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Gender Equality in Neurology Careers: Are We There Yet?.
Burch, Rebecca MD; Strowd, Roy MD, MEd, MS
doi : 10.1212/WNL.0000000000200761
Volume 100(5) pgs. 221-265,e454-e557 January 31, 2023
Optimizing Choice of Dual Antiplatelet Therapy in CYP2C19 Loss-of-Function Carriers.
Brown, Tiffany MD; Gonzales, Nicole
SLC35A2-Related Epilepsy: Global Neuronal Consequences of a Focal Disruption in Glycosylation.
Goldman, Alica M. MD, PhD, MSc *; Thio, K. Liu Lin MD, PhD *
Gender Disparities in the Career of Neurology Researchers.
Hall, Deborah A. MD, PhD; Cahill, Carolyn BA; Meyer, Ana-Claire L. MD, MSHSH; Peltier, Amanda MD; Dy-Hollins, Marisela MD; Goldman, Myla MD, MS; on behalf of The American Academy of Neurology Clinical Research Subcommittee
doi : 10.1212/WNL.0000000000200773
To assess gender disparities in neurology researcher careers in the United States. Methods: A 34-question survey was distributed to 4,644 US-based American Academy of Neurology members who self-identified as researchers in 2020 addressing the following domains: research and funding, scholarly activities, coronavirus disease 2019 (COVID-19) effect, and local institutional climate.
Gender Representation Among Physician Authors of Practice Guidelines Developed, Endorsed, or Affirmed by the American Academy of Neurology.
Ross, Lindsay MD; Hassett, Catherine DO; Brown, Peter DO; Spurgeon, Elizabeth MD; Mathew, Rachael BA; Bal, Gabriella BA; Hussain, Muhammad Shazam MD; Martin, Amarilis MD; Silver, Julie K. MD *; Rensel, Mary MD *
doi : 10.1212/WNL.0000000000200567
To assess American Academy of Neurology (AAN)-recommended Practice Guidelines (PGs) for equity in gender representation among physician authors.
Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort.
Planche, Vincent MD, PhD; Bouteloup, Vincent PharmD; Pellegrin, Isabelle MD, PhD; Mangin, Jean-Francois PhD; Dubois, Bruno MD PhD; Ousset, Pierre-Jean MD; Pasquier, Florence MD PhD; Blanc, Frederic MD, PhD; Paquet, Claire MD, PhD; Hanon, Olivier MD, PhD; Bennys, Karim MD; Ceccaldi, Mathieu MD, PhD; Annweiler, Cedric MD, PhD; Krolak-Salmon, Pierre MD; Godefroy, Olivier MD, PhD; Wallon, David MD, PhD; Sauvee, Mathilde MD; Boutoleau-Bretonniere, Claire MD, PhD; Bourdel-Marchasson, Isabelle MD, PhD; Jalenques, Isabelle MD, PhD; Chene, Genevieve MD, PhD *; Dufouil, Carole PhD *; and the MEMENTO Study Group
doi : 10.1212/WNL.0000000000201479
Blood biomarkers for Alzheimer disease (AD) have consistently proven to be associated with CSF or PET biomarkers and effectively discriminate AD from other neurodegenerative diseases.
Involvement of Thalamocortical Networks in Patients With Poststroke Thalamic Aphasia.
Stockert, Anika MD *; Hormig-Rauber, Sophia *; Wawrzyniak, Max MD; Klingbeil, Julian MD; Schneider, Hans Ralf; Pirlich, Mandy MD; Schob, Stefan MD; Hoffmann, Karl-Titus MD; Saur, Dorothee MD
doi : 10.1212/WNL.0000000000201488
Theories assume that thalamic stroke may cause aphasia because of dysfunction in connected cortical networks. This takes into account that brain functions are organized in distributed networks, and in turn, localized damage may result in a network disorder such as thalamic aphasia.
Ticagrelor Aspirin vs Clopidogrel Aspirin in CYP2C19 Loss-of-Function Carriers With Minor Stroke or TIA Stratified by Risk Profile.
Wang, Anxin PhD *; Meng, Xia MD *; Tian, Xue PhD; Zuo, Yingting PhD; Bath, Philip M. D.Sc.; Li, Hao PhD; Xie, Xuewei MD; Jing, Jing MD; Lin, Jinxi MD; Wang, Yilong MD; Zhao, Xingquan MD; Liu, Liping MD; Li, Zixiao MD, PhD; Jiang, Yong MD, PhD; Xu, Jie MD; Wang, Feng MD; Chen, Weifeng BM; Cao, Minghua MD; Li, Jianhua MD; Wang, Yongjun MD
doi : 10.1212/WNL.0000000000201454
Genotype data of the Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) trial showed that efficacy of clopidogrel aspirin depended on CYP2C19 genotype and risk profile.
Cumulative Alcohol Consumption Burden and the Risk of Stroke in Young Adults: A Nationwide Population-Based Study.
Chung, Jae-wook MD *; Lee, So-Ryoung MD, PhD *; Choi, Eue-Keun MD, PhD; Park, Sang-Hyeon MD; Lee, HuiJin MD; Choi, JungMin MD; Han, Minju MD; Ahn, Hyo-Jeong MD; Kwon, Soonil MD; Lee, SeungWoo; Han, Kyungdo PhD; Kim, Sunhwa MD; Oh, Seil MD, PhD; Lip, Gregory Y. H. FRCP
doi : 10.1212/WNL.0000000000201473
Alcohol consumption is one of the important modifiable risk factors for stroke in young adults. The association between the cumulative burden of alcohol consumption and its impact on incident stroke in young adults is unknown.
Prospective Study of Gray Matter Atrophy Following Pediatric Mild Traumatic Brain Injury.
Mayer, Andrew R. PhD; Meier, Timothy B. PhD; Dodd, Andrew B. MS; Stephenson, David D. PhD; Robertson-Benta, Cidney R. BS; Ling, Josef M. BA; Pabbathi Reddy, Sharvani MS; Zotev, Vadim PhD; Vakamudi, Kishore MS; Campbell, Richard A. PhD; Sapien, Robert E. MD; Erhardt, Erik B. PhD; Phillips, John P. MD; Vakhtin, Andrei A. PhD
doi : 10.1212/WNL.0000000000201470
The clinical and physiologic time course for recovery following pediatric mild traumatic brain injury (pmTBI) remains actively debated. The primary objective of the current study was to prospectively examine structural brain changes (cortical thickness and subcortical volumes) and age-at-injury effects.
Clinical Features, Neuropathology, and Surgical Outcome in Patients With Refractory Epilepsy and Brain Somatic Variants in the SLC35A2 Gene.
Barba, Carmen MD, PhD; Blumcke, Ingmar MD; Winawer, Melodie R. MD, MS; Hartlieb, Till MD; Kang, Hoon-Chul MD; Grisotto, Laura PhD; Chipaux, Mathilde MD, PhD; Bien, Christian G. MD; Hermanovska, Barbora MD; Porter, Brenda E. MD, PhD; Lidov, Hart G.W. MD, PhD; Cetica, Valentina PhD; Woermann, Friedrich G. MD; Lopez-Rivera, Javier A. PhD; Canoll, Peter D. MD, PhD; Mader, Irina MD; D'Incerti, Ludovico MD; Baldassari, Sara PhD; Yang, Edward MD, PhD; Gaballa, Ahmed MBBS; Vogel, Hannes MD; Straka, Barbora MD, PhD; Macconi, Letizia MD; Polster, Tilman MD; Grant, Gerald A. MD; Krskova, Lenka MD, PhD; Shin, Hui Jin MD; Ko, Ara MD; Crino, Peter B. MD, PhD; Krsek, Pavel MD, PhD; Lee, Jeong Ho MD, PhD; Lal, Dennis PhD; Baulac, Stephanie PhD; Poduri, Annapurna MD; Guerrini, Renzo MD, FRCP; on behalf of the SLC35A2 Study Group
doi : 10.1212/WNL.0000000000201471
AB Background and Objectives: The SLC35A2 gene, located at chromosome Xp11.23, encodes for a uridine diphosphate-galactose transporter. We describe clinical, genetic, neuroimaging, EEG, and histopathologic findings and assess possible predictors of postoperative seizure and cognitive outcome in 47 patients with refractory epilepsy and brain somatic SLC35A2 gene variants.
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome.
Ronco, Riccardo MD *; Perini, Cecilia MSc *; Curro, Riccardo MD *; Dominik, Natalia MSc *; Facchini, Stefano PhD; Gennari, Alice MSc; Simone, Roberto PhD; Stuart, Skye MSc; Nagy, Sara MD; Vegezzi, Elisa MD; Quartesan, Ilaria MD; El-Saddig, Amar MD; Lavin, Timothy MD; Tucci, Arianna MD, PhD; Szymura, Agnieszka BSc; Novis De Farias, Luiz Eduardo MD; Gary, Alexander MSc; Delfeld, Megan MSc; Kandikatla, Priscilla MSc; Niu, Nifang MBBS, PhD; Tawde, Sanjukta MSc; Shaw, Joseph MSc; Polke, James PhD; Reilly, Mary M.; Wood, Nick W. MD, PhD; Crespan, Emmanuele PhD; Gomez, Christopher MD, PhD; Chen, Jin Yun Helen MSc; Schmahmann, Jeremy Dan MD; Gosal, David MD; Houlden, Henry MD, PhD +; Das, Soma PhD +; Cortese, Andrea MD, PhD +
doi : 10.1212/WNL.0000000000201486
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is an autosomal recessive neurodegenerative disease characterized by adult-onset and slowly progressive sensory neuropathy, cerebellar dysfunction, and vestibular impairment
Where's the Vision? The Importance of Visual Outcomes in Neurologic Disorders: The 2021 H. Houston Merritt Lecture.
Patil, Sachi A. MD; Grossman, Scott MD; Kenney, Rachel PhD; Balcer, Laura J. MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000201490
AB Neurologists have long recognized the importance of the visual system in the diagnosis and monitoring of neurologic disorders. This is particularly true because approximately 50% of the brain's pathways subserve afferent and efferent aspects of vision.
Clinical Reasoning: A 66-Year-Old Woman With Progressive Encephalopathy and Bilateral Hearing Loss.
Rivers, Dustin MD; Gunnell, Spencer DO; Clark, Jeffrey DO; Lenehan, Richard MD; Phenis, Richard Psy.D; Shan, Yuan MD; Castro, Eduardo MD
Teaching NeuroImage: Acute Onset Gait Instability and Lateropulsion Secondary to Cerebellar Vermis Stroke.
Gheihman, Galina MD; Yomtoob, Jacob MD; Viswanathan, Anand MD, PhD
Gray Matter Matters in Mild Traumatic Brain Injury.
Bigler, Erin D. PhD
Editors' Note: Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults.
Daly, Timothy
Author Response: Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults.
Demnitz-King, Harriet; Marchant, Natalie L.
Editors' Note: An International Perspective on Preceding Infections in Guillain-Barre Syndrome: The IGOS-1000 Cohort.
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
Reader Response: An International Perspective on Preceding Infections in Guillain-Barre Syndrome: The IGOS-1000 Cohort.
Debnath, Monojit; Nagappa, Madhu
Author Response: An International Perspective on Preceding Infections in Guillain-Barre Syndrome: The IGOS-1000 Cohort.
Leonhard, Sonja E.; van der Eijk, Annemiek A.; Willison, Hugh J.; Jacobs, Bart C.
Gender Representation Among Physician Authors of Practice Guidelines Developed, Endorsed, or Affirmed by the American Academy of Neurology.
Impulsivity Trait Profiles in Patients With Cerebellar Ataxia and Parkinson Disease.
Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy.
