra CRNP 1; Bannon, Jaclyn MHA 1; Goddard, Dillon 1; Mostafa, Heba PhD 3; Werbel, William MD, PhD 3; Shah, Pali MD 3; Segev, Dorry MD, PhD 4; Brennan, Daniel MD 3; Avery, Robin MD 3
First Booster of SARS-COV-2 mRNA Vaccine Is Not Associated With Alloimmunization and Subclinical Injury of Kidney Allograft.
Petr, Vojtech MD 1; Zahradka, Ivan MD 1; Modos, Istvan PhD 2; Roder, Matej MSc 3; Prewett, Adam MBA 4; Fialova, Martina MSc 5; Machkova, Jana MSc 6; Hruba, Petra PhD 6; Magicova, Maria MD 1; Slavcev, Antonij MD, PhD 3; Striz, Ilja MD, PhD 5; Viklicky, Ondrej MD, PhD 1,6
Detection of Transmissible Severe Acute Respiratory Syndrome Coronavirus-2 From Deceased Kidney Donors: Implications for Kidney Transplant Recipients.
Azhar, Ambreen MD, MS 1; Kleiboeker, Steve PhD 2; Khorsandi, Shiba MD 1; Duncan Kilpatrick, M. BS 1; Khan, Aamir MD 1; Gungor, Ahmet PhD 3; Molnar, Miklos Z. MD, PhD 4; Morales, Megan MD 1; Levy, Marlon MD, MBA 1; Kamal, Layla MD 1; Moinuddin, Irfan MD 1; Kumar, Dhiren MD 1; Tanriover, Bekir MD, MPH, MBA 3; Gupta, Gaurav MD 1
First Experience of Optimization of Tacrolimus Therapeutic Drug Monitoring in a Patient Cotreated With Nirmatrelvir/Ritonavir: How Microsampling Approach Changes Everything.
Golbin, Leonard MD 1,2; Tron, Camille MD 2,3,4; Franck, Benedicte MD, PhD 2,3,4; Vigneau, Cecile MD, PhD 1,2,3,4; Verdier, Marie-Clemence MD 2,3,4; Lemaitre, Florian MD, PhD 2,3,4
Complete Endovascular Stenting of the Inferior Vena Cava Following Its Twisting After Liver Transplantation.
Toniutto, Pierluigi MD 1; Vit, Alessandro MD 2; Bitetto, Davide MD 1; Fornasiere, Ezio MD 1; Fumolo, Elisa MD 1; Sponza, Massimo MD 2
Immunogenicity, Reactogenicity, and Reinfection After 2 Doses of the Inactivated Whole-virion CoronaVac Vaccine in Kidney Transplant Recipients Convalescents From COVID-19.
Amorim, Laysla Verhalen Pouzo 1,2; Cristelli, Marina Pontello PhD 1; Viana, Laila Almeida MD 1; Dreige, Yasmim Cardoso MsC 1,2; Requiao-Moura, Lucio R. PhD 1,2; Nakamura, Monica Rika MsC 1,2; Foresto, Renato Demarchi MD 1,2; Medina-Pestana, Jose PhD 1,2; Tedesco-Silva, Helio PhD 1,2
Overcoming Challenges of Deceased Organ Donation in Indian Private Hospitals.
Seth, Avnish Kumar MBBS, MD, DM 1; Pandit, Rahul MBBS, MD, FCICM 2; Gopashetty, Mahesh MBBS, MS, MRCS 3; Rajarathinam, Buddhan MBBS, MD, EDIC, IDCCM 4; Saseedharan, Sanjith MBBS, EDIC, DA, MD 5; Prakash, Om MBBS, DA 1; Chauhan, Munish MBBS, MD, FNB, EDIC 1; Sharma, Gauri Shankar MBBS, MD, FRCP 6; Sircar, Mrinal MBBS, MD, DNB, EDIC, EDARM 7; Paliwal, Yashesh MBBS, MD, FRCA, EDIC 8; Gore, Sudhir B. MBBS, DA, IDCCM 9; Mahay, Harjit Singh MBBS, MD, EDIC 10; Joad, Shabbar H.K. MBBS, MD, FNB-CCM, IDCCM 11; Dhir, Jasrita BA, MBA, AMPH 12; Lal, Sukhvinder BA, MSW 1; Singh, Twinkle BSc, MBA 1
doi : 10.1097/TP.0000000000004229
Volume 107(2) pgs. 283-547,e45-e73 February 2023
Research Highlights.
Atallah, Nora MSc 1; Beckett, Joseph MBiol 1; Issa, Fadi DPhil, FRCS (Plast) 1
Acute Inflammatory Recovery-A Matter of Sophisticated Interaction of Two Cell Populations?.
Heim, Christian MD 1; Ensminger, Stephan MD, DPhil 2
Achieving Equity in Organ Transplantation: Recommendations for Action Based on the National Academies of Sciences, Engineering, and Medicine Report.
Dageforde, Leigh Anne MD, MPH 1,2; English, Rebecca A. MPH 3; Kizer, Kenneth W. MD, MPH 4
doi : 10.1097/TP.0000000000004464
AB The United States organ transplantation system has recently reached a historic milestone of a cumulative 1 million transplants. Despite this considerable success in providing life-saving organ transplants to patients with end organ failure, there are ample opportunities for improvement, particularly with regard to achieving equity.
The Destiny of Articles When Pairing "Traditional"-With Open Access Sibling Journals.
van den Berg, Tamar A.J. MD 1; Benjamens, Stan MD, PhD 1,2; Bakker, Stephan J.L. MD, PhD 3; Chapman, Jeremy R. MD, PhD 4; Geissler, Edward K. MD, PhD 5; Pol, Robert A. MD, PhD 1
Monkeypox a Concern for Donor-derived Infection?.
Boan, Peter MBBS, FRACP, FRCPA 1,2
Intragraft B Cells, Just Not Like the Others.
Zorn, Emmanuel PhD 1
Commentary on "Lung Transplantation for COVID-19 Pulmonary Sequelae": Beautiful Story, Already History?.
Zappella, Nathalie MD 1; Montravers, Philippe MD, PhD 1,2
Replacing the Endomyocardial Biopsy: Easier Said Than Done.
Baran, David A. MD 1
Amelioration of Diabetes and Neuropathy After Pancreas Transplantation: Measurable Differences in Vibration Perception Thresholds Impact Outcomes.
Parsons, Ronald F. MD 1
In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Determination Death: Organ Utilization, Outcomes, and Elusiveness of a Randomized Clinical Trial.
Hessheimer, Amelia J. MD, PhD 1
Current Status of ABO-incompatible Liver Transplantation.
Egawa, Hiroto MD, PhD 1; Ohdan, Hideki MD, PhD 2; Saito, Kazuhide MD, PhD 3
doi : 10.1097/TP.0000000000004250
AB By 2014, strategies to prevent antibody-mediated rejection (AMR) after ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) were established in Japan and expanded primarily to Asia, where LDLT is now the predominant form of LT owing to the scarcity of brain-dead donors.
Abdominal Organ Preservation Solutions in the Age of Machine Perfusion.
Ramos, Pedro MD 1; Williams, Paul MD 2; Salinas, Javier MD, PhD 1,3; Vengohechea, Jordi BS 3,4; Lodge, J. Peter A. MD, PhD 2; Fondevila, Constantino MD, PhD 1,3,5; Hessheimer, Amelia J. MD, PhD 1,3,5
doi : 10.1097/TP.0000000000004269
AB The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs. Perfusion is dynamic and offers several advantages in comparison with static cold storage.
Biomarkers for Chronic Lung Allograft Dysfunction: Ready for Prime Time?.
Verleden, Stijn E. PhD 1,2,3; Hendriks, Jeroen M.H. MD, PhD 1,2; Lauwers, Patrick MD 1,2; Yogeswaran, Suresh Krishan MD 1,2; Verplancke, Veronique MD 3; Kwakkel-Van-Erp, Johanna M. MD, PhD 3,4
doi : 10.1097/TP.0000000000004270
AB Chronic lung allograft dysfunction (CLAD) remains a major hurdle impairing lung transplant outcome. Parallel to the better clinical identification and characterization of CLAD and CLAD phenotypes, there is an increasing urge to find adequate biomarkers that could assist in the earlier detection and differential diagnosis of CLAD phenotypes, as well as disease prognostication.
Desensitization in Crossmatch-positive Kidney Transplant Candidates.
Noble, Johan MD 1,2; Jouve, Thomas MD, PhD 1,2; Malvezzi, Paolo MD 1; Rostaing, Lionel MD, PhD 1,2,3
doi : 10.1097/TP.0000000000004279
AB Access to kidney transplantation is limited by HLA-specific sensitization. Desensitization strategies enable crossmatch-positive kidney transplantation. In this review, we describe clinical experience gained over the last 20 y using desensitization strategies before kidney transplantation and describe the different tools used (both drugs and apheresis options), including IVIg, rituximab, apheresis techniques, interleukin-6 interference, proteasome inhibition, enzymatic degradation of HLA antibodies, complement inhibition, and B cytokine interference. Although access to transplantation for highly sensitized kidney transplantation candidates has been vastly improved by desensitization strategies, it remains, however, limited by the recurrence of HLA antibodies after transplantation and the occurrence of antibody-mediated rejection. Copyright (C) 2023 Wolters Kluwer Health, Inc. All rights reserved.
Heart Transplantation From DCD Donors in Australia: Lessons Learned From the First 74 Cases.
Joshi, Yashutosh MBBS 1,2,3; Scheuer, Sarah MD 1,2,3; Chew, Hong PhD 1,2,3; Ru Qiu, Min PhD 3,4; Soto, Claudio MSc 1,5; Villanueva, Jeanette PhD 2; Gao, Ling PhD 2; Doyle, Aoife MSc 2; Takahara, Shingo PhD 1; Jenkinson, Charles MBBS 1; Vaidhya, Nikunj MS 1; Matsumoto, Yorihiko MD 1; Hwang, Bridget BMed, MD 3; Zhao, Christine MD 3; Iyer, Arjun PhD 1,2,3; Connellan, Mark MBBS 1; Watson, Alasdair PhD 1; Granger, Emily MBBS 1; Muthiah, Kavitha PhD 1; Jabbour, Andrew PhD 1; Kotlyar, Eugene PhD 1; Keogh, Anne MD 1; Bart, Nicole K. PhD 1,2,3; Hayward, Chris MD 1; Dhital, Kumud PhD 1,2,3; Jansz, Paul PhD 1,2; Macdonald, Peter S. PhD 1,2,3
doi : 10.1097/TP.0000000000004294
AB Heart transplantation from donation after circulatory death (DCD) donors has the potential to substantially increase overall heart transplant activity. The aim of this report is to review the first 8 y of our clinical heart transplant program at St Vincent's Hospital Sydney, to describe how our program has evolved and to report the impact that changes to our retrieval protocols have had on posttransplant outcomes.
TIGIT-Fc Prolongs Corneal Allograft Survival in Mice by Upregulating TIGIT/CD226 Expression and the Proportion of Helios+Foxp3+ Treg Cells.
Li, Shang MD, PhD 1; Zhang, Peng BSMed 1; Li, Ao BSMed 1; Bao, Jiayu DS, PhD 1; Pan, Zhiqiang MD, PhD 1; Jie, Ying MD, PhD 1
doi : 10.1097/TP.0000000000004257
AB Background. Reduction of graft rejection remains key issue for supporting long-term graft retention after corneal transplantation. The relevance of Treg in reduction of corneal allografts rejection has been demonstrated.
P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients.
Udomkarnjananun, Suwasin MD 1,2,3; Francke, Marith I. BSc 1,2; Dieterich, Marjolein BSc 1; van De Velde, Daan BSc 4; Litjens, Nicolle H.R. PhD 1,2; Boer, Karin PhD 1,2; De Winter, Brenda C.M. PharmD, PhD 2,4; Baan, Carla C. PhD 1,2; Hesselink, Dennis A. MD, PhD 1,2
doi : 10.1097/TP.0000000000004287
Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0.
The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice.
Zou, Zhimiao MD 1,2,3,4; Shang, Runshi MS 1,2,3,4; Zhou, Liang MS 1,2,3,4; Du, Dunfeng PhD 1,2,3,4; Yang, Yang MD 1,2,3,4; Xie, Yalong MD 1,2,3,4; Li, Zeyang MD 1,2,3,4; Zhao, Minghui MS 1,2,3,4; Jiang, Fengchao PhD 5; Zhang, Limin PhD 1,2,3,4; Zhou, Ping PhD 1,2,3,4
doi : 10.1097/TP.0000000000004317
With the development of medical technology and increased surgical experience, the number of patients receiving liver transplants has increased. However, restoration of liver function in patients is limited by the occurrence of hepatic ischemia-reperfusion injury (IRI).
Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation.
Zhang, Hengcheng MD, PhD 1; Cavazzoni, Cecilia B. PhD 1; Hanson, Benjamin L. 1; Bechu, Elsa D. 1; Podesta, Manuel A. MD 1,2; Azzi, Jamil MD 1; Blazar, Bruce R. MD 3; Chong, Anita S. PhD 4; Kreisel, Daniel MD, PhD 5; Alessandrini, Alessandro PhD 6; Sage, Peter T. PhD 1
doi : 10.1097/TP.0000000000004398
Following allogeneic kidney transplantation, a substantial proportion of graft loss is attributed to the formation of donor-specific antibodies and antibody-mediated rejection.
Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome.
Kwong, Allison J. MD, MS 1; Kim, W. Ray MD 1,2; Lake, John MD 2,3; Stock, Peter G. MD, PhD 2,4; Wang, Connie J. MD 5; Wetmore, James B. MD, MS 5; Melcher, Marc L. MD, PhD 6; Wey, Andrew PhD 2; Salkowski, Nicholas PhD 2; Snyder, Jon J. PhD, MS 2,7; Israni, Ajay K. MD, MS 2,5,7
doi : 10.1097/TP.0000000000004291
The Scientific Registry of Transplant Recipients (SRTR) had not traditionally considered biopsy results in risk-adjustment models, yet biopsy results may influence outcomes and thus decisions regarding organ acceptance.
Nodular Regenerative Hyperplasia Is Not a Rare Condition After Liver Transplantation: Incidence, Predictive Factors, and Impact on Survival.
Kounis, Ilias MD 1,2,3,4; Sebagh, Mylene MD 2,3,4,5; Evain, Manon MD 1; Cailliez, Valerie 1,2,3,4; Roche, Bruno MD 1,2,3,4; De Martin, Eleonora MD, PhD 1,2,3,4; Sobesky, Rodolphe MD, PhD 1,2,3,4; Guettier, Catherine MD, PhD 2,3,4,5; Allard, Marc Antoine MD, PhD 1,2,3,4; Golse, Nicolas MD, PhD 1,2,3,4; Azoulay, Daniel MD, PhD 1,2,3,4; Vibert, Eric MD, PhD 1,2,3,4; Duclos Vallee, Jean Charles MD, PhD 1,2,3,4; Feray, Cyrille MD, PhD 1,2,3,4; Samuel, Didier MD, PhD 1,2,3,4; Coilly, Audrey MD, PhD 1,2,3,4
Personality Traits in Patients With Cirrhosis Are Different From Those of the General Population and Impact Likelihood of Liver Transplantation.
Thuluvath, Avesh J. MD 1,2; Siddiqui, Osama BS 1; Lai, Jennifer C. MD, MBA 3; Peipert, John PhD 1,4; Levitsky, Josh MD, MS 2; Daud, Amna MBBS, MPH 1; Mazumder, Nikhilesh R. MD, MPH 1,2; Flores, Anne-Marie PT, PhD 1; Borja-Cacho, Daniel MD 1,5; Caicedo, Juan C. MD 1,5; Loftus, Corinne BS 1; Wong, Randi BS 3; Mroczek, Dan PhD 4,6; Ladner, Daniela P. MD, MPH 1,4,5
doi : 10.1097/TP.0000000000004304
Personality traits influence clinical outcomes in chronic diseases, but their impact in cirrhosis is unknown. We studied the personality of patients with cirrhosis undergoing liver transplant (LT) evaluation and determined their correlation to clinical outcomes.
The Conundrum of Patients With Compensated Cirrhosis Requiring Kidney Transplantation; Kidney Alone or Simultaneous Liver Kidney Transplantation.
Dodge, Jennifer L. MPH 1,2; Lee, Brian T. MD 3; Kassem, Ali Casey Z. MD 4; Biggins, Scott W. MD 5; Rana, Prachi A. MD 3; Nadim, Mitra K. MD 6; Asrani, Sumeet K. MD, MS 4; Fong, Tse-Ling MD 1,7
doi : 10.1097/TP.0000000000004311
Patients with compensated cirrhosis and chronic kidney disease are increasing along with demand for simultaneous liver kidney transplant (SLKT) and shortages of organs for transplantation.
Improved Organ Utilization and Better Transplant Outcomes With In Situ Normothermic Regional Perfusion in Controlled Donation After Circulatory Death.
Oniscu, Gabriel C. MD 1,,2; Mehew, Jennifer PhD 3; Butler, Andrew J. MChir 4,,5; Sutherland, Andrew DPhil 1,,2; Gaurav, Rohit MS 5; Hogg, Rachel MSc 3; Currie, Ian PhD 1,,2; Jones, Mark MSc 3; Watson, Christopher J.E. MD 4,,5
doi : 10.1097/TP.0000000000004280
We evaluated whether the use of normothermic regional perfusion (NRP) was associated with increased organ recovery and improved transplant outcomes from controlled donation after circulatory death (cDCD).
Lung Transplantation for COVID-19 Pulmonary Sequelae.
Kehara, Hiromu MD, PhD 1; Mangukia, Chirantan MD 1; Sunagawa, Gengo MD 1; Iturra, Sebastian A. MD 1; Yanagida, Roh MD, PhD 1; Kashem, Mohammed MD, PhD 1; Persidsky, Yuri MD, PhD 2; Shenoy, Kartik MD 3; Mamary, Albert J. MD 3; Marchetti, Nathaniel DO 3; Cordova, Francis MD 3; Criner, Gerard J. MD 3; Toyoda, Yoshiya MD, PhD 1; Shigemura, Norihisa MD, PhD 1,3
doi : 10.1097/TP.0000000000004428
The role of lung transplantation for coronavirus disease 2019 (COVID-19)-related lung failure is evolving as the pandemic persists. Methods. From January 2021 to April 2022, 20 patients (median age 62 y; range 31-77) underwent lung transplantation for COVID-related lung failure at our institution. We reviewed their clinical and intraoperative characteristics and early outcomes including postoperative complications.
Dynamics of Humoral and Cellular Responses in Renal Transplant Recipients Receiving 3 Doses of SARS-CoV-2 mRNA Vaccine.
Arias-Cabrales, Carlos PhD 1; Folgueiras, Montserrat BS 1; Faura, Anna BSN 1; Eguia, Jorge BPharm 2; Padilla, Eduardo BPharm 2; Hurtado, Sara MD 3; Ribera, Laura MD 3; Echeverria-Esnal, Daniel PhD 4; Perez-Saez, Maria Jose PhD 1; Redondo-Pachon, Dolores PhD 1; Burballa, Carla PhD 1; Buxeda, Anna MD 1; Llinas-Mallol, Laura PhD 1; Cao, Higini MD 1; Barbosa, Francesc MD 1; Rovira, Xavier DTech 5; Cima, Florencia MD 6; Pascual, Julio PhD 7; Crespo, Marta PhD 1
doi : 10.1097/TP.0000000000004433
The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity after 2 doses in KT.
Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients.
Perez-Carrillo, Lorena PhD 1; Gimenez-Escamilla, Isaac PhD 1; Sanchez-Lazaro, Ignacio MD 1,2; Trivino, Juan Carlos PhD 3; Feijoo-Bandin, Sandra PhD 4; Lago, Francisca PhD 4; Gonzalez-Juanatey, Jose Ramon MD 4; Martinez-Dolz, Luis MD 1,2; Portoles, Manuel PhD 1; Tarazon, Estefania PhD 1; Rosello-Lleti, Esther PhD 1
doi : 10.1097/TP.0000000000004273
Given the central role of sarcomeric dysfunction in cardiomyocyte biology and sarcomere alterations described in endomyocardial biopsies of transplant patients with rejection, we hypothesized that the serum expression levels of genes encoding sarcomeric proteins were altered in acute cellular rejection (ACR).
Diabetic Neuropathy Is Independently Associated With Worse Graft Outcomes and Incident Cardiovascular Disease After Pancreas Transplantation: A Retrospective Cohort Study in Type 1 Diabetes.
Boswell, Laura MD 1,2; Ventura-Aguiar, Pedro MD, PhD 3,4; Alejaldre, Aida MD, PhD 5; Navarro-Otano, Judith MD, PhD 5; Cofan, Frederic MD, PhD 3,4; Seres-Noriega, Tonet MD 1; Pane, Adriana MD 1; Montagud-Marrahi, Enrique MD 3; Molina-Andujar, Alicia MD 3; Ruiz, Montserrat RN 1; Cucchiari, David MD, PhD 3; Musquera, Mireia MD, PhD 6; Ferrer-Fabrega, Joana MD, PhD 7; Diekmann, Fritz MD, PhD 3,4,8; Esmatjes, Enric MD, PhD 9,10; Amor, Antonio J. MD, PhD 1
doi : 10.1097/TP.0000000000004275
Information about the impact of diabetic neuropathy (DN) on outcomes after pancreas transplantation (PT) is scarce. We assessed the independent relationship between DN markers with both graft survival and incident cardiovascular disease (CVD) after transplantation.
The Molecular Diagnosis Might Be Clinically Useful in Discrepant Kidney Allograft Biopsy Findings: An Analysis of Clinical Outcomes.
Schachtner, Thomas MD 1; von Moos, Seraina MD 1; Kokkonen, Sanna M. BSc 1; Helmchen, Birgit MD 2; Gaspert, Ariana MD 2; Mackova, Martina PhD 3; Halloran, Philip F. MD, PhD 3; Mueller, Thomas F. MD 1
doi : 10.1097/TP.0000000000004284
The Molecular Microscope Diagnostic System (MMDx) may overcome histology shortcomings. Previous studies have simply examined discrepant findings but have not attempted to determine clinical endpoints.
Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena.
Borski, Anita MD 1; Eskandary, Farsad MD, PhD 1; Haindl, Susanne BSc 1; Doberer, Konstantin MD 1; Muhlbacher, Jakob MD, PhD 2; Mayer, Katharina A. MD 1; Budde, Klemens MD 3; Halloran, Philip F. MD, PhD 4; Chong, Edward MD 5; Jilma, Bernd MD 6; Bohmig, Georg A. MD 1; Wahrmann, Markus PhD 1
doi : 10.1097/TP.0000000000004285
Blockade of interleukin-6 (IL-6) has emerged as a promising therapeutic option for antibody-mediated rejection. Subtherapeutic anti-IL-6 antibody level or treatment cessation following prolonged cytokine neutralization may result in proinflammatory rebound phenomena via accumulation of IL-6 and/or modulated gene expression of major components of the IL-6/IL-6 receptor (IL-6R) axis.
Apheresis of Deceased Donors as a New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance.
Sosa, Rebecca A. PhD 1,,2; Mone, Thomas MS 3; Naini, Bita V. MD 1; Kohn, Donald B. MD 4,5,6; Reed, Elaine F. PhD 1,2; Wheeler, Kristina BSN 3; Campo-Fernandez, Beatriz PhD 4; Davila, Alejandra BS 4; Chaffin, Donald J. MD 7; DiNorcia, Joseph MD 8; Kaldas, Fady M. MD 8; Cohen, Aaron MS 3; Lum, Erik L. MD 9; Veale, Jeffrey L. MD 10; Kogut, Neil M. MD 10
doi : 10.1097/TP.0000000000004288
Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure; however, recipients must remain on lifelong immunosuppression, leaving them susceptible to infections and cancer.
Dynamics of Human Anelloviruses in Plasma and Clinical Outcomes Following Kidney Transplantation.
Forque, Lorena PharmD 1,2; Fernandez-Ruiz, Mario MD, PhD 2,3,4; Albert, Eliseo PharmD 1,2; Gimenez, Estela PhD 1,2; Monzo, Carolina MSc 5; Chaves, Javier PhD 5; Redondo, Natalia PhD 2,3; Rodriguez-Goncer, Isabel MD, PhD 2,3; Ruiz-Merlo, Tamara BSN 2,3; Parra, Patricia CLS 2,3; Andres, Amado MD, PhD 4,6; Aguado, Jose Maria MD, PhD 2-4; Navarro, David MD, PhD 1,2,7
doi : 10.1097/TP.0000000000004292
Torque teno virus, the major member of the genus Alphatorquevirus, is an emerging biomarker of the net state of immunosuppression after kidney transplantation. Genetic diversity constitutes a main feature of the Anelloviridae family, although its posttransplant dynamics and clinical correlates are largely unknown.
Recipient and Graft Outcomes in Simultaneous Kidney and Pancreas Transplantation With Steroid Avoidance in the United States.
Cerise, Adam MD 1; Shaker, Tamer MD 1; LeNguyen, Phuoc MD 1; Dinesh, Anant MD 1; Jackson, Scott MS 2; Kandaswamy, Raja MD 1; Riad, Samy MD, MS 3,4
doi : 10.1097/TP.0000000000004295
Steroid avoidance in kidney transplantation has been proven noninferior. Long-term outcome data on steroid avoidance in simultaneous pancreas-kidney (SPK) remains scant. Methods.
Transplantation of Organs From DCD and DBD Donors Who Died After Ligature Asphyxiation.
Trotter, Patrick B. PhD 1,2,3; Dark, John FRCS 2,4; Fisher, Andrew J. FRCP 2,4; Robb, Matthew PhD 2,3; Watson, Christopher MD 2,5; Neuberger, James DM 6
doi : 10.1097/TP.0000000000004296
The United Kingdom transplant registry data demonstrated similar transplant outcomes for recipients of kidneys from donors who died following ligature asphyxiation and those who received organs from donors dying from other causes.
Analysis of Native Kidney Function Recovery With Renal Scintigraphy Following Simultaneous Liver-Kidney Transplantation.
Werneburg, Glenn T. MD, PhD 1; Hettel, Daniel R. MD 1; Mahajan, Paresh MD 3; Goldfarb, David A. MD 1,2; Fatica, Richard A. MD 1,2; Eltemamy, Mohamed MD 1,2; Menon, K.V. Narayanan MD 4; Lindenmeyer, Christina C. MD 4; Krishnamurthi, Venkatesh MD 1,2; Wee, Alvin MD 1,2
doi : 10.1097/TP.0000000000004310
Patients undergoing simultaneous liver-kidney transplantation (SLK) have impaired native kidney function. The relative contribution of allograft versus native function after SLK is unknown.
Kidney Transplant Patients Generate Varicella Zoster-Reactive T-cell and Humoral Immunity Following Protein-based Varicella Zoster Vaccination.
Roch, Toralf PhD 1,2; Wehler, Patrizia PhD 1,2; Blazquez-Navarro, Arturo PhD 2; Bachmann, Friederike MD 3; Neumann, Isabel E. BSc 2; Kaliszczyk, Sviatlana 2; Thieme, Constantin J. MD, PhD 2; Anft, Moritz PhD 1; Stervbo, Ulrik PhD 1,2; Westhoff, Timm H. MD 1; Babel, Nina MD 1,2; Choi, Mira MD 3
COVID-19 Outcomes in Solid Organ Transplant Recipients Who Received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab Treatment in a Nurse-driven Monoclonal Antibody Program During the Omicron Surge.
Cochran, Willa MSN, CRNP 1; Salto-Alejandre, Sonsoles MD 2; Barker, Lindsay CRNP 1; Langlee, Julie CRNP 1; Freed, Kristin CRNP 1; Carter, Debra CRNP 1; Bannon, Jaclyn MHA 1; Goddard, Dillon 1; Mostafa, Heba PhD 3; Werbel, William MD, PhD 3; Shah, Pali MD 3; Segev, Dorry MD, PhD 4; Brennan, Daniel MD 3; Avery, Robin MD 3
First Booster of SARS-COV-2 mRNA Vaccine Is Not Associated With Alloimmunization and Subclinical Injury of Kidney Allograft.
Petr, Vojtech MD 1; Zahradka, Ivan MD 1; Modos, Istvan PhD 2; Roder, Matej MSc 3; Prewett, Adam MBA 4; Fialova, Martina MSc 5; Machkova, Jana MSc 6; Hruba, Petra PhD 6; Magicova, Maria MD 1; Slavcev, Antonij MD, PhD 3; Striz, Ilja MD, PhD 5; Viklicky, Ondrej MD, PhD 1,6
Detection of Transmissible Severe Acute Respiratory Syndrome Coronavirus-2 From Deceased Kidney Donors: Implications for Kidney Transplant Recipients.
Azhar, Ambreen MD, MS 1; Kleiboeker, Steve PhD 2; Khorsandi, Shiba MD 1; Duncan Kilpatrick, M. BS 1; Khan, Aamir MD 1; Gungor, Ahmet PhD 3; Molnar, Miklos Z. MD, PhD 4; Morales, Megan MD 1; Levy, Marlon MD, MBA 1; Kamal, Layla MD 1; Moinuddin, Irfan MD 1; Kumar, Dhiren MD 1; Tanriover, Bekir MD, MPH, MBA 3; Gupta, Gaurav MD 1
First Experience of Optimization of Tacrolimus Therapeutic Drug Monitoring in a Patient Cotreated With Nirmatrelvir/Ritonavir: How Microsampling Approach Changes Everything.
Golbin, Leonard MD 1,2; Tron, Camille MD 2,3,4; Franck, Benedicte MD, PhD 2,3,4; Vigneau, Cecile MD, PhD 1,2,3,4; Verdier, Marie-Clemence MD 2,3,4; Lemaitre, Florian MD, PhD 2,3,4
Complete Endovascular Stenting of the Inferior Vena Cava Following Its Twisting After Liver Transplantation.
Toniutto, Pierluigi MD 1; Vit, Alessandro MD 2; Bitetto, Davide MD 1; Fornasiere, Ezio MD 1; Fumolo, Elisa MD 1; Sponza, Massimo MD 2
Immunogenicity, Reactogenicity, and Reinfection After 2 Doses of the Inactivated Whole-virion CoronaVac Vaccine in Kidney Transplant Recipients Convalescents From COVID-19.
Amorim, Laysla Verhalen Pouzo 1,2; Cristelli, Marina Pontello PhD 1; Viana, Laila Almeida MD 1; Dreige, Yasmim Cardoso MsC 1,2; Requiao-Moura, Lucio R. PhD 1,2; Nakamura, Monica Rika MsC 1,2; Foresto, Renato Demarchi MD 1,2; Medina-Pestana, Jose PhD 1,2; Tedesco-Silva, Helio PhD 1,2
