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European Crohn’s and Colitis Guidelines on Sexuality, Fertility, Pregnancy, and Lactation
Joana Torres, MarÃa Chaparro, Mette Julsgaard, Konstantinos Katsanos, Zuzana Zelinkova, Manasi Agrawal, Sandro Ardizzone, Marjo Campmans-Kuijpers, Gabriele Dragoni, Marc Ferrante, Gionata Fiorino, Emma Flanagan, Catarina Frias Gomes, Ailsa Hart, Charlotte Rose Hedin, Pascal Juillerat, Annemarie Mulders, Pär Myrelid, Aoibhlinn O’Toole, Pauline Rivière, Michael Scharl, Christian Philipp Selinger, Elena Sonnenberg, Murat Toruner, Jantien Wieringa, C Janneke Van der Woude
doi : 10.1093/ecco-jcc/jjac115
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 1–27
IBD Risk—It Is All in the Family!
Mohmmed Tauseef Sharip, Sreedhar Subramanian
doi : 10.1093/ecco-jcc/jjac118
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 28–29
Risk Factors for Developing Inflammatory Bowel Disease Within and Across Families with a Family History of IBD
Joana Torres, Catarina Gomes, Camilla B Jensen, Manasi Agrawal, Francisco Ribeiro-Mourão, Tine Jess, Jean-Frédéric Colombel, Kristine H Allin, Johan Burisch
doi : 10.1093/ecco-jcc/jjac111
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 30–36
A family history of inflammatory bowel disease [IBD] is the strongest risk factor for disease. However, some first-degree relatives (FDRs) will develop disease, while others will not.
The Impact of COVID-19 on Patients with IBD in a Prospective European Cohort Study
Aurelien Amiot, Jean-Francois Rahier, Filip Baert, Stephane Nahon, Ailsa Hart, Nikos Viazis, Livia Biancone, Eugeni Domenech, Catherine Reenears, Laurent Peyrin-Biroulet, Laurent Beaugerie, Johan Burisch, I-CARE collaborator group
doi : 10.1093/ecco-jcc/jjac091
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 37–48
There are concerns regarding the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease [IBD]. We report on the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD
Chromosomal Numerical Aberrations and Rare Copy Number Variation in Patients with Inflammatory Bowel Disease
Paulina Dirvanskyte, Bhaskar Gurram, Chrissy Bolton, Neil Warner, Kelsey D J Jones, Helen R Griffin, Genomics England Research Consortium, Jason Y Park, Klaus-Michael Keller, Kimberly C Gilmour, Sophie Hambleton, Aleixo M Muise, Christian Wysocki, Holm H Uhlig
doi : 10.1093/ecco-jcc/jjac103
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 49–60
Inflammatory bowel diseases [IBD] have a complex polygenic aetiology. Rare genetic variants can cause monogenic intestinal inflammation. The impact of chromosomal aberrations and large structural abnormalities on IBD susceptibility is not clear. We aimed to comprehensively characterise the phenotype and prevalence of patients with IBD who possess rare numerical and structural chromosomal abnormalities.
Successful Dietary Therapy in Paediatric Crohn’s Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards Healthy Controls
Charlotte M Verburgt, Katherine A Dunn, Mohammed Ghiboub, James D Lewis, Eytan Wine, Rotem Sigall Boneh, Konstantinos Gerasimidis, Raanan Shamir, Susanne Penny, Devanand M Pinto, Alejandro Cohen, Paul Bjorndahl, Vaios Svolos, Joseph P Bielawski, Marc A Benninga, Wouter J de Jonge, Johan E Van Limbergen
doi : 10.1093/ecco-jcc/jjac105
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 61–72
Nutritional therapy with the Crohn’s Disease Exclusion Diet + Partial Enteral Nutrition [CDED+PEN] or Exclusive Enteral Nutrition [EEN] induces remission and reduces inflammation in mild-to-moderate paediatric Crohn’s disease [CD]. We aimed to assess if reaching remission with nutritional therapy is mediated by correcting compositional or functional dysbiosis.
Risk Prediction for Complications in Inflammatory Bowel Disease Surgery: External Validation of the American College of Surgeons’ National Surgical Quality Improvement Program Surgical Risk Calculator
Viviane Lin, Seyma Gögenur, Frederik Pachler, Tina Fransgaard, Ismail Gögenur
doi : 10.1093/ecco-jcc/jjac114
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 73–82
Many patients with inflammatory bowel disease [IBD] require surgery during their disease course. Having individual risk predictions available prior to surgery could aid in better informed decision making for personalised treatment trajectories in IBD surgery.
Effectiveness and Safety of Ustekinumab in Elderly Patients with Crohn’s Disease: Real World Evidence From the ENEIDA Registry
Diego Casas-Deza, Luis Javier Lamuela-Calvo, Fernando Gomollón, José Miguel Arbonés-Mainar, Berta Caballol, Javier P Gisbert, Montserrat Rivero, Eugenia Sánchez-RodrÃguez, Lara Arias GarcÃa, Ana Gutiérrez Casbas, Olga Merino, LucÃa Márquez, Viviana Laredo, MarÃa Dolores MartÃn-Arranz, Pilar López Serrano, Sabino Riestra Menéndez, Carlos González-Muñoza, Luisa de Castro Parga, Marta Calvo Moya, Esteban Fuentes-Valenzuela, Maria Esteve, Marisa Iborra, Miguel Dura Gil, Manuel Barreiro-De Acosta, Rufo Humberto Lorente-Poyatos, Noemà Manceñido, Margalida Calafat, Iago RodrÃguez-Lago, Jordi Guardiola Capo, Maria Antonia Payeras, VÃctor Jair Morales Alvarado, Carlos Tardillo, Luis Bujanda, José Fernando Muñoz-Nuñez, Yolanda Ber Nieto, Fernando Bermejo, Pedro Almela, Mercè Navarro-Llavat, Pilar MartÃnez Montiel, Cristina RodrÃguez Gutiérrez, Manuel Van Domselaar, Eva Sesé, Teresa MartÃnez Pérez, Elena Ricart, MarÃa Chaparro, MarÃa José GarcÃa, Antonio López-Sanromán, Beatriz Sicilia, Beatriz Orts, Alicia López-GarcÃa, Eduardo MartÃn-Arranz, José Lázaro Pérez-Calle, Ruth de Francisco, Esther GarcÃa-Planella, Eugeni Domènech, y Santiago GarcÃa-López on behalf of the ENEIDA Registry by GETECCU
doi : 10.1093/ecco-jcc/jjac108
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 83–91
Clinical trials and real-life studies with ustekinumab in Crohn’s disease [CD] have revealed a good efficacy and safety profile. However, these data are scarcely available in elderly patients. Therefore, we aim to assess the effectiveness and safety of ustekinumab in elderly patients with CD.
Proteomic Analysis Identifies Three Reliable Biomarkers of Intestinal Inflammation in the Stools of Patients With Inflammatory Bowel Disease
Roberta Vitali, Francesca Palone, Alessandro Armuzzi, Valerio Fulci, Anna Negroni, Claudia Carissimi, Salvatore Cucchiara, Laura Stronati
doi : 10.1093/ecco-jcc/jjac110
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 92–102,
Faecal biomarkers have emerged as important tools in managing of inflammatory bowel disease [IBD], which includes Crohn’s disease [CD] and ulcerative colitis [UC].
Venous Thromboembolism Following Discharge from Hospital in Patients Admitted for Inflammatory Bowel Disease
Philip R Harvey, Benjamin Coupland, Jemma Mytton, Shanika De Silva, Nigel J Trudgill
doi : 10.1093/ecco-jcc/jjac112
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 103–110
Patients admitted to hospital with inflammatory bowel disease[IBD] are at increased risk of venous thromboembolism[VTE]. This study aims to identify IBD patients at increased VTE risk on hospital discharge and to develop a risk scoring system to recognise them.
A Protective Role of NOD2 on Oxazolone-induced Intestinal Inflammation Through IL-1β-mediated Signalling Pathway
Thomas Secher, Aurélie Couturier, Ludovic Huot, Helene Bouscayrol, Teddy Grandjean, Olivier Boulard, David Hot, Bernhard Ryffel, Mathias Chamaillard
doi : 10.1093/ecco-jcc/jjac106
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 111–122
NOD2 has emerged as a critical player in the induction of both Th1 and Th2 responses for potentiation and polarisation of antigen-dependent immunity.
Placebo Rates in Randomized Controlled Trials of Proctitis Therapy: A Systematic Review and Meta-Analysis Placebo Response in Proctitis
Theshani A De Silva, Lotus Alphonsus, Christopher Ma, Malcolm Hogan, Rocio Sedano, Neeraj Narula, Silvio Danese, Laurent Peyrin-Biroulet, John K MacDonald, Siddharth Singh, Vipul Jairath
doi : 10.1093/ecco-jcc/jjac109
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 123–136
Treatment options for proctitis are limited. To assist trial design for novel therapeutics, we conducted a systematic review and meta-analysis of proctitis randomized controlled trials [RCTs] to quantify placebo rates and identify factors influencing them.
Available Methods for Benefit-risk Assessment: Lessons for Inflammatory Bowel Disease Drugs
Bénédicte Caron, Ferdinando D’Amico, Vipul Jairath, Patrick Netter, Silvio Danese, Laurent Peyrin-Biroulet
doi : 10.1093/ecco-jcc/jjac113
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 137–143
Medical treatment for inflammatory bowel disease has advanced significantly over the two past decades. The advent of biologics and small molecules has revolutionised outcomes for patients with inflammatory bowel disease.
Ustekinumab-Induced Inflammatory Demyelinating Polyneuropathy in a Patient with Ulcerative Colitis
Sailish Honap, Peter M Irving, Mark A Samaan
doi : 10.1093/ecco-jcc/jjac116
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 144–145
Evaluating Discriminative Accuracy of Biomarkers in Relation to Binary Study Outcomes: First Validate, Then Celebrate?
Arno R Bourgonje
doi : 10.1093/ecco-jcc/jjac117
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Page 146
Response to: Evaluating Discriminative Accuracy of Biomarkers in Relation to Binary Study Outcomes: First Validate, Then Celebrate?
Akhilesh Swaminathan, Chris M Frampton, Grace M Borichevsky, Anthony J Kettle, Richard B Gearry
doi : 10.1093/ecco-jcc/jjac126
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Pages 147–148
Correction
doi : 10.1093/ecco-jcc/jjac104
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Page 149
Corrigendum to: P169 Vitamin D levels are inversely associated with inflammation in pediatric Inflammatory Bowel Disease patients
doi : 10.1093/ecco-jcc/jjac107
Journal of Crohn's and Colitis, Volume 17, Issue 1, January 2023, Page 150
