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James T. Willerson, MD
Joseph A. Hill, Joseph Loscalzo
doi : 10.1161/CIRCULATIONAHA.120.051690
Circulation. 2021 | Volume 143, Issue 16: 1537–1538
Transcatheter Closure of Patent Foramen Ovale
Ashish H. Shah, Rishi Puri, Richard A. Krasuski
doi : 10.1161/CIRCULATIONAHA.120.050961
Circulation. 2021 | Volume 143, Issue 16: 1539–1541
Blood Pressure Effects of Sodium Reduction
Tommaso Filippini, Marcella Malavolti, Paul K. Whelton, Androniki Naska, Nicola Orsini, Marco Vinceti
doi : 10.1161/CIRCULATIONAHA.120.050371
Circulation. 2021 | Volume 143, Issue 16: 1542–1567
The relationship between dietary sodium intake and blood pressure (BP) has been tested in clinical trials and nonexperimental human studies, indicating a direct association. The exact shape of the dose–response relationship has been difficult to assess in clinical trials because of the lack of random-effects dose–response statistical models that can include 2-arm comparisons.
Sodium, Blood Pressure, and the Likely Massive Avoidable Burden of Cardiovascular Disease
Bruce Neal, Jason Wu
doi : 10.1161/CIRCULATIONAHA.120.052654
Circulation. 2021 | Volume 143, Issue 16: 1568–1570
Very High Coronary Artery Calcium (?1000) and Association With Cardiovascular Disease Events, Non–Cardiovascular Disease Outcomes, and Mortality
Allison W. Peng, Zeina A. Dardari, Roger S. Blumenthal, Omar Dzaye, Olufunmilayo H. Obisesan, S.M. Iftekhar Uddin, Khurram Nasir, Ron Blankstein, Matthew J. Budoff, Martin B?dtker Mortensen, Parag H. Joshi, John Page, Michael J. Blaha
doi : 10.1161/CIRCULATIONAHA.120.050545
Circulation. 2021 | Volume 143, Issue 16: 1571–1583
There are limited data on the unique cardiovascular disease (CVD), non-CVD, and mortality risks of primary prevention individuals with very high coronary artery calcium (CAC; ?1000), especially compared with rates observed in secondary prevention populations.
Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model
Mahdieh Danesh Yazdi, Yan Wang, Qian Di, Yaguang Wei, Weeberb J. Requia, Liuhua Shi, Matthew Benjamin Sabath, Francesca Dominici, Brent A. Coull, John S. Evans, Petros Koutrakis, Joel D. Schwartz
doi : 10.1161/CIRCULATIONAHA.120.050252
Circulation. 2021 | Volume 143, Issue 16: 1584–1596
Studies examining the nonfatal health outcomes of exposure to air pollution have been limited by the number of pollutants studied and focus on short-term exposures.
MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G.S. Costa, Charline Fagnen, Catherine Vénien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschênes, Ji-Dong Fu
doi : 10.1161/CIRCULATIONAHA.120.050098
Circulation. 2021 | Volume 143, Issue 16: 1597–1613
MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs modulate physiologic homeostasis of the heart through noncanonical mechanisms.
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J. Mills, Kevin I. Watt, Kwaku D. Abu-Bonsrah, Ravi K.R. Kalathur, Holly K. Voges, Doan T. Dinh, Menno ter Huurne, Celine J. Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, Leanne M.D. Delbridge, Rebecca L. Robker, Paul Gregorevic, Cristobal G. dos Remedios, Sean Lal, Adam T. Piers, Igor E. Konstantinov, David A. Elliott, Assam El-Osta, Alicia Oshlack, James E. Hudson, Enzo R. Porrello
doi : 10.1161/CIRCULATIONAHA.120.051921
Circulation. 2021 | Volume 143, Issue 16: 1614–1628
Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal maturation of the human heart.
Novel Approaches Expand Access to Cardiovascular Preventive Care
Bridget M. Kuehn
doi : 10.1161/CIRCULATIONAHA.121.054577
Circulation. 2021 | Volume 143, Issue 16: 1629–1630
Palpitations in the Clinic
Jacob L. Ransom, Ka C. Wong
doi : 10.1161/CIRCULATIONAHA.121.053934
Circulation. 2021 | Volume 143, Issue 16: 1631–1634
Engrafted Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Undergo Clonal Expansion In Vivo
Danny El-Nachef, Darrian Bugg, Kevin M. Beussman, Sonette Steczina, Amy M. Martinson, Charles E. Murry, Nathan J. Sniadecki, Jennifer Davis
doi : 10.1161/CIRCULATIONAHA.119.044974
Circulation. 2021 | Volume 143, Issue 16: 1635–1638
Letter by Narayan Regarding Article, “Long-Term Results of the RAPCO Trials”
Pradeep Narayan
doi : 10.1161/CIRCULATIONAHA.120.052522
Circulation. 2021 | Volume 143, Issue 16: e832–e833
Response by Hare to Letter Regarding Article, “Long-Term Results of the RAPCO Trials”
David L. Hare
doi : 10.1161/CIRCULATIONAHA.121.053194
Circulation. 2021 | Volume 143, Issue 16: e834–e835
Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses: A Scientific Statement From the American Heart Association
Cameron Dezfulian, Aaron M. Orkin, Bradley A. Maron, Jonathan Elmer, Saket Girotra, Mark T. Gladwin, Raina M. Merchant, Ashish R. Panchal, Sarah M. Perman, Monique Anderson Starks, Sean van Diepen, Eric J. Lavonas and On behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Council on Clinical Cardiology
doi : 10.1161/CIR.0000000000000958
Circulation. 2021 | Volume 143, Issue 16: e836–e870
Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and opioid use disorder affects >2 million Americans. The epidemiology of opioid-associated out-of-hospital cardiac arrest in the United States is changing rapidly, with exponential increases in death resulting from synthetic opioids and linear increases in heroin deaths more than offsetting modest reductions in deaths from prescription opioids. The pathophysiology of polysubstance toxidromes involving opioids, asphyxial death, and prolonged hypoxemia leading to global ischemia (cardiac arrest) differs from that of sudden cardiac arrest. People who use opioids may also develop bacteremia, central nervous system vasculitis and leukoencephalopathy, torsades de pointes, pulmonary vasculopathy, and pulmonary edema. Emergency management of opioid poisoning requires recognition by the lay public or emergency dispatchers, prompt emergency response, and effective ventilation coupled to compressions in the setting of opioid-associated out-of-hospital cardiac arrest. Effective ventilation is challenging to teach, whereas naloxone, an opioid antagonist, can be administered by emergency medical personnel, trained laypeople, and the general public with dispatcher instruction to prevent cardiac arrest. Opioid education and naloxone distributions programs have been developed to teach people who are likely to encounter a person with opioid poisoning how to administer naloxone, deliver high-quality compressions, and perform rescue breathing. Current American Heart Association recommendations call for laypeople and others who cannot reliably establish the presence of a pulse to initiate cardiopulmonary resuscitation in any individual who is unconscious and not breathing normally; if opioid overdose is suspected, naloxone should also be administered. Secondary prevention, including counseling, opioid overdose education with take-home naloxone, and medication for opioid use disorder, is important to prevent recurrent opioid overdose.
Correction to: Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction
doi : 10.1161/CIR.0000000000000977
Circulation. 2021 | Volume 143, Issue 16: e871
