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Clinical utility of intraoperative electrocorticography for epilepsy surgery: A systematic review and meta-analysis
Keshav Goel, Valérie Pek, Nathan A. Shlobin, Jia-Shu Chen, Andrew Wang, George M. Ibrahim, Aristides Hadjinicolaou, Karl Roessler, Roy W. Dudley, Dang K. Nguyen, Riëm El-Tahry, Aria Fallah, Alexander G. Weil
doi : 10.1111/epi.17472
Despite the widespread use of intraoperative electrocorticography (iECoG) during resective epilepsy surgery, there are conflicting data on its overall efficacy and inability to predict benefit per pathology.
Task-based functional magnetic resonance imaging prediction of postsurgical cognitive outcomes in temporal lobe epilepsy: A systematic review, meta-analysis, and new data
Andrew J. D. Crow, Alisha Thomas, Yash Rao, Ashithkumar Beloor-Suresh, David Weinstein, Walter A. Hinds, Joseph I. Tracy
doi : 10.1111/epi.17475
Task-based functional magnetic resonance imaging (tfMRI) has developed as a common alternative in epilepsy surgery to the intracarotid amobarbital procedure, also known as the Wada procedure.
Does the ketogenic ratio matter when using ketogenic diet therapy in pediatric epilepsy?
Suvasini Sharma, Robyn Whitney, Eric H. Kossoff, Rajesh RamachandranNair
doi : 10.1111/epi.17476
The ketogenic diet (KD) is a widely used therapeutic option for individuals with medically refractory epilepsy.
Transforming epilepsy research: A systematic review on natural language processing applications
Arister N. J. Yew, Marijn Schraagen, Willem M. Otte, Eric van Diessen
doi : 10.1111/epi.17474
Despite improved ancillary investigations in epilepsy care, patients' narratives remain indispensable for diagnosing and treatment monitoring.
Acute symptomatic seizures, epilepsy, and autoimmune encephalitis: Clarifying terminology in neural antibody-associated disease
Adrian Budhram, Jorge G. Burneo
doi : 10.1111/epi.17478
In silico screening for clinical efficacy of antiseizure medications: Not all central nervous system drugs are alike
Roaa Hamed, Amit David Eyal, Erez Berman, Sara Eyal
doi : 10.1111/epi.17479
Somatic symptoms and related disorders in a large cohort of people with epilepsy: A cohort study
Sisi Shen, Zaiquan Dong, Josemir W. Sander, Dong Zhou, Jinmei Li
doi : 10.1111/epi.17453
This study was undertaken to characterize somatic symptoms and related disorders (SSD) in epilepsy.
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy
Christian Hoppe, Kassandra Beeres, Juri-Alexander Witt, Robert Sassen, Christoph Helmstaedter
doi : 10.1111/epi.17477
Pediatric epilepsy surgery promises seizure freedom or even cure of epilepsy. We evaluated the long-term (≥10 years) adult clinical outcome including surgery-related adverse events and complications, which are generally underreported.
Intrinsic and secondary epileptogenicity in focal cortical dysplasia type II
Emma Macdonald-Laurs, Aaron E. L. Warren, Wei Shern Lee, Joseph Yuan-Mou Yang, Duncan MacGregor, Paul J. Lockhart, Richard J. Leventer, Andrew Neal, A. Simon Harvey
doi : 10.1111/epi.17495
Favorable seizure outcome is reported following resection of bottom-of-sulcus dysplasia (BOSD). We assessed the distribution of epileptogenicity and dysplasia in and around BOSD to better understand this clinical outcome and the optimal surgical approach.
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults
Michael A. Rogawski, Gary Slatko
doi : 10.1111/epi.17459
The pharmacokinetics of oral diazepam are affected by food, but food-effect studies have not been conducted for diazepam nasal spray because it is believed that most absorption occurs via the nasal mucosa.
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination
Jacqueline French, Victor Biton, Hina Dave, Kamil Detyniecki, Michael A. Gelfand, Hui Gong, Kore Liow, Terence J. O'Brien, Ahmed Sadek, Bree DiVentura, Brittany Reich, Jouko Isojarvi
doi : 10.1111/epi.17441
Alprazolam administered via the Staccato® breath-actuated device is delivered into the deep lung for rapid systemic exposure and is a potential therapy for rapid epileptic seizure termination (REST).
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex
Matthew Lynch, Kirsty Smith, Kate Riney
doi : 10.1111/epi.17454
The objectives of this study were to assess the accuracy of parental seizure detection in infants with antenatally diagnosed tuberous sclerosis complex (TSC), and to document the total seizure burden (clinical and subclinical) in those patients who met criteria for prolonged electroencephalography (EEG) recording.
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries
Daniel M. Goldenholz, M. Brandon Westover
doi : 10.1111/epi.17471
A realistic seizure diary simulator is currently unavailable for many research needs, including clinical trial analysis and evaluation of seizure detection and seizure-forecasting tools.
Prospective, longitudinal, multicenter study on the provision of information regarding sudden unexpected death in epilepsy to adults with epilepsy
Nora-Elena Wadle, Christina Schwab, Carola Seifart, Felix von Podewils, Susanne Knake, Laurent M. Willems, Katja Menzler, Juliane Schulz, Nadine Conradi, Felix Rosenow, Adam Strzelczyk
doi : 10.1111/epi.17481
Despite increased awareness of the serious epilepsy complication sudden unexpected death in epilepsy (SUDEP), a substantial population of people with epilepsy (PWE) remain poorly informed.
Contribution of the μ-opioid receptor system to affective disorders in temporal lobe epilepsy: A bidirectional relationship?
Daichi Sone, Marian Galovic, Jim Myers, Georg Leonhardt, Ilan Rabiner, John S. Duncan, Matthias J. Koepp, Jacqueline Foong
doi : 10.1111/epi.17463
Affective disorders are frequent comorbidities of temporal lobe epilepsy (TLE). The endogenous opioid system has been implicated in both epilepsy and affective disorders, and may play a significant role in their bidirectional relationship.
Evaluating whole-brain tissue-property changes in MRI-negative pharmacoresistant focal epilepsies using MR fingerprinting
Ting-Yu Su, Yingying Tang, Joon Yul Choi, Siyuan Hu, Ken Sakaie, Hiroatsu Murakami, Stephen Jones, Ingmar Blümcke, Imad Najm, Dan Ma, Zhong Irene Wang
doi : 10.1111/epi.17488
We aim to quantify whole-brain tissue-property changes in patients with magnetic resonance imaging (MRI)–negative pharmacoresistant focal epilepsy by three-dimensional (3D) magnetic resonance fingerprinting (MRF).
De novo KCNA6 variants with attenuated KV1.6 channel deactivation in patients with epilepsy
Vincenzo Salpietro, Valentina Galassi Deforie, Stephanie Efthymiou, Emer O'Connor, Anna Marcé-Grau, Reza Maroofian, Pasquale Striano, Federico Zara, Michelle M. Morrow, SYNAPS Study Group, Adi Reich, Amy Blevins, Júlia Sala-Coromina, Andrea Accogli, Sara Fortuna, Marie Alesandrini, P. Y. Billie Au, Nilika Shah Singhal, Benjamin Cogne, Bertrand Isidor, Michael G. Hanna, Alfons Macaya, Dimitri M. Kullmann, Henry Houlden, Roope Männikkö
doi : 10.1111/epi.17455
Mutations in the genes encoding neuronal ion channels are a common cause of Mendelian neurological diseases. We sought to identify novel de novo sequence variants in cases with early infantile epileptic phenotypes and neurodevelopmental anomalies.
Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy
Andreea M. Pavel, John M. O'Toole, Jacopo Proietti, Vicki Livingstone, Subhabrata Mitra, William P. Marnane, Mikael Finder, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan, ANSeR Consortium
doi : 10.1111/epi.17468
To assess if early clinical and electroencephalography (EEG) features predict later seizure development in infants with hypoxic-ischemic encephalopathy (HIE).
Duration of epileptic seizure types: A data-driven approach
Pirgit Meritam Larsen, Stephan Wüstenhagen, Daniella Terney, Elena Gardella, Harald Aurlien, Sándor Beniczky
doi : 10.1111/epi.17492
To determine the duration of epileptic seizure types in patients who did not undergo withdrawal of antiseizure medication.
Latent class analysis of eHealth behaviors among adults with epilepsy
Dustin Kee, Nathalie Jetté, Leah J. Blank, Benjamin R. Kummer, Madhu Mazumdar, Parul Agarwal
doi : 10.1111/epi.17483
The objective of this study was to determine the proportions of uptake and factors associated with electronic health (eHealth) behaviors among adults with epilepsy.
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population
Payam Tabaee Damavandi, Benedetta Storti, Natalia Fabin, Elisa Bianchi, Carlo Ferrarese, Jacopo C. DiFrancesco
doi : 10.1111/epi.17489
Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous intracranial hemorrhage in older adults. Epilepsy represents a possible sequela of the disease. To date, studies on epilepsy in CAA are lacking, and the few data available mainly focus on CAA-related inflammation (CAA-ri), the inflammatory form of the disease.
Increased uptake of the P2X7 receptor radiotracer 18F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice
James Morgan, Oscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gómez-Vallejo, Jordi Llop, Tobias Engel
doi : 10.1111/epi.17484
The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released adenosine triphosphate. Expression of the P2X7R is increased in the brain in experimental and human epilepsy, and genetic or pharmacologic targeting of the receptor can reduce seizure frequency and severity in preclinical models.
Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy
Safwan K. Hyder, Anjik Ghosh, Patrick A. Forcelli
doi : 10.1111/epi.17469
Decades of studies have indicated that activation of the deep and intermediate layers of the superior colliculus can suppress seizures in a wide range of experimental models of epilepsy.
Epilepsia�February 2023�Announcements
doi : 10.1111/epi.17510
Perampanel, a noncompetitive antagonist of the postsynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor, is effective for controlling focal to bilateral tonic–clonic seizures but is also known to increase feelings of anger.
Verbal fluency functional magnetic resonance imaging detects anti-seizure effects and affective side effects of perampanel in people with focal epilepsy
Fenglai Xiao, Lorenzo Caciagli, Britta Wandschneider, Marine Fleury, Lawrence Binding, Davide Giampiccolo, Andrea Hill, Marian Galovic, Jaqueline Foong, Dong Zhou, Josemir W. Sander, John S. Duncan, Matthias J. Koepp
doi : 10.1111/epi.17493
Responsive neurostimulation with low-frequency stimulation
Juan Luis Alcala-Zermeno, Keith Starnes, Nicholas M. Gregg, Greg Worrell, Brian N. Lundstrom
doi : 10.1111/epi.17467
Deep brain stimulation and responsive neurostimulation (RNS) use high-frequency stimulation (HFS) per the pivotal trials and manufacturer-recommended therapy protocols.
Daily resting-state intracranial EEG connectivity for seizure risk forecasts
Louis Cousyn, Rémy Ben Messaoud, Katia Lehongre, Valerio Frazzini, Virginie Lambrecq, Claude Adam, Bertrand Mathon, Vincent Navarro, Mario Chavez
doi : 10.1111/epi.17480
Forecasting seizure risk aims to detect proictal states in which seizures would be more likely to occur. Classical seizure prediction models are trained over long-term electroencephalographic (EEG) recordings to detect specific preictal changes for each seizure, independently of those induced by shifts in states of vigilance.
