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Methotrexate Pulmonary Toxicity: Deep Inspiration
Joel M. Kremer
doi : 10.1002/art.41451
Volume72, Issue12,December 2020,Pages 1959-1962
Synergy Between Cytokines and Risk Factors in the Cytokine Storm of COVID?19: Does Ongoing Use of Cytokine Inhibitors Have a Protective Effect?
Pierre Miossec
doi : 10.1002/art.41458
Volume72, Issue12,December 2020,Pages 1963-1966
Damage Accrual in Rheumatoid Arthritis: Evaluating the Joint and Beyond
George E. Fragoulis,Katerina Chatziodionysiou,Elena Nikiphorou,Andrew Cope,Iain B. McInnes
doi : 10.1002/art.41449
Volume72, Issue12,December 2020,Pages 1967-1970
Cerebral Vertebral Artery Vasculitis Presenting as Neck Pain and Fever
Jonathan Broner,Benjamin Chambert,Erik Arnaud,Radjiv Goulabchand
doi : 10.1002/art.41448
Volume72, Issue12,December 2020,Pages 1970-1970
Leveraging the United States Epicenter to Provide Insights on COVID?19 in Patients With Systemic Lupus Erythematosus
Ruth Fernandez?Ruiz,Mala Masson,Mimi Y. Kim,Benjamin Myers,Rebecca H. Haberman,Rochelle Castillo,Jose U. Scher,Allison Guttmann,Philip M. Carlucci,Kristina K. Deonaraine,Michael Golpanian,Kimberly Robins,Miao Chang,H. Michael Belmont,Jill P. Buyon,Ashira D. Blazer,Amit Saxena,Peter M. Izmirly,on behalf of the NYU WARCOV Investigators
doi : 10.1002/art.41450
Volume72, Issue12,December 2020,Pages 1971-1980
To characterize patients with systemic lupus erythematosus (SLE) affected by coronavirus disease 2019 (COVID?19) and to analyze associations of comorbidities and medications on infection outcomes.
COVID?19 in Patients With Inflammatory Arthritis: A Prospective Study on the Effects of Comorbidities and Disease?Modifying Antirheumatic Drugs on Clinical Outcomes
Rebecca H. Haberman,Rochelle Castillo,Alan Chen,Di Yan,Deborah Ramirez,Vaish Sekar,Robert Lesser,Gary Solomon,Andrea L. Neimann,Rebecca B. Blank,Peter Izmirly,Dan E. Webster,Alexis Ogdie,Andrea B. Troxel,Samrachana Adhikari,Jose U. Scher,the NYU WARCOV Investigators
doi : 10.1002/art.41456
Volume72, Issue12,December 2020,Pages 1981-1989
To characterize the hospitalization and death rates among patients with inflammatory arthritis (IA) affected by coronavirus disease 2019 (COVID?19) and to analyze the associations of comorbidities and immunomodulatory medications with infection outcomes.
Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID?19: A Case Series
Iris Navarro?Mill?n,Sebastian E. Sattui,Amit Lakhanpal,Diane Zisa,Caroline H. Siegel,Mary K. Crow
doi : 10.1002/art.41422
Volume72, Issue12,December 2020,Pages 1990-1997
To report the clinical experience with anakinra in preventing mechanical ventilation in patients with coronavirus disease 2019 (COVID?19), symptoms of cytokine storm syndrome, and acute hypoxemic respiratory failure.
Antiphospholipid Antibodies in Critically Ill Patients With COVID?19
Meng Xiao,Yan Zhang,Shulan Zhang,Xuzhen Qin,Peng Xia,Wei Cao,Wei Jiang,Huan Chen,Xin Ding,Hua Zhao,Hongmin Zhang,...
doi : 10.1002/art.41425
Volume72, Issue12,December 2020,Pages 1998-2004
Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID?19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role in COVID?19 remains unclear. This study was undertaken to determine the prevalence and characteristics of aPLs in patients with COVID?19.
Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets
Willem J. J. Falkenburg,Nienke Oskam,Jana Koers,Laurette van Boheemen,Pleuni Ooijevaar?de Heer,Gwenny M. Verstappen,Hendrika Bootsma
doi : 10.1002/art.41430
Volume72, Issue12,December 2020,Pages 2005-2016
Rheumatoid factors (RFs), which are anti?IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and in healthy individuals. RFs bind to various epitopes in the constant (Fc?) domain of IgG.
Association of Dysregulated Central Pain Processing and Response to Disease–Modifying Antirheumatic Drug Therapy in Rheumatoid Arthritis
Andrew C. Heisler,Jing Song,Lutfiyya N. Muhammad,Alyssa Wohlfahrt,Wendy Marder,Marcy B. Bolster,Clifton O. Bingham III,Daniel J. Clauw
doi : 10.1002/art.41440
Volume72, Issue12,December 2020,Pages 2017-2024
To determine the association between dysregulated central pain processing and treatment response in rheumatoid arthritis (RA).
Autoantibodies to Malondialdehyde–Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies
Ted R. Mikuls,Jess Edison,Elizabeth Meeshaw,Harlan Sayles,Bryant R. England,Michael J. Duryee,Carlos D. Hunter,Lindsay B. Kelmenson,Laura Kay Moss,Marie L. Feser,Brandie Wagner,Mark C. Parish,Kevin D. Deane,Geoffrey M. Thiele
doi : 10.1002/art.41424
Volume72, Issue12,December 2020,Pages 2025-2029
To examine serum autoantibodies to malondialdehyde–acetaldehyde (MAA) prior to rheumatoid arthritis (RA) diagnosis.
MicroRNA?17?5p Reduces Inflammation and Bone Erosions in Mice With Collagen?Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast?like Synoviocytes
Aurélie Najm,François?Marie Masson,Pauline Preuss,Steven Georges,Benjamin Ory,Thibaut Quillard,Shatakshi Sood,Carl S. Goodyear,Douglas J. Veale
doi : 10.1002/art.41441
Volume72, Issue12,December 2020,Pages 2030-2039
We undertook this study to examine microRNA (miRNA) expression across rheumatoid arthritis (RA) phenotypes, along with the effects and mechanisms of action of miRNA?17?5p (miR?17).
Physiologic Target, Molecular Evolution, and Pathogenic Functions of a Monoclonal Anti–Citrullinated Protein Antibody Obtained From a Patient With Rheumatoid Arthritis
Tatsuhiko Ozawa,Kazuhisa Ouhara,Reina Tsuda,Syuichi Munenaga,Hidemi Kurihara,Hiroki Kohno,Hiroshi Hamana,Eiji Kobayashi,Hirofumi Taki
doi : 10.1002/art.41426
Volume72, Issue12,December 2020,Pages 2040-2049
In plasma from a patient with rheumatoid arthritis (RA), we previously isolated a human monoclonal anti–citrullinated protein antibody (ACPA), CCP?Ab1, that recognizes various citrullinated antigens. In this study, we aimed to explore the physiologic target of CCP?Ab1 and the role of molecular evolution, through affinity maturation, of this ACPA in the onset and the exacerbation of RA.
Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis
M. Margarida Souto?Carneiro,Karel D. Klika,M?nica T. Abreu,André P. Meyer,Rainer Saffrich,Roger Sandhoff,Richard Jennemann,Franziska V. Kraus
doi : 10.1002/art.41420
Volume72, Issue12,December 2020,Pages 2050-2064
CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient?poor microenvironment such as the synovial membrane. This study was undertaken to explore the mechanisms through which CD8+ T cells meet their metabolic demands in the blood and synovial membrane of patients with RA.
Pulmonary Adverse Events in Patients Receiving Low?Dose Methotrexate in the Randomized, Double?Blind, Placebo?Controlled Cardiovascular Inflammation Reduction Trial
Jeffrey A. Sparks,Paul F. Dellaripa,Robert J. Glynn,Nina P. Paynter,Chang Xu,Paul M. Ridker,Daniel H. Solomon
doi : 10.1002/art.41452
Volume72, Issue12,December 2020,Pages 2065-2071
We previously reported that low?dose methotrexate (MTX) was associated with an increased risk of pulmonary adverse events (AEs) in a large randomized, placebo?controlled trial. Herein, we report details on the predictors and severity of pulmonary AEs.
The Role of the Non?neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis
Alice Courties,Ariane Do,Sarah Leite,Manon Legris,Laure Sudre,Audrey Pigenet,Juliette Petit,Geoffroy Nourissat,Adeline Cambon?Binder,Uwe Maskos,Francis Berenbaum,Jérémie Sellam
doi : 10.1002/art.41429
Volume72, Issue12,December 2020,Pages 2072-2082
The non?neuronal cholinergic system represents non?neuronal cells that have the biochemical machinery to synthetize de novo and/or respond to acetylcholine (ACh). We undertook this study to investigate this biochemical machinery in chondrocytes and its involvement in osteoarthritis (OA).
Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis?
Isabell S. von Loga,Vicky Batchelor,Clare Driscoll,Annika Burleigh,Shi?Lu L. Chia,Bryony Stott,Jadwiga Miotla?Zarebska,David Riley
doi : 10.1002/art.41421
Volume72, Issue12,December 2020,Pages 2083-2093
Female C57BL/6 mice exhibit less severe chondropathy than male mice. This study was undertaken to test the robustness of this observation and explore underlying mechanisms.
Antibodies Against Three Novel Peptides in Early Axial Spondyloarthritis Patients From Two Independent Cohorts
Dana Quaden,Patrick Vandormael,Pieter Ruytinx,Piet Geusens,Kristoff Corten,Johan Vanhoof,Jori Liesenborgs,Frank van Reeth,Anouk Agten
doi : 10.1002/art.41427
Volume72, Issue12,December 2020,Pages 2094-2105
This study was undertaken to identify novel autoantibodies in axial spondyloarthritis (SpA) and determine their diagnostic potential in patients with early axial SpA and controls from 2 independent cohorts.
Taurine Metabolism Aggravates the Progression of Lupus by Promoting the Function of Plasmacytoid Dendritic Cells
Jun Li,Huihua Ding,Yao Meng,Guanhua Li,Qiong Fu,Qiang Guo,Zhihua Yin,Zhizhong Ye,Haibo Zhou,Nan Shen
doi : 10.1002/art.41419
Volume72, Issue12,December 2020,Pages 2106-2117
Type I interferons (IFNs) are critical in the development of systemic lupus erythematosus (SLE). Metabolic abnormalities cause dysregulation of multiple immune cells, but the metabolic regulation of type I IFN production is not well clarified in SLE. We undertook this study to define amino acid metabolism features in SLE and to explore the function of disease?relevant metabolites in the control of plasmacytoid dendritic cell (pDC)–mediated type I IFN production and the progression of SLE.
Effects of Gasdermin D in Modulating Murine Lupus and its Associated Organ Damage
Xinghao Wang,Luz P. Blanco,Carmelo Carmona?Rivera,Shuichiro Nakabo,Hege L. Pedersen,Zu?Xi Yu,Mariana J. Kaplan
doi : 10.1002/art.41444
Volume72, Issue12,December 2020,Pages 2118-2129
Gasdermin D (GSDMD) is the key executioner of an inflammatory cell death mechanism known as pyroptosis. Recent reports have also implicated GSDMD in other mechanisms of cell death, including apoptosis, necroptosis, and NETosis. Given the role of dysregulated cell death in autoimmune syndromes such as systemic lupus erythematosus (SLE), this study was undertaken in a murine lupus model to investigate whether GSDMD plays a pathogenic role in systemic autoimmunity by promoting inflammatory cell death, leading to increased generation of nuclear autoantigens and autoantibodies.
Anti–Neutrophil Extracellular Trap Antibodies and Impaired Neutrophil Extracellular Trap Degradation in Antiphospholipid Syndrome
Yu Zuo,Srilakshmi Yalavarthi,Kelsey Gockman,Jacqueline A. Madison,Johann E. Gudjonsson,J. Michelle Kahlenberg,W. Joseph McCune,Paula L. Bockenstedt,David R. Karp,Jason S. Knight
doi : 10.1002/art.41460
Volume72, Issue12,December 2020,Pages 2130-2135
The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils has recently been recognized to play an important role in antiphospholipid syndrome (APS). This study was undertaken to evaluate autoantibodies targeting NETs in patients with primary APS, and to determine their potential functions and clinical associations.
Error in Reported Baricitinib Dose in the Article by Meesilpavikkai et al (Arthritis Rheumatol, May 2019)
doi : 10.1002/art.41564
Volume72, Issue12,December 2020,Pages 2135-2135
No abstract is available for this article.
Error in Units of Measure on Figures in the Article by Li et al (Arthritis Rheumatol, July 2020)
doi : 10.1002/art.41606
Volume72, Issue12,December 2020,Pages 2135-2135
No abstract is available for this article.
Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma?like Vasculopathy in KLF5+/?;Fli?1+/? Mice
Kouki Nakamura,Takashi Taniguchi,Megumi Hirabayashi,Takashi Yamashita,Ryosuke Saigusa,Shunsuke Miura,Takehiro Takahashi,Tetsuo Toyama,Yohei Ichimura
doi : 10.1002/art.41423
Volume72, Issue12,December 2020,Pages 2136-2146
In prevous studies, we established a new animal model, KLF5+/?;Fli?1+/? mice, in which fundamental pathologic features of systemic sclerosis (SSc) are broadly recapitulated. SSc vasculopathy is believed to occur as a result of impaired vascular remodeling, but its detailed mechanism of action remains unknown.
Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results From an Open?Label, Active?Treatment Extension Study
Hermine I. Brunner,Pierre Quartier,Ekaterina Alexeeva,Tamàs Constantin,Isabelle Koné?Paut,Katherine Marzan,Rayfel Schneider,Nico M. Wulffraat,Vyacheslav Chasnyk
doi : 10.1002/art.41436
Volume72, Issue12,December 2020,Pages 2147-2158
To evaluate the long?term efficacy and safety of canakinumab and explore prediction of response in patients with systemic juvenile idiopathic arthritis (JIA) with or without fever at treatment initiation.
Proteomic mapping of rheumatoid factors in early rheumatoid arthritis
Jing J. Wang,Adrian Y.S. Lee,Alex D. Colella,Tim K. Chataway,Tom P. Gordon,Mihir D. Wechalekar
doi : 10.1002/art.41446
Volume72, Issue12,December 2020,Pages 2159-2161
JNK Pathway as a Target for Osteoarthritis: Comment on the Article by Loeser et al
Wang?Dong Xu,An?Fang Huang
doi : 10.1002/art.41432
Volume72, Issue12,December 2020,Pages 2162-2162
Reply
Richard F. Loeser,John A. Collins,Brian O. Diekman,Cathy S. Carlson
doi : 10.1002/art.41431
Volume72, Issue12,December 2020,Pages 2162-2163
Challenges in Systematic Reviews That Include Observational Studies: Comment on the Article by Karmacharya et al
Yan Luo,Satoshi Funada,Takashi Yoshioka,Toshi A. Furukawa
doi : 10.1002/art.41442
Volume72, Issue12,December 2020,Pages 2163-2164
Reply
Paras Karmacharya,Ali Duarte-Garcia,M. Hassan Murad,Maureen Dubreuil,Ravi Shahukhal,Pragya Shrestha,Elena Myasoedova,Cynthia S. Crowson,Kerry Wright,John M. Davis III
doi : 10.1002/art.41443
Volume72, Issue12,December 2020,Pages 2164-2165
Do Hydroxychloroquine Blood Levels and Dose Identify Different Populations at Risk of Retinopathy? Comment on the Article by Petri et al
Michael R. Bubb
doi : 10.1002/art.41464
Volume72, Issue12,December 2020,Pages 2165-2166
Reply
Michelle Petri,Jessica Li,Marwa Elkhalifa,Laurence S. Magder,Daniel W. Goldman
doi : 10.1002/art.41462
Volume72, Issue12,December 2020,Pages 2166-2166
Early Recognition of Relapsing Polychondritis: Comment on the Article by Ferrada et al
Lei Zhang,Tianfang Li,Shengyun Liu,Xiaojun Liu
doi : 10.1002/art.41439
Volume72, Issue12,December 2020,Pages 2166-2167
Reply
Marcela A. Ferrada,Peter C. Grayson
doi : 10.1002/art.41438
Volume72, Issue12,December 2020,Pages 2167-2168
IgG4?Related Orbital Pseudotumor
Wen?Chi Wu,Hsien?Tzung Liao
doi : 10.1002/art.41465
Volume72, Issue12,December 2020,Pages 2168-2168
