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COP27 climate change conference: urgent action needed for Africa and the world
Chris Zielinski
doi : 10.1136/bjo-2022-322731
Review of glaucoma medication adherence monitoring in the digital health era
Alaa Erras, Bita Shahrvini, Robert N Weinreb, Sally L Baxter
doi : 10.1136/bjophthalmol-2020-317918
Current glaucoma treatments aim to lower intraocular pressure, often with topical ocular hypotensive medications. Unfortunately, the effectiveness of these medications depends on sustained patient adherence to regimens which may involve instilling multiple medications several times daily.
Interventions recommended for myopia prevention and control among children and adolescents in China: a systematic review
Zhuoting Zhu, Yanxian Chen, Zachary Tan, Ruilin Xiong, Myra Beth McGuinness, Andreas Müller
doi : 10.1136/bjophthalmol-2021-319306
In 2018, a consortium of government bodies in China led by the Ministry of Education released the Comprehensive Plan to Prevent Nearsightedness among Children and Teenagers (CPPNCT), aiming to reduce the incidence of myopia and control myopic progression in China.
Normative data and percentile curves for axial length and axial length/corneal curvature in Chinese children and adolescents aged 4–18 years
Xiangui He, Padmaja Sankaridurg, Thomas Naduvilath, Jingjing Wang, Shuyu Xiong, Rebecca Weng, Linlin Du, Jun Chen, Haidong Zou, Xun Xu
doi : 10.1136/bjophthalmol-2021-319431
Purpose To develop age-specific and gender-specific reference percentile charts for axial length (AL) and AL/corneal radius of curvature (AL/CR) and, to use percentiles to determine probability of myopia and estimate refractive error (RE).
Progression of keratoconus in children and adolescents
Jay J Meyer, Akilesh Gokul, Hans R Vellara, Charles N J McGhee
doi : 10.1136/bjophthalmol-2020-316481
Aims To evaluate the rates of keratoconus progression and associated factors in eyes of children and adolescents.
Dropless penetrating keratoplasty using a subconjunctival dexamethasone implant: safety pilot study
Marie Caroline Trone, Sylvain Poinard, Emmanuel Crouzet, Thibaud Garcin, Marielle Mentek, Fabien Forest, Marie Matray, Gilles Thuret, Philippe Gain
doi : 10.1136/bjophthalmol-2021-319376
Background/aim Rejection is the main cause of graft failure after penetrating keratoplasty (PK). Its prevention by repeated instillation of steroid eye-drops has not evolved in decades. Poor adherence and discontinuous nature of eye-drop treatment may explain some PK failures. In a rabbit model, we previously demonstrated that a subconjunctival dexamethasone implant was well tolerated and prevented rejection efficiently in the first 5–6 weeks. This clinical trial investigates its tolerance and safety after PK.
Prognostic significance of matrix metalloproteinase 9 in COMET operated chronic ocular Stevens-Johnson syndrome
Renu Venugopal, Namrata Sharma, Seema Sen, Sujata Mohanty, Seema Kashyap, Tushar Agarwal, Jasbir Kaur, Rasik B Vajpayee
doi : 10.1136/bjophthalmol-2021-319302
Purpose Molecular pathogenesis underlying persistent ocular surface inflammation in chronic Stevens-Johnson syndrome (SJS) still remains largely unexplored.
Morphological variants of meibomian glands: correlation of meibography features with histopathology findings
Swati Singh, Gorrepati C Naidu, Geeta Vemuganti, Sayan Basu
doi : 10.1136/bjophthalmol-2021-318876
Purpose This study describes the histopathological features of different morphological variants of human meibomian glands (MGs) seen on infrared imaging.
Big-data and artificial-intelligence-assisted vault prediction and EVO-ICL size selection for myopia correction
Yang Shen, Lin Wang, Weijun Jian, Jianmin Shang, Xin Wang, Lie Ju, Meiyan Li, Jing Zhao, Xun Chen, Zongyuan Ge, Xiaoying Wang, Xingtao Zhou
doi : 10.1136/bjophthalmol-2021-319618
Aims To predict the vault and the EVO-implantable collamer lens (ICL) size by artificial intelligence (AI) and big data analytics.
Central macular OCTA parameters in glaucoma
Takashi Nishida, Won Hyuk Oh, Sasan Moghimi, Adeleh Yarmohammadi, Huiyuan Hou, Ryan Caezar C David, Alireza Kamalipour, Takuhei Shoji, Nevin El-Nimri, Jasmin Rezapour, Linda M Zangwill, Robert N Weinreb
doi : 10.1136/bjophthalmol-2021-319574
Background/aims To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects.
Glucagon-like peptide 1 receptor agonist use is associated with reduced risk for glaucoma
Jacob Sterling, Peiying Hua, Joshua L Dunaief, Qi N Cui, Brian L VanderBeek
doi : 10.1136/bjophthalmol-2021-319232
Background/aims Glucagon-like peptide-1 receptor (GLP-1R) agonists regulate blood glucose and are commonly used to treat type 2 diabetes mellitus.
Low-dose transscleral cyclophotocoagulation with subsequent phacoemulsification in the treatment of prolonged acute primary angle closure
Yan Shi, Julius Oatts, Jiaxin Tian, Chunyan Qiao, Qing Zhang, Ying Han, Ningli Wang
doi : 10.1136/bjophthalmol-2021-318880
Background To explore the outcomes and mechanisms of intraocular pressure (IOP) control using low-dose transscleral cyclophotocoagulation (LDTSCP) followed by phacoemulsification in patients with prolonged acute primary angle closure (APAC).
CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma
Sushmita Kaushik, Manni Luthra-Guptasarma, Dimple Prasher, Deepika Dhingra, Nirbhai Singh, Aman Kumar, Surya Prakash Sharma, Harpreet Kaur, Sagarika Snehi, Faisal Thattaruthody, Surinder Singh Pandav
doi : 10.1136/bjophthalmol-2020-318563
Objective To compare CYP1B1 and MYOC variants in a cohort of neonatal-onset (NO) and infantile-onset (IO) primary congenital glaucoma (PCG).
Spectral domain optical coherence tomography-based retinochoroidal cystine crystal score: a window into infantile nephropathic cystinosis
Leonie Keidel, Katharina Hohenfellner, Benedikt Schworm, Siegfried Priglinger, Nikolaus Luft, Claudia Priglinger
doi : 10.1136/bjophthalmol-2021-319612
Précis Cystinosis is a lysosomal storage disease leading to an accumulation of cystine crystals in several organs. We aim to comprehensively describe chorioretinal cystine crystals via spectral domain optical coherence tomography (SD-OCT) and elaborate a new biomarker for systemic disease control.
Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age
Liangbo L Shen, Shwetha Mangalesh, Suzanne M Michalak, Brendan McGeehan, Neeru Sarin, Joanne Finkle, Katrina P Winter, Du Tran-Viet, Eric J Benner, Lejla Vajzovic, Sharon F Freedman, Noelle Younge, C Michael Cotten, Mays El-Dairi, Gui-Shuang Ying, Cynthia Toth
doi : 10.1136/bjophthalmol-2021-319254
Background/aims Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thickness in preterm infants.
Charles Bonnet syndrome in patients with Stargardt disease: prevalence and risk factors
Patty P A Dhooge, Rob J Teunisse, Bart Liefers, Stanley Lambertus, Nathalie M Bax, Carel B Hoyng, Johannes R M Cruysberg, B Jeroen Klevering
doi : 10.1136/bjophthalmol-2021-319525
Aims To describe the prevalence of the Charles Bonnet syndrome (CBS) and search for potential CBS risk factors in a Dutch Stargardt disease (STGD1) cohort.
Contrast sensitivity and quality of life following intravitreal ranibizumab injection for central retinal vein occlusion
Tomoya Murakami, Fumiki Okamoto, Yoshimi Sugiura, Shohei Morikawa, Yoshifumi Okamoto, Takahiro Hiraoka, Tetsuro Oshika
doi : 10.1136/bjophthalmol-2021-319863
Synopsis/precis We investigated the relationship between contrast sensitivity (CS) and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion following ranibizumab intravitreal injection; CS showed a stronger association with VR-QOL than visual acuity.
Associations of systemic health and medication use with the enlargement rate of geographic atrophy in age-related macular degeneration
Liangbo L Shen, Yangyiran Xie, Mengyuan Sun, Aneesha Ahluwalia, Michael M Park, Benjamin K Young, Lucian V Del Priore
doi : 10.1136/bjophthalmol-2021-319426
Background The associations of geographic atrophy (GA) progression with systemic health status and medication use are unclear.
Predicting the immediate impact of national lockdown on neovascular age-related macular degeneration and associated visual morbidity: an INSIGHT Health Data Research Hub for Eye Health report
Susan P Mollan, Dun Jack Fu, Ching-Yi Chuo, Jacqueline G Gannon, Wen Hwa Lee, J Jill Hopkins, Cian Hughes, Alastair K Denniston, Pearse A Keane, Ronald Cantrell
doi : 10.1136/bjophthalmol-2021-319383
Objective Predicting the impact of neovascular age-related macular degeneration (nAMD) service disruption on visual outcomes following national lockdown in the UK to contain SARS-CoV-2.
Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
Xianwen Shang, Zhuoting Zhu, Yu Huang, Xueli Zhang, Wei Wang, Danli Shi, Yu Jiang, Xiaohong Yang, Mingguang He
doi : 10.1136/bjophthalmol-2021-319508
Aims To examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia.
Change in the ophthalmoscopical optic disc size and shape in a 10-year follow-up: the Beijing Eye Study 2001–2011
Jost B Jonas, Qi Zhang, Liang Xu, Wen Bin Wei, Rahul A Jonas, Ya Xing Wang
doi : 10.1136/bjophthalmol-2021-319632
Background To assess prevalence and associated factors of changes in the ophthalmoscopic optic disc size and shape.
Dacryolithiasis diagnosis and treatment: a 25-year experience using nasal endoscopy
Alexis Khorrami Kashi, Chafik Keilani, Thien-Huong Nguyen, Pierre Keller, Sina Elahi, Jean-Marie Piaton
doi : 10.1136/bjophthalmol-2021-319671
Background Dacryolith-induced epiphora is caused by a chronic obstruction of the nasolacrimal duct whose aetiology is often specified peroperatively.
Changing trends in ocular trauma during the COVID-19 pandemic in the USA
Omar A Halawa, David S Friedman, Ana M Roldan, Nazlee Zebardast
doi : 10.1136/bjophthalmol-2021-319627
Background/aims The COVID-19 pandemic has been associated with a decline in emergency department (ED) presentations for trauma. The purpose of this study is to compare the estimated number and characteristics of eye injuries in 2020, the year of the COVID-19 pandemic, to those in 2011–2019.
