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Epithelioid and Spindle Cell Hemangioma: Clinicopathologic Analysis of 18 Primary Bone and Soft Tissue Tumors Highlighting a Predilection for the Hands and Feet, Frequent Multicentricity, and Benign Behavior.
Papke, David J. Jr MD, PhD *; Jagannathan, Jyothi MD +; Dong, Fei MD *; Dickson, Brendan C. MD, MSc ++,[S]; Mertens, Fredrik MD, PhD [//]; Hornick, Jason L. MD, PhD *; Fletcher, Christopher D.M. MD, FRCPath *
doi : 10.1097/PAS.0000000000001974
Volume 47(2) pgs. 147-277 February 2023
AB Epithelioid and spindle cell hemangioma was initially described in 1999 in a series of primary bone tumors and was subsequently suggested by some to represent a variant of epithelioid hemangioma. Here, we studied 18 epithelioid and spindle cell hemangiomas. Nine patients (50%) were male. Age at presentation ranged from 12 to 78 years (median: 38.5 y).
Uterine Inflammatory Myofibroblastic Tumors: Proposed Risk Stratification Model Using Integrated Clinicopathologic and Molecular Analysis.
Ladwig, Nicholas R. MD *; Bean, Gregory R. MD, PhD +; Pekmezci, Melike MD *; Boscardin, John PhD ++; Joseph, Nancy M. MD, PhD *; Therrien, Nicole MD [S]; Sangoi, Ankur R. MD [//]; Piening, Brian PhD [P]; Rajamanickam, Venkatesh BS [P]; Galvin, Matthew BS [P]; Bernard, Brady PhD [P]; Zaloudek, Charles MD *; Rabban, Joseph T. MD *; Garg, Karuna MD #; Umetsu, Sarah E. MD, PhD *
doi : 10.1097/PAS.0000000000001987
AB Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare mesenchymal tumor with largely benign behavior; however, a small subset demonstrate aggressive behavior. While clinicopathologic features have been previously associated with aggressive behavior, these reports are based on small series, and these features are imperfect predictors of clinical behavior.
Changes in the Diagnoses of Breast Core Needle Biopsies on Second Review at a Tertiary Care Center: Implications for Surgical Management.
Calle, Catarina MD *,+; Zhong, Elaine MD *; Hanna, Matthew G. MD *; Ventura, Katia BS *; Friedlander, Maria A. CT(ASCP) *; Morrow, Monica MD ++; Cody, Hiram III MD ++; Brogi, Edi MD, PhD *
doi : 10.1097/PAS.0000000000002002
AB Core needle biopsy (CNB) of breast lesions is routine for diagnosis and treatment planning. Despite refinement of diagnostic criteria, the diagnosis of breast lesions on CNB can be challenging.
Molecular Classification of Extrapulmonary Neuroendocrine Carcinomas With Emphasis on POU2F3-positive Tuft Cell Carcinoma.
Koh, Jiwon MD, PhD *; Kim, Haeryoung MD, PhD *; Moon, Kyung Chul MD, PhD *; Lee, Cheol MD, PhD *; Lee, Kyoungbun MD, PhD *; Ryu, Han Suk MD, PhD *; Jung, Kyeong Cheon MD, PhD *; Jeon, Yoon Kyung MD, PhD *,+
doi : 10.1097/PAS.0000000000001977
AB Extrapulmonary neuroendocrine carcinomas (EP-NECs) are associated with a poor clinical outcome, and limited information is available on the biology and treatment of EP-NECs. We studied EP-NECs by applying the recent novel findings from studies of pulmonary neuroendocrine carcinomas, including POU2F3, the master regulator of tuft cell variant of small cell lung carcinomas
Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18: ZBTB7A Fusion.
Weinreb, Ilan MD *,+; Hahn, Elan MD *,+; Dickson, Brendan C. MD +,++; Rooper, Lisa M. MD [S]; Rupp, Niels J. MD [//]; Freiberger, Sandra N. PhD [//]; Lubin, Daniel MD [P]; Gagan, Jeffrey MD, PhD #; Bishop, Justin A. MD #
doi : 10.1097/PAS.0000000000001980
AB The landscape of salivary gland carcinomas is ever-changing, with a growing list of new tumors and newly elucidated variants of well-known tumor entities. The routine use of next-generation sequencing has been instrumental in identifying novel fusions and tumor entities, which has helped bring the classification to a more objective and evidenced-based model.
Intravascular Large B-Cell Lymphoma Genomic Profile Is Characterized by Alterations in Genes Regulating NF-[kappa]B and Immune Checkpoints.
Gonzalez-Farre, Blanca MD, PhD *,+,++; Ramis-Zaldivar, Joan E. PhD +,++; Castrejon de Anta, Natalia MD *,+; Rivas-Delgado, Alfredo MD +,[S]; Nadeu, Ferran PhD +,++; Salmeron-Villalobos, Julia BS +,++; Enjuanes, Anna PhD +; Karube, Kennosuke MD, PhD [//]; Balague, Olga MD, PhD *,+,++; Cobo, Francesc MD, PhD [P]; Kelleher, Nicholas MD #; Victoria, Ingrid BS *; Veloza, Luis MD, PhD *,**; Teixido, Cristina MD, PhD *,+; Gine, Eva MD, PhD +,++,[S]; Lopez-Guerra, Monica PhD *,+,++; Quintanilla-Martinez, Leticia MD, PhD ++; Lopez-Guillermo, Armando MD, PhD +,++,[S]; Salaverria, Itziar PhD +,++; Campo, Elias MD, PhD *,+,++
doi : 10.1097/PAS.0000000000001978
AB Intravascular large B-cell lymphoma (IVLBCL) is an uncommon lymphoma with an aggressive clinical course characterized by selective growth of tumor cells within the vessels. Its pathogenesis is still uncertain and there is little information on the underlying genomic alterations.
Diagnostic Discrepancies in Small-volume Biopsy for the Initial Diagnosis, Recurrence, and Transformation of Follicular Lymphoma: A Multi-Institutional Collaborative Study.
Volaric, Ashley K. MD *,+; Lin, Oscar MD, PhD ++; Balassanian, Ronald MD [S]; Cook, Stephen MD [//]; Falchi, Lorenzo MD [P]; Fitzpatrick, Megan J. MD #; Frank, Annabel K. MD **; Gupta, Srishti MD +; Hasserjian, Robert P. MD #; Long, Steven MD [S]; Ly, Amy MD #; Menke, Joshua R. MD *; Mou, Eric MD ++; Natkunam, Yasodha MD, PhD *; Reed, Daniel R. ++++; Ruiz-Cordero, Roberto MD [S]; Wang, Linlin MD, PhD [S]; Wen, Kwun Wah MD, PhD [S],[P]; Xie, Yi MD, PhD [S]; Zadeh, Sara L. MD +; Gratzinger, Dita MD, PhD *; the Cyto-Heme Institutional Collaborative (CHIC) Consortium
doi : 10.1097/PAS.0000000000001985
AB Small-volume biopsies (SVBs) including fine-needle aspiration (FNA), cell block, and needle core biopsies (NCB) are increasingly utilized to diagnose and guide the clinical management of lymphoma.
Myxoid Pseudotumor Involving the Renal Sinus: Clinicopathologic Study of 33 Cases Supporting a Distinct Benign Non-neoplastic Lesion.
Hogan, Kevin MD *; McKenney, Jesse K. MD *; Cox, Roni M. MD *; Nguyen, Jane K. MD, PhD *; Shah, Rajal B. MD +; Billings, Steven D. MD *; Przybycin, Christopher G. MD *
doi : 10.1097/PAS.0000000000001968
AB We describe 33 cases of myxoid pseudotumor involving the renal sinus from 31 patients. Patients included 21 men and 10 women, ages 30 to 95 years. Twenty-seven cases (82%) had an associated malignancy, including urothelial carcinoma of the renal pelvis (22 cases), clear cell renal cell carcinoma (3 cases), urothelial carcinoma of the bladder (1 case), and poorly differentiated carcinoma of uncertain lineage (1 case).
Comprehensive Molecular Profiling of Sinonasal Teratocarcinosarcoma Highlights Recurrent SMARCA4 Inactivation and CTNNB1 Mutations.
Rooper, Lisa M. MD *,+; Agaimy, Abbas MD ++; Gagan, Jeffrey MD, PhD [S]; Simpson, Roderick H.W. MB, ChB, FRCPath [//]; Thompson, Lester D.R. MD [P]; Trzcinska, Anna M. DMD #; Ud Din, Nasir MBBS **; Bishop, Justin A. MD [S]
doi : 10.1097/PAS.0000000000001976
AB Sinonasal teratocarcinosarcoma (TCS) is a rare tumor defined by intermixed neuroepithelial, mesenchymal, and epithelial elements. While its etiology was historically ambiguous, we recently reported frequent SMARCA4 loss by immunohistochemistry, suggesting that TCS might be related to SMARCA4-deficient sinonasal carcinomas
Uterine Tumors Resembling Ovarian Sex Cord Tumors: A Clinicopathologic Study of 75 Cases Emphasizing Features Predicting Adverse Outcome and Differential Diagnosis.
Boyraz, Baris MD, PhD; Watkins, Jaclyn C. MD, MS; Young, Robert H. MD, FRCPath; Oliva, Esther MD
doi : 10.1097/PAS.0000000000001981
AB Uterine tumors resembling ovarian sex cord tumors (UTROSCTs), first characterized by Drs Clement and Scully in 1976, are rare neoplasms showing clinical, morphologic, and immunohistochemical overlap with a number of other uterine tumors, most being mesenchymal.
Head and Neck Mesenchymal Tumors with Kinase Fusions: A Report of 15 Cases With Emphasis on Wide Anatomic Distribution and Diverse Histologic Appearance.
Xu, Bin MD, PhD *; Suurmeijer, Albert J.H. MD +; Agaram, Narasimhan P. MD *; Antonescu, Cristina R. MD *
doi : 10.1097/PAS.0000000000001982
AB Mesenchymal tumors harboring various kinase fusions were recently recognized as emerging entities mainly in the soft tissues. We herein investigate the clinicopathologic and molecular characteristics of head and neck mesenchymal tumors harboring kinase fusions.
Epithelioid and Clear Cell Solitary Fibrous Tumors: Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 13 Cases.
Suster, David I. MD *; Mackinnon, Alexander C. MD, PhD +; Mejbel, Haider A. MD +,++; Gross, John M. MD [S]; Suster, Saul MD [//]
doi : 10.1097/PAS.0000000000001983
AB Solitary fibrous tumors (SFTs) are ubiquitous soft tissue neoplasms known for their protean histology and potentially aggressive behavior. Although most cases are composed of a monotonous proliferation of spindle cells, some tumors show unusual cytologic features.
Epithelioid and Spindle Cell Hemangioma: Clinicopathologic Analysis of 18 Primary Bone and Soft Tissue Tumors Highlighting a Predilection for the Hands and Feet, Frequent Multicentricity, and Benign Behavior.
Papke, David J. Jr MD, PhD *; Jagannathan, Jyothi MD +; Dong, Fei MD *; Dickson, Brendan C. MD, MSc ++,[S]; Mertens, Fredrik MD, PhD [//]; Hornick, Jason L. MD, PhD *; Fletcher, Christopher D.M. MD, FRCPath *
doi : 10.1097/PAS.0000000000001974
Volume 47(2) pgs. 147-277 February 2023
AB Epithelioid and spindle cell hemangioma was initially described in 1999 in a series of primary bone tumors and was subsequently suggested by some to represent a variant of epithelioid hemangioma. Here, we studied 18 epithelioid and spindle cell hemangiomas. Nine patients (50%) were male. Age at presentation ranged from 12 to 78 years (median: 38.5 y).
Uterine Inflammatory Myofibroblastic Tumors: Proposed Risk Stratification Model Using Integrated Clinicopathologic and Molecular Analysis.
Ladwig, Nicholas R. MD *; Bean, Gregory R. MD, PhD +; Pekmezci, Melike MD *; Boscardin, John PhD ++; Joseph, Nancy M. MD, PhD *; Therrien, Nicole MD [S]; Sangoi, Ankur R. MD [//]; Piening, Brian PhD [P]; Rajamanickam, Venkatesh BS [P]; Galvin, Matthew BS [P]; Bernard, Brady PhD [P]; Zaloudek, Charles MD *; Rabban, Joseph T. MD *; Garg, Karuna MD #; Umetsu, Sarah E. MD, PhD *
doi : 10.1097/PAS.0000000000001987
AB Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare mesenchymal tumor with largely benign behavior; however, a small subset demonstrate aggressive behavior. While clinicopathologic features have been previously associated with aggressive behavior, these reports are based on small series, and these features are imperfect predictors of clinical behavior.
Changes in the Diagnoses of Breast Core Needle Biopsies on Second Review at a Tertiary Care Center: Implications for Surgical Management.
Calle, Catarina MD *,+; Zhong, Elaine MD *; Hanna, Matthew G. MD *; Ventura, Katia BS *; Friedlander, Maria A. CT(ASCP) *; Morrow, Monica MD ++; Cody, Hiram III MD ++; Brogi, Edi MD, PhD *
doi : 10.1097/PAS.0000000000002002
AB Core needle biopsy (CNB) of breast lesions is routine for diagnosis and treatment planning. Despite refinement of diagnostic criteria, the diagnosis of breast lesions on CNB can be challenging.
Molecular Classification of Extrapulmonary Neuroendocrine Carcinomas With Emphasis on POU2F3-positive Tuft Cell Carcinoma.
Koh, Jiwon MD, PhD *; Kim, Haeryoung MD, PhD *; Moon, Kyung Chul MD, PhD *; Lee, Cheol MD, PhD *; Lee, Kyoungbun MD, PhD *; Ryu, Han Suk MD, PhD *; Jung, Kyeong Cheon MD, PhD *; Jeon, Yoon Kyung MD, PhD *,+
doi : 10.1097/PAS.0000000000001977
AB Extrapulmonary neuroendocrine carcinomas (EP-NECs) are associated with a poor clinical outcome, and limited information is available on the biology and treatment of EP-NECs. We studied EP-NECs by applying the recent novel findings from studies of pulmonary neuroendocrine carcinomas, including POU2F3, the master regulator of tuft cell variant of small cell lung carcinomas
Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18: ZBTB7A Fusion.
Weinreb, Ilan MD *,+; Hahn, Elan MD *,+; Dickson, Brendan C. MD +,++; Rooper, Lisa M. MD [S]; Rupp, Niels J. MD [//]; Freiberger, Sandra N. PhD [//]; Lubin, Daniel MD [P]; Gagan, Jeffrey MD, PhD #; Bishop, Justin A. MD #
doi : 10.1097/PAS.0000000000001980
AB The landscape of salivary gland carcinomas is ever-changing, with a growing list of new tumors and newly elucidated variants of well-known tumor entities. The routine use of next-generation sequencing has been instrumental in identifying novel fusions and tumor entities, which has helped bring the classification to a more objective and evidenced-based model.
Intravascular Large B-Cell Lymphoma Genomic Profile Is Characterized by Alterations in Genes Regulating NF-[kappa]B and Immune Checkpoints.
Gonzalez-Farre, Blanca MD, PhD *,+,++; Ramis-Zaldivar, Joan E. PhD +,++; Castrejon de Anta, Natalia MD *,+; Rivas-Delgado, Alfredo MD +,[S]; Nadeu, Ferran PhD +,++; Salmeron-Villalobos, Julia BS +,++; Enjuanes, Anna PhD +; Karube, Kennosuke MD, PhD [//]; Balague, Olga MD, PhD *,+,++; Cobo, Francesc MD, PhD [P]; Kelleher, Nicholas MD #; Victoria, Ingrid BS *; Veloza, Luis MD, PhD *,**; Teixido, Cristina MD, PhD *,+; Gine, Eva MD, PhD +,++,[S]; Lopez-Guerra, Monica PhD *,+,++; Quintanilla-Martinez, Leticia MD, PhD ++; Lopez-Guillermo, Armando MD, PhD +,++,[S]; Salaverria, Itziar PhD +,++; Campo, Elias MD, PhD *,+,++
doi : 10.1097/PAS.0000000000001978
AB Intravascular large B-cell lymphoma (IVLBCL) is an uncommon lymphoma with an aggressive clinical course characterized by selective growth of tumor cells within the vessels. Its pathogenesis is still uncertain and there is little information on the underlying genomic alterations.
Diagnostic Discrepancies in Small-volume Biopsy for the Initial Diagnosis, Recurrence, and Transformation of Follicular Lymphoma: A Multi-Institutional Collaborative Study.
Volaric, Ashley K. MD *,+; Lin, Oscar MD, PhD ++; Balassanian, Ronald MD [S]; Cook, Stephen MD [//]; Falchi, Lorenzo MD [P]; Fitzpatrick, Megan J. MD #; Frank, Annabel K. MD **; Gupta, Srishti MD +; Hasserjian, Robert P. MD #; Long, Steven MD [S]; Ly, Amy MD #; Menke, Joshua R. MD *; Mou, Eric MD ++; Natkunam, Yasodha MD, PhD *; Reed, Daniel R. ++++; Ruiz-Cordero, Roberto MD [S]; Wang, Linlin MD, PhD [S]; Wen, Kwun Wah MD, PhD [S],[P]; Xie, Yi MD, PhD [S]; Zadeh, Sara L. MD +; Gratzinger, Dita MD, PhD *; the Cyto-Heme Institutional Collaborative (CHIC) Consortium
doi : 10.1097/PAS.0000000000001985
AB Small-volume biopsies (SVBs) including fine-needle aspiration (FNA), cell block, and needle core biopsies (NCB) are increasingly utilized to diagnose and guide the clinical management of lymphoma.
Myxoid Pseudotumor Involving the Renal Sinus: Clinicopathologic Study of 33 Cases Supporting a Distinct Benign Non-neoplastic Lesion.
Hogan, Kevin MD *; McKenney, Jesse K. MD *; Cox, Roni M. MD *; Nguyen, Jane K. MD, PhD *; Shah, Rajal B. MD +; Billings, Steven D. MD *; Przybycin, Christopher G. MD *
doi : 10.1097/PAS.0000000000001968
AB We describe 33 cases of myxoid pseudotumor involving the renal sinus from 31 patients. Patients included 21 men and 10 women, ages 30 to 95 years. Twenty-seven cases (82%) had an associated malignancy, including urothelial carcinoma of the renal pelvis (22 cases), clear cell renal cell carcinoma (3 cases), urothelial carcinoma of the bladder (1 case), and poorly differentiated carcinoma of uncertain lineage (1 case).
Comprehensive Molecular Profiling of Sinonasal Teratocarcinosarcoma Highlights Recurrent SMARCA4 Inactivation and CTNNB1 Mutations.
Rooper, Lisa M. MD *,+; Agaimy, Abbas MD ++; Gagan, Jeffrey MD, PhD [S]; Simpson, Roderick H.W. MB, ChB, FRCPath [//]; Thompson, Lester D.R. MD [P]; Trzcinska, Anna M. DMD #; Ud Din, Nasir MBBS **; Bishop, Justin A. MD [S]
doi : 10.1097/PAS.0000000000001976
AB Sinonasal teratocarcinosarcoma (TCS) is a rare tumor defined by intermixed neuroepithelial, mesenchymal, and epithelial elements. While its etiology was historically ambiguous, we recently reported frequent SMARCA4 loss by immunohistochemistry, suggesting that TCS might be related to SMARCA4-deficient sinonasal carcinomas
Uterine Tumors Resembling Ovarian Sex Cord Tumors: A Clinicopathologic Study of 75 Cases Emphasizing Features Predicting Adverse Outcome and Differential Diagnosis.
Boyraz, Baris MD, PhD; Watkins, Jaclyn C. MD, MS; Young, Robert H. MD, FRCPath; Oliva, Esther MD
doi : 10.1097/PAS.0000000000001981
AB Uterine tumors resembling ovarian sex cord tumors (UTROSCTs), first characterized by Drs Clement and Scully in 1976, are rare neoplasms showing clinical, morphologic, and immunohistochemical overlap with a number of other uterine tumors, most being mesenchymal.
Head and Neck Mesenchymal Tumors with Kinase Fusions: A Report of 15 Cases With Emphasis on Wide Anatomic Distribution and Diverse Histologic Appearance.
Xu, Bin MD, PhD *; Suurmeijer, Albert J.H. MD +; Agaram, Narasimhan P. MD *; Antonescu, Cristina R. MD *
doi : 10.1097/PAS.0000000000001982
AB Mesenchymal tumors harboring various kinase fusions were recently recognized as emerging entities mainly in the soft tissues. We herein investigate the clinicopathologic and molecular characteristics of head and neck mesenchymal tumors harboring kinase fusions.
Epithelioid and Clear Cell Solitary Fibrous Tumors: Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 13 Cases.
Suster, David I. MD *; Mackinnon, Alexander C. MD, PhD +; Mejbel, Haider A. MD +,++; Gross, John M. MD [S]; Suster, Saul MD [//]
doi : 10.1097/PAS.0000000000001983
AB Solitary fibrous tumors (SFTs) are ubiquitous soft tissue neoplasms known for their protean histology and potentially aggressive behavior. Although most cases are composed of a monotonous proliferation of spindle cells, some tumors show unusual cytologic features.
TRAF7-mutated Fibromyxoid Spindle Cell Tumors Are Associated With an Aggressive Clinical Course and Harbor an Undifferentiated Sarcoma Methylation Signature: A Molecular and Clinicopathologic Study of 3 Cases.
Dermawan, Josephine K. MD, PhD *; Villafania, Liliana BS *; Bale, Tejus MD *; Singer, Samuel MD +; D'Angelo, Sandra P. MD ++; Tap, William D. MD ++; Antonescu, Cristina R. MD *
doi : 10.1097/PAS.0000000000001997
AB TRAF7 somatic mutations are rare and have been reported in meningiomas, intraneural perineuriomas, and mesotheliomas. Triggered by an index case of an unclassified low-grade mesenchymal tumor with TRAF7 mutation as the only genetic alteration, we searched our files and identified 2 additional cases with similar features
