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NPP’s approach toward improving rigor and transparency in clinical trials research
Sofiya Hupalo, Chloe J. Jordan, Terri Bowen, Jennifer Mahar, Elizabeth Yepez, Lori Kunath, Sarah Timm, Keri Martinowich, William A. Carlezon Jr., Lisa M. Monteggia & Tony P. GeorgeÂ
doi : 10.1038/s41386-022-01409-y
Volume 48 Issue 3, February 2023
Compulsion and substance use disorder: potential importance of boundary conditions
Cassandra D. Gipson & Joshua S. BeckmannÂ
Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse
Collin M. Lehmann & Khaled MoussawiÂ
Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking
Maria Nalberczak-Skóra, Anna Beroun, Edyta Skonieczna, Anna CaÅ‚y, Magdalena Ziółkowska, Roberto Pagano, Pegah Taheri, Katarzyna Kalita, Ahmad Salamian & Kasia RadwanskaÂ
doi : 10.1038/s41386-022-01464-5
Both human and animal studies indicate that the dentate gyrus (DG) of the hippocampus is highly exploited by drug and alcohol abuse. Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors.
Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice
Vincent Pascoli, Agnès Hiver, Yue Li, Masaya Harada, Vahid Esmaeili & Christian LüscherÂ
doi : 10.1038/s41386-022-01429-8
Addiction-related compulsion-like behavior can be modeled in rodents with drug self-administration (SA) despite harmful consequences.
High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats
Sarah E. Swinford-Jackson, Phillip J. Huffman, Melissa C. Knouse, Arthur S. Thomas, Matthew T. Rich, Sharvari Mankame, Samantha J. Worobey, Mateo Sarmiento, Ayanna Coleman & R. Christopher PierceÂ
doi : 10.1038/s41386-022-01495-y
Previous work indicated that deep brain stimulation (DBS) of the nucleus accumbens shell in male rats attenuated reinstatement of cocaine seeking, an animal model of craving.
Association of functional connectivity of the executive control network or default mode network with cognitive impairment in older adults with remitted major depressive disorder or mild cognitive impairment
Neda Rashidi-Ranjbar, Tarek K. Rajji, Colin Hawco, Sanjeev Kumar, Nathan Herrmann, Linda Mah, Alastair J. Flint, Corinne E. Fischer, Meryl A. Butters, Bruce G. Pollock, Erin W. Dickie, Christopher R. Bowie, Matan Soffer, Benoit H. Mulsant & Aristotle N. VoineskosÂ
doi : 10.1038/s41386-022-01308-2
Major depressive disorder (MDD) is associated with an increased risk of developing dementia. The present study aimed to better understand this risk by comparing resting state functional connectivity (rsFC) in the executive control network (ECN) and the default mode network (DMN) in older adults with MDD or mild cognitive impairment (MCI).
Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens
Jia-Ying Li, Yang-Jung Yu, Chun-Lin Su, Yu-Qi Shen, Chih-Hua Chang & Po-Wu GeanÂ
doi : 10.1038/s41386-022-01417-y
Drug-associated conditioned cues promote subjects to recall drug reward memory, resulting in drug-seeking and reinstatement.
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats
Ruth H. Asch, Santosh Pothula, Takuya Toyonaga, Krista Fowles, Stephanie M. Groman, Rolando Garcia-Milian, Ralph J. DiLeone, Jane R. Taylor & Irina EsterlisÂ
doi : 10.1038/s41386-022-01441-y
Clinical investigations suggest involvement of the metabotropic glutamate receptor 5 (mGluR5) in the pathophysiology of fear learning that underlies trauma-related disorders.
Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats
Connor J. McNulty, Isabella P. Fallon, Jose Amat, Rory J. Sanchez, Nathan R. Leslie, David H. Root, Steven F. Maier & Michael V. BarattaÂ
doi : 10.1038/s41386-022-01443-w
Stress-linked disorders are more prevalent in women than in men and differ in their clinical presentation. Thus, investigating sex differences in factors that promote susceptibility or resilience to stress outcomes, and the circuit elements that mediate their effects, is important.
Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter
Ping Su, Shuxin Yan, Jian Yang, Junchao Tong, James Samsom, Fan You, Yun Li, Qiuyue Chen, Anlong Jiang, Dongxu Zhai, Jiahao Chen, Zuoli Sun, Jingjing Zhou, Min Liu, Frank J. S. Lee, Zhi-Qing David Xu, Xin Wang, Neil Vasdev, Albert H. C. Wong & Fang LiuÂ
doi : 10.1038/s41386-022-01449-4
Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits including those in Alzheimer’s disease.
Transcriptional signatures of the cortical morphometric similarity network gradient in first-episode, treatment-naive major depressive disorder
Kaizhong Xue, Lining Guo, Wenshuang Zhu, Sixiang Liang, Qiang Xu, Lin Ma, Mengge Liu, Yong Zhang & Feng LiuÂ
doi : 10.1038/s41386-022-01474-3
Recent studies have shown that major depressive disorder (MDD) is accompanied by alterations in functional and structural network gradients. However, whether changes are present in the cortical morphometric similarity (MS) network gradient, and the relationship between alterations of the gradient and gene expression remains largely unknown.
The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice
Lionel A. Rodriguez, Sun-Hong Kim, Stephanie C. Page, Claudia V. Nguyen, Elizabeth A. Pattie, Henry L. Hallock, Jessica Valerino, Kristen R. Maynard, Andrew E. Jaffe & Keri MartinowichÂ
doi : 10.1038/s41386-022-01487-y
The lateral septum (LS) is a basal forebrain GABAergic region that is implicated in social novelty. However, the neural circuits and cell signaling pathways that converge on the LS to mediate social behaviors aren’t well understood.
Adolescent �-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions
Marta De Felice, Chaochao Chen, Mar RodrÃÂguez-Ruiz, Hanna J. Szkudlarek, Michael Lam, Selvi Sert, Shawn N. Whitehead, Ken K.-C. Yeung, Walter J. Rushlow & Steven R. LavioletteÂ
doi : 10.1038/s41386-022-01496-x
Chronic exposure to �-9-tetrahydrocannabinol (THC) during adolescence is associated with long-lasting cognitive impairments and enhanced susceptibility to anxiety and mood disorders. Previous evidence has revealed functional and anatomical dissociations between the posterior vs.
Working memory processing deficit associated with a nonlinear response pattern of the anterior cingulate cortex in first-episode and drug-naïve schizophrenia
Nana Feng, Lena Palaniyappan, Trevor W. Robbins, Luolong Cao, Shuanfeng Fang, Xingwei Luo, Xiang Wang & Qiang LuoÂ
doi : 10.1038/s41386-022-01499-8
Impaired working memory (WM) is a core neuropsychological dysfunction of schizophrenia, however complex interactions among the information storage, information processing and attentional aspects of WM tasks make it difficult to uncover the psychophysiological mechanisms of this deficit
Neural underpinnings of open-label placebo effects in emotional distress
Michael Schaefer, Anja Kühnel, Felix Schweitzer, Sören Enge & Matti GärtnerÂ
doi : 10.1038/s41386-022-01501-3
While placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have beneficial effects even when given without deception.
Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first episode psychosis: data from the STRATA collaboration
Alice Egerton, Kira Griffiths, Cecila Casetta, Bill Deakin, Richard Drake, Oliver D. Howes, Laura Kassoumeri, Sobia Khan, Steve Lankshear, Jane Lees, Shon Lewis, Elena Mikulskaya, Edward Millgate, Ebenezer Oloyede, Rebecca Pollard, Nathalie Rich, Aviv Segev, Kyra-Verena Sendt & James H. MacCabeÂ
doi : 10.1038/s41386-022-01508-w
Elevated brain glutamate has been implicated in non-response to antipsychotic medication in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from the first episode of psychosis (FEP) could allow stratification of patients; for example, patients predicted not to respond to standard antipsychotics could be fast-tracked to clozapine.
IN MEMORIAM�Norton Herbert Neff, Ph.D. (1935–2022)
Michael J. McCarthy & Maria HadjiconstantinouÂ
