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Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios
Wenting Wu, Quan Ding, Zhiwei Zhou, Wenliang Kuang, Lipeng Jiang, Peng Liu, Weiping Ai & Weifeng Zhu
doi : 10.1208/s12249-022-02454-y
Volume 24, issue 2, February 2023
In order to better promote the application of the polymeric mixed micelles (PMMs) in oral delivery, in addition to focusing on the improvement of micellar structural stability, it is necessary to obtain the absorption characteristics of the intact micellar particles.
An Innovative Approach for Formulation of Rutin Tablets Targeted for Colon Cancer Treatment
Aliaa Ismail, Ebtesam El-Biyally & Wedad Sakran
doi : 10.1208/s12249-023-02518-7
The aim of this study was the improvement of rutin solubility along with targeting its release to colon for effective treatment of colon cancer.
An Overview of Taste-Masking Technologies: Approaches, Application, and Assessment Methods
Shuqin Hu, Xiaoxuan Liu, Shuangshuang Zhang & Danyi Quan
doi : 10.1208/s12249-023-02520-z
It is well-known that plenty of active pharmaceutical ingredients (API) inherently possess an unpleasant taste, which influences the acceptance of patients, especially children. Therefore, manufacturing taste-masked dosage forms has attracted a lot of attention.
Ocular Drug Delivery: a Comprehensive Review
Sadek Ahmed, Maha M. Amin & Sinar Sayed
doi : 10.1208/s12249-023-02516-9
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades.
PhysioCell®; — a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics
Marcela Staniszewska, Michal Romanski, Justyna Dobosz, Bartosz Kolodziej, Uladzimir Lipski, Grzegorz Garbacz & Dorota Danielak
doi : 10.1208/s12249-022-02494-4
The physiologically relevant dissolution apparatuses simulate various aspects of gastrointestinal physiology and help to understand and predict the in vivo behavior of an oral dosage form.
Liposomal Doxorubicin: the Sphingomyelin/Cholesterol System Significantly Enhances the Antitumor Efficacy of Doxorubicin
Xianmin Meng, Hongxia Zhang, Lingyan Chen, Mingqi Wang, Kaituo Zhang, Xinrong Liu, Yihui Deng & Yanzhi Song
doi : 10.1208/s12249-022-02489-1
Doxorubicin (DOX) has a cytotoxic effect on many tumor cells; however, its clinical application is limited owing to its strong side effects. Although Doxil® reduces the cardiotoxicity of free DOX, it has also introduced a new dose-limiting toxicity.
Correction: Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels
Kandarp M. Dave, Wanzhu Zhao, Catherine Hoover, Anisha D’Souza & Devika S Manickam
Mitigating Drug Stability Challenges Through Cocrystallization
Jamshed Haneef, Mohd Amir, Nadeem Ahmed Sheikh & Renu Chadha
doi : 10.1208/s12249-023-02522-x
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire life cycle of a product. Various formulation approaches have been employed to overcome drug stability issues.
Facile Technology for Extemporaneous Preparation of Long-Acting Injectable Microparticulate Suspensions at the Patient Side
Sukhada S. Shevade, Maharukh T. Rustomjee & Padma V. Devarajan
doi : 10.1208/s12249-023-02519-6
In this study, we present an innovative and facile in situ approach for extemporaneous preparation of sterile microparticles. An amazingly simple approach, in situ technology circumvents the stability, and scale up challenges as well as sterilization issues associated with long-acting particulate systems.
Nitroso Impurities in Drug Products: An Overview of Risk Assessment, Regulatory Milieu, and Control Strategy
Naseem A. Charoo, Sathish Dharani, Mansoor A. Khan & Ziyaur Rahman
doi : 10.1208/s12249-023-02523-w
Many nitrosamines have been recognized to be carcinogenic for many decades. Despite the fact that several nitrosamine precursors are frequently used in the manufacturing of pharmaceutical products, their potential presence in pharmaceutical products has previously been overlooked due to a lack of understanding on how they form during the manufacturing process.
Best Practices for Integration of Dissolution Data into Physiologically Based Biopharmaceutics Models (PBBM): A Biopharmaceutics Modeling Scientist Perspective
Sivacharan Kollipara1 · Adithya Karthik Bhattiprolu1 · Rajkumar Boddu 1 · Tausif Ahmed 1 · Siddharth Chachad
doi : 10.1208/s12249-023-02521-y
Dissolution is considered as a critical input into physiologically based biopharmaceutics models (PBBM)Â as it governs in vivo exposure. Despite many workshops, initiatives by academia, industry, and regulatory, wider practices are followed for dissolution data input into PBBM models.
Vitamin D3-Loaded Nanoemulsions as a Potential Drug Delivery System for Autistic Children: Formulation Development, Safety, and Pharmacokinetic Studies
Marwa Hasanein Asfour, Sameh Hosam Abd El-Alim, Ahmed Alaa Kassem, Abeer Salama, Amr Sobhi Gouda, Walaa Samy Nazim, Neveen Hassan Nashaat, Maha Hemimi & Nagwa Abdel Meguid
doi : 10.1208/s12249-023-02501-2
The aim of the current study is the development of a vitamin D3 (VD3)-loaded nanoemulsion (NE) formulation to improve VD3 oral bioavailability for management of vitamin D inadequacy in autistic children.
Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review
Derick Muhindo, Rasha Elkanayati, Priyanka Srinivasan, Michael A. Repka & Eman A. Ashour
doi : 10.1208/s12249-023-02524-9
There has been a tremendous increase in the investigations of three-dimensional (3D) printing for biomedical and pharmaceutical applications, and drug delivery in particular, ever since the US FDA approved the first 3D printed medicine, SPRITAM® (levetiracetam) in 2015.
Synthesis of Submicrometric Chitosan Particles Loaded with Calcium Phosphate for Biomedical Applications
Diana Pereira Lopes, Selma Regina Muniz Freitas, Carina Baptiston Tanaka, Giovanne Delechiave, Lucia Nobuco Takamori Kikuchi, Roberto R. Braga, Jamie J. Kruzic, Maria Stella Moreira, Leticia Cristina Cidreira Boaro, Luiz Henrique Catalani & Flávia Gonçalves
doi : 10.1208/s12249-023-02517-8
Chitosan particles loaded with dibasic calcium phosphate anhydrous (DCPA) is a promising strategy for combining antimicrobial and osteoconduction properties in regenerative medicine.
A Hematological and Histopathological Study on Diphenhydramine Nasal Nano-gel and Nano-emulgel for the Management of Allergic Rhinitis in Animal Model
Hina Javed, Syed Nisar Hussain Shah, Furqan Muhammad Iqbal, Nida Javed & Benish Saeed
doi : 10.1208/s12249-023-02515-w
The study aims to determine histamine efficacy on hematologic values in experimental animal model, under physiological and pathological conditions after inducing diphenhydramine-formulated nasal nano-gel/nano-emulgel in comparison with conventional nasal spray regime.
Dermaplaning for Transdermal Drug Permeation Enhancement: A Qualitative and Quantitative Assessment
Akeemat O. Tijani, Dorcas Frempong, Jagroop Kaur, Sophia Sergent, Kara Shaw, Rebecca Lessaint, Maryam Al Shawi, Gabrielle Verana & Ashana Puri
doi : 10.1208/s12249-023-02505-y
In this study, we sought to investigate the effect of dermaplaning, a popular cosmeceutical skin rejuvenation technique on the permeation of drugs. Baclofen and diclofenac were used as hydrophilic and hydrophobic model drugs, respectively.
