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Making Sense of Multimorbidity in Rheumatoid Arthritis
Claire E. H. Barber, Christie M. Bartels
doi : 10.1002/acr.24986
Using Unsupervised Machine Learning Methods to Cluster Comorbidities in a Population-Based Cohort of Patients With Rheumatoid Arthritis
Cynthia S. Crowson, Tina M. Gunderson, John M. Davis III, Elena Myasoedova, Vanessa L. Kronzer, Caitrin M. Coffey, Elizabeth J. Atkinson
doi : 10.1002/acr.24973
To identify clusters of comorbidities in patients with rheumatoid arthritis (RA) using 4 methods and to compare to patients without RA.
Identification of Multimorbidity Patterns in Rheumatoid Arthritis Through Machine Learning
Bryant R. England, Yangyuna Yang, Punyasha Roul, Christian Haas, Lotfollah Najjar, Harlan Sayles, Fang Yu, Brian C. Sauer, Joshua F. Baker, Fenglong Xie, Kaleb Michaud, Jeffrey R. Curtis, Ted R. Mikuls
doi : 10.1002/acr.24956
Recognizing that the interrelationships between chronic conditions that complicate rheumatoid arthritis (RA) are poorly understood, we aimed to identify patterns of multimorbidity and to define their prevalence in RA through machine learning.
Influence of Multimorbidity on New Treatment Initiation and Achieving Target Disease Activity Thresholds in Active Rheumatoid Arthritis: A Cohort Study Using the Rheumatology Informatics System for Effectiveness Registry
Bryant R. England, Huifeng Yun, Lang Chen, Jared Vanderbleek, Kaleb Michaud, Ted R. Mikuls, Jeffrey R. Curtis
doi : 10.1002/acr.24762
To determine whether multimorbidity is associated with treatment changes and achieving target disease activity thresholds in patients with active rheumatoid arthritis (RA).
Effectiveness and Safety of Tofacitinib in Canadian Patients With Rheumatoid Arthritis: Primary Results From a Prospective Observational Study
Boulos Haraoui, Majed Khraishi, Denis Choquette, Larissa Lisnevskaia, Michelle Teo, Cassandra Kinch, Corina Galos, Patrice Roy, David Gruben, John C. Woolcott, Julie Vaillancourt, John S. Sampalis, Edward C. Keystone
doi : 10.1002/acr.24966
The Canadian Tofacitinib for Rheumatoid Arthritis Observational (CANTORAL) is the first Canadian prospective, observational study assessing tofacitinib. The objective was to assess effectiveness and safety for moderate to severe rheumatoid arthritis (RA). Coprimary and secondary outcomes are reported from an interim analysis.
Vehicle Control as a Measure of Real-World Driving Performance in Patients With Rheumatoid Arthritis
Ted R. Mikuls, Jennifer Merickel, Yeongjin Gwon, Harlan Sayles, Alison Petro, Amy Cannella, Marcus H. Snow, Michael Feely, Bryant R. England, Kaleb Michaud, Matthew Rizzo
doi : 10.1002/acr.24769
To quantify vehicle control as a metric of automobile driving performance in patients with rheumatoid arthritis (RA).
Risk of Cancer After Initiation of Targeted Therapies in Patients With Rheumatoid Arthritis and a Prior Cancer: Systematic Review With Meta-Analysis
Amélie Wetzman, Cédric Lukas, Cécile Gaujoux-Viala, Ronac Mamtani, Thomas Barnetche, Bernard Combe, Jacques Morel, Paulina Szafors
doi : 10.1002/acr.24784
To determine the risk of recurrent or new malignancy with exposure to targeted disease-modifying antirheumatic drugs (DMARDs) in adults with rheumatoid arthritis (RA), axial spondyloarthritis (SpA), or psoriatic arthritis (PsA) and a history of cancer.
Association of Healthy Lifestyle Behaviors and the Risk of Developing Rheumatoid Arthritis Among Women
Jill Hahn, Susan Malspeis, May Y. Choi, Emma Stevens, Elizabeth W. Karlson, Bing Lu, Jing Cui, Kazuki Yoshida, Laura Kubzansky, Jeffrey A. Sparks, Karen H. Costenbader
doi : 10.1002/acr.24862
To investigate whether a healthy lifestyle, defined by a healthy lifestyle index score (HLIS), was associated with rheumatoid arthritis (RA) risk, overall and with seropositive/seronegative subtypes.
Cardiovascular Disease Risk in Calcium Pyrophosphate Deposition Disease: A Nationwide Study of Veterans
Maaman Bashir, Katherine A. Sherman, Daniel H. Solomon, Ann Rosenthal, Sara K. Tedeschi
doi : 10.1002/acr.24783
Calcium pyrophosphate deposition (CPPD) disease represents a common crystalline arthritis with a range of manifestations. Our goal was to investigate risks for cardiovascular events in patients with CPPD.
Confirming Prior and Identifying Novel Correlates of Acute Calcium Pyrophosphate Crystal Arthritis
Sara K. Tedeschi, Kazuki Yoshida, Weixing Huang, Daniel H. Solomon
doi : 10.1002/acr.24770
To investigate previously identified and novel correlates of acute calcium pyrophosphate (CPP) crystal arthritis among well-characterized cases.
Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype
Jenice X. Cheah, Jamie Perin, Elizabeth R. Volkmann, Laura K. Hummers, Pankaj J. Pasricha, Fredrick M. Wigley, Zsuzsanna H. McMahan
doi : 10.1002/acr.24767
Up to 50% of patients with systemic sclerosis (SSc) experience slow colonic transit, which may be associated with severe outcomes. Our objective, therefore, was to identify specific clinical features associated with slow colonic transit in SSc.
Ultrasound Classification of Finger Pulp Blood Flow in Patients With Systemic Sclerosis: A Pilot Study
Alain Lescoat, François Robin, Nicolas Belhomme, Alice Ballerie, Marine de Saint Riquier, Martine Sebillot, Jean-David Albert, Thomas Le Gallou, Aleth Perdriger, Patrick Jégo, Guillaume Coiffier, Claire Cazalets
doi : 10.1002/acr.24779
To define a semiquantitative classification of finger pulp blood flow (FPBF) and to evaluate whether this classification could be used to assess FPBF in healthy controls and in systemic sclerosis (SSc) patients.
Clinical and Molecular Findings After Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data
Lynette Keyes-Elstein, Ashley Pinckney, Ellen Goldmuntz, Beverly Welch, Jennifer M. Franks, Viktor Martyanov, Tammara A. Wood, Leslie Crofford, Maureen Mayes, Peter McSweeney, Richard Nash, George Georges, M. E. Csuka, Robert Simms, Daniel Furst, Dinesh Khanna, E. William St Clair, Michael L. Whitfield, Keith M. Sullivan
doi : 10.1002/acr.24785
Among individuals with systemic sclerosis (SSc) randomized to cyclophosphamide (CYC) (n = 34) or hematopoietic stem cell transplantation (HSCT) (n = 33), we examined longitudinal trends of clinical, pulmonary function, and quality of life measures while accounting for the influence of early failures on treatment comparisons.
Understanding COVID-19 Risk in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Analysis of SARS–CoV-2 Testing
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
doi : 10.1002/acr.24781
To investigate the incidence of and factors associated with SARS–CoV-2 testing and infection in immune-mediated inflammatory disease (IMID) patients versus matched non-IMID comparators from the general population.
Increased Relapse Rate During COVID-19 Lockdown in an Italian Cohort of Children With Juvenile Idiopathic Arthritis
Roberta Naddei, Renata Alfani, Martina Bove, Valentina Discepolo, Filomena Mozzillo, Alfredo Guarino, Maria Alessio
doi : 10.1002/acr.24768
Changes of routine disease management associated with COVID-19 lockdown might have potentially affected the clinical course of juvenile idiopathic arthritis (JIA). The aim of our study was to assess the rate of disease flare before and during COVID-19 lockdown to investigate its impact on disease course in children with JIA.
Incidence of Ankylosing Spondylitis Among Male and Female United States Army Personnel
D. Alan Nelson, Robert M. Kaplan, Lianne M. Kurina, Michael H. Weisman
doi : 10.1002/acr.24774
Incidence rates of ankylosing spondylitis (AS) among males versus females are poorly understood. Results of prior research have been mixed, including findings of a 3:1 incidence ratio for males versus females, but with increasing AS rates among females. The objective was to estimate the incidence of AS among members of the US military.
Association Between Structural Change Over Eighteen Months and Subsequent Symptom Change in Middle-Aged Patients Treated for Meniscal Tear
Jeffrey N. Katz, Jamie E. Collins, Morgan Jones, Kurt P. Spindler, Robert G. Marx, Lisa A. Mandl, Bruce A. Levy, Rick Wright, Mohamed Jarraya, Ali Guermazi, Lindsey A. MacFarlane, Elena Losina, Yuchiao Chang
doi : 10.1002/acr.24796
Middle-aged subjects with meniscal tear treated with arthroscopic partial meniscectomy (APM) experience greater progression of damage to joint structures on imaging than subjects treated nonoperatively.
Incidence, Prevalence, and Mortality of Dermatomyositis: A Population-Based Cohort Study
Vanessa L. Kronzer, Bradly A. Kimbrough, Cynthia S. Crowson, John M. Davis III, Marie Holmqvist, Floranne C. Ernste
doi : 10.1002/acr.24786
We aimed to determine the population-based incidence, prevalence, and mortality of dermatomyositis (DM) using European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria.
Polypharmacy and Potentially Inappropriate Medication Use in Older Adults With Systemic Lupus Erythematosus
Dale Jean-Guy Séguin, Christine A. Peschken, Cassandra Dolovich, Ruby E. Grymonpre, Philip D. St. John, Annaliese Tisseverasinghe
doi : 10.1002/acr.24766
To assess the prevalence and potential risk factors for polypharmacy and prescribing of the potentially inappropriate medications, opioids and benzodiazepines/Z-drugs, in older adults with systemic lupus erythematosus (SLE).
Using Patient-Reported Health Data From Social Media to Identify Diverse Lupus Patients and Assess Their Symptom and Medication Expressions: A Feasibility Study
Swamy Venuturupalli, Amit Kumar, Alden Bunyan, Nikhil Davuluri, Natalie Fortune, Katja Reuter
doi : 10.1002/acr.24868
Patient communities use social media for peer support and information seeking. This study assessed the feasibility of using public patient-generated health data from the social network Twitter to identify diverse lupus patients and gather their perspectives about disease symptoms and medications.
Development and Validation of a Juvenile Spondyloarthritis Disease Flare Measure: Ascertaining Flare in Patients With Inactive Disease
Pamela F. Weiss, Timothy G. Brandon, Meghan E. Ryan, Erin B. Treemarcki, Stephanie Armendariz, Tracey B. Wright, Chetna Godiwala, Matthew L. Stoll, Rui Xiao, Daniel Lovell
doi : 10.1002/acr.24763
Our objective was to develop and validate a composite disease flare definition for juvenile spondyloarthritis (SpA) that would closely approximate the clinical decision made to reinitiate or not reinitiate systemic therapy after therapy de-escalation.
Comparison of Patient-Reported Outcomes Measurement Information System Computerized Adaptive Testing Versus Fixed Short Forms in Juvenile Myositis
Ruchi N. Patel, Valeria G. Esparza, Jin-Shei Lai, Elizabeth L. Gray, Bryce B. Reeve, Rowland W. Chang, David Cella, Kaveh Ardalan
doi : 10.1002/acr.24760
Patient-Reported Outcomes Measurement Information System (PROMIS) measures can be administered via computerized adaptive testing (CAT) or fixed short forms (FSFs), but the empirical benefits of CAT versus FSFs are unknown in juvenile myositis (JM).
Validity and Reliability of Four Parent/Patient–Reported Outcome Measures for Juvenile Idiopathic Arthritis Remote Monitoring
E. H. Pieter van Dijkhuizen, Francesca Ridella, Roberta Naddei, Chiara Trincianti, Ilia Avrusin, Marta Mazzoni, Diana Sutera, Nuray Aktay Ayaz, Inmaculada Calvo Penades, Tamas Constantin, Troels Herlin, Sheila K. Oliveira, Marite Rygg, Helga Sanner, Gordana Susic, Flavio Sztajnbok, Boriana Varbanova, Nicolino Ruperto, Angelo Ravelli, Alessandro Consolaro, for the Paediatric Rheumatology International Trials Organisation (PRINTO)
doi : 10.1002/acr.24855
The aim of this work was to provide evidence of validity and reliability for 4 parent/child–reported outcome measures included in the Outcome Measures in Rheumatology juvenile idiopathic arthritis core domain set: the evaluation of the child's pain and level of disease activity, the assessment of morning stiffness duration, and an active joint count for proxy/self-assessment.
Musculoskeletal Ultrasound in Childhood Arthritis Limited Examination: A Comprehensive, Reliable, Time-Efficient Assessment of Synovitis
Patricia Vega-Fernandez, Tracy V. Ting, Edward J. Oberle, Courtney McCracken, Janet Figueroa, Mekibib Altaye, Amy Cassedy, Gurjit S. Kaeley, Johannes Roth, for the CARRA Musculoskeletal Ultrasound Workgroup
doi : 10.1002/acr.24759
To develop and initially validate a comprehensive pediatric musculoskeletal ultrasound (MSUS) joint-specific scoring system, and to determine the minimum number of joints needed to identify active disease.
Dosing Variation at Initiation of Adalimumab and Etanercept and Clinical Outcomes in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study
Ruud H. J. Verstegen, Peter Shrader, Stephen J. Balevic, Timothy Beukelman, Colleen Correll, Anne Dennos, Thomas Phillips, Brian M. Feldman, for the CARRA Registry Investigators
doi : 10.1002/acr.24859
To determine the dose–response relationship of tumor necrosis factor (TNF) inhibition in the treatment of juvenile idiopathic arthritis (JIA).
Biopsychosocial Rehabilitation for Inflammatory Arthritis and Osteoarthritis Patients: A Systematic Review and Meta-Analysis of Randomized Trials
Morten B. Pedersen, Peter Thinggaard, Rinie Geenen, Marianne U. Rasmussen, Maarten De Wit, Lyn March, Philip Mease, Ernest Choy, Philip G. Conaghan, Lee Simon, Anne Faber Hansen, Simon Tarp, Berit Schiøttz-Christensen, Carsten B. Juhl, Sabrina M. Nielsen, Kirstine Amris, Robin Christensen
doi : 10.1002/acr.24816
To assess the benefits and harms associated with biopsychosocial rehabilitation in patients with inflammatory arthritis and osteoarthritis (OA).
Ambulatory Medication Safety: Vaccination and Laboratory Screening for Patients Receiving Immunomodulatory Therapies
Anne M. McDonnell, Maura Iversen, Roaa M. Khinkar, Michelle Frits, Julie Fiskio, Sonali Desai
doi : 10.1002/acr.24764
Immunomodulatory therapies improve the management of chronic diseases but can be associated with infectious risk.
Setting an interdisciplinary framework to improve functional outcomes in axial spondyloarthritis: comment on the article by Barnett and Sengupta
Eugénio Moita Gonçalves, Tiago Melo Beirão, Flávio Costa, PatrÃcia Pinto, Ana Campolargo, Cátia Brazete, Inês Andrade
doi : 10.1002/acr.25012
