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Tumor Necrosis Factor [alpha] Blockers and the Risk of Multiple Sclerosis.
Strijbis, Eva M.M. MD, PhD; Koch, Marcus W. MD, PhD
doi : 10.1212/WNL.0000000000201629
Volume 100(6) pgs. 267-312,e558-e650 February 7, 2023
New Insight in Causal Pathways Following Subcortical Stroke: From Correlation to Causation.
Roy, Bhaskar MD; Marshall, Randolph S. MD, MS
Deferral of Consent in Randomized Clinical Trials of Acute Stroke: Ethical, Methodologic, and Practical Challenges.
Dippel, Diederik W.J. MD, PhD *; Warach, Steven J. MD *
Risk of Multiple Sclerosis Among Users of Antitumor Necrosis Factor [alpha] in 4 Canadian Provinces: A Population-Based Study.
Li, Lingyi MSc; Avina-Zubieta, J. Antonio MD, MSc, PhD *; Bernstein, Charles N. MD; Kaplan, Gilaad G. MD, MPH; Tremlett, Helen PhD; Xie, Hui PhD; Pena-Sanchez, Juan-Nicolas MD, PhD; Marrie, Ruth Ann MD, PhD; Etminan, Mahyar PharmD, MSc *
doi : 10.1212/WNL.0000000000201472
Antitumor necrosis factor [alpha] (TNF[alpha]) agents are a class of biologic drugs used for the treatment of several immune-mediated conditions. An increased risk of multiple sclerosis (MS) with their use has been suggested, but studies have been limited.
Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization.
Huang, Jian PhD *; Su, Bowen MD, PhD *; Karhunen, Ville PhD; Gill, Dipender MD, PhD; Zuber, Verena PhD; Ahola-Olli, Ari MD, PhD; Palaniswamy, Saranya PhD; Auvinen, Juha MD, PhD; Herzig, Karl-Heinz MD, PhD; Keinanen-Kiukaanniemi, Sirkka MD, PhD; Salmi, Marko MD, PhD; Jalkanen, Sirpa MD, PhD; Lehtimaki, Terho MD, PhD; Salomaa, Veikko MD, PhD; Raitakari, Olli T. MD, PhD; Matthews, Paul M. MD, DPhil; Elliott, Paul MBBS, PhD; Tsilidis, Konstantinos K. PhD; Jarvelin, Marjo-riitta MD, PhD; Tzoulaki, Ioanna PhD +; Dehghan, Abbas MD, PhD +
doi : 10.1212/WNL.0000000000201489
Whether chronic autoimmune inflammatory diseases causally affect the risk of Alzheimer disease (AD) is controversial. We characterized the relationship between inflammatory diseases and risk of AD and explored the role of circulating inflammatory biomarkers in the relationships between inflammatory diseases and AD.
Association of Regional Atrophy With Naming Decline in Primary Progressive Aphasia.
Breining, Bonnie L. PhD; Faria, Andreia Vasconcellos MD; Tippett, Donna Clark MA, MPH; Stockbridge, Melissa Dawn PhD; Meier, Erin L. PhD; Caffo, Brian PhD; Hermann, Olivia MA; Friedman, Rhonda PhD; Meyer, Aaron PhD; Tsapkini, Kyrana PhD; Hillis, Argye Elizabeth MD, MA
doi : 10.1212/WNL.0000000000201491
Primary progressive aphasia (PPA) is a neurodegenerative condition that predominantly impairs language. Most investigations of how focal atrophy affects language consider 1 time point compared with healthy controls.
Association Between Supplemental Nutrition Assistance Program Use and Memory Decline: Findings From the Health and Retirement Study.
Lu, Peiyi PhD; Kezios, Katrina PhD; Lee, Jongseong MS; Calonico, Sebastian PhD; Wimer, Christopher PhD; Zeki Al Hazzouri, Adina PhD
doi : 10.1212/WNL.0000000000201499
Studies on the effect of the Supplemental Nutrition Assistance Program (SNAP) on the cognitive health of older adults are scarce. We sought to examine the associations between SNAP use and memory decline among SNAP-eligible US older adults.
Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage-Sensing and Pore Domains of KCNH5.
Happ, Hannah C. BA; Sadleir, Lynette G. MBChB, MD; Zemel, Matthew DO; de Valles-Ibanez, Guillem PhD; Hildebrand, Michael S. PhD; McConkie-Rosell, Allyn PhD; McDonald, Marie MD; May, Halie CGC; Sands, Tristan MD; Aggarwal, Vimla MBBS; Elder, Christopher MD; Feyma, Timothy MD; Bayat, Allan MD; Moller, Rikke S. PhD; Fenger, Christina D. PhD; Klint Nielsen, Jens Erik MD; Datta, Anita N. MD; Gorman, Kathleen M. MD; King, Mary D. MD; Linhares, Natalia D. PhD; Burton, Barbara K. MD; Paras, Andrea MS; Ellard, Sian PhD; Rankin, Julia MD; Shukla, Anju MBBS; Majethia, Purvi; Olson, Rory J. MD; Muthusamy, Karthik MBBS; Schimmenti, Lisa A. MD; Starnes, Keith MD; Sedlackova, Lucie PhD; Sterbova, Katalin MD; Vlckova, Marketa PhD; Lassuthova, Petra PhD; Jahodova, Alena PhD; Porter, Brenda E. MD, PhD; Couque, Nathalie MD; Colin, Estelle; Prouteau, Clement MD; Collet, Corinne; Smol, Thomas MD; Caumes, Roseline MD; Vansenne, Fleur MD, PhD; Bisulli, Francesca MD; Licchetta, Laura MD, PhD; Person, Richard PhD; Torti, Erin MS; McWalter, Kirsty CGC; Webster, Richard MD; Gerard, Elizabeth E. MD; Lesca, Gaetan MD, PhD; Szepetowski, Pierre MD, PhD; Scheffer, Ingrid E. PhD; Mefford, Heather C. MD, PhD; Carvill, Gemma L. PhD
doi : 10.1212/WNL.0000000000201492
KCNH5 encodes the voltage-gated potassium channel EAG2/Kv10.2. We aimed to delineate the neurodevelopmental and epilepsy phenotypic spectrum associated with de novo KCNH5 variants.
Pathway-Specific Mediation Effect Between Structure, Function, and Motor Impairment After Subcortical Stroke.
Yu, Qiurong MS *; Yin, Dazhi PhD *; Kaiser, Marcus PhD; Xu, Guojun PhD; Guo, Miao MS; Liu, Fan MS; Li, Jianqi PhD +; Fan, Mingxia MD +
doi : 10.1212/WNL.0000000000201495
To investigate the pathway-specific correspondence between structural and functional changes resulting from focal subcortical stroke and their causal influence on clinical symptom.
Association of Perfusion Lesion Variables With Functional Outcome in Patients With Mild Stroke and Large Vessel Occlusion Managed Medically.
Wang, Peng MD *; Chen, Wenhuo MD *; Chen, Chushuang PhD *; Bivard, Andrew PhD; Yu, Geng MD; Parsons, Mark W. PhD +; Lin, Longting PhD +; on behalf of INSPIRE
doi : 10.1212/WNL.0000000000201498
The best management of patients with mild stroke and large vessel occlusion (LVO) remains unclear. This study aimed to identify perfusion imaging predictors of poor functional outcome in such patients.
Relationship of Impairments in Associative Learning With Intellectual Disability and Cerebellar Hypoplasia in Autistic Children.
Welsh, John P. PhD; Munson, Jeffrey PhD; St John, Tanya PhD; Meehan, Christina N. EdS; Tran Abraham, Elise MEd; Reitz, Frederick B. PhD; Begay, K. Kawena PhD; Dager, Stephen R. MD; Estes, Annette M. PhD
doi : 10.1212/WNL.0000000000201496
The severity of autism spectrum disorder (ASD) varies widely and is associated with intellectual disability (ID) and brain dysmorphology. We tested the hypothesis that the heterogeneity of ASD can be accounted for, in part, by altered associative learning measured by eye-blink conditioning (EBC) paradigms, used to test for forebrain and cerebellar dysfunction across the full range of ASD severity and intellectual ability.
Protocol for Deferral of Consent in Acute Stroke Trials.
Faris, Hannah BSc; Dewar, Brian MLIS; Fedyk, Mark PhD; Dowlatshahi, Dar MD, PhD, FRCPC; Menon, Bijoy MD, MSc; Swartz, Richard H. MD; Hill, Michael D. MD, MSc, FRCPC; Shamy, Michel MD, MA, FRCPC
doi : 10.1212/WNL.0000000000201533
AB The challenges of conducting hyperacute stroke research and obtaining informed consent have been increasingly recognized within the stroke research community in recent years.
Clinical Reasoning: A 12-Year-Old Girl With Acute-Onset Diplopia, Dizziness, and Upbeat Nystagmus.
Chenji, Gaurav MD; Figgie, Mark Phillips MD; Rondinelli, Monica MD; Ticku, Hemani MD; Fotedar, Neel MD
doi : 10.1212/WNL.0000000000201534
AB We report a case of a 12-year-old girl who presented with acute-onset diplopia, dizziness, and upbeat nystagmus. On examination, she had right internuclear ophthalmoplegia with right eye hypertropia and exotropia and impaired convergence.
Teaching NeuroImage: Mobile Hypopyon as a Clinical Clue for the Diagnosis of Behcet Disease.
Almeida, Igor Melo de MD; Rezende Filho, Flavio Moura MD, PhD; Pedroso, Jose Luiz MD, PhD; Barsottini, Orlando MD, PhD
Editors' Note: Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.
Cao, Shugang; Zhu, Yunfei; Xue, Qun; Xia, Mingwu
Author Response: Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.
Chen, John; Shah, Shailee
Editors' Note: Teaching Video NeuroImage: Bilateral Hemifacial Spasm in Giant Cell Arteritis.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Teaching Video NeuroImage: Bilateral Hemifacial Spasm in Giant Cell Arteritis.
Cornblath, Wayne; Eggenberger, Eric
Author Response: Teaching Video NeuroImage: Bilateral Hemifacial Spasm in Giant Cell Arteritis.
Sechi, Elia; Defazio, Giovanni; Erre, Gian Luca; Solla, Paolo
